3P8PA

Crystal structure of human dimethylarginine dimethylaminohydrolase-1 (ddah-1) variant c274s bound with n5-(1-iminopentyl)-l-ornithine
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
275
structure length
275
Chain Sequence
AAFGRATHAVVRALPESLGQHALRSAKGEEVDVARAERQHQLYVGVLGSKLGLQVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADGLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDIAANCIYLNIPNKGHVLLHRTPEEYPESAKVYEKLKDHMLIPVSMSELEKVDGLLTSCSVLINKK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Characterization of C-Alkyl Amidines as Bioavailable Covalent Reversible Inhibitors of Human DDAH-1.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
total genus 88
structure length 275
sequence length 275
chains with identical sequence B
ec nomenclature ec 3.5.3.18: Dimethylargininase.
pdb deposition date 2010-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02274 Amidinotransf Amidinotransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.75.10.10 Alpha Beta 5-stranded Propeller L-arginine/glycine Amidinotransferase; Chain A L-arginine/glycine Amidinotransferase; Chain A 3p8pA00
6JDWA 1RXXA 2JAIA 2C6ZA 1JDWA 4BOFA 5M3QA 1BWDA 4N2KA 3APMA 2DW5A 4YTGA 1JDXA 3P8PA 1WD9A 2CMUA 1ZBRA 2DEYX 4E4JA 1G61A 5AK7A 5JDWA 1WD8A 2DEXX 2CI4A 2EWOA 3P8EA 2JDXA 3H7CX 2ABRA 3JDWA 2Q3UA 4YT9A 2A9GA 3B1UA 1S9RA 1LXYA 4N2IA 3BPBA 4N2NA 5HP5A 2CI6A 3I4AA 5AK8A 4N2AA 4N2FA 3APNA 4X8CA 4N2CA 4N2BA 4N2DA 4N20A 9JDWA 2CI3A 2ACIA 4N22A 4X8GA 4N2EA 4N2HA 2JAJA 7JDWA 3B1TA 4YTBA 4N2MA 2JDWA 3HVMA 5AN9I 1VKPA 4N26A 2DEWX 2JERA 3I2EA 4N2LA 4N25A 2CI1A 3H7KA 4DKTA 4N2GA 3RHYA 2AAFA 4N24A 1G62A 1WDAA 4N28A 8JDWA 4JDWA 1XKNA 1H70A 2CI7A 2CI5A
chains in the Genus database with same CATH superfamily
6JDWA 1RXXA 2JAIA 2C6ZA 1JDWA 4BOFA 5M3QA 1BWDA 4N2KA 3APMA 2DW5A 4YTGA 1JDXA 3P8PA 1WD9A 2CMUA 1ZBRA 2DEYX 4E4JA 1G61A 5AK7A 5JDWA 1WD8A 1YNHA 2DEXX 2CI4A 1YNFA 2EWOA 3P8EA 2JDXA 3H7CX 2ABRA 3JDWA 2Q3UA 4YT9A 2A9GA 3B1UA 1S9RA 1LXYA 4N2IA 3BPBA 4N2NA 5HP5A 2CI6A 3I4AA 5AK8A 4N2AA 4N2FA 3APNA 4X8CA 4N2CA 4N2BA 4N2DA 4N20A 9JDWA 2CI3A 2ACIA 4N22A 4X8GA 4N2EA 4N2HA 2JAJA 7JDWA 3B1TA 4YTBA 4N2MA 2JDWA 3HVMA 5AN9I 1VKPA 4N26A 2DEWX 2JERA 3I2EA 4N2LA 4N25A 2CI1A 3H7KA 4DKTA 4N2GA 3RHYA 2AAFA 4N24A 1G62A 1WDAA 4N28A 8JDWA 4JDWA 1XKNA 1H70A 2CI7A 2CI5A 1YNIA
chains in the Genus database with same CATH topology
6JDWA 1RXXA 2JAIA 2C6ZA 1JDWA 4BOFA 5M3QA 1BWDA 4N2KA 3APMA 2DW5A 4YTGA 1JDXA 3P8PA 1WD9A 2CMUA 1ZBRA 2DEYX 4E4JA 1G61A 5AK7A 5JDWA 1WD8A 2DEXX 2CI4A 2EWOA 3P8EA 2JDXA 3H7CX 2ABRA 3JDWA 2Q3UA 4YT9A 2A9GA 3B1UA 1S9RA 1LXYA 4N2IA 3BPBA 4N2NA 5HP5A 2CI6A 3I4AA 5AK8A 4N2AA 4N2FA 3APNA 4X8CA 4N2CA 4N2BA 4N2DA 4N20A 9JDWA 2CI3A 2ACIA 4N22A 4X8GA 4N2EA 4N2HA 2JAJA 7JDWA 3B1TA 4YTBA 4N2MA 2JDWA 3HVMA 5AN9I 1VKPA 4N26A 2DEWX 2JERA 3I2EA 4N2LA 4N25A 2CI1A 3H7KA 4DKTA 4N2GA 