2CX8A

Crystal structure of methyltransferase with ligand(sah)
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
Knots found
sequence length
225
structure length
225
Chain Sequence
HRAFSPGLTGVLPLRETRHLVEVLRARVGDRFTVFDGEREALAEVVDLGPPLRYRVLEERRPEREVGVEVVLYVALLKGDKLAEVVRAATELGATRIQPLVTRHSVPKEMGEGKLRRLRAVALEAAKQSGRVVVPEVLPPIPLKAVPQVAQGLVAHVGATARVREVLDPEKPLALAVGPEGGFAEEEVALLEARGFTPVSLGRRILRAETAALALLALCTAGEGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of methyltransferase with ligand(SAH)
rcsb
molecule tags Transferase
source organism Thermus thermophilus
molecule keywords methyl transferase
total genus 70
structure length 225
sequence length 225
chains with identical sequence B
other databases KnotProt 2.0: K +31
ec nomenclature
pdb deposition date 2005-06-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04452 Methyltrans_RNA RNA methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.20 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Hypothetical PUA domain-like; domain 1 2cx8A01
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 2cx8A02
1P9PA 3KY7A 4YQSA 5GM8A 4CNDA 3AI9X 4YQ9A 3OINA 1VH0A 4YVKA 1V2XA 3OIIA 1NS5A 4JALA 4YQGA 2YY8A 2NWAA 4YQCA 4YQLA 1UALA 4YQBA 4YQ8A 1UAJA 4CNEA 4YPYA 3N4JA 2I6DA 4YPWA 5GMCA 4YQ4A 4RG1A 4JAKA 4YPZA 3AXZA 2V3KA 4L69A 3GYQA 1V6ZA 3KNUA 5GMBA 4X3MA 2QMMA 1Z85A 5CO4A 4YQ0A 2Z0YA 4YQ1A 3E5YA 4YVGA 2EGVA 4YQNA 1J85A 1ZJRA 4H3ZA 1X7OA 3OIJA 4YPXA 5FAIA 3N4KA 5D9FA 2CX8A 1UAKA 4H3YA 3KTYA 4E8BA 4YQJA 3BBHA 4YQ2A 1O6DA 1NXZA 4J3CA 4YQAA 3O7BA 1TO0A 3BBDA 4MCDA 4YQ3A 2V3JA 4PZKA 4IG6A 1VHYA 1MXIA 4YVJA 3ILKA 4YQDA 3ONPA 4XBOA 2HA8A 4MCCA 3DCMX 4X3LA 4FAKA 4YQRA 4YQ6A 1X7PA 3NK6A 4YQ7A 4YQIA 3QUVA 3BBEA 3KW2A 4CNGA 2O3AA 4CNFA 3IC6A 4YQQA 4YQOA 1OY5A 1VHKA 1UAMA 4YVIA 3NK7A 1K3RA 3L8UA 4YQKA 4YQ5A 3IEFA 1GZ0A 3AIAA 4KGNA 4YVHA 4MCBA 2EGWA 2QWVA 1IPAA 4KDZA 4YQPA 4YQTA
chains in the Genus database with same CATH superfamily
