3GISA

Crystal structure of na-free thrombin in complex with thrombomodulin
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
46
structure length
46
Chain Sequence
SEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Molecular basis of thrombomodulin activation of slow thrombin
pubmed doi rcsb
molecule keywords Prothrombin
molecule tags Blood clotting
source organism Homo sapiens
total genus 3
structure length 46
sequence length 46
chains with identical sequence C, E
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2009-03-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF09396 Thrombin_light Thrombin light chain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 3gisA00
1TBRJ 3GISA 2B5TA 1TBQJ 3BEIA 1JMOL 1AVGL 2PGQA 1A0HA 3B9FL 4DY7A 3EDXA 3HK6A 4RKOA 2PUXA 3BEFA 2ODYA 3HKIA 1TQ7A 2A1DA 3LU9A 1TB6L 3E6PL 1Z8JA 2PV9A 1JOUA
chains in the Genus database with same CATH superfamily
1TBRJ 3GISA 2B5TA 1TBQJ 3BEIA 1JMOL 1AVGL 2PGQA 1A0HA 3B9FL 4DY7A 3EDXA 3HK6A 4RKOA 2PUXA 3BEFA 2ODYA 3HKIA 1TQ7A 2A1DA 3LU9A 1TB6L 3E6PL 1Z8JA 2PV9A 1JOUA
chains in the Genus database with same CATH topology
1TBRJ 3GISA 2B5TA 1TBQJ 3BEIA 1JMOL 1AVGL 2PGQA 1A0HA 3B9FL 4DY7A 3EDXA 3HK6A 4RKOA 2PUXA 3BEFA 2ODYA 3HKIA 1TQ7A 2A1DA 3LU9A 1TB6L 3E6PL 1Z8JA 2PV9A 1JOUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TBR J;  3GIS A;  2B5T A;  1TBQ J;  3BEI A;  1JMO L;  1AVG L;  2PGQ A;  1A0H A;  3B9F L;  4DY7 A;  3EDX A;  3HK6 A;  4RKO A;  2PUX A;  3BEF A;  2ODY A;  3HKI A;  1TQ7 A;  2A1D A;  3LU9 A;  1TB6 L;  3E6P L;  1Z8J A;  2PV9 A;  1JOU A; 
#chains in the Genus database with same CATH topology
 1TBR J;  3GIS A;  2B5T A;  1TBQ J;  3BEI A;  1JMO L;  1AVG L;  2PGQ A;  1A0H A;  3B9F L;  4DY7 A;  3EDX A;  3HK6 A;  4RKO A;  2PUX A;  3BEF A;  2ODY A;  3HKI A;  1TQ7 A;  2A1D A;  3LU9 A;  1TB6 L;  3E6P L;  1Z8J A;  2PV9 A;  1JOU A; 
#chains in the Genus database with same CATH homology
 1TBR J;  3GIS A;  2B5T A;  1TBQ J;  3BEI A;  1JMO L;  1AVG L;  2PGQ A;  1A0H A;  3B9F L;  4DY7 A;  3EDX A;  3HK6 A;  4RKO A;  2PUX A;  3BEF A;  2ODY A;  3HKI A;  1TQ7 A;  2A1D A;  3LU9 A;  1TB6 L;  3E6P L;  1Z8J A;  2PV9 A;  1JOU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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