3RHYA 2AAFA 4N24A 1G62A 1WDAA 4N28A 8JDWA 4JDWA 1XKNA 1H70A 2CI7A 2CI5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 6JDW A;  1RXX A;  2JAI A;  2C6Z A;  1JDW A;  4BOF A;  5M3Q A;  1BWD A;  4N2K A;  3APM A;  2DW5 A;  4YTG A;  1JDX A;  3P8P A;  1WD9 A;  2CMU A;  1ZBR A;  2DEY X;  4E4J A;  1G61 A;  5AK7 A;  5JDW A;  1WD8 A;  2DEX X;  2CI4 A;  2EWO A;  3P8E A;  2JDX A;  3H7C X;  2ABR A;  3JDW A;  2Q3U A;  4YT9 A;  2A9G A;  3B1U A;  1S9R A;  1LXY A;  4N2I A;  3BPB A;  4N2N A;  5HP5 A;  2CI6 A;  3I4A A;  5AK8 A;  4N2A A;  4N2F A;  3APN A;  4X8C A;  4N2C A;  4N2B A;  4N2D A;  4N20 A;  9JDW A;  2CI3 A;  2ACI A;  4N22 A;  4X8G A;  4N2E A;  4N2H A;  2JAJ A;  7JDW A;  3B1T A;  4YTB A;  4N2M A;  2JDW A;  3HVM A;  5AN9 I;  1VKP A;  4N26 A;  2DEW X;  2JER A;  3I2E A;  4N2L A;  4N25 A;  2CI1 A;  3H7K A;  4DKT A;  4N2G A;  3RHY A;  2AAF A;  4N24 A;  1G62 A;  1WDA A;  4N28 A;  8JDW A;  4JDW A;  1XKN A;  1H70 A;  2CI7 A;  2CI5 A; 
#chains in the Genus database with same CATH topology
 6JDW A;  1RXX A;  2JAI A;  2C6Z A;  1JDW A;  4BOF A;  5M3Q A;  1BWD A;  4N2K A;  3APM A;  2DW5 A;  4YTG A;  1JDX A;  3P8P A;  1WD9 A;  2CMU A;  1ZBR A;  2DEY X;  4E4J A;  1G61 A;  5AK7 A;  5JDW A;  1WD8 A;  1YNH A;  2DEX X;  2CI4 A;  1YNF A;  2EWO A;  3P8E A;  2JDX A;  3H7C X;  2ABR A;  3JDW A;  2Q3U A;  4YT9 A;  2A9G A;  3B1U A;  1S9R A;  1LXY A;  4N2I A;  3BPB A;  4N2N A;  5HP5 A;  2CI6 A;  3I4A A;  5AK8 A;  4N2A A;  4N2F A;  3APN A;  4X8C A;  4N2C A;  4N2B A;  4N2D A;  4N20 A;  9JDW A;  2CI3 A;  2ACI A;  4N22 A;  4X8G A;  4N2E A;  4N2H A;  2JAJ A;  7JDW A;  3B1T A;  4YTB A;  4N2M A;  2JDW A;  3HVM A;  5AN9 I;  1VKP A;  4N26 A;  2DEW X;  2JER A;  3I2E A;  4N2L A;  4N25 A;  2CI1 A;  3H7K A;  4DKT A;  4N2G A;  3RHY A;  2AAF A;  4N24 A;  1G62 A;  1WDA A;  4N28 A;  8JDW A;  4JDW A;  1XKN A;  1H70 A;  2CI7 A;  2CI5 A;  1YNI A; 
#chains in the Genus database with same CATH homology
 6JDW A;  1RXX A;  2JAI A;  2C6Z A;  1JDW A;  4BOF A;  5M3Q A;  1BWD A;  4N2K A;  3APM A;  2DW5 A;  4YTG A;  1JDX A;  3P8P A;  1WD9 A;  2CMU A;  1ZBR A;  2DEY X;  4E4J A;  1G61 A;  5AK7 A;  5JDW A;  1WD8 A;  2DEX X;  2CI4 A;  2EWO A;  3P8E A;  2JDX A;  3H7C X;  2ABR A;  3JDW A;  2Q3U A;  4YT9 A;  2A9G A;  3B1U A;  1S9R A;  1LXY A;  4N2I A;  3BPB A;  4N2N A;  5HP5 A;  2CI6 A;  3I4A A;  5AK8 A;  4N2A A;  4N2F A;  3APN A;  4X8C A;  4N2C A;  4N2B A;  4N2D A;  4N20 A;  9JDW A;  2CI3 A;  2ACI A;  4N22 A;  4X8G A;  4N2E A;  4N2H A;  2JAJ A;  7JDW A;  3B1T A;  4YTB A;  4N2M A;  2JDW A;  3HVM A;  5AN9 I;  1VKP A;  4N26 A;  2DEW X;  2JER A;  3I2E A;  4N2L A;  4N25 A;  2CI1 A;  3H7K A;  4DKT A;  4N2G A;  3RHY A;  2AAF A;  4N24 A;  1G62 A;  1WDA A;  4N28 A;  8JDW A;  4JDW A;  1XKN A;  1H70 A;  2CI7 A;  2CI5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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