3SIGA

The x-ray crystal structure of poly(adp-ribose) glycohydrolase (parg) bound to adp-ribose from thermomonospora curvata
Total Genus 92
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
92
Knots found
sequence length
274
structure length
265
Chain Sequence
RHSRRAIAAETVEILERGRYTAPSGRVVPIADHVAQAVRGTRLYRPEKLAVLLEGTRIEVTEETTLAAARRLTGAAGDQVACLNFASAEHPGGGFLSGAHAQEEGLARSSGLYASLRAVPQFYAFHHRQRDPLYSDHLIYSPGVPVFRDDAGRLLEEPYRVAFLTSPAPNRRAIGDLRTVEEIGRVLRGRAAKVLAAARHHGHRRLVLGAWGCGVFGNDPAQVAETFAGLLLDGGPFAGRFAHVVFAVWDTAPGAPRHAAFARRF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase.
pubmed doi rcsb
molecule tags Hydrolase
source organism Thermomonospora curvata
molecule keywords poly(ADP-ribose) glycohydrolase
total genus 92
structure length 265
sequence length 274
other databases KnotProt 2.0: K +31
ec nomenclature ec 3.2.1.143: Poly(ADP-ribose) glycohydrolase.
pdb deposition date 2011-06-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF10021 DUF2263 Uncharacterized protein conserved in bacteria (DUF2263)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 3sigA00
5E3BA 3KR4A 4K0CA 3EWQA 4ZX8A 1ZR5A 3EWOA 4GVWA 1SPVA 4ZI6A 3ETIA 3JRUA 3T8WA 3GPQA 3V45A 4ZX9A 3KZWA 3PEIA 3SIIA 4ABKA 2XD7A 4KSIA 4ZY2A 5FSYA 2BFRA 2FXKA 3GQEA 4UMLA 1NJRA 3SIGA 4JCAA 2X47A 4J5SA 5CB5A 1GYTA 4JVVA 2AFCA 1LAPA 4R6TA 3Q6ZA 3H8EA 4TU0A 3EWRA 5DUSA 2FG1A 3IJ3A 5FSXA 1YD9A 4KYBA 5FSUA 2BFQA 1BLLE 4JGKA 4ETJA 4R76A 3SIJA 2J9AA 1LANA 1BPNA 3H8GA 4ABLA 5FSZA 3IIFA 3EJFA 1LAMA 3VFQA 4ZY0A 3IIDA 2FAVA 2L8RA 4ZYQA 3GPGA 4R7MA 4GVVA 3H8FA 5HOLA 4X2TA 4GUAA 1TXZA 4K3NA 3SIHA 2LGRA 1LCPA 2ACFA 4ETKA 3Q71A 3KR5A 1BPMA 2VRIA 3KQXA 2EWBA 1TY8A 5FSVA 1VHUA 3EKEA 3GQOA 2DX6A 3V2BA 5AILA 3EWPA 5D8NA 4IQYA 3EW5A 3EJGA 5CB3A 3GPOA 4ESSA 1HJZA 2EEEA 4J5QA 5HIHA 1ZR3A 3KQZA 4ZY1A 4D86A 5CMSA 3JZTA 5CBMA 4J4ZA 4J5RA 4JLLA
chains in the Genus database with same CATH superfamily
5E3BA 3KR4A 4K0CA 3EWQA 4ZX8A 1ZR5A 3EWOA 4GVWA 1SPVA 4ZI6A 3ETIA 3JRUA 3T8WA 3GPQA 3V45A 4ZX9A 3KZWA 3PEIA 3SIIA 4ABKA 2JZEA 2XD7A 4KSIA 4ZY2A 5FSYA 2BFRA 2FXKA 3GQEA 4UMLA 1NJRA 3SIGA 4JCAA 2X47A 4J5SA 5CB5A 1GYTA 2JZDA 4JVVA 2AFCA 1LAPA 4R6TA 3Q6ZA 3H8EA 4TU0A 3EWRA 5DUSA 2RNKA 2FG1A 3IJ3A 5FSXA 1YD9A 2WCTA 4KYBA 5FSUA 2BFQA 1BLLE 4JGKA 4ETJA 4R76A 3SIJA 2J9AA 1LANA 1BPNA 3H8GA 4ABLA 5FSZA 3IIFA 3EJFA 1LAMA 3VFQA 4ZY0A 3IIDA 2FAVA 2L8RA 4ZYQA 2JZFA 3GPGA 4R7MA 4GVVA 3H8FA 2KQVA 5HOLA 4X2TA 4GUAA 1TXZA 4K3NA 3SIHA 2LGRA 1LCPA 2ACFA 4ETKA 3Q71A 3KR5A 1BPMA 2VRIA 2W2GA 3KQXA 2EWBA 1TY8A 5FSVA 1VHUA 3EKEA 3GQOA 2DX6A 3V2BA 5AILA 4JLLA 3EWPA 5D8NA 4IQYA 3EJGA 5CB3A 3GPOA 4ESSA 1HJZA 2EEEA 4J5QA 5HIHA 1ZR3A 3KQZA 4ZY1A 4D86A 5CMSA 3JZTA 5CBMA 4J4ZA 4J5RA 3EW5A
