4RKOA

Crystal structure of thrombin mutant s195t bound with ppack
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
40
structure length
40
Chain Sequence
TFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYID
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Why ser and not thr brokers catalysis in the trypsin fold.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Thrombin heavy chain
total genus 3
structure length 40
sequence length 40
ec nomenclature ec 3.4.21.5: Thrombin.
pdb deposition date 2014-10-13
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin; Chain L Thrombin light chain domain 4rkoA00
1JOUA 1AVGL 1TQ7A 3GISA 2PUXA 3BEFA 4DY7A 1A0HA 3EDXA 1TB6L 2B5TA 1JMOL 3E6PL 1TBQJ 1Z8JA 2PGQA 2A1DA 3LU9A 4RKOA 3HK6A 2ODYA 3B9FL 3BEIA 3HKIA 1TBRJ 2PV9A
chains in the Genus database with same CATH superfamily
1JOUA 1AVGL 1TQ7A 3GISA 2PUXA 3BEFA 4DY7A 1A0HA 3EDXA 1TB6L 2B5TA 1JMOL 3E6PL 1TBQJ 1Z8JA 2PGQA 2A1DA 3LU9A 4RKOA 3HK6A 2ODYA 3B9FL 3BEIA 3HKIA 1TBRJ 2PV9A
chains in the Genus database with same CATH topology
1JOUA 1AVGL 1TQ7A 3GISA 2PUXA 3BEFA 4DY7A 1A0HA 3EDXA 1TB6L 2B5TA 1JMOL 3E6PL 1TBQJ 1Z8JA 2PGQA 2A1DA 3LU9A 4RKOA 3HK6A 2ODYA 3B9FL 3BEIA 3HKIA 1TBRJ 2PV9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1JOU A;  1AVG L;  1TQ7 A;  3GIS A;  2PUX A;  3BEF A;  4DY7 A;  1A0H A;  3EDX A;  1TB6 L;  2B5T A;  1JMO L;  3E6P L;  1TBQ J;  1Z8J A;  2PGQ A;  2A1D A;  3LU9 A;  4RKO A;  3HK6 A;  2ODY A;  3B9F L;  3BEI A;  3HKI A;  1TBR J;  2PV9 A; 
#chains in the Genus database with same CATH topology
 1JOU A;  1AVG L;  1TQ7 A;  3GIS A;  2PUX A;  3BEF A;  4DY7 A;  1A0H A;  3EDX A;  1TB6 L;  2B5T A;  1JMO L;  3E6P L;  1TBQ J;  1Z8J A;  2PGQ A;  2A1D A;  3LU9 A;  4RKO A;  3HK6 A;  2ODY A;  3B9F L;  3BEI A;  3HKI A;  1TBR J;  2PV9 A; 
#chains in the Genus database with same CATH homology
 1JOU A;  1AVG L;  1TQ7 A;  3GIS A;  2PUX A;  3BEF A;  4DY7 A;  1A0H A;  3EDX A;  1TB6 L;  2B5T A;  1JMO L;  3E6P L;  1TBQ J;  1Z8J A;  2PGQ A;  2A1D A;  3LU9 A;  4RKO A;  3HK6 A;  2ODY A;  3B9F L;  3BEI A;  3HKI A;  1TBR J;  2PV9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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