1TW6A

Structure of an ml-iap/xiap chimera bound to a 9mer peptide derived from smac
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
90
structure length
90
Chain Sequence
GPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHAKWFPGCQFLLRSKGQEYINNIH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP
pubmed doi rcsb
molecule tags Inhibitor/apoptosis
source organism Homo sapiens
molecule keywords Baculoviral IAP repeat-containing protein 7
total genus 23
structure length 90
sequence length 90
chains with identical sequence B
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2004-06-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00653 BIR Inhibitor of Apoptosis domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1170.10 Mainly Alpha Orthogonal Bundle Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A 1tw6A00
3UEDA 4J47A 1TFQA 5C3HA 5C7CA 4WVTA 3UEHA 4KJVA 2POPB 1JD5A 2RAXA 3UW4A 3UEIA 1TFTA 1E31A 2RAWA 4J45A 1M4MA 3CLXA 2VSLA 1G73C 1JD6A 3GT9A 2QRAA 1JD4A 1XB0A 3M1DA 3UECA 1OXQA 3UW5A 4J48A 1Q4QA 1F9XA 4MTIA 3F7HA 3SIPE 3F7GA 3D9TA 3GTAA 4J3YA 1XOXA 2I3IA 4OXCA 2OPYA 5C0LA 1OXNA 3F7IA 4A0NA 1TW6A 3MUPA 1QBHA 4KMPA 3SIQA 5C7AA 4A0IA 5C7DA 4HY4A 3UEEA 4WVSA 2OPZA 4A0JA 5C0KA 2POIA 3G76A 3M0AD 1G3FA 2VM5A 4LGUA 1NW9A 1SDZA 4J44A 4WVUA 5C84A 5C7BA 3UIIA 5C83A 3UEGA 1I3OE 3T6PA 2QFAA 3UIJA 4KMNA 3UIKA 1C9QA 4LGEA 3HL5A 4EC4A 3OZ1A 3M0DD 1F3HA 4KJUA 4HY5A 1OY7A 4MTZA 4EB9A 3UEFA 2I3HA 1SE0A 2JK7A 2UVLA 3UIGA 4J46A 4MU7A 4HY0A 3CM7A 3CM2A 3UIHA 3EYLA 1XB1A 5C3KA 3D9UA
chains in the Genus database with same CATH superfamily
3UEDA 4J47A 1TFQA 5C3HA 5C7CA 4WVTA 3UEHA 4KJVA 2POPB 1JD5A 2RAXA 3UW4A 3UEIA 1TFTA 1E31A 2RAWA 4J45A 1M4MA 3CLXA 2VSLA 1G73C 1JD6A 3GT9A 2QRAA 1JD4A 1XB0A 3M1DA 3UECA 1OXQA 3UW5A 4J48A 1Q4QA 1F9XA 4MTIA 3F7HA 3SIPE 3F7GA 3D9TA 3GTAA 4J3YA 1XOXA 2I3IA 4OXCA 2OPYA 5C0LA 1OXNA 3F7IA 4A0NA 1TW6A 3MUPA 1QBHA 4KMPA 3SIQA 5C7AA 4A0IA 5C7DA 4HY4A 3UEEA 4WVSA 2OPZA 4A0JA 5C0KA 2POIA 3G76A 3M0AD 1G3FA 2VM5A 4LGUA 1NW9A 1SDZA 4J44A 4WVUA 5C84A 5C7BA 3UIIA 5C83A 3UEGA 1I3OE 3T6PA 2QFAA 3UIJA 4KMNA 3UIKA 1C9QA 4LGEA 3HL5A 4EC4A 3OZ1A 3M0DD 1F3HA 4KJUA 4HY5A 1OY7A 4MTZA 4EB9A 3UEFA 2I3HA 1SE0A 2JK7A 2UVLA 3UIGA 4J46A 4MU7A 4HY0A 3CM7A 3CM2A 3UIHA 3EYLA 1XB1A 5C3KA 3D9UA
