3I2EA

Crystal structure of human dimethylarginine dymethylaminohydrolase-1 (ddah-1)
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
275
structure length
275
Chain Sequence
AAFGRATHAVVRALPESLGQHALRSAKGEEVDVARAERQHQLYVGVLGSKLGLQVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADGLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDIAANCIYLNIPNKGHVLLHRTPEEYPESAKVYEKLKDHMLIPVSMSELEKVDGLLTCCSVLINKK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
total genus 91
structure length 275
sequence length 275
chains with identical sequence B
ec nomenclature ec 3.5.3.18: Dimethylargininase.
pdb deposition date 2009-06-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02274 Amidinotransf Amidinotransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.75.10.10 Alpha Beta 5-stranded Propeller L-arginine/glycine Amidinotransferase; Chain A L-arginine/glycine Amidinotransferase; Chain A 3i2eA00
3P8PA 4BOFA 7JDWA 6JDWA 4N2IA 2JAJA 4N26A 4N2LA 1WD9A 1WD8A 3HVMA 4N2HA 2CI6A 4N2MA 2C6ZA 2JDXA 5AK7A 3BPBA 4N2FA 1LXYA 1BWDA 2Q3UA 3H7KA 4N2CA 2AAFA 5AK8A 2ACIA 3P8EA 2JAIA 3JDWA 9JDWA 4X8GA 4YTGA 2EWOA 4N2NA 4JDWA 2JERA 2CI4A 4E4JA 3RHYA 4DKTA 4N2GA 2DEWX 1S9RA 4YT9A 5JDWA 1VKPA 1XKNA 2DEXX 2DW5A 2CI7A 3B1TA 2CI5A 2JDWA 4N20A 4N2BA 5HP5A 3I4AA 1G62A 2CI1A 1RXXA 3H7CX 3I2EA 4N24A 2ABRA 4X8CA 1G61A 4N25A 4YTBA 8JDWA 4N2EA 5AN9I 5M3QA 3B1UA 2A9GA 4N22A 3APMA 1ZBRA 2DEYX 4N28A 4N2DA 4N2AA 1H70A 2CMUA 1JDXA 1JDWA 4N2KA 2CI3A 3APNA 1WDAA
chains in the Genus database with same CATH superfamily
3P8PA 4BOFA 7JDWA 6JDWA 4N2IA 2JAJA 4N26A 4N2LA 1WD9A 1WD8A 3HVMA 4N2HA 2CI6A 4N2MA 2C6ZA 2JDXA 5AK7A 3BPBA 4N2FA 1LXYA 1BWDA 2Q3UA 3H7KA 4N2CA 2AAFA 5AK8A 2ACIA 3P8EA 2JAIA 3JDWA 9JDWA 4X8GA 4YTGA 2EWOA 4N2NA 4JDWA 2JERA 2CI4A 4E4JA 3RHYA 4DKTA 4N2GA 2DEWX 1S9RA 4YT9A 5JDWA 1VKPA 1XKNA 2DEXX 2DW5A 2CI7A 3B1TA 2CI5A 2JDWA 4N20A 4N2BA 5HP5A 3I4AA 1G62A 2CI1A 1RXXA 3H7CX 3I2EA 4N24A 2ABRA 1YNFA 4X8CA 1G61A 4N25A 4YTBA 8JDWA 4N2EA 5AN9I 5M3QA 3B1UA 1YNIA 2A9GA 4N22A 1YNHA 3APMA 1ZBRA 2DEYX 4N28A 4N2DA 4N2AA 1H70A 2CMUA 1JDXA 1JDWA 4N2KA 2CI3A 3APNA 1WDAA
chains in the Genus database with same CATH topology
3P8PA 4BOFA 7JDWA 6JDWA 4N2IA 2JAJA 4N26A 4N2LA 1WD9A 1WD8A 3HVMA 4N2HA 2CI6A 4N2MA 2C6ZA 2JDXA 5AK7A 3BPBA 4N2FA 1LXYA 1BWDA 2Q3UA 3H7KA 4N2CA 2AAFA 5AK8A 2ACIA 3P8EA 2JAIA 3JDWA 9JDWA 4X8GA 4YTGA 2EWOA 4N2NA 4JDWA 2JERA 2CI4A 4E4JA 3RHYA 4DKTA 4N2GA 2DEWX 1S9RA 4YT9A 5JDWA 1VKPA 1XKNA 2DEXX 2DW5A 2CI7A 3B1TA 2CI5A 2JDWA 4N20A 4N2BA 5HP5A 3I4AA 1G62A 2CI1A 1RXXA 3H7CX 3I2EA 4N24A 2ABRA 4X8CA 1G61A 4N25A 4YTBA 8JDWA 4N2EA 5AN9I 5M3QA 3B1UA 2A9GA 4N22A 3APMA 1ZBRA 2DEYX 4N28A 4N2DA 4N2AA 1H70A 2CMUA 1JDXA 1JDWA 4N2KA 2CI3A 3APNA 1WDAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3P8P