3WX1A

Mouse cereblon thalidomide binding domain, selenomethionine derivative
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
108
structure length
108
Chain Sequence
GPTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Metal binding protein
molecule keywords Protein cereblon
publication title Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs
pubmed doi rcsb
source organism Mus musculus
total genus 21
structure length 108
sequence length 108
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-07-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 3wx1A00
3WX1A 4V31A 4V2YA 1L1DA 3WX2A 4TZ4C 4CI3B 2KV1A 3E0OA 4TZCA 3HCIA 5AMHA 4TZUA 3CEZA 4CI1B 4CI2B 4V30A 4V2ZA 3CXKA 3HCJA 3HCHA 3E0MA 3MAOA 3HCGA 2K8DA 2KZNA
chains in the Genus database with same CATH superfamily
2RQBA 3WX1A 5E3HA 5F9FA 2QFBA 4V31A 3ZD7A 4AY2A 3EBMA 4A2VA 4V2YA 1L1DA 3WX2A 1H7YA 4TZ4C 1YZ1A 4CI3B 2KV1A 3E0OA 3OG8A 2QFDA 3DJMA 1H6QA 4TZCA 3HCIA 5AMHA 4TZUA 3LRRA 1HXRA 3CEZA 3FACA 4CI1B 3EQTA 4CI2B 3P3KA 2RQAA 4V30A 2FU5A 4V2ZA 2KWBA 2RMJA 2YKGA 5F9HA 3CXKA 2LVLA 3ZD6A 3NCUA 5F98A 3HCJA 3HCHA 3E0MA 2W4RA 3MAOA 4BPBA 3HCGA 1TXJA 2HR9A 4A2XA 2LOYA 2K8DA 3LRNA 3GA3A 1FWQA 2KZNA
chains in the Genus database with same CATH topology
3WX1A 4V31A 4V2YA 1L1DA 3WX2A 4TZ4C 4CI3B 2KV1A 3E0OA 4TZCA 3HCIA 5AMHA 4TZUA 3CEZA 4CI1B 4CI2B 4V30A 4V2ZA 3CXKA 3HCJA 3HCHA 3E0MA 3MAOA 3HCGA 2K8DA 2KZNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WX1 A;  4V31 A;  4V2Y A;  1L1D A;  3WX2 A;  4TZ4 C;  4CI3 B;  2KV1 A;  3E0O A;  4TZC A;  3HCI A;  5AMH A;  4TZU A;  3CEZ A;  4CI1 B;  4CI2 B;  4V30 A;  4V2Z A;  3CXK A;  3HCJ A;  3HCH A;  3E0M A;  3MAO A;  3HCG A;  2K8D A;  2KZN A; 
#chains in the Genus database with same CATH topology
 2RQB A;  3WX1 A;  5E3H A;  5F9F A;  2QFB A;  4V31 A;  3ZD7 A;  4AY2 A;  3EBM A;  4A2V A;  4V2Y A;  1L1D A;  3WX2 A;  1H7Y A;  4TZ4 C;  1YZ1 A;  4CI3 B;  2KV1 A;  3E0O A;  3OG8 A;  2QFD A;  3DJM A;  1H6Q A;  4TZC A;  3HCI A;  5AMH A;  4TZU A;  3LRR A;  1HXR A;  3CEZ A;  3FAC A;  4CI1 B;  3EQT A;  4CI2 B;  3P3K A;  2RQA A;  4V30 A;  2FU5 A;  4V2Z A;  2KWB A;  2RMJ A;  2YKG A;  5F9H A;  3CXK A;  2LVL A;  3ZD6 A;  3NCU A;  5F98 A;  3HCJ A;  3HCH A;  3E0M A;  2W4R A;  3MAO A;  4BPB A;  3HCG A;  1TXJ A;  2HR9 A;  4A2X A;  2LOY A;  2K8D A;  3LRN A;  3GA3 A;  1FWQ A;  2KZN A; 
#chains in the Genus database with same CATH homology
 3WX1 A;  4V31 A;  4V2Y A;  1L1D A;  3WX2 A;  4TZ4 C;  4CI3 B;  2KV1 A;  3E0O A;  4TZC A;  3HCI A;  5AMH A;  4TZU A;  3CEZ A;  4CI1 B;  4CI2 B;  4V30 A;  4V2Z A;  3CXK A;  3HCJ A;  3HCH A;  3E0M A;  3MAO A;  3HCG A;  2K8D A;  2KZN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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