The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
129
|
sequence length |
436
|
structure length |
418
|
Chain Sequence |
SSSIPMPAGVNPADLAAELAAVVTESVDEDYLLYECDGQWVLAAGVQAMVELDSDELRVIRDGVTRRQQWSGRPGAALGEAVDRLLLETDQAFGWVAFEFGVHRYGLQQRLAPHTPLARVFSPRTRIMVSEKEIRLFDAGIRHREAIDRLLATGVREVPQSRSVDVSDDPSGFRRRVAVAVDEIAAGRYHKVILSRCVEVPFAIDFPLTYRLGRRHNTPVRSFLLQLGGIRALGYSPELVTAVRADGVVITEPLAGTDDLESNSKEIVEHAISVRSSLEEITDIAEPGSAAVIDFMTVRVQHLGSTIRARLDPSSDRMAALEALFPAVTASGIPKAAGVEAIFRLDECPRGLYSGAVVMLSADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLSTLTPYLVARQ
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
pubmed doi rcsb |
| molecule tags |
Isomerase/isomerase inhibitor
|
| source organism |
Mycobacterium tuberculosis
|
| molecule keywords |
Isochorismate synthase/isochorismate-pyruvate lyase mbtI
|
| total genus |
129
|
| structure length |
418
|
| sequence length |
436
|
| chains with identical sequence |
B, C, D
|
| ec nomenclature |
ec
4.2.99.21: Isochorismate lyase. |
| pdb deposition date | 2011-05-06 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00425 | Chorismate_bind | chorismate binding enzyme |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | 4-Layer Sandwich | Anthranilate synthase | Anthranilate synthase |
#chains in the Genus database with same CATH superfamily 3R75 A; 1K0G A; 3OS6 A; 2EUA A; 1K0E A; 1I1Q A; 2FN0 A; 3H9M A; 3LOG A; 3R76 A; 3BZM A; 1I7Q A; 3GSE A; 2G5F A; 1I7S A; 3BZN A; 3VEH A; 3RV8 A; 5JY4 B; 5JXZ A; 5JY8 A; 5JY4 A; 3RV7 A; 2FN1 A; 3RV9 A; 4GRH A; 5KCK A; 2I6Y A; 1QDL A; 3R74 A; 5JZD A; 3RV6 A; 5JY9 A; 3HWO A; 5CWA A; 3ST6 A; #chains in the Genus database with same CATH topology 3R75 A; 1K0G A; 3OS6 A; 2EUA A; 1K0E A; 1I1Q A; 2FN0 A; 3H9M A; 3LOG A; 3R76 A; 3BZM A; 1I7Q A; 3GSE A; 2G5F A; 1I7S A; 3BZN A; 3VEH A; 3RV8 A; 5JY4 B; 5JXZ A; 5JY8 A; 5JY4 A; 3RV7 A; 2FN1 A; 3RV9 A; 4GRH A; 5KCK A; 2I6Y A; 1QDL A; 3R74 A; 5JZD A; 3RV6 A; 5JY9 A; 3HWO A; 5CWA A; 3ST6 A; #chains in the Genus database with same CATH homology 3R75 A; 1K0G A; 3OS6 A; 2EUA A; 1K0E A; 1I1Q A; 2FN0 A; 3H9M A; 3LOG A; 3R76 A; 3BZM A; 1I7Q A; 3GSE A; 2G5F A; 1I7S A; 3BZN A; 3VEH A; 3RV8 A; 5JY4 B; 5JXZ A; 5JY8 A; 5JY4 A; 3RV7 A; 2FN1 A; 3RV9 A; 4GRH A; 5KCK A; 2I6Y A; 1QDL A; 3R74 A; 5JZD A; 3RV6 A; 5JY9 A; 3HWO A; 5CWA A; 3ST6 A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
