|
42
|
159
|
6vsfA |
Mycobacterium tuberculosis dihydrofolate reductase in complex with 4-(3,4-dihydro-2h-benzo[b][1,4]dioxepin-7-yl)-4-oxobutanoic acid(fragment 16) |
|
40
|
159
|
6vv7A |
Mycobacterium tuberculosis dihydrofolate reductase in complex with jeb136 |
|
45
|
160
|
6vvbA |
Mycobacterium tuberculosis dihydrofolate reductase in complex with 6-methyl-5-(4-phenylthiazol-2-yl)-2- (trifluoromethyl)nicotinic acid (fragment 10) |
|
40
|
159
|
6vs6A |
Mycobacterium tuberculosis dihydrofolate reductase in complex with 3-(furan-2-yl)-1-methyl-1h-pyrazole-5-carboxylic acid (fragment 2) |
|
39
|
159
|
6vsdA |
Mycobacterium tuberculosis dihydrofolate reductase in complex with 3-((thiophen-2-ylthio)methyl)benzoic acid (fragment 13) |
|
39
|
159
|
6vv9A |
Mycobacterium tuberculosis dihydrofolate reductase in complex with jeb300 |
|
42
|
159
|
6vsgA |
Mycobacterium tuberculosis dihydrofolate reductase in complex with 4-(trifluoromethyl)benzene-1,2-diamine(fragment 17) |
|
40
|
159
|
6vseA |
Mycobacterium tuberculosis dihydrofolate reductase in complex with 3-(phenoxymethyl)benzoic acid(fragment 14) |
|
41
|
159
|
6vs5A |
Mycobacterium tuberculosis dihydrofolate reductase in complex with 5-methyl-1-phenyl-1h-pyrazole-4-carboxylic acid (fragment 1) |
|
41
|
159
|
6vs8A |
Mycobacterium tuberculosis dihydrofolate reductase in complex with ethyl 2-methyl thiazole-4-carboxylate(fragment 3) |
|
39
|
159
|
6vv8A |
Mycobacterium tuberculosis dihydrofolate reductase in complex with jeb285 |
|
41
|
162
|
6prbA |
S. aureus dihydrofolate reductase co-crystallized with cyclopropyl-dimethyoxydihydropthalazine inhibitor and nadp(h) |
|
41
|
162
|
6pr8A |
S. aureus dihydrofoate reductase co-crystallized with 3,5-dimethylphenyl-dihydropthalazine inhibitor and nadp(h) |
|
42
|
163
|
6praA |
S. aureus dihydrofolate reductase with nadp(h) and empty folate pocket |
|
42
|
162
|
6pr6A |
S. aureus dihydrofolate reductase co-crystallized with para-tolyl-dihydropthalazine inhibitor and nadp(h) |
|
44
|
162
|
6pr9A |
S. aureus dihydrofolate reductase co-crystallized with 1-ethylpropyl-dihydropthalazine inhibitor and nadp(h) |
|
42
|
162
|
6prdA |
S. aureus dihydrofolate reductase co-crystallized with para-methoxyphenyl-dimethyoxydihydropthalazine inhibitor and nadp(h) |
|
41
|
163
|
6pr7A |
S. aureus dihydrofolate reductase co-crystallized with benzyl-dihydropthalazine inhibitor and nadp(h) |
|
43
|
159
|
4p3rA |
Cryogenic wt dhfr, time-averaged ensemble |
|
32
|
162
|
1bzfA |
Nmr solution structure and dynamics of the complex of lactobacillus casei dihydrofolate reductase with the new lipophilic antifolate drug trimetrexate, 22 structures |
|
30
|
162
|
1ao8A |
Dihydrofolate reductase complexed with methotrexate, nmr, 21 structures |
|
41
|
162
|
1diuA |
Dihydrofolate reductase (e.c.1.5.1.3) complex with brodimoprim-4,6-dicarboxylate |
|
44
|
159
|
4pthA |
Ensemble model for escherichia coli dihydrofolate reductase at 100k |
|
38
|
159
|
4p3qA |
Room-temperature wt dhfr, time-averaged ensemble |
|
42
|
157
|
5ispX |
Staphylococcus aureus f98y dihydrofolate reductase mutant complexed with beta-nadph and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (ucp1106) |
|
165
|
564
|
6n1sA |
Toxoplasma gondii ts-dhfr in complex with selective inhibitor 29 |
|
144
|
564
|
6n1tA |
Toxoplasma gondii ts-dhfr in complex with selective inhibitor 3 |
|
42
|
161
|
6cyvA |
E. coli dhfr ternary complex with nadp and dihydrofolate |
|
43
|
162
|
6cw7A |
E. coli dhfr product complex with (6s)-5,6,7,8-tetrahydrofolate |
|
37
|
159
|
6cqaA |
E. coli dhfr complex with inhibitor ampqd |
|
45
|
165
|
6cxkA |
E. coli dhfr substrate complex with dihydrofolate |
|
57
|
186
|
6a7eA |
Human dihydrofolate reductase complexed with nadph and bt2 |
|
45
|
162
|
6mr9A |
E. coli dhfr complex with a reaction intermediate |
|
45
|
162
|
6mt8A |
E. coli dhfr complex modeled with two ligand states |
|
41
|
159
|
4ptjA |
Ensemble model for escherichia coli dihydrofolate reductase at 277k |
|
58
|
186
|
6a7cA |
Human dihydrofolate reductase complexed with nadph and bt1 |
|
42
|
157
|
5isqX |
Staphylococcus aureus h30n, f98y dihydrofolate reductase mutant complexed with beta-nadph and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (ucp1106) |
|
42
|
157
|
5istX |
Staphylococcus aureus dihydrofolate reductase complexed with beta-nadph, cyclic alpha-nadph anomer and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (ucp1106) |
|
169
|
608
|
3um8A |
Wild-type plasmodium falciparum dhfr-ts complexed with cycloguanil and nadph |
|
45
|
165
|
3sa2A |
Bacuills anthracis dihydrofolate reductase bound propargyl-linked tmp analog, ucp1014 |
|
46
|
164
|
3sa1A |
Bacuills anthracis dihydrofolate reductase bound propargyl-linked tmp analog, ucp1021 |
|
43
|
165
|
3s9uA |
Bacillus anthracis dihydrofolate reductase bound to propargyl-linked tmp analog, ucp120j |
|
45
|
165
|
3saiA |
Bacuills anthracis dihydrofolate reductase bound to propargyl-linked tmp analog, ucp1015 |
|
45
|
162
|
6mthA |
E. coli dhfr complex modeled with three ligand states |
|
41
|
157
|
5jg0X |
Staphylococcus aureus dihydrofolate reductase complexed with beta-nadph and ucp1191 |
|
43
|
159
|
5ja3A |
Mycobacterium tuberculosis dihydrofolate reductase complexed with beta- nadph and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-b iphenyl]-4-carboxylic acid (ucp1106) |
|
54
|
186
|
5hvbA |
5-methyl-6-(1-naphthylthio)thieno[2,3-d]pyrimidine 2,4-diamine |
|
57
|
186
|
5hsrA |
Fluorine substituted 5-methyl-6-(3',4'-difluoromethoxyphenythio)thieno[2,3-d]pyrimidine-2,4-diamine |
|
60
|
186
|
5hveA |
5-methyl-6-(3'-trifluromethoxyphenylthio)[2,3-d]pyrimidine 2,4-diamine |
|
53
|
186
|
5ht5A |
6-substituted pyrrolo[2,3-d]pyrimidine 6-thieno-(4-methoxyphenyl) |
