|
42
|
163
|
6praA |
S. aureus dihydrofolate reductase with nadp(h) and empty folate pocket |
|
44
|
162
|
6pr9A |
S. aureus dihydrofolate reductase co-crystallized with 1-ethylpropyl-dihydropthalazine inhibitor and nadp(h) |
|
42
|
162
|
6prdA |
S. aureus dihydrofolate reductase co-crystallized with para-methoxyphenyl-dimethyoxydihydropthalazine inhibitor and nadp(h) |
|
41
|
163
|
6pr7A |
S. aureus dihydrofolate reductase co-crystallized with benzyl-dihydropthalazine inhibitor and nadp(h) |
|
43
|
159
|
4p3rA |
Cryogenic wt dhfr, time-averaged ensemble |
|
32
|
162
|
1bzfA |
Nmr solution structure and dynamics of the complex of lactobacillus casei dihydrofolate reductase with the new lipophilic antifolate drug trimetrexate, 22 structures |
|
30
|
162
|
1ao8A |
Dihydrofolate reductase complexed with methotrexate, nmr, 21 structures |
|
41
|
162
|
1diuA |
Dihydrofolate reductase (e.c.1.5.1.3) complex with brodimoprim-4,6-dicarboxylate |
|
44
|
159
|
4pthA |
Ensemble model for escherichia coli dihydrofolate reductase at 100k |
|
38
|
159
|
4p3qA |
Room-temperature wt dhfr, time-averaged ensemble |
|
42
|
157
|
5ispX |
Staphylococcus aureus f98y dihydrofolate reductase mutant complexed with beta-nadph and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (ucp1106) |
|
165
|
564
|
6n1sA |
Toxoplasma gondii ts-dhfr in complex with selective inhibitor 29 |
|
144
|
564
|
6n1tA |
Toxoplasma gondii ts-dhfr in complex with selective inhibitor 3 |
|
42
|
161
|
6cyvA |
E. coli dhfr ternary complex with nadp and dihydrofolate |
|
43
|
162
|
6cw7A |
E. coli dhfr product complex with (6s)-5,6,7,8-tetrahydrofolate |
|
37
|
159
|
6cqaA |
E. coli dhfr complex with inhibitor ampqd |
|
45
|
165
|
6cxkA |
E. coli dhfr substrate complex with dihydrofolate |
|
57
|
186
|
6a7eA |
Human dihydrofolate reductase complexed with nadph and bt2 |
|
45
|
162
|
6mt8A |
E. coli dhfr complex modeled with two ligand states |
|
45
|
162
|
6mr9A |
E. coli dhfr complex with a reaction intermediate |
|
41
|
159
|
4ptjA |
Ensemble model for escherichia coli dihydrofolate reductase at 277k |
|
58
|
186
|
6a7cA |
Human dihydrofolate reductase complexed with nadph and bt1 |
|
42
|
157
|
5isqX |
Staphylococcus aureus h30n, f98y dihydrofolate reductase mutant complexed with beta-nadph and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (ucp1106) |
|
42
|
157
|
5istX |
Staphylococcus aureus dihydrofolate reductase complexed with beta-nadph, cyclic alpha-nadph anomer and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (ucp1106) |
|
169
|
608
|
3um8A |
Wild-type plasmodium falciparum dhfr-ts complexed with cycloguanil and nadph |
|
46
|
164
|
3sa1A |
Bacuills anthracis dihydrofolate reductase bound propargyl-linked tmp analog, ucp1021 |
|
43
|
165
|
3s9uA |
Bacillus anthracis dihydrofolate reductase bound to propargyl-linked tmp analog, ucp120j |
|
45
|
165
|
3sa2A |
Bacuills anthracis dihydrofolate reductase bound propargyl-linked tmp analog, ucp1014 |
|
45
|
165
|
3saiA |
Bacuills anthracis dihydrofolate reductase bound to propargyl-linked tmp analog, ucp1015 |
