3P8PA

Crystal structure of human dimethylarginine dimethylaminohydrolase-1 (ddah-1) variant c274s bound with n5-(1-iminopentyl)-l-ornithine
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
275
structure length
275
Chain Sequence
AAFGRATHAVVRALPESLGQHALRSAKGEEVDVARAERQHQLYVGVLGSKLGLQVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADGLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDIAANCIYLNIPNKGHVLLHRTPEEYPESAKVYEKLKDHMLIPVSMSELEKVDGLLTSCSVLINKK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Characterization of C-Alkyl Amidines as Bioavailable Covalent Reversible Inhibitors of Human DDAH-1.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
total genus 88
structure length 275
sequence length 275
chains with identical sequence B
ec nomenclature ec 3.5.3.18: Dimethylargininase.
pdb deposition date 2010-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02274 Amidinotransf Amidinotransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.75.10.10 Alpha Beta 5-stranded Propeller L-arginine/glycine Amidinotransferase; Chain A L-arginine/glycine Amidinotransferase; Chain A 3p8pA00
4N22A 3RHYA 4N2NA 4DKTA 1WDAA 2JAJA 4N2FA 4X8CA 5AK7A 4N2HA 3I4AA 2C6ZA 4JDWA 1S9RA 3I2EA 4N2KA 1XKNA 3P8EA 2DEYX 2A9GA 3H7KA 1WD8A 2JDWA 3B1UA 7JDWA 4YTBA 4E4JA 8JDWA 2DW5A 3APMA 4BOFA 2CI6A 3H7CX 5JDWA 3B1TA 4YT9A 4N24A 1BWDA 2DEXX 9JDWA 1WD9A 5M3QA 2Q3UA 3APNA 2ACIA 5HP5A 3BPBA 4N26A 3P8PA 4N2DA 5AN9I 2CI4A 4N2AA 1G61A 4N20A 2AAFA 4N2BA 2JERA 2CI5A 4N25A 2EWOA 4YTGA 2CI3A 4N28A 4N2LA 4N2MA 1LXYA 4N2IA 2CI7A 3HVMA 2CI1A 6JDWA 3JDWA 1JDXA 2DEWX 1RXXA 4N2EA 2ABRA 1VKPA 2JDXA 1G62A 2CMUA 4N2CA 2JAIA 4X8GA 4N2GA 1JDWA 1H70A 1ZBRA 5AK8A
chains in the Genus database with same CATH superfamily
1YNIA 4N22A 3RHYA 4N2NA 4DKTA 1WDAA 2JAJA 4N2FA 4X8CA 5AK7A 4N2HA 3I4AA 2C6ZA 4JDWA 1S9RA 3I2EA 4N2KA 1XKNA 3P8EA 2DEYX 2A9GA 3H7KA 1WD8A 2JDWA 3B1UA 7JDWA 4YTBA 4E4JA 8JDWA 2DW5A 3APMA 4BOFA 2CI6A 3H7CX 5JDWA 3B1TA 4YT9A 4N24A 1BWDA 2DEXX 9JDWA 1WD9A 1YNHA 5M3QA 2Q3UA 3APNA 2ACIA 5HP5A 3BPBA 4N26A 3P8PA 4N2DA 5AN9I 2CI4A 4N2AA 1G61A 4N20A 2AAFA 4N2BA 2JERA 2CI5A 4N25A 2EWOA 4YTGA 2CI3A 4N28A 4N2LA 4N2MA 1LXYA 4N2IA 2CI7A 3HVMA 2CI1A 6JDWA 3JDWA 1JDXA 2DEWX 1RXXA 4N2EA 1YNFA 2ABRA 1VKPA 2JDXA 1G62A 2CMUA 4N2CA 2JAIA 4X8GA 4N2GA 1JDWA 1H70A 1ZBRA 5AK8A
chains in the Genus database with same CATH topology
4N22A 3RHYA 4N2NA 4DKTA 1WDAA 2JAJA 4N2FA 4X8CA 5AK7A 4N2HA 3I4AA 2C6ZA 4JDWA 1S9RA 3I2EA 4N2KA 1XKNA 3P8EA 2DEYX 2A9GA 3H7KA 1WD8A 2JDWA 3B1UA 7JDWA 4YTBA 4E4JA 8JDWA 2DW5A 3APMA 4BOFA 2CI6A 3H7CX 5JDWA 3B1TA 4YT9A 4N24A 1BWDA 2DEXX 9JDWA 1WD9A 5M3QA 2Q3UA 3APNA 2ACIA 5HP5A 3BPBA 4N26A 3P8PA 4N2DA 5AN9I 2CI4A 4N2AA 1G61A 4N20A 2AAFA 4N2BA 2JERA 2CI5A 4N25A 2EWOA 4YTGA 2CI3A 4N28A 4N2LA 4N2MA 1LXYA 4N2IA 2CI7A 3HVMA 2CI1A 6JDWA 3JDWA 1JDXA 2DEWX 1RXXA 4N2EA 2ABRA 