chains in the Genus database with same CATH topology
5E3BA 3KR4A 4K0CA 3EWQA 4ZX8A 1ZR5A 3EWOA 4GVWA 1SPVA 4ZI6A 3ETIA 3JRUA 3T8WA 3GPQA 3V45A 4ZX9A 3KZWA 3PEIA 3SIIA 4ABKA 2XD7A 4KSIA 4ZY2A 5FSYA 2BFRA 2FXKA 3GQEA 4UMLA 1NJRA 3SIGA 4JCAA 2X47A 4J5SA 5CB5A 1GYTA 4JVVA 2AFCA 1LAPA 4R6TA 3Q6ZA 3H8EA 4TU0A 3EWRA 5DUSA 2FG1A 3IJ3A 5FSXA 1YD9A 4KYBA 5FSUA 2BFQA 1BLLE 4JGKA 4ETJA 4R76A 3SIJA 2J9AA 1LANA 1BPNA 3H8GA 4ABLA 5FSZA 3IIFA 3EJFA 1LAMA 3VFQA 4ZY0A 3IIDA 2FAVA 2L8RA 4ZYQA 3GPGA 4R7MA 4GVVA 3H8FA 5HOLA 4X2TA 4GUAA 1TXZA 4K3NA 3SIHA 2LGRA 1LCPA 2ACFA 4ETKA 3Q71A 3KR5A 1BPMA 2VRIA 3KQXA 2EWBA 1TY8A 5FSVA 1VHUA 3EKEA 3GQOA 2DX6A 3V2BA 5AILA 3EWPA 5D8NA 4IQYA 3EW5A 3EJGA 5CB3A 3GPOA 4ESSA 1HJZA 2EEEA 4J5QA 5HIHA 1ZR3A 3KQZA 4ZY1A 4D86A 5CMSA 3JZTA 5CBMA 4J4ZA 4J5RA 4JLLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5E3B A;  3KR4 A;  4K0C A;  3EWQ A;  4ZX8 A;  1ZR5 A;  3EWO A;  4GVW A;  1SPV A;  4ZI6 A;  3ETI A;  3JRU A;  3T8W A;  3GPQ A;  3V45 A;  4ZX9 A;  3KZW A;  3PEI A;  3SII A;  4ABK A;  2XD7 A;  4KSI A;  4ZY2 A;  5FSY A;  2BFR A;  2FXK A;  3GQE A;  4UML A;  1NJR A;  3SIG A;  4JCA A;  2X47 A;  4J5S A;  5CB5 A;  1GYT A;  4JVV A;  2AFC A;  1LAP A;  4R6T A;  3Q6Z A;  3H8E A;  4TU0 A;  3EWR A;  5DUS A;  2FG1 A;  3IJ3 A;  5FSX A;  1YD9 A;  4KYB A;  5FSU A;  2BFQ A;  1BLL E;  4JGK A;  4ETJ A;  4R76 A;  3SIJ A;  2J9A A;  1LAN A;  1BPN A;  3H8G A;  4ABL A;  5FSZ A;  3IIF A;  3EJF A;  1LAM A;  3VFQ A;  4ZY0 A;  3IID A;  2FAV A;  2L8R A;  4ZYQ A;  3GPG A;  4R7M A;  4GVV A;  3H8F A;  5HOL A;  4X2T A;  4GUA A;  1TXZ A;  4K3N A;  3SIH A;  2LGR A;  1LCP A;  2ACF A;  4ETK A;  3Q71 A;  3KR5 A;  1BPM A;  2VRI A;  3KQX A;  2EWB A;  1TY8 A;  5FSV A;  1VHU A;  3EKE A;  3GQO A;  2DX6 A;  3V2B A;  5AIL A;  3EWP A;  5D8N A;  4IQY A;  3EW5 A;  3EJG A;  5CB3 A;  3GPO A;  4ESS A;  1HJZ A;  2EEE A;  4J5Q A;  5HIH A;  1ZR3 A;  3KQZ A;  4ZY1 A;  4D86 A;  5CMS A;  3JZT A;  5CBM A;  4J4Z A;  4J5R A;  4JLL A; 
#chains in the Genus database with same CATH topology
