3BEIA

Crystal structure of the slow form of thrombin in a self_inhibited conformation
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
41
structure length
41
Chain Sequence
YQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural identification of the pathway of long-range communication in an allosteric enzyme.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Prothrombin
total genus 3
structure length 41
sequence length 41
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2007-11-19
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 3beiA00
1JOUA 1JMOL 3E6PL 3GISA 2PV9A 2PGQA 3EDXA 2B5TA 1TB6L 1AVGL 3BEIA 2PUXA 1TBQJ 2A1DA 1TBRJ 2ODYA 3LU9A 4DY7A 4RKOA 3B9FL 1TQ7A 1A0HA 1Z8JA 3HKIA 3BEFA 3HK6A
chains in the Genus database with same CATH superfamily
1JOUA 1JMOL 3E6PL 3GISA 2PV9A 2PGQA 3EDXA 2B5TA 1TB6L 1AVGL 3BEIA 2PUXA 1TBQJ 2A1DA 1TBRJ 2ODYA 3LU9A 4DY7A 4RKOA 3B9FL 1TQ7A 1A0HA 1Z8JA 3HKIA 3BEFA 3HK6A
chains in the Genus database with same CATH topology
1JOUA 1JMOL 3E6PL 3GISA 2PV9A 2PGQA 3EDXA 2B5TA 1TB6L 1AVGL 3BEIA 2PUXA 1TBQJ 2A1DA 1TBRJ 2ODYA 3LU9A 4DY7A 4RKOA 3B9FL 1TQ7A 1A0HA 1Z8JA 3HKIA 3BEFA 3HK6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1JOU A;  1JMO L;  3E6P L;  3GIS A;  2PV9 A;  2PGQ A;  3EDX A;  2B5T A;  1TB6 L;  1AVG L;  3BEI A;  2PUX A;  1TBQ J;  2A1D A;  1TBR J;  2ODY A;  3LU9 A;  4DY7 A;  4RKO A;  3B9F L;  1TQ7 A;  1A0H A;  1Z8J A;  3HKI A;  3BEF A;  3HK6 A; 
#chains in the Genus database with same CATH topology
 1JOU A;  1JMO L;  3E6P L;  3GIS A;  2PV9 A;  2PGQ A;  3EDX A;  2B5T A;  1TB6 L;  1AVG L;  3BEI A;  2PUX A;  1TBQ J;  2A1D A;  1TBR J;  2ODY A;  3LU9 A;  4DY7 A;  4RKO A;  3B9F L;  1TQ7 A;  1A0H A;  1Z8J A;  3HKI A;  3BEF A;  3HK6 A; 
#chains in the Genus database with same CATH homology
 1JOU A;  1JMO L;  3E6P L;  3GIS A;  2PV9 A;  2PGQ A;  3EDX A;  2B5T A;  1TB6 L;  1AVG L;  3BEI A;  2PUX A;  1TBQ J;  2A1D A;  1TBR J;  2ODY A;  3LU9 A;  4DY7 A;  4RKO A;  3B9F L;  1TQ7 A;  1A0H A;  1Z8J A;  3HKI A;  3BEF A;  3HK6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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