1VKPA 2JDXA 1G62A 2CMUA 4N2CA 2JAIA 4X8GA 4N2GA 1JDWA 1H70A 1ZBRA 5AK8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4N22 A;  3RHY A;  4N2N A;  4DKT A;  1WDA A;  2JAJ A;  4N2F A;  4X8C A;  5AK7 A;  4N2H A;  3I4A A;  2C6Z A;  4JDW A;  1S9R A;  3I2E A;  4N2K A;  1XKN A;  3P8E A;  2DEY X;  2A9G A;  3H7K A;  1WD8 A;  2JDW A;  3B1U A;  7JDW A;  4YTB A;  4E4J A;  8JDW A;  2DW5 A;  3APM A;  4BOF A;  2CI6 A;  3H7C X;  5JDW A;  3B1T A;  4YT9 A;  4N24 A;  1BWD A;  2DEX X;  9JDW A;  1WD9 A;  5M3Q A;  2Q3U A;  3APN A;  2ACI A;  5HP5 A;  3BPB A;  4N26 A;  3P8P A;  4N2D A;  5AN9 I;  2CI4 A;  4N2A A;  1G61 A;  4N20 A;  2AAF A;  4N2B A;  2JER A;  2CI5 A;  4N25 A;  2EWO A;  4YTG A;  2CI3 A;  4N28 A;  4N2L A;  4N2M A;  1LXY A;  4N2I A;  2CI7 A;  3HVM A;  2CI1 A;  6JDW A;  3JDW A;  1JDX A;  2DEW X;  1RXX A;  4N2E A;  2ABR A;  1VKP A;  2JDX A;  1G62 A;  2CMU A;  4N2C A;  2JAI A;  4X8G A;  4N2G A;  1JDW A;  1H70 A;  1ZBR A;  5AK8 A; 
#chains in the Genus database with same CATH topology
 1YNI A;  4N22 A;  3RHY A;  4N2N A;  4DKT A;  1WDA A;  2JAJ A;  4N2F A;  4X8C A;  5AK7 A;  4N2H A;  3I4A A;  2C6Z A;  4JDW A;  1S9R A;  3I2E A;  4N2K A;  1XKN A;  3P8E A;  2DEY X;  2A9G A;  3H7K A;  1WD8 A;  2JDW A;  3B1U A;  7JDW A;  4YTB A;  4E4J A;  8JDW A;  2DW5 A;  3APM A;  4BOF A;  2CI6 A;  3H7C X;  5JDW A;  3B1T A;  4YT9 A;  4N24 A;  1BWD A;  2DEX X;  9JDW A;  1WD9 A;  1YNH A;  5M3Q A;  2Q3U A;  3APN A;  2ACI A;  5HP5 A;  3BPB A;  4N26 A;  3P8P A;  4N2D A;  5AN9 I;  2CI4 A;  4N2A A;  1G61 A;  4N20 A;  2AAF A;  4N2B A;  2JER A;  2CI5 A;  4N25 A;  2EWO A;  4YTG A;  2CI3 A;  4N28 A;  4N2L A;  4N2M A;  1LXY A;  4N2I A;  2CI7 A;  3HVM A;  2CI1 A;  6JDW A;  3JDW A;  1JDX A;  2DEW X;  1RXX A;  4N2E A;  1YNF A;  2ABR A;  1VKP A;  2JDX A;  1G62 A;  2CMU A;  4N2C A;  2JAI A;  4X8G A;  4N2G A;  1JDW A;  1H70 A;  1ZBR A;  5AK8 A; 
#chains in the Genus database with same CATH homology
 4N22 A;  3RHY A;  4N2N A;  4DKT A;  1WDA A;  2JAJ A;  4N2F A;  4X8C A;  5AK7 A;  4N2H A;  3I4A A;  2C6Z A;  4JDW A;  1S9R A;  3I2E A;  4N2K A;  1XKN A;  3P8E A;  2DEY X;  2A9G A;  3H7K A;  1WD8 A;  2JDW A;  3B1U A;  7JDW A;  4YTB A;  4E4J A;  8JDW A;  2DW5 A;  3APM A;  4BOF A;  2CI6 A;  3H7C X;  5JDW A;  3B1T A;  4YT9 A;  4N24 A;  1BWD A;  2DEX X;  9JDW A;  1WD9 A;  5M3Q A;  2Q3U A;  3APN A;  2ACI A;  5HP5 A;  3BPB A;  4N26 A;  3P8P A;  4N2D A;  5AN9 I;  2CI4 A;  4N2A A;  1G61 A;  4N20 A;  2AAF A;  4N2B A;  2JER A;  2CI5 A;  4N25 A;  2EWO A;  4YTG A;  2CI3 A;  4N28 A;  4N2L A;  4N2M A;  1LXY A;  4N2I A;  2CI7 A;  3HVM A;  2CI1 A;  6JDW A;  3JDW A;  1JDX A;  2DEW X;  1RXX A;  4N2E A;  2ABR A;  1VKP A;  2JDX A;  1G62 A;  2CMU A;  4N2C A;  2JAI A;  4X8G A;  4N2G A;  1JDW A;  1H70 A;  1ZBR A;  5AK8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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