 5E3B A;  3KR4 A;  4K0C A;  3EWQ A;  4ZX8 A;  1ZR5 A;  3EWO A;  4GVW A;  1SPV A;  4ZI6 A;  3ETI A;  3JRU A;  3T8W A;  3GPQ A;  3V45 A;  4ZX9 A;  3KZW A;  3PEI A;  3SII A;  4ABK A;  2JZE A;  2XD7 A;  4KSI A;  4ZY2 A;  5FSY A;  2BFR A;  2FXK A;  3GQE A;  4UML A;  1NJR A;  3SIG A;  4JCA A;  2X47 A;  4J5S A;  5CB5 A;  1GYT A;  2JZD A;  4JVV A;  2AFC A;  1LAP A;  4R6T A;  3Q6Z A;  3H8E A;  4TU0 A;  3EWR A;  5DUS A;  2RNK A;  2FG1 A;  3IJ3 A;  5FSX A;  1YD9 A;  2WCT A;  4KYB A;  5FSU A;  2BFQ A;  1BLL E;  4JGK A;  4ETJ A;  4R76 A;  3SIJ A;  2J9A A;  1LAN A;  1BPN A;  3H8G A;  4ABL A;  5FSZ A;  3IIF A;  3EJF A;  1LAM A;  3VFQ A;  4ZY0 A;  3IID A;  2FAV A;  2L8R A;  4ZYQ A;  2JZF A;  3GPG A;  4R7M A;  4GVV A;  3H8F A;  2KQV A;  5HOL A;  4X2T A;  4GUA A;  1TXZ A;  4K3N A;  3SIH A;  2LGR A;  1LCP A;  2ACF A;  4ETK A;  3Q71 A;  3KR5 A;  1BPM A;  2VRI A;  2W2G A;  3KQX A;  2EWB A;  1TY8 A;  5FSV A;  1VHU A;  3EKE A;  3GQO A;  2DX6 A;  3V2B A;  5AIL A;  4JLL A;  3EWP A;  5D8N A;  4IQY A;  3EJG A;  5CB3 A;  3GPO A;  4ESS A;  1HJZ A;  2EEE A;  4J5Q A;  5HIH A;  1ZR3 A;  3KQZ A;  4ZY1 A;  4D86 A;  5CMS A;  3JZT A;  5CBM A;  4J4Z A;  4J5R A;  3EW5 A; 
#chains in the Genus database with same CATH homology
 5E3B A;  3KR4 A;  4K0C A;  3EWQ A;  4ZX8 A;  1ZR5 A;  3EWO A;  4GVW A;  1SPV A;  4ZI6 A;  3ETI A;  3JRU A;  3T8W A;  3GPQ A;  3V45 A;  4ZX9 A;  3KZW A;  3PEI A;  3SII A;  4ABK A;  2XD7 A;  4KSI A;  4ZY2 A;  5FSY A;  2BFR A;  2FXK A;  3GQE A;  4UML A;  1NJR A;  3SIG A;  4JCA A;  2X47 A;  4J5S A;  5CB5 A;  1GYT A;  4JVV A;  2AFC A;  1LAP A;  4R6T A;  3Q6Z A;  3H8E A;  4TU0 A;  3EWR A;  5DUS A;  2FG1 A;  3IJ3 A;  5FSX A;  1YD9 A;  4KYB A;  5FSU A;  2BFQ A;  1BLL E;  4JGK A;  4ETJ A;  4R76 A;  3SIJ A;  2J9A A;  1LAN A;  1BPN A;  3H8G A;  4ABL A;  5FSZ A;  3IIF A;  3EJF A;  1LAM A;  3VFQ A;  4ZY0 A;  3IID A;  2FAV A;  2L8R A;  4ZYQ A;  3GPG A;  4R7M A;  4GVV A;  3H8F A;  5HOL A;  4X2T A;  4GUA A;  1TXZ A;  4K3N A;  3SIH A;  2LGR A;  1LCP A;  2ACF A;  4ETK A;  3Q71 A;  3KR5 A;  1BPM A;  2VRI A;  3KQX A;  2EWB A;  1TY8 A;  5FSV A;  1VHU A;  3EKE A;  3GQO A;  2DX6 A;  3V2B A;  5AIL A;  3EWP A;  5D8N A;  4IQY A;  3EW5 A;  3EJG A;  5CB3 A;  3GPO A;  4ESS A;  1HJZ A;  2EEE A;  4J5Q A;  5HIH A;  1ZR3 A;  3KQZ A;  4ZY1 A;  4D86 A;  5CMS A;  3JZT A;  5CBM A;  4J4Z A;  4J5R A;  4JLL A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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