chains in the Genus database with same CATH topology
3UEDA 4J47A 1TFQA 5C3HA 5C7CA 4WVTA 3UEHA 4KJVA 2POPB 1JD5A 2RAXA 3UW4A 3UEIA 1TFTA 1E31A 2RAWA 4J45A 1M4MA 3CLXA 2VSLA 1G73C 1JD6A 3GT9A 2QRAA 1JD4A 1XB0A 3M1DA 3UECA 1OXQA 3UW5A 4J48A 1Q4QA 1F9XA 4MTIA 3F7HA 3SIPE 3F7GA 3D9TA 3GTAA 4J3YA 1XOXA 2I3IA 4OXCA 2OPYA 5C0LA 1OXNA 3F7IA 4A0NA 1TW6A 3MUPA 1QBHA 4KMPA 3SIQA 5C7AA 4A0IA 5C7DA 4HY4A 3UEEA 4WVSA 2OPZA 4A0JA 5C0KA 2POIA 3G76A 3M0AD 1G3FA 2VM5A 4LGUA 1NW9A 1SDZA 4J44A 4WVUA 5C84A 5C7BA 3UIIA 5C83A 3UEGA 1I3OE 3T6PA 2QFAA 3UIJA 4KMNA 3UIKA 1C9QA 4LGEA 3HL5A 4EC4A 3OZ1A 3M0DD 1F3HA 4KJUA 4HY5A 1OY7A 4MTZA 4EB9A 3UEFA 2I3HA 1SE0A 2JK7A 2UVLA 3UIGA 4J46A 4MU7A 4HY0A 3CM7A 3CM2A 3UIHA 3EYLA 1XB1A 5C3KA 3D9UA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3UED A;  4J47 A;  1TFQ A;  5C3H A;  5C7C A;  4WVT A;  3UEH A;  4KJV A;  2POP B;  1JD5 A;  2RAX A;  3UW4 A;  3UEI A;  1TFT A;  1E31 A;  2RAW A;  4J45 A;  1M4M A;  3CLX A;  2VSL A;  1G73 C;  1JD6 A;  3GT9 A;  2QRA A;  1JD4 A;  1XB0 A;  3M1D A;  3UEC A;  1OXQ A;  3UW5 A;  4J48 A;  1Q4Q A;  1F9X A;  4MTI A;  3F7H A;  3SIP E;  3F7G A;  3D9T A;  3GTA A;  4J3Y A;  1XOX A;  2I3I A;  4OXC A;  2OPY A;  5C0L A;  1OXN A;  3F7I A;  4A0N A;  1TW6 A;  3MUP A;  1QBH A;  4KMP A;  3SIQ A;  5C7A A;  4A0I A;  5C7D A;  4HY4 A;  3UEE A;  4WVS A;  2OPZ A;  4A0J A;  5C0K A;  2POI A;  3G76 A;  3M0A D;  1G3F A;  2VM5 A;  4LGU A;  1NW9 A;  1SDZ A;  4J44 A;  4WVU A;  5C84 A;  5C7B A;  3UII A;  5C83 A;  3UEG A;  1I3O E;  3T6P A;  2QFA A;  3UIJ A;  4KMN A;  3UIK A;  1C9Q A;  4LGE A;  3HL5 A;  4EC4 A;  3OZ1 A;  3M0D D;  1F3H A;  4KJU A;  4HY5 A;  1OY7 A;  4MTZ A;  4EB9 A;  3UEF A;  2I3H A;  1SE0 A;  2JK7 A;  2UVL A;  3UIG A;  4J46 A;  4MU7 A;  4HY0 A;  3CM7 A;  3CM2 A;  3UIH A;  3EYL A;  1XB1 A;  5C3K A;  3D9U A; 
#chains in the Genus database with same CATH topology
