3PR0A

Crystal structure of a covalently bound alpha-ketoheterocycle inhibitor (phenhexyl/oxadiazole/pyridine) to a humanized variant of fatty acid amide hydrolase
Total Genus 225
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
225
sequence length
545
structure length
545
Chain Sequence
GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSTGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNNMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent alpha-ketoheterocycle inhibitor of fatty acid amide hydrolase.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Rattus norvegicus
molecule keywords Fatty Acid Amide Hydrolase 1
total genus 225
structure length 545
sequence length 545
chains with identical sequence B
ec nomenclature ec 3.5.1.99: Fatty acid amide hydrolase.
pdb deposition date 2010-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01425 Amidase Amidase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1300.10 Alpha Beta Alpha-Beta Complex Amidase signature (AS) enzymes Amidase signature (AS) domain 3pr0A00
1OCMA 3AL0A 3K84A 2G5IA 1OBKA 3QKVA 3LJ7A 3A2QA 1O9PA 1OCKA 2DC0A 3K7FA 3OJ8A 4N0IA 1O9QA 2F2AA 3A1KA 2WJ2A 4GYSA 1OCHA 1O9NA 1OBJA 4GYRA 3K83A 2VYAA 2WAPA 4J5PA 2DQNA 2GI3A 1OBIA 1O9OA 3QK5A 4CP8A 2DF4A 5AC3A 3IP4A 4YJ6A 4ISTA 4YJIA 1M21A 1M22A 2G5HA 1OBLA 1MT5A 2WJ1A 3H0RA 3A2PA 3H0LA 5EWQA 4WJ3A 3H0MA 3LJ6A 3PPMA 4N0HA 4DO3A 4ISSA 3QJ9A 3KFUE 4HBPA 3A1IA 1OCLA 3QJ8A 3PR0A
chains in the Genus database with same CATH superfamily
1OCMA 3AL0A 3K84A 2G5IA 1OBKA 3QKVA 3LJ7A 3A2QA 1O9PA 1OCKA 2DC0A 3K7FA 3OJ8A 4N0IA 1O9QA 2F2AA 3A1KA 2WJ2A 4GYSA 1OCHA 1O9NA 1OBJA 4GYRA 3K83A 2VYAA 2WAPA 4J5PA 2DQNA 2GI3A 1OBIA 1O9OA 3QK5A 4CP8A 2DF4A 5AC3A 3IP4A 4YJ6A 4ISTA 4YJIA 1M21A 1M22A 2G5HA 1OBLA 1MT5A 2WJ1A 3H0RA 3A2PA 3H0LA 5EWQA 4WJ3A 3H0MA 3LJ6A 3PPMA 4N0HA 4DO3A 4ISSA 3QJ9A 3KFUE 4HBPA 3A1IA 1OCLA 3QJ8A 3PR0A
chains in the Genus database with same CATH topology
1OCMA 3AL0A 3K84A 2G5IA 1OBKA 3QKVA 3LJ7A 3A2QA 1O9PA 1OCKA 2DC0A 3K7FA 3OJ8A 4N0IA 1O9QA 2F2AA 3A1KA 2WJ2A 4GYSA 1OCHA 1O9NA 1OBJA 4GYRA 3K83A 2VYAA 2WAPA 4J5PA 2DQNA 2GI3A 1OBIA 1O9OA 3QK5A 4CP8A 2DF4A 5AC3A 3IP4A 4YJ6A 4ISTA 4YJIA 1M21A 1M22A 2G5HA 1OBLA 1MT5A 2WJ1A 3H0RA 3A2PA 3H0LA 5EWQA 4WJ3A 3H0MA 3LJ6A 3PPMA 4N0HA 4DO3A 4ISSA 3QJ9A 3KFUE 4HBPA 3A1IA 1OCLA 3QJ8A 3PR0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1OCM A;  3AL0 A;  3K84 A;  2G5I A;  1OBK A;  3QKV A;  3LJ7 A;  3A2Q A;  1O9P A;  1OCK A;  2DC0 A;  3K7F A;  3OJ8 A;  4N0I A;  1O9Q A;  2F2A A;  3A1K A;  2WJ2 A;  4GYS A;  1OCH A;  1O9N A;  1OBJ A;  4GYR A;  3K83 A;  2VYA A;  2WAP A;  4J5P A;  2DQN A;  2GI3 A;  1OBI A;  1O9O A;  3QK5 A;  4CP8 A;  2DF4 A;  5AC3 A;  3IP4 A;  4YJ6 A;  4IST A;  4YJI A;  1M21 A;  1M22 A;  2G5H A;  1OBL A;  1MT5 A;  2WJ1 A;  3H0R A;  3A2P A;  3H0L A;  5EWQ A;  4WJ3 A;  3H0M A;  3LJ6 A;  3PPM A;  4N0H A;  4DO3 A;  4ISS A;  3QJ9 A;  3KFU E;  4HBP A;  3A1I A;  1OCL A;  3QJ8 A;  3PR0 A; 
#chains in the Genus database with same CATH topology
 1OCM A;  3AL0 A;  3K84 A;  2G5I A;  1OBK A;  3QKV A;  3LJ7 A;  3A2Q A;  1O9P A;  1OCK A;  2DC0 A;  3K7F A;  3OJ8 A;  4N0I A;  1O9Q A;  2F2A A;  3A1K A;  2WJ2 A;  4GYS A;  1OCH A;  1O9N A;  1OBJ A;  4GYR A;  3K83 A;  2VYA A;  2WAP A;  4J5P A;  2DQN A;  2GI3 A;  1OBI A;  1O9O A;  3QK5 A;  4CP8 A;  2DF4 A;  5AC3 A;  3IP4 A;  4YJ6 A;  4IST A;  4YJI A;  1M21 A;  1M22 A;  2G5H A;  1OBL A;  1MT5 A;  2WJ1 A;  3H0R A;  3A2P A;  3H0L A;  5EWQ A;  4WJ3 A;  3H0M A;  3LJ6 A;  3PPM A;  4N0H A;  4DO3 A;  4ISS A;  3QJ9 A;  3KFU E;  4HBP A;  3A1I A;  1OCL A;  3QJ8 A;  3PR0 A; 
#chains in the Genus database with same CATH homology
 1OCM A;  3AL0 A;  3K84 A;  2G5I A;  1OBK A;  3QKV A;  3LJ7 A;  3A2Q A;  1O9P A;  1OCK A;  2DC0 A;  3K7F A;  3OJ8 A;  4N0I A;  1O9Q A;  2F2A A;  3A1K A;  2WJ2 A;  4GYS A;  1OCH A;  1O9N A;  1OBJ A;  4GYR A;  3K83 A;  2VYA A;  2WAP A;  4J5P A;  2DQN A;  2GI3 A;  1OBI A;  1O9O A;  3QK5 A;  4CP8 A;  2DF4 A;  5AC3 A;  3IP4 A;  4YJ6 A;  4IST A;  4YJI A;  1M21 A;  1M22 A;  2G5H A;  1OBL A;  1MT5 A;  2WJ1 A;  3H0R A;  3A2P A;  3H0L A;  5EWQ A;  4WJ3 A;  3H0M A;  3LJ6 A;  3PPM A;  4N0H A;  4DO3 A;  4ISS A;  3QJ9 A;  3KFU E;  4HBP A;  3A1I A;  1OCL A;  3QJ8 A;  3PR0 A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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