2AFYX

Formylglycine generating enzyme c341s mutant
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
286
structure length
273
Chain Sequence
LAHSKMVPIPAGVFTMGTDDPQIKQDGEAPARRVTIDAFYMDAYEVSNTEFEKFVNSTGYLTEAEKFGDSFVFEGMLAAAPWWLPVKGANWRHPEGPDSTILHRPDHPVLHVSWNDAVAYCTWAGKRLPTEAEWEYSCRGGLHNRLFPWGNKLQPKGQHYANIWQGEFPVTNTGEDGFQGTAPVDAFPPNGYGLYNIVGNAWEWTSDWWTVHHSVEETLNPKGPPSGKDRVKKGGSYMHRSYSYRYRCAARSQNTPDSSASNLGFRCAADRLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A general binding mechanism for all human sulfatases by the formylglycine-generating enzyme
pubmed doi rcsb
molecule tags Hydrolase activator, protein binding
source organism Homo sapiens
molecule keywords Sulfatase modifying factor 1
total genus 79
structure length 273
sequence length 286
ec nomenclature ec 1.8.3.7: Formylglycine-generating enzyme.
pdb deposition date 2005-07-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
X PF03781 FGE-sulfatase Sulfatase-modifying factor enzyme 1
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1580.10 Alpha Beta Alpha-Beta Complex paralog of FGE (formylglycine-generating enzyme) paralog of FGE (formylglycine-generating enzyme) 2afyX00
2AFTX 1Y1EX 1YU4A 2HIBX 1Y1FX 2AIIX 1Z70X 2Y3CA 2HI8X 1Y1HX 2AFYX 1Y4JA 1Y1JX 1Y1GX 1YU3A 1Y1IX 1YU2A 1YU0A 2Q17A 2AIKX 2IOUA 1YU1A 2AIJX
chains in the Genus database with same CATH superfamily
2AFTX 1Y1EX 1YU4A 2HIBX 1Y1FX 2AIIX 1Z70X 2Y3CA 2HI8X 1Y1HX 2AFYX 1Y4JA 1Y1JX 1Y1GX 1YU3A 1Y1IX 1YU2A 1YU0A 2Q17A 2AIKX 2IOUA 1YU1A 2AIJX
chains in the Genus database with same CATH topology
2AFTX 1Y1EX 1YU4A 2HIBX 1Y1FX 2AIIX 1Z70X 2Y3CA 2HI8X 1Y1HX 2AFYX 1Y4JA 1Y1JX 1Y1GX 1YU3A 1Y1IX 1YU2A 1YU0A 2Q17A 2AIKX 2IOUA 1YU1A 2AIJX
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2AFT X;  1Y1E X;  1YU4 A;  2HIB X;  1Y1F X;  2AII X;  1Z70 X;  2Y3C A;  2HI8 X;  1Y1H X;  2AFY X;  1Y4J A;  1Y1J X;  1Y1G X;  1YU3 A;  1Y1I X;  1YU2 A;  1YU0 A;  2Q17 A;  2AIK X;  2IOU A;  1YU1 A;  2AIJ X; 
#chains in the Genus database with same CATH topology
 2AFT X;  1Y1E X;  1YU4 A;  2HIB X;  1Y1F X;  2AII X;  1Z70 X;  2Y3C A;  2HI8 X;  1Y1H X;  2AFY X;  1Y4J A;  1Y1J X;  1Y1G X;  1YU3 A;  1Y1I X;  1YU2 A;  1YU0 A;  2Q17 A;  2AIK X;  2IOU A;  1YU1 A;  2AIJ X; 
#chains in the Genus database with same CATH homology
 2AFT X;  1Y1E X;  1YU4 A;  2HIB X;  1Y1F X;  2AII X;  1Z70 X;  2Y3C A;  2HI8 X;  1Y1H X;  2AFY X;  1Y4J A;  1Y1J X;  1Y1G X;  1YU3 A;  1Y1I X;  1YU2 A;  1YU0 A;  2Q17 A;  2AIK X;  2IOU A;  1YU1 A;  2AIJ X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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