4USGA

Crystal structure of pc4 w89y mutant complex with dna
Total Genus 16
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
16
sequence length
66
structure length
66
Chain Sequence
AMFQIGKMRYVSVRDFKGKVLIDIREYYMDPEGEMKPGRKGISLNPEQWSQLKEQISDIDDAVRKL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Substitution of Tryptophan 89 with Tyrosine Switches the DNA Binding Mode of Pc4.
pubmed doi rcsb
molecule tags Transcription
source organism Homo sapiens
molecule keywords ACTIVATED RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR P15
total genus 16
structure length 66
sequence length 66
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-07-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02229 PC4 Transcriptional Coactivator p15 (PC4)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.31.10 Mainly Beta Roll Transcriptional Co-activator pc4; Chain A Transcriptional Coactivator Pc4; Chain A 4usgA00
3N1KA 2PHEA 3N1JA 3R9ZA 2NVNA 2C62A 1PCFA 4KOOA 3N1HA 3N1IA 3N1LA 4KOQA 4BG7A 1L3AA 4USGA 2IT9A 4AGHA 3RA0A 4KOPA 4BHMA 3R9YA
chains in the Genus database with same CATH superfamily
4BOBA 3N1KA 2PHEA 3N1JA 3R9ZA 3MTVA 2NVNA 2C62A 4BODA 1PCFA 4KOOA 2GJEA 4J38A 2GJED 3N1HA 4BF3A 3N1IA 2GIAB 4KOQA 3N1LA 3CM1A 4BG7A 2GIDB 2GIAA 2M4FA 2GIDA 1L3AA 4BXMA 2IT9A 4USGA 4AGHA 3OBHA 3RA0A 4KOPA 5FGPA 3K44A 4BHMA 3R9YA
chains in the Genus database with same CATH topology
3N1KA 2PHEA 3N1JA 3R9ZA 2NVNA 2C62A 1PCFA 4KOOA 3N1HA 3N1IA 3N1LA 4KOQA 4BG7A 1L3AA 4USGA 2IT9A 4AGHA 3RA0A 4KOPA 4BHMA 3R9YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3N1K A;  2PHE A;  3N1J A;  3R9Z A;  2NVN A;  2C62 A;  1PCF A;  4KOO A;  3N1H A;  3N1I A;  3N1L A;  4KOQ A;  4BG7 A;  1L3A A;  4USG A;  2IT9 A;  4AGH A;  3RA0 A;  4KOP A;  4BHM A;  3R9Y A; 
#chains in the Genus database with same CATH topology
 4BOB A;  3N1K A;  2PHE A;  3N1J A;  3R9Z A;  3MTV A;  2NVN A;  2C62 A;  4BOD A;  1PCF A;  4KOO A;  2GJE A;  4J38 A;  2GJE D;  3N1H A;  4BF3 A;  3N1I A;  2GIA B;  4KOQ A;  3N1L A;  3CM1 A;  4BG7 A;  2GID B;  2GIA A;  2M4F A;  2GID A;  1L3A A;  4BXM A;  2IT9 A;  4USG A;  4AGH A;  3OBH A;  3RA0 A;  4KOP A;  5FGP A;  3K44 A;  4BHM A;  3R9Y A; 
#chains in the Genus database with same CATH homology
 3N1K A;  2PHE A;  3N1J A;  3R9Z A;  2NVN A;  2C62 A;  1PCF A;  4KOO A;  3N1H A;  3N1I A;  3N1L A;  4KOQ A;  4BG7 A;  1L3A A;  4USG A;  2IT9 A;  4AGH A;  3RA0 A;  4KOP A;  4BHM A;  3R9Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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