3K83A

Crystal structure analysis of a biphenyl/oxazole/carboxypyridine alpha-ketoheterocycle inhibitor bound to a humanized variant of fatty acid amide hydrolase
Total Genus 222
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
222
sequence length
546
structure length
546
Chain Sequence
GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSTGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNNMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase.
pubmed doi rcsb
molecule tags Hydrolase
source organism Rattus norvegicus
molecule keywords Fatty-acid amide hydrolase 1
total genus 222
structure length 546
sequence length 546
chains with identical sequence B
ec nomenclature ec 3.5.1.99: Fatty acid amide hydrolase.
pdb deposition date 2009-10-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01425 Amidase Amidase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1300.10 Alpha Beta Alpha-Beta Complex Amidase signature (AS) enzymes Amidase signature (AS) domain 3k83A00
3A1KA 3QKVA 4GYRA 3A2QA 1OBJA 4HBPA 3LJ6A 2WJ1A 1OCKA 5EWQA 3AL0A 4WJ3A 2WJ2A 1M22A 1OBIA 3KFUE 3H0MA 3K84A 4DO3A 3A2PA 2F2AA 3PR0A 4YJ6A 4ISTA 4N0HA 2WAPA 3A1IA 3QJ8A 3H0LA 3QJ9A 2DC0A 4YJIA 1MT5A 3LJ7A 4ISSA 4CP8A 2VYAA 1OBLA 1OBKA 3OJ8A 3QK5A 3K83A 4GYSA 2DF4A 2G5HA 1O9OA 5AC3A 1OCLA 1OCHA 2DQNA 3H0RA 1O9PA 3IP4A 3K7FA 3PPMA 4N0IA 1O9NA 2GI3A 1M21A 1O9QA 4J5PA 1OCMA 2G5IA
chains in the Genus database with same CATH superfamily
3A1KA 3QKVA 4GYRA 3A2QA 1OBJA 4HBPA 3LJ6A 2WJ1A 1OCKA 5EWQA 3AL0A 4WJ3A 2WJ2A 1M22A 1OBIA 3KFUE 3H0MA 3K84A 4DO3A 3A2PA 2F2AA 3PR0A 4YJ6A 4ISTA 4N0HA 2WAPA 3A1IA 3QJ8A 3H0LA 3QJ9A 2DC0A 4YJIA 1MT5A 3LJ7A 4ISSA 4CP8A 2VYAA 1OBLA 1OBKA 3OJ8A 3QK5A 3K83A 4GYSA 2DF4A 2G5HA 1O9OA 5AC3A 1OCLA 1OCHA 2DQNA 3H0RA 1O9PA 3IP4A 3K7FA 3PPMA 4N0IA 1O9NA 2GI3A 1M21A 1O9QA 4J5PA 1OCMA 2G5IA
chains in the Genus database with same CATH topology
3A1KA 3QKVA 4GYRA 3A2QA 1OBJA 4HBPA 3LJ6A 2WJ1A 1OCKA 5EWQA 3AL0A 4WJ3A 2WJ2A 1M22A 1OBIA 3KFUE 3H0MA 3K84A 4DO3A 3A2PA 2F2AA 3PR0A 4YJ6A 4ISTA 4N0HA 2WAPA 3A1IA 3QJ8A 3H0LA 3QJ9A 2DC0A 4YJIA 1MT5A 3LJ7A 4ISSA 4CP8A 2VYAA 1OBLA 1OBKA 3OJ8A 3QK5A 3K83A 4GYSA 2DF4A 2G5HA 1O9OA 5AC3A 1OCLA 1OCHA 2DQNA 3H0RA 1O9PA 3IP4A 3K7FA 3PPMA 4N0IA 1O9NA 2GI3A 1M21A 1O9QA 4J5PA 1OCMA 2G5IA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3A1K A;  3QKV A;  4GYR A;  3A2Q A;  1OBJ A;  4HBP A;  3LJ6 A;  2WJ1 A;  1OCK A;  5EWQ A;  3AL0 A;  4WJ3 A;  2WJ2 A;  1M22 A;  1OBI A;  3KFU E;  3H0M A;  3K84 A;  4DO3 A;  3A2P A;  2F2A A;  3PR0 A;  4YJ6 A;  4IST A;  4N0H A;  2WAP A;  3A1I A;  3QJ8 A;  3H0L A;  3QJ9 A;  2DC0 A;  4YJI A;  1MT5 A;  3LJ7 A;  4ISS A;  4CP8 A;  2VYA A;  1OBL A;  1OBK A;  3OJ8 A;  3QK5 A;  3K83 A;  4GYS A;  2DF4 A;  2G5H A;  1O9O A;  5AC3 A;  1OCL A;  1OCH A;  2DQN A;  3H0R A;  1O9P A;  3IP4 A;  3K7F A;  3PPM A;  4N0I A;  1O9N A;  2GI3 A;  1M21 A;  1O9Q A;  4J5P A;  1OCM A;  2G5I A; 
#chains in the Genus database with same CATH topology
 3A1K A;  3QKV A;  4GYR A;  3A2Q A;  1OBJ A;  4HBP A;  3LJ6 A;  2WJ1 A;  1OCK A;  5EWQ A;  3AL0 A;  4WJ3 A;  2WJ2 A;  1M22 A;  1OBI A;  3KFU E;  3H0M A;  3K84 A;  4DO3 A;  3A2P A;  2F2A A;  3PR0 A;  4YJ6 A;  4IST A;  4N0H A;  2WAP A;  3A1I A;  3QJ8 A;  3H0L A;  3QJ9 A;  2DC0 A;  4YJI A;  1MT5 A;  3LJ7 A;  4ISS A;  4CP8 A;  2VYA A;  1OBL A;  1OBK A;  3OJ8 A;  3QK5 A;  3K83 A;  4GYS A;  2DF4 A;  2G5H A;  1O9O A;  5AC3 A;  1OCL A;  1OCH A;  2DQN A;  3H0R A;  1O9P A;  3IP4 A;  3K7F A;  3PPM A;  4N0I A;  1O9N A;  2GI3 A;  1M21 A;  1O9Q A;  4J5P A;  1OCM A;  2G5I A; 
#chains in the Genus database with same CATH homology
 3A1K A;  3QKV A;  4GYR A;  3A2Q A;  1OBJ A;  4HBP A;  3LJ6 A;  2WJ1 A;  1OCK A;  5EWQ A;  3AL0 A;  4WJ3 A;  2WJ2 A;  1M22 A;  1OBI A;  3KFU E;  3H0M A;  3K84 A;  4DO3 A;  3A2P A;  2F2A A;  3PR0 A;  4YJ6 A;  4IST A;  4N0H A;  2WAP A;  3A1I A;  3QJ8 A;  3H0L A;  3QJ9 A;  2DC0 A;  4YJI A;  1MT5 A;  3LJ7 A;  4ISS A;  4CP8 A;  2VYA A;  1OBL A;  1OBK A;  3OJ8 A;  3QK5 A;  3K83 A;  4GYS A;  2DF4 A;  2G5H A;  1O9O A;  5AC3 A;  1OCL A;  1OCH A;  2DQN A;  3H0R A;  1O9P A;  3IP4 A;  3K7F A;  3PPM A;  4N0I A;  1O9N A;  2GI3 A;  1M21 A;  1O9Q A;  4J5P A;  1OCM A;  2G5I A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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