 3UED A;  4J47 A;  1TFQ A;  5C3H A;  5C7C A;  4WVT A;  3UEH A;  4KJV A;  2POP B;  1JD5 A;  2RAX A;  3UW4 A;  3UEI A;  1TFT A;  1E31 A;  2RAW A;  4J45 A;  1M4M A;  3CLX A;  2VSL A;  1G73 C;  1JD6 A;  3GT9 A;  2QRA A;  1JD4 A;  1XB0 A;  3M1D A;  3UEC A;  1OXQ A;  3UW5 A;  4J48 A;  1Q4Q A;  1F9X A;  4MTI A;  3F7H A;  3SIP E;  3F7G A;  3D9T A;  3GTA A;  4J3Y A;  1XOX A;  2I3I A;  4OXC A;  2OPY A;  5C0L A;  1OXN A;  3F7I A;  4A0N A;  1TW6 A;  3MUP A;  1QBH A;  4KMP A;  3SIQ A;  5C7A A;  4A0I A;  5C7D A;  4HY4 A;  3UEE A;  4WVS A;  2OPZ A;  4A0J A;  5C0K A;  2POI A;  3G76 A;  3M0A D;  1G3F A;  2VM5 A;  4LGU A;  1NW9 A;  1SDZ A;  4J44 A;  4WVU A;  5C84 A;  5C7B A;  3UII A;  5C83 A;  3UEG A;  1I3O E;  3T6P A;  2QFA A;  3UIJ A;  4KMN A;  3UIK A;  1C9Q A;  4LGE A;  3HL5 A;  4EC4 A;  3OZ1 A;  3M0D D;  1F3H A;  4KJU A;  4HY5 A;  1OY7 A;  4MTZ A;  4EB9 A;  3UEF A;  2I3H A;  1SE0 A;  2JK7 A;  2UVL A;  3UIG A;  4J46 A;  4MU7 A;  4HY0 A;  3CM7 A;  3CM2 A;  3UIH A;  3EYL A;  1XB1 A;  5C3K A;  3D9U A; 
#chains in the Genus database with same CATH homology
 3UED A;  4J47 A;  1TFQ A;  5C3H A;  5C7C A;  4WVT A;  3UEH A;  4KJV A;  2POP B;  1JD5 A;  2RAX A;  3UW4 A;  3UEI A;  1TFT A;  1E31 A;  2RAW A;  4J45 A;  1M4M A;  3CLX A;  2VSL A;  1G73 C;  1JD6 A;  3GT9 A;  2QRA A;  1JD4 A;  1XB0 A;  3M1D A;  3UEC A;  1OXQ A;  3UW5 A;  4J48 A;  1Q4Q A;  1F9X A;  4MTI A;  3F7H A;  3SIP E;  3F7G A;  3D9T A;  3GTA A;  4J3Y A;  1XOX A;  2I3I A;  4OXC A;  2OPY A;  5C0L A;  1OXN A;  3F7I A;  4A0N A;  1TW6 A;  3MUP A;  1QBH A;  4KMP A;  3SIQ A;  5C7A A;  4A0I A;  5C7D A;  4HY4 A;  3UEE A;  4WVS A;  2OPZ A;  4A0J A;  5C0K A;  2POI A;  3G76 A;  3M0A D;  1G3F A;  2VM5 A;  4LGU A;  1NW9 A;  1SDZ A;  4J44 A;  4WVU A;  5C84 A;  5C7B A;  3UII A;  5C83 A;  3UEG A;  1I3O E;  3T6P A;  2QFA A;  3UIJ A;  4KMN A;  3UIK A;  1C9Q A;  4LGE A;  3HL5 A;  4EC4 A;  3OZ1 A;  3M0D D;  1F3H A;  4KJU A;  4HY5 A;  1OY7 A;  4MTZ A;  4EB9 A;  3UEF A;  2I3H A;  1SE0 A;  2JK7 A;  2UVL A;  3UIG A;  4J46 A;  4MU7 A;  4HY0 A;  3CM7 A;  3CM2 A;  3UIH A;  3EYL A;  1XB1 A;  5C3K A;  3D9U A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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