3WX2A

Mouse cereblon thalidomide binding domain, native
Total Genus 20
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
20
sequence length
108
structure length
108
Chain Sequence
GPTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Metal binding protein
molecule keywords Protein cereblon
publication title Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs
pubmed doi rcsb
source organism Mus musculus
total genus 20
structure length 108
sequence length 108
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-07-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 3wx2A00
3HCHA 4CI3B 4TZCA 4TZUA 3CEZA 3E0OA 4V31A 4V2YA 3HCGA 3WX1A 2KV1A 1L1DA 3MAOA 3HCIA 4TZ4C 3E0MA 4V30A 3WX2A 4V2ZA 4CI2B 2K8DA 3HCJA 3CXKA 2KZNA 5AMHA 4CI1B
chains in the Genus database with same CATH superfamily
2LOYA 3HCHA 4CI3B 2FU5A 4TZCA 4BPBA 4TZUA 1HXRA 2HR9A 3LRNA 3GA3A 3EBMA 3CEZA 5E3HA 3E0OA 3ZD7A 3P3KA 3ZD6A 4V31A 4V2YA 3LRRA 3HCGA 2RMJA 2RQAA 3WX1A 3FACA 2W4RA 3OG8A 2KV1A 2QFBA 1L1DA 3MAOA 3HCIA 4TZ4C 3E0MA 4V30A 3WX2A 4CI1B 5F9FA 4V2ZA 4AY2A 4CI2B 2K8DA 2YKGA 4A2XA 1FWQA 3HCJA 3CXKA 2KZNA 1YZ1A 3NCUA 5AMHA 5F98A 3EQTA 2QFDA 2RQBA 5F9HA 4A2VA 1H7YA 1H6QA 2KWBA 3DJMA 1TXJA 2LVLA
chains in the Genus database with same CATH topology
3HCHA 4CI3B 4TZCA 4TZUA 3CEZA 3E0OA 4V31A 4V2YA 3HCGA 3WX1A 2KV1A 1L1DA 3MAOA 3HCIA 4TZ4C 3E0MA 4V30A 3WX2A 4V2ZA 4CI2B 2K8DA 3HCJA 3CXKA 2KZNA 5AMHA 4CI1B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HCH A;  4CI3 B;  4TZC A;  4TZU A;  3CEZ A;  3E0O A;  4V31 A;  4V2Y A;  3HCG A;  3WX1 A;  2KV1 A;  1L1D A;  3MAO A;  3HCI A;  4TZ4 C;  3E0M A;  4V30 A;  3WX2 A;  4V2Z A;  4CI2 B;  2K8D A;  3HCJ A;  3CXK A;  2KZN A;  5AMH A;  4CI1 B; 
#chains in the Genus database with same CATH topology
 2LOY A;  3HCH A;  4CI3 B;  2FU5 A;  4TZC A;  4BPB A;  4TZU A;  1HXR A;  2HR9 A;  3LRN A;  3GA3 A;  3EBM A;  3CEZ A;  5E3H A;  3E0O A;  3ZD7 A;  3P3K A;  3ZD6 A;  4V31 A;  4V2Y A;  3LRR A;  3HCG A;  2RMJ A;  2RQA A;  3WX1 A;  3FAC A;  2W4R A;  3OG8 A;  2KV1 A;  2QFB A;  1L1D A;  3MAO A;  3HCI A;  4TZ4 C;  3E0M A;  4V30 A;  3WX2 A;  4CI1 B;  5F9F A;  4V2Z A;  4AY2 A;  4CI2 B;  2K8D A;  2YKG A;  4A2X A;  1FWQ A;  3HCJ A;  3CXK A;  2KZN A;  1YZ1 A;  3NCU A;  5AMH A;  5F98 A;  3EQT A;  2QFD A;  2RQB A;  5F9H A;  4A2V A;  1H7Y A;  1H6Q A;  2KWB A;  3DJM A;  1TXJ A;  2LVL A; 
#chains in the Genus database with same CATH homology
 3HCH A;  4CI3 B;  4TZC A;  4TZU A;  3CEZ A;  3E0O A;  4V31 A;  4V2Y A;  3HCG A;  3WX1 A;  2KV1 A;  1L1D A;  3MAO A;  3HCI A;  4TZ4 C;  3E0M A;  4V30 A;  3WX2 A;  4V2Z A;  4CI2 B;  2K8D A;  3HCJ A;  3CXK A;  2KZN A;  5AMH A;  4CI1 B; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...