3PR0A

Crystal structure of a covalently bound alpha-ketoheterocycle inhibitor (phenhexyl/oxadiazole/pyridine) to a humanized variant of fatty acid amide hydrolase
Total Genus 225
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
225
sequence length
545
structure length
545
Chain Sequence
GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSTGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNNMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/hydrolase inhibitor
source organism Rattus norvegicus
publication title Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent alpha-ketoheterocycle inhibitor of fatty acid amide hydrolase.
pubmed doi rcsb
molecule keywords Fatty Acid Amide Hydrolase 1
total genus 225
structure length 545
sequence length 545
chains with identical sequence B
ec nomenclature ec 3.5.1.99: Fatty acid amide hydrolase.
pdb deposition date 2010-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01425 Amidase Amidase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1300.10 Alpha Beta Alpha-Beta Complex Amidase signature (AS) enzymes Amidase signature (AS) domain 3pr0A00
3OJ8A 4GYSA 2DF4A 2G5IA 3A2PA 3K84A 4ISTA 1OCLA 4ISSA 3KFUE 3QKVA 3QJ9A 2WJ1A 4HBPA 1M22A 3A1IA 2GI3A 2WAPA 3IP4A 4WJ3A 3PR0A 4J5PA 3A2QA 3A1KA 4CP8A 1M21A 2G5HA 3QK5A 3LJ6A 1OCKA 3QJ8A 4YJIA 2F2AA 1OBIA 2WJ2A 4N0HA 3AL0A 1O9QA 1OCHA 3K7FA 1O9OA 3K83A 2DC0A 3H0LA 3H0MA 4DO3A 1OCMA 1MT5A 3H0RA 2VYAA 4GYRA 4YJ6A 3PPMA 4N0IA 5EWQA 1OBLA 2DQNA 1OBJA 3LJ7A 5AC3A 1OBKA 1O9NA 1O9PA
chains in the Genus database with same CATH superfamily
3OJ8A 4GYSA 2DF4A 2G5IA 3A2PA 3K84A 4ISTA 1OCLA 4ISSA 3KFUE 3QKVA 3QJ9A 2WJ1A 4HBPA 1M22A 3A1IA 2GI3A 2WAPA 3IP4A 4WJ3A 3PR0A 4J5PA 3A2QA 3A1KA 4CP8A 1M21A 2G5HA 3QK5A 3LJ6A 1OCKA 3QJ8A 4YJIA 2F2AA 1OBIA 2WJ2A 4N0HA 3AL0A 1O9QA 1OCHA 3K7FA 1O9OA 3K83A 2DC0A 3H0LA 3H0MA 4DO3A 1OCMA 1MT5A 3H0RA 2VYAA 4GYRA 4YJ6A 3PPMA 4N0IA 5EWQA 1OBLA 2DQNA 1OBJA 3LJ7A 5AC3A 1OBKA 1O9NA 1O9PA
chains in the Genus database with same CATH topology
3OJ8A 4GYSA 2DF4A 2G5IA 3A2PA 3K84A 4ISTA 1OCLA 4ISSA 3KFUE 3QKVA 3QJ9A 2WJ1A 4HBPA 1M22A 3A1IA 2GI3A 2WAPA 3IP4A 4WJ3A 3PR0A 4J5PA 3A2QA 3A1KA 4CP8A 1M21A 2G5HA 3QK5A 3LJ6A 1OCKA 3QJ8A 4YJIA 2F2AA 1OBIA 2WJ2A 4N0HA 3AL0A 1O9QA 1OCHA 3K7FA 1O9OA 3K83A 2DC0A 3H0LA 3H0MA 4DO3A 1OCMA 1MT5A 3H0RA 2VYAA 4GYRA 4YJ6A 3PPMA 4N0IA 5EWQA 1OBLA 2DQNA 1OBJA 3LJ7A 5AC3A 1OBKA 1O9NA 1O9PA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3OJ8 A;  4GYS A;  2DF4 A;  2G5I A;  3A2P A;  3K84 A;  4IST A;  1OCL A;  4ISS A;  3KFU E;  3QKV A;  3QJ9 A;  2WJ1 A;  4HBP A;  1M22 A;  3A1I A;  2GI3 A;  2WAP A;  3IP4 A;  4WJ3 A;  3PR0 A;  4J5P A;  3A2Q A;  3A1K A;  4CP8 A;  1M21 A;  2G5H A;  3QK5 A;  3LJ6 A;  1OCK A;  3QJ8 A;  4YJI A;  2F2A A;  1OBI A;  2WJ2 A;  4N0H A;  3AL0 A;  1O9Q A;  1OCH A;  3K7F A;  1O9O A;  3K83 A;  2DC0 A;  3H0L A;  3H0M A;  4DO3 A;  1OCM A;  1MT5 A;  3H0R A;  2VYA A;  4GYR A;  4YJ6 A;  3PPM A;  4N0I A;  5EWQ A;  1OBL A;  2DQN A;  1OBJ A;  3LJ7 A;  5AC3 A;  1OBK A;  1O9N A;  1O9P A; 
#chains in the Genus database with same CATH topology
 3OJ8 A;  4GYS A;  2DF4 A;  2G5I A;  3A2P A;  3K84 A;  4IST A;  1OCL A;  4ISS A;  3KFU E;  3QKV A;  3QJ9 A;  2WJ1 A;  4HBP A;  1M22 A;  3A1I A;  2GI3 A;  2WAP A;  3IP4 A;  4WJ3 A;  3PR0 A;  4J5P A;  3A2Q A;  3A1K A;  4CP8 A;  1M21 A;  2G5H A;  3QK5 A;  3LJ6 A;  1OCK A;  3QJ8 A;  4YJI A;  2F2A A;  1OBI A;  2WJ2 A;  4N0H A;  3AL0 A;  1O9Q A;  1OCH A;  3K7F A;  1O9O A;  3K83 A;  2DC0 A;  3H0L A;  3H0M A;  4DO3 A;  1OCM A;  1MT5 A;  3H0R A;  2VYA A;  4GYR A;  4YJ6 A;  3PPM A;  4N0I A;  5EWQ A;  1OBL A;  2DQN A;  1OBJ A;  3LJ7 A;  5AC3 A;  1OBK A;  1O9N A;  1O9P A; 
#chains in the Genus database with same CATH homology
 3OJ8 A;  4GYS A;  2DF4 A;  2G5I A;  3A2P A;  3K84 A;  4IST A;  1OCL A;  4ISS A;  3KFU E;  3QKV A;  3QJ9 A;  2WJ1 A;  4HBP A;  1M22 A;  3A1I A;  2GI3 A;  2WAP A;  3IP4 A;  4WJ3 A;  3PR0 A;  4J5P A;  3A2Q A;  3A1K A;  4CP8 A;  1M21 A;  2G5H A;  3QK5 A;  3LJ6 A;  1OCK A;  3QJ8 A;  4YJI A;  2F2A A;  1OBI A;  2WJ2 A;  4N0H A;  3AL0 A;  1O9Q A;  1OCH A;  3K7F A;  1O9O A;  3K83 A;  2DC0 A;  3H0L A;  3H0M A;  4DO3 A;  1OCM A;  1MT5 A;  3H0R A;  2VYA A;  4GYR A;  4YJ6 A;  3PPM A;  4N0I A;  5EWQ A;  1OBL A;  2DQN A;  1OBJ A;  3LJ7 A;  5AC3 A;  1OBK A;  1O9N A;  1O9P A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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