1P9PA 3KY7A 4YQSA 5GM8A 4CNDA 1QRUA 3AI9X 4YQ9A 1O0CA 3OINA 1VH0A 4YVKA 4H3SA 1V2XA 3OIIA 2ZJPS 1NS5A 4JALA 4YQGA 3AIIA 5GAHW 2YY8A 2PJJA 4JYZA 2NWAA 4WF9S 3X1LB 4YQCA 1UALA 4YQLA 5JVHS 4YQBA 5HL7S 3PIOS 1UAJA 4YQ8A 4CNEA 4YPYA 3N4JA 4JXZA 2I6DA 4YPWA 5GMCA 4P2BA 1FEUA 3DLLS 1DFUP 4YQ4A 4RG1A 4JWJA 5DM6S 4JAKA 4YPZA 2G5DA 3AXZA 2V3KA 1QRTA 1QRSA 4L69A 3GYQA 4WFNS 3W2VB 1V6ZA 3KNUA 5GMBA 5GAGW 4JXXA 4IOAS 2QMMA 1Z85A 4X3MA 5CO4A 4YQ0A 3J7ZV 2Z0YA 4YQ1A 3E5YA 4YVGA 2EGVA 4H4KA 1J85A 4YQNA 1ZJRA 1QTQA 5BNZA 4H3ZA 1D6KA 1X7OA 1EUQA 4FMWA 2GAEA 1ZJWA 2HZ7A 3OIJA 4YPXA 5FAIA 3N4KA 5D9FA 4V194 2CX8A 1UAKA 4H3YA 2PI8A 4WFBS 3KTYA 4E8BA 5GAEW 3PIPS 4YQJA 3BBHA 4YQ2A 4IO9S 1O6DA 1NXZA 1O0BA 4J3CA 5IZNA 4YQAA 3O7BA 1B75A 2G6GA 1TO0A 3BBDA 4MCDA 4YQ3A 5GADW 2V3JA 4PZKA 4IG6A 1VHYA 1MXIA 4YVJA 3ILKA 2PICA 4WFAS 4YQDA 5DM7S 3ONPA 2RD2A 4XBOA 2HA8A 4MCCA 3DCMX 4X3LA 2ZJRS 1GTRA 4FAKA 4YQRA 4WCES 4YQ6A 3CF5S 1X7PA 3NK6A 4YQ7A 4YQIA 5JVGS 3QUVA 1UDXA 3BBEA 1NYLA 3KW2A 4CNGA 2RE8A 2O3AA 4CNFA 3IC6A 2PNWA 4IOCS 4U67S 4YQQA 4YQOA 2AE0X 1OY5A 1VHKA 1UAMA 4JWHA 4JWGA 4YVIA 3CZBA 3NK7A 1K3RA 3L8UA 4YQKA 4YQ5A 3IEFA 2ZJQS 1GZ0A 3AIAA 4KGNA 4YVHA 4UY88 4JWFA 4MCBA 2EGWA 1EXDA 1EUYA 3W2WB 2QWVA 1GTSA 1IPAA 4KDZA 4YQPA 4YQTA
chains in the Genus database with same CATH topology
1P9PA 3KY7A 4YQSA 5GM8A 4CNDA 3AI9X 4YQ9A 3OINA 1VH0A 4YVKA 1V2XA 3OIIA 1NS5A 4JALA 4YQGA 2YY8A 2NWAA 4YQCA 4YQLA 1UALA 4YQBA 4YQ8A 1UAJA 4CNEA 4YPYA 3N4JA 2I6DA 4YPWA 5GMCA 4YQ4A 4RG1A 4JWJA 4JAKA 4YPZA 3AXZA 2V3KA 4L69A 3GYQA 1V6ZA 3KNUA 5GMBA 4X3MA 2QMMA 1Z85A 5CO4A 4YQ0A 2Z0YA 4YQ1A 3E5YA 4YVGA 2EGVA 4YQNA 1J85A 1ZJRA 4H3ZA 1X7OA 4FMWA 3OIJA 4YPXA 5FAIA 3N4KA 5D9FA 2CX8A 1UAKA 4H3YA 3KTYA 4E8BA 4YQJA 3BBHA 4YQ2A 1O6DA 1NXZA 4J3CA 4YQAA 3O7BA 1TO0A 3BBDA 4MCDA 4YQ3A 2V3JA 4PZKA 4IG6A 1VHYA 1MXIA 4YVJA 3ILKA 4YQDA 3ONPA 4XBOA 2HA8A 4MCCA 3DCMX 4X3LA 4FAKA 4YQRA 4YQ6A 1X7PA 3NK6A 4YQ7A 4YQIA 3QUVA 3BBEA 3KW2A 4CNGA 2O3AA 4CNFA 3IC6A 4YQQA 4YQOA 1OY5A 1VHKA 1UAMA 4JWHA 4JWGA 4YVIA 3NK7A 1K3RA 3L8UA 4YQKA 4YQ5A 3IEFA 1GZ0A 3AIAA 4KGNA 4YVHA 4JWFA 4MCBA 2EGWA 2QWVA 1IPAA 4KDZA 4YQPA 4YQTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1P9P A;  3KY7 A;  4YQS A;  5GM8 A;  4CND A;  3AI9 X;  4YQ9 A;  3OIN A;  1VH0 A;  4YVK A;  1V2X A;  3OII A;  1NS5 A;  4JAL A;  4YQG A;  2YY8 A;  2NWA A;  4YQC A;  4YQL A;  1UAL A;  4YQB