4USGA

Crystal structure of pc4 w89y mutant complex with dna
Total Genus 16
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
16
sequence length
66
structure length
66
Chain Sequence
AMFQIGKMRYVSVRDFKGKVLIDIREYYMDPEGEMKPGRKGISLNPEQWSQLKEQISDIDDAVRKL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Substitution of Tryptophan 89 with Tyrosine Switches the DNA Binding Mode of Pc4.
pubmed doi rcsb
molecule tags Transcription
source organism Homo sapiens
molecule keywords ACTIVATED RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR P15
total genus 16
structure length 66
sequence length 66
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-07-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02229 PC4 Transcriptional Coactivator p15 (PC4)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.31.10 Mainly Beta Roll Transcriptional Co-activator pc4; Chain A Transcriptional Coactivator Pc4; Chain A 4usgA00
4AGHA 4BHMA 4USGA 3N1KA 3R9YA 4KOQA 4KOOA 3N1JA 2C62A 2IT9A 3R9ZA 3N1LA 2PHEA 4BG7A 3RA0A 3N1IA 1PCFA 2NVNA 4KOPA 3N1HA 1L3AA
chains in the Genus database with same CATH superfamily
4BODA 4BXMA 4AGHA 4BHMA 3MTVA 3K44A 4USGA 3N1KA 3R9YA 2GIDA 2GIDB 2M4FA 4KOOA 4KOQA 5FGPA 3N1JA 3OBHA 2C62A 2IT9A 3R9ZA 4BF3A 3N1LA 2PHEA 4BG7A 2GJED 3RA0A 2GIAA 3N1IA 1PCFA 3CM1A 4BOBA 2GJEA 2GIAB 4J38A 2NVNA 4KOPA 3N1HA 1L3AA
chains in the Genus database with same CATH topology
4AGHA 4BHMA 4USGA 3N1KA 3R9YA 4KOQA 4KOOA 3N1JA 2C62A 2IT9A 3R9ZA 3N1LA 2PHEA 4BG7A 3RA0A 3N1IA 1PCFA 2NVNA 4KOPA 3N1HA 1L3AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AGH A;  4BHM A;  4USG A;  3N1K A;  3R9Y A;  4KOQ A;  4KOO A;  3N1J A;  2C62 A;  2IT9 A;  3R9Z A;  3N1L A;  2PHE A;  4BG7 A;  3RA0 A;  3N1I A;  1PCF A;  2NVN A;  4KOP A;  3N1H A;  1L3A A; 
#chains in the Genus database with same CATH topology
 4BOD A;  4BXM A;  4AGH A;  4BHM A;  3MTV A;  3K44 A;  4USG A;  3N1K A;  3R9Y A;  2GID A;  2GID B;  2M4F A;  4KOO A;  4KOQ A;  5FGP A;  3N1J A;  3OBH A;  2C62 A;  2IT9 A;  3R9Z A;  4BF3 A;  3N1L A;  2PHE A;  4BG7 A;  2GJE D;  3RA0 A;  2GIA A;  3N1I A;  1PCF A;  3CM1 A;  4BOB A;  2GJE A;  2GIA B;  4J38 A;  2NVN A;  4KOP A;  3N1H A;  1L3A A; 
#chains in the Genus database with same CATH homology
 4AGH A;  4BHM A;  4USG A;  3N1K A;  3R9Y A;  4KOQ A;  4KOO A;  3N1J A;  2C62 A;  2IT9 A;  3R9Z A;  3N1L A;  2PHE A;  4BG7 A;  3RA0 A;  3N1I A;  1PCF A;  2NVN A;  4KOP A;  3N1H A;  1L3A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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