A;  4BOF A;  7JDW A;  6JDW A;  4N2I A;  2JAJ A;  4N26 A;  4N2L A;  1WD9 A;  1WD8 A;  3HVM A;  4N2H A;  2CI6 A;  4N2M A;  2C6Z A;  2JDX A;  5AK7 A;  3BPB A;  4N2F A;  1LXY A;  1BWD A;  2Q3U A;  3H7K A;  4N2C A;  2AAF A;  5AK8 A;  2ACI A;  3P8E A;  2JAI A;  3JDW A;  9JDW A;  4X8G A;  4YTG A;  2EWO A;  4N2N A;  4JDW A;  2JER A;  2CI4 A;  4E4J A;  3RHY A;  4DKT A;  4N2G A;  2DEW X;  1S9R A;  4YT9 A;  5JDW A;  1VKP A;  1XKN A;  2DEX X;  2DW5 A;  2CI7 A;  3B1T A;  2CI5 A;  2JDW A;  4N20 A;  4N2B A;  5HP5 A;  3I4A A;  1G62 A;  2CI1 A;  1RXX A;  3H7C X;  3I2E A;  4N24 A;  2ABR A;  4X8C A;  1G61 A;  4N25 A;  4YTB A;  8JDW A;  4N2E A;  5AN9 I;  5M3Q A;  3B1U A;  2A9G A;  4N22 A;  3APM A;  1ZBR A;  2DEY X;  4N28 A;  4N2D A;  4N2A A;  1H70 A;  2CMU A;  1JDX A;  1JDW A;  4N2K A;  2CI3 A;  3APN A;  1WDA A; 
#chains in the Genus database with same CATH topology
 3P8P A;  4BOF A;  7JDW A;  6JDW A;  4N2I A;  2JAJ A;  4N26 A;  4N2L A;  1WD9 A;  1WD8 A;  3HVM A;  4N2H A;  2CI6 A;  4N2M A;  2C6Z A;  2JDX A;  5AK7 A;  3BPB A;  4N2F A;  1LXY A;  1BWD A;  2Q3U A;  3H7K A;  4N2C A;  2AAF A;  5AK8 A;  2ACI A;  3P8E A;  2JAI A;  3JDW A;  9JDW A;  4X8G A;  4YTG A;  2EWO A;  4N2N A;  4JDW A;  2JER A;  2CI4 A;  4E4J A;  3RHY A;  4DKT A;  4N2G A;  2DEW X;  1S9R A;  4YT9 A;  5JDW A;  1VKP A;  1XKN A;  2DEX X;  2DW5 A;  2CI7 A;  3B1T A;  2CI5 A;  2JDW A;  4N20 A;  4N2B A;  5HP5 A;  3I4A A;  1G62 A;  2CI1 A;  1RXX A;  3H7C X;  3I2E A;  4N24 A;  2ABR A;  1YNF A;  4X8C A;  1G61 A;  4N25 A;  4YTB A;  8JDW A;  4N2E A;  5AN9 I;  5M3Q A;  3B1U A;  1YNI A;  2A9G A;  4N22 A;  1YNH A;  3APM A;  1ZBR A;  2DEY X;  4N28 A;  4N2D A;  4N2A A;  1H70 A;  2CMU A;  1JDX A;  1JDW A;  4N2K A;  2CI3 A;  3APN A;  1WDA A; 
#chains in the Genus database with same CATH homology
 3P8P A;  4BOF A;  7JDW A;  6JDW A;  4N2I A;  2JAJ A;  4N26 A;  4N2L A;  1WD9 A;  1WD8 A;  3HVM A;  4N2H A;  2CI6 A;  4N2M A;  2C6Z A;  2JDX A;  5AK7 A;  3BPB A;  4N2F A;  1LXY A;  1BWD A;  2Q3U A;  3H7K A;  4N2C A;  2AAF A;  5AK8 A;  2ACI A;  3P8E A;  2JAI A;  3JDW A;  9JDW A;  4X8G A;  4YTG A;  2EWO A;  4N2N A;  4JDW A;  2JER A;  2CI4 A;  4E4J A;  3RHY A;  4DKT A;  4N2G A;  2DEW X;  1S9R A;  4YT9 A;  5JDW A;  1VKP A;  1XKN A;  2DEX X;  2DW5 A;  2CI7 A;  3B1T A;  2CI5 A;  2JDW A;  4N20 A;  4N2B A;  5HP5 A;  3I4A A;  1G62 A;  2CI1 A;  1RXX A;  3H7C X;  3I2E A;  4N24 A;  2ABR A;  4X8C A;  1G61 A;  4N25 A;  4YTB A;  8JDW A;  4N2E A;  5AN9 I;  5M3Q A;  3B1U A;  2A9G A;  4N22 A;  3APM A;  1ZBR A;  2DEY X;  4N28 A;  4N2D A;  4N2A A;  1H70 A;  2CMU A;  1JDX A;  1JDW A;  4N2K A;  2CI3 A;  3APN A;  1WDA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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