A;  4YQ8 A;  1UAJ A;  4CNE A;  4YPY A;  3N4J A;  2I6D A;  4YPW A;  5GMC A;  4YQ4 A;  4RG1 A;  4JAK A;  4YPZ A;  3AXZ A;  2V3K A;  4L69 A;  3GYQ A;  1V6Z A;  3KNU A;  5GMB A;  4X3M A;  2QMM A;  1Z85 A;  5CO4 A;  4YQ0 A;  2Z0Y A;  4YQ1 A;  3E5Y A;  4YVG A;  2EGV A;  4YQN A;  1J85 A;  1ZJR A;  4H3Z A;  1X7O A;  3OIJ A;  4YPX A;  5FAI A;  3N4K A;  5D9F A;  2CX8 A;  1UAK A;  4H3Y A;  3KTY A;  4E8B A;  4YQJ A;  3BBH A;  4YQ2 A;  1O6D A;  1NXZ A;  4J3C A;  4YQA A;  3O7B A;  1TO0 A;  3BBD A;  4MCD A;  4YQ3 A;  2V3J A;  4PZK A;  4IG6 A;  1VHY A;  1MXI A;  4YVJ A;  3ILK A;  4YQD A;  3ONP A;  4XBO A;  2HA8 A;  4MCC A;  3DCM X;  4X3L A;  4FAK A;  4YQR A;  4YQ6 A;  1X7P A;  3NK6 A;  4YQ7 A;  4YQI A;  3QUV A;  3BBE A;  3KW2 A;  4CNG A;  2O3A A;  4CNF A;  3IC6 A;  4YQQ A;  4YQO A;  1OY5 A;  1VHK A;  1UAM A;  4YVI A;  3NK7 A;  1K3R A;  3L8U A;  4YQK A;  4YQ5 A;  3IEF A;  1GZ0 A;  3AIA A;  4KGN A;  4YVH A;  4MCB A;  2EGW A;  2QWV A;  1IPA A;  4KDZ A;  4YQP A;  4YQT A; 
#chains in the Genus database with same CATH topology
 1P9P A;  3KY7 A;  4YQS A;  5GM8 A;  4CND A;  1QRU A;  3AI9 X;  4YQ9 A;  1O0C A;  3OIN A;  1VH0 A;  4YVK A;  4H3S A;  1V2X A;  3OII A;  2ZJP S;  1NS5 A;  4JAL A;  4YQG A;  3AII A;  5GAH W;  2YY8 A;  2PJJ A;  4JYZ A;  2NWA A;  4WF9 S;  3X1L B;  4YQC A;  1UAL A;  4YQL A;  5JVH S;  4YQB A;  5HL7 S;  3PIO S;  1UAJ A;  4YQ8 A;  4CNE A;  4YPY A;  3N4J A;  4JXZ A;  2I6D A;  4YPW A;  5GMC A;  4P2B A;  1FEU A;  3DLL S;  1DFU P;  4YQ4 A;  4RG1 A;  4JWJ A;  5DM6 S;  4JAK A;  4YPZ A;  2G5D A;  3AXZ A;  2V3K A;  1QRT A;  1QRS A;  4L69 A;  3GYQ A;  4WFN S;  3W2V B;  1V6Z A;  3KNU A;  5GMB A;  5GAG W;  4JXX A;  4IOA S;  2QMM A;  1Z85 A;  4X3M A;  5CO4 A;  4YQ0 A;  3J7Z V;  2Z0Y A;  4YQ1 A;  3E5Y A;  4YVG A;  2EGV A;  4H4K A;  1J85 A;  4YQN A;  1ZJR A;  1QTQ A;  5BNZ A;  4H3Z A;  1D6K A;  1X7O A;  1EUQ A;  4FMW A;  2GAE A;  1ZJW A;  2HZ7 A;  3OIJ A;  4YPX A;  5FAI A;  3N4K A;  5D9F A;  4V19 4;  2CX8 A;  1UAK A;  4H3Y A;  2PI8 A;  4WFB S;  3KTY A;  4E8B A;  5GAE W;  3PIP S;  4YQJ A;  3BBH A;  4YQ2 A;  4IO9 S;  1O6D A;  1NXZ A;  1O0B A;  4J3C A;  5IZN A;  4YQA A;  3O7B A;  1B75 A;  