4DY7A

Crystal structures of protease nexin-1 in complex with s195a thrombin
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
45
structure length
45
Chain Sequence
EYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
pubmed doi rcsb
molecule keywords Thrombin light chain
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
total genus 1
structure length 45
sequence length 45
chains with identical sequence D
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2012-02-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF09396 Thrombin_light Thrombin light chain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 4dy7A00
2PUXA 1Z8JA 4RKOA 3HKIA 3BEFA 2PGQA 3GISA 1TBQJ 3EDXA 3E6PL 3HK6A 1TQ7A 1JOUA 3BEIA 2PV9A 3B9FL 4DY7A 3LU9A 1TB6L 1AVGL 1A0HA 2A1DA 1TBRJ 1JMOL 2ODYA 2B5TA
chains in the Genus database with same CATH superfamily
2PUXA 1Z8JA 4RKOA 3HKIA 3BEFA 2PGQA 3GISA 1TBQJ 3EDXA 3E6PL 3HK6A 1TQ7A 1JOUA 3BEIA 2PV9A 3B9FL 4DY7A 3LU9A 1TB6L 1AVGL 1A0HA 2A1DA 1TBRJ 1JMOL 2ODYA 2B5TA
chains in the Genus database with same CATH topology
2PUXA 1Z8JA 4RKOA 3HKIA 3BEFA 2PGQA 3GISA 1TBQJ 3EDXA 3E6PL 3HK6A 1TQ7A 1JOUA 3BEIA 2PV9A 3B9FL 4DY7A 3LU9A 1TB6L 1AVGL 1A0HA 2A1DA 1TBRJ 1JMOL 2ODYA 2B5TA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PUX A;  1Z8J A;  4RKO A;  3HKI A;  3BEF A;  2PGQ A;  3GIS A;  1TBQ J;  3EDX A;  3E6P L;  3HK6 A;  1TQ7 A;  1JOU A;  3BEI A;  2PV9 A;  3B9F L;  4DY7 A;  3LU9 A;  1TB6 L;  1AVG L;  1A0H A;  2A1D A;  1TBR J;  1JMO L;  2ODY A;  2B5T A; 
#chains in the Genus database with same CATH topology
 2PUX A;  1Z8J A;  4RKO A;  3HKI A;  3BEF A;  2PGQ A;  3GIS A;  1TBQ J;  3EDX A;  3E6P L;  3HK6 A;  1TQ7 A;  1JOU A;  3BEI A;  2PV9 A;  3B9F L;  4DY7 A;  3LU9 A;  1TB6 L;  1AVG L;  1A0H A;  2A1D A;  1TBR J;  1JMO L;  2ODY A;  2B5T A; 
#chains in the Genus database with same CATH homology
 2PUX A;  1Z8J A;  4RKO A;  3HKI A;  3BEF A;  2PGQ A;  3GIS A;  1TBQ J;  3EDX A;  3E6P L;  3HK6 A;  1TQ7 A;  1JOU A;  3BEI A;  2PV9 A;  3B9F L;  4DY7 A;  3LU9 A;  1TB6 L;  1AVG L;  1A0H A;  2A1D A;  1TBR J;  1JMO L;  2ODY A;  2B5T A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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