|
45
|
162
|
6mthA |
E. coli dhfr complex modeled with three ligand states |
|
41
|
157
|
5jg0X |
Staphylococcus aureus dihydrofolate reductase complexed with beta-nadph and ucp1191 |
|
43
|
159
|
5ja3A |
Mycobacterium tuberculosis dihydrofolate reductase complexed with beta- nadph and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-b iphenyl]-4-carboxylic acid (ucp1106) |
|
57
|
186
|
5hsrA |
Fluorine substituted 5-methyl-6-(3',4'-difluoromethoxyphenythio)thieno[2,3-d]pyrimidine-2,4-diamine |
|
54
|
186
|
5hvbA |
5-methyl-6-(1-naphthylthio)thieno[2,3-d]pyrimidine 2,4-diamine |
|
60
|
186
|
5hveA |
5-methyl-6-(3'-trifluromethoxyphenylthio)[2,3-d]pyrimidine 2,4-diamine |
|
50
|
186
|
5hpbA |
Human dihydrofolate reductase complex with nadph and 5-methyl-6-(phenylthio-4'trifluoromethyl)thieno[2,3-d]pyrimidine-2,4-diamine |
|
53
|
186
|
5ht5A |
6-substituted pyrrolo[2,3-d]pyrimidine 6-thieno-(4-methoxyphenyl) |
|
56
|
186
|
5hsuA |
Fluorine substituted 5-methyl-6-(2',4'-difluoromethoxyphenythio)thieno[2,3-d]pyrimidine-2,4-diamine |
|
53
|
186
|
5huiA |
6-substituted pyrido[3,2-d]pyrimidine--6-4'-trifluoromethoxyphenyl) |
|
55
|
186
|
5hqzA |
Fluorine substituted 5-methyl-6-(4'-trifluoromethoxyphenythio)thieno[2,3-d]pyrimidine-2,4-diamine |
|
53
|
186
|
5hqyA |
Human dihydrofolate reductase complex with nadph and 5-methyl-6-(2',3',4'-trifluorophenylthio)thieno[2,3-d]pyrimidine-2,4-diamine |
|
54
|
186
|
8dfrA |
Refined crystal structures of chicken liver dihydrofolate reductase. 3 angstroms apo-enzyme and 1.7 angstroms nadph holo-enzyme complex |
|
40
|
159
|
7dfrA |
Crystal structures of escherichia coli dihydrofolate reductase. the nadp+ holoenzyme and the folate(dot)nadp+ ternary complex. substrate binding and a model for the transition state |
|
42
|
159
|
6e4eA |
Crystal structure of dihydrofolate reductase from staphylococcus aureus mw2 bound to nadp and p218 |
|
44
|
159
|
6ddwA |
Mycobacterium tuberculosis dihydrofolate reductase complexed with beta-nadph and n-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}-2-hydroxybenzene-1-carbonyl)-l-glutamic acid |
|
42
|
159
|
6ddpA |
Mycobacterium tuberculosis dihydrofolate reductase complexed with beta-nadph and 3'-[(2r)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-5'-methoxy[1,1'-biphenyl]-4-carboxylic acid |
|
41
|
159
|
6ddsA |
Mycobacterium tuberculosis dihydrofolate reductase complexed with beta-nadph and 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-5-methoxy-phenyl]benzoic acid |
|
57
|
186
|
6davA |
Crystal structure of human dhfr complexed with nadp and n10formyltetrahydrofolate |
|
53
|
186
|
6de4A |
Homo sapiens dihydrofolate reductase complexed with beta-nadph and 3'-[(2r)-4-(2,4-diamino-6-ethylphenyl)but-3-yn-2-yl]-5'-methoxy-[1,1'-biphenyl]-4-carboxylic acid |
|
40
|
159
|
6dfrA |
Crystal structures of escherichia coli dihydrofolate reductase. the nadp+ holoenzyme and the folate(dot)nadp+ ternary complex. substrate binding and a model for the transition state |