2G6G A;  1TO0 A;  3BBD A;  4MCD A;  4YQ3 A;  5GAD W;  2V3J A;  4PZK A;  4IG6 A;  1VHY A;  1MXI A;  4YVJ A;  3ILK A;  2PIC A;  4WFA S;  4YQD A;  5DM7 S;  3ONP A;  2RD2 A;  4XBO A;  2HA8 A;  4MCC A;  3DCM X;  4X3L A;  2ZJR S;  1GTR A;  4FAK A;  4YQR A;  4WCE S;  4YQ6 A;  3CF5 S;  1X7P A;  3NK6 A;  4YQ7 A;  4YQI A;  5JVG S;  3QUV A;  1UDX A;  3BBE A;  1NYL A;  3KW2 A;  4CNG A;  2RE8 A;  2O3A A;  4CNF A;  3IC6 A;  2PNW A;  4IOC S;  4U67 S;  4YQQ A;  4YQO A;  2AE0 X;  1OY5 A;  1VHK A;  1UAM A;  4JWH A;  4JWG A;  4YVI A;  3CZB A;  3NK7 A;  1K3R A;  3L8U A;  4YQK A;  4YQ5 A;  3IEF A;  2ZJQ S;  1GZ0 A;  3AIA A;  4KGN A;  4YVH A;  4UY8 8;  4JWF A;  4MCB A;  2EGW A;  1EXD A;  1EUY A;  3W2W B;  2QWV A;  1GTS A;  1IPA A;  4KDZ A;  4YQP A;  4YQT A; 
#chains in the Genus database with same CATH homology
 1P9P A;  3KY7 A;  4YQS A;  5GM8 A;  4CND A;  3AI9 X;  4YQ9 A;  3OIN A;  1VH0 A;  4YVK A;  1V2X A;  3OII A;  1NS5 A;  4JAL A;  4YQG A;  2YY8 A;  2NWA A;  4YQC A;  4YQL A;  1UAL A;  4YQB A;  4YQ8 A;  1UAJ A;  4CNE A;  4YPY A;  3N4J A;  2I6D A;  4YPW A;  5GMC A;  4YQ4 A;  4RG1 A;  4JWJ A;  4JAK A;  4YPZ A;  3AXZ A;  2V3K A;  4L69 A;  3GYQ A;  1V6Z A;  3KNU A;  5GMB A;  4X3M A;  2QMM A;  1Z85 A;  5CO4 A;  4YQ0 A;  2Z0Y A;  4YQ1 A;  3E5Y A;  4YVG A;  2EGV A;  4YQN A;  1J85 A;  1ZJR A;  4H3Z A;  1X7O A;  4FMW A;  3OIJ A;  4YPX A;  5FAI A;  3N4K A;  5D9F A;  2CX8 A;  1UAK A;  4H3Y A;  3KTY A;  4E8B A;  4YQJ A;  3BBH A;  4YQ2 A;  1O6D A;  1NXZ A;  4J3C A;  4YQA A;  3O7B A;  1TO0 A;  3BBD A;  4MCD A;  4YQ3 A;  2V3J A;  4PZK A;  4IG6 A;  1VHY A;  1MXI A;  4YVJ A;  3ILK A;  4YQD A;  3ONP A;  4XBO A;  2HA8 A;  4MCC A;  3DCM X;  4X3L A;  4FAK A;  4YQR A;  4YQ6 A;  1X7P A;  3NK6 A;  4YQ7 A;  4YQI A;  3QUV A;  3BBE A;  3KW2 A;  4CNG A;  2O3A A;  4CNF A;  3IC6 A;  4YQQ A;  4YQO A;  1OY5 A;  1VHK A;  1UAM A;  4JWH A;  4JWG A;  4YVI A;  3NK7 A;  1K3R A;  3L8U A;  4YQK A;  4YQ5 A;  3IEF A;  1GZ0 A;  3AIA A;  4KGN A;  4YVH A;  4JWF A;  4MCB A;  2EGW A;  2QWV A;  1IPA A;  4KDZ A;  4YQP A;  4YQT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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