4V2ZA

Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with pomalidomide
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
105
structure length
105
Chain Sequence
ASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
molecule keywords CEREBLON ISOFORM 4
publication title Thalidomide Mimics Uridine Binding to an Aromatic Cage in Cereblon.
pubmed doi rcsb
source organism Magnetospirillum gryphiswaldense
total genus 23
structure length 105
sequence length 105
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2014-10-15
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4v2zA00
3HCGA 2K8DA 4V2YA 1L1DA 4V2ZA 4CI3B 4CI2B 3WX1A 3WX2A 2KV1A 3HCJA 4TZUA 4TZCA 2KZNA 3CXKA 3HCIA 5AMHA 4V30A 3E0OA 3E0MA 3MAOA 4CI1B 3HCHA 3CEZA 4V31A 4TZ4C
chains in the Genus database with same CATH superfamily
3DJMA 1TXJA 4BPBA 3HCGA 2K8DA 2W4RA 1L1DA 4V2YA 5F9HA 2RQAA 1FWQA 4V2ZA 4CI3B 3ZD6A 2LVLA 1YZ1A 5F98A 2FU5A 4A2VA 5E3HA 4CI2B 1H7YA 3WX1A 1HXRA 4AY2A 2QFDA 2LOYA 3P3KA 3WX2A 1H6QA 2KV1A 3OG8A 3HCJA 4TZUA 4A2XA 3GA3A 4TZCA 2QFBA 2RQBA 2KZNA 3LRRA 3CXKA 3NCUA 3HCIA 5AMHA 2YKGA 4V30A 2KWBA 3E0OA 3E0MA 3FACA 3MAOA 4CI1B 3HCHA 3LRNA 3CEZA 3EBMA 4V31A 5F9FA 3ZD7A 2RMJA 2HR9A 4TZ4C 3EQTA
chains in the Genus database with same CATH topology
3HCGA 2K8DA 4V2YA 1L1DA 4V2ZA 4CI3B 4CI2B 3WX1A 3WX2A 2KV1A 3HCJA 4TZUA 4TZCA 2KZNA 3CXKA 3HCIA 5AMHA 4V30A 3E0OA 3E0MA 3MAOA 4CI1B 3HCHA 3CEZA 4V31A 4TZ4C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HCG A;  2K8D A;  4V2Y A;  1L1D A;  4V2Z A;  4CI3 B;  4CI2 B;  3WX1 A;  3WX2 A;  2KV1 A;  3HCJ A;  4TZU A;  4TZC A;  2KZN A;  3CXK A;  3HCI A;  5AMH A;  4V30 A;  3E0O A;  3E0M A;  3MAO A;  4CI1 B;  3HCH A;  3CEZ A;  4V31 A;  4TZ4 C; 
#chains in the Genus database with same CATH topology
 3DJM A;  1TXJ A;  4BPB A;  3HCG A;  2K8D A;  2W4R A;  1L1D A;  4V2Y A;  5F9H A;  2RQA A;  1FWQ A;  4V2Z A;  4CI3 B;  3ZD6 A;  2LVL A;  1YZ1 A;  5F98 A;  2FU5 A;  4A2V A;  5E3H A;  4CI2 B;  1H7Y A;  3WX1 A;  1HXR A;  4AY2 A;  2QFD A;  2LOY A;  3P3K A;  3WX2 A;  1H6Q A;  2KV1 A;  3OG8 A;  3HCJ A;  4TZU A;  4A2X A;  3GA3 A;  4TZC A;  2QFB A;  2RQB A;  2KZN A;  3LRR A;  3CXK A;  3NCU A;  3HCI A;  5AMH A;  2YKG A;  4V30 A;  2KWB A;  3E0O A;  3E0M A;  3FAC A;  3MAO A;  4CI1 B;  3HCH A;  3LRN A;  3CEZ A;  3EBM A;  4V31 A;  5F9F A;  3ZD7 A;  2RMJ A;  2HR9 A;  4TZ4 C;  3EQT A; 
#chains in the Genus database with same CATH homology
 3HCG A;  2K8D A;  4V2Y A;  1L1D A;  4V2Z A;  4CI3 B;  4CI2 B;  3WX1 A;  3WX2 A;  2KV1 A;  3HCJ A;  4TZU A;  4TZC A;  2KZN A;  3CXK A;  3HCI A;  5AMH A;  4V30 A;  3E0O A;  3E0M A;  3MAO A;  4CI1 B;  3HCH A;  3CEZ A;  4V31 A;  4TZ4 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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