5CWAA

Structure of anthranilate synthase component i (trpe) from mycobacterium tuberculosis with inhibitor bound
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
sequence length
509
structure length
505
Chain Sequence
ADLAATTSREDFRLLAAEHRVVPVTRKVLADSETPLSAYRKLAANRPGTFLLESAENGRSWSRWSFIGAGAPTALTVREGQAVWLGAVPKDAPTGGDPLRALQVTLELLATADPGLPPLSGGMVGFFAYDMVRRLERLPERAVDDLCLPDMLLLLATDVAAVDHHEGTITLIANAVNWNGTDERVDWAYDDAVARLDVMTAALGQPLPSTVATFSRPEPRHRAQRTVEEYGAIVEYLVDQIAAGEAFQVVPSQRFEMDTDVDPIDVYRILRVTNPSPYMYLLQVPNSDGAVDFSIVGSSPEALVTVHEGWATTHPIAGTRWRGRTDDEDVLLEKELLADDKERAEHLMLVDLGRNDLGRVCTPGTVRVEDYSHIERYSHVMHLVSTVTGKLGEGRTALDAVTACFPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVVGYLDFAGNADFAIAIRTALMRNGTAYVQAGGGVVADSNGSYEYNEARNKARAVLNAIAAAETLAAPGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex.
pubmed doi rcsb
molecule tags Lyase/lyase inhibitor
source organism Mycobacterium tuberculosis (strain cdc 1551 / oshkosh)
molecule keywords Anthranilate synthase component 1
total genus 159
structure length 505
sequence length 509
ec nomenclature ec 4.1.3.27: Anthranilate synthase.
pdb deposition date 2015-07-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00425 Chorismate_bind chorismate binding enzyme
A PF04715 Anth_synt_I_N Anthranilate synthase component I, N terminal region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.120.10 Alpha Beta 4-Layer Sandwich Anthranilate synthase Anthranilate synthase 5cwaA00
1I7SA 3RV8A 2FN1A 3LOGA 1K0GA 2FN0A 3GSEA 5CWAA 3RV9A 5JZDA 3BZNA 5JXZA 3R75A 3BZMA 5JY4A 2I6YA 1I1QA 3VEHA 2EUAA 1QDLA 1K0EA 4GRHA 3R76A 3ST6A 3OS6A 5KCKA 3RV7A 3H9MA 1I7QA 3R74A 5JY8A 5JY4B 5JY9A 2G5FA 3HWOA 3RV6A
chains in the Genus database with same CATH superfamily
1I7SA 3RV8A 2FN1A 3LOGA 1K0GA 2FN0A 3GSEA 5CWAA 3RV9A 5JZDA 3BZNA 5JXZA 3R75A 3BZMA 5JY4A 2I6YA 1I1QA 3VEHA 2EUAA 1QDLA 1K0EA 4GRHA 3R76A 3ST6A 3OS6A 5KCKA 3RV7A 3H9MA 1I7QA 3R74A 5JY8A 5JY4B 5JY9A 2G5FA 3HWOA 3RV6A
chains in the Genus database with same CATH topology
1I7SA 3RV8A 2FN1A 3LOGA 1K0GA 2FN0A 3GSEA 5CWAA 3RV9A 5JZDA 3BZNA 5JXZA 3R75A 3BZMA 5JY4A 2I6YA 1I1QA 3VEHA 2EUAA 1QDLA 1K0EA 4GRHA 3R76A 3ST6A 3OS6A 5KCKA 3RV7A 3H9MA 1I7QA 3R74A 5JY8A 5JY4B 5JY9A 2G5FA 3HWOA 3RV6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I7S A;  3RV8 A;  2FN1 A;  3LOG A;  1K0G A;  2FN0 A;  3GSE A;  5CWA A;  3RV9 A;  5JZD A;  3BZN A;  5JXZ A;  3R75 A;  3BZM A;  5JY4 A;  2I6Y A;  1I1Q A;  3VEH A;  2EUA A;  1QDL A;  1K0E A;  4GRH A;  3R76 A;  3ST6 A;  3OS6 A;  5KCK A;  3RV7 A;  3H9M A;  1I7Q A;  3R74 A;  5JY8 A;  5JY4 B;  5JY9 A;  2G5F A;  3HWO A;  3RV6 A; 
#chains in the Genus database with same CATH topology
 1I7S A;  3RV8 A;  2FN1 A;  3LOG A;  1K0G A;  2FN0 A;  3GSE A;  5CWA A;  3RV9 A;  5JZD A;  3BZN A;  5JXZ A;  3R75 A;  3BZM A;  5JY4 A;  2I6Y A;  1I1Q A;  3VEH A;  2EUA A;  1QDL A;  1K0E A;  4GRH A;  3R76 A;  3ST6 A;  3OS6 A;  5KCK A;  3RV7 A;  3H9M A;  1I7Q A;  3R74 A;  5JY8 A;  5JY4 B;  5JY9 A;  2G5F A;  3HWO A;  3RV6 A; 
#chains in the Genus database with same CATH homology
 1I7S A;  3RV8 A;  2FN1 A;  3LOG A;  1K0G A;  2FN0 A;  3GSE A;  5CWA A;  3RV9 A;  5JZD A;  3BZN A;  5JXZ A;  3R75 A;  3BZM A;  5JY4 A;  2I6Y A;  1I1Q A;  3VEH A;  2EUA A;  1QDL A;  1K0E A;  4GRH A;  3R76 A;  3ST6 A;  3OS6 A;  5KCK A;  3RV7 A;  3H9M A;  1I7Q A;  3R74 A;  5JY8 A;  5JY4 B;  5JY9 A;  2G5F A;  3HWO A;  3RV6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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