1I3OE

Crystal structure of the complex of xiap-bir2 and caspase 3
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
111
structure length
111
Chain Sequence
FALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for the inhibition of caspase-3 by XIAP.
pubmed doi rcsb
molecule tags Apoptosis
source organism Homo sapiens
molecule keywords CASPASE 3
total genus 24
structure length 111
sequence length 111
chains with identical sequence F
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2001-02-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF00653 BIR Inhibitor of Apoptosis domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1170.10 Mainly Alpha Orthogonal Bundle Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A 1i3oE00
5C7DA 5C7CA 1TFTA 3MUPA 3HL5A 4LGEA 2POIA 1C9QA 3GTAA 4KJVA 1Q4QA 1TW6A 3M1DA 1XOXA 1JD6A 2QFAA 4WVTA 1OXQA 3UEDA 3F7IA 4HY4A 4OXCA 1JD5A 4EB9A 2RAXA 4A0IA 1G73C 3UEFA 3G76A 3UEHA 4EC4A 3D9UA 5C7BA 1E31A 2RAWA 3M0DD 4WVSA 2OPYA 5C84A 1G3FA 2I3HA 4J45A 2I3IA 4KMNA 1XB1A 4J44A 2JK7A 1TFQA 4MTIA 3UW5A 1M4MA 4MU7A 3F7GA 5C3HA 1JD4A 3GT9A 1XB0A 3UEEA 4MTZA 3CM7A 1F9XA 4J48A 5C0LA 4J46A 5C0KA 4A0NA 3D9TA 2POPB 5C7AA 4WVUA 3UIKA 2QRAA 1OXNA 2VSLA 4A0JA 3UEGA 1NW9A 4HY0A 4KJUA 3UIGA 3UIIA 3EYLA 3T6PA 1SE0A 1OY7A 2OPZA 4LGUA 2UVLA 3CM2A 3SIQA 1QBHA 5C83A 3CLXA 4J3YA 3OZ1A 1F3HA 4HY5A 3UW4A 5C3KA 1SDZA 3M0AD 4KMPA 3F7HA 3UIJA 2VM5A 1I3OE 4J47A 3UEIA 3UIHA 3SIPE 3UECA
chains in the Genus database with same CATH superfamily
5C7DA 5C7CA 1TFTA 3MUPA 3HL5A 4LGEA 2POIA 1C9QA 3GTAA 4KJVA 1Q4QA 1TW6A 3M1DA 1XOXA 1JD6A 2QFAA 4WVTA 1OXQA 3UEDA 3F7IA 4HY4A 4OXCA 1JD5A 4EB9A 2RAXA 4A0IA 1G73C 3UEFA 3G76A 3UEHA 4EC4A 3D9UA 5C7BA 1E31A 2RAWA 3M0DD 4WVSA 2OPYA 5C84A 1G3FA 2I3HA 4J45A 2I3IA 4KMNA 1XB1A 4J44A 2JK7A 1TFQA 4MTIA 3UW5A 1M4MA 4MU7A 3F7GA 5C3HA 1JD4A 3GT9A 1XB0A 3UEEA 4MTZA 3CM7A 1F9XA 4J48A 5C0LA 4J46A 5C0KA 4A0NA 3D9TA 2POPB 5C7AA 4WVUA 3UIKA 2QRAA 1OXNA 2VSLA 4A0JA 3UEGA 1NW9A 4HY0A 4KJUA 3UIGA 3UIIA 3EYLA 3T6PA 1SE0A 1OY7A 2OPZA 4LGUA 2UVLA 3CM2A 3SIQA 1QBHA 5C83A 3CLXA 4J3YA 3OZ1A 1F3HA 4HY5A 3UW4A 5C3KA 1SDZA 3M0AD 4KMPA 3F7HA 3UIJA 2VM5A 1I3OE 4J47A 3UEIA 3UIHA 3SIPE 3UECA
chains in the Genus database with same CATH topology
5C7DA 5C7CA 1TFTA 3MUPA 3HL5A 4LGEA 2POIA 1C9QA 3GTAA 4KJVA 1Q4QA 1TW6A 3M1DA 1XOXA 1JD6A 2QFAA 4WVTA 1OXQA 3UEDA 3F7IA 4HY4A 4OXCA 1JD5A 4EB9A 2RAXA 4A0IA 1G73C 3UEFA 3G76A 3UEHA 4EC4A 3D9UA 5C7BA 1E31A 2RAWA 3M0DD 4WVSA 2OPYA 5C84A 1G3FA 2I3HA 4J45A 2I3IA 4KMNA 1XB1A 4J44A 2JK7A 1TFQA 4MTIA 3UW5A 1M4MA 4MU7A 3F7GA 5C3HA 1JD4A 3GT9A 1XB0A 3UEEA 4MTZA 3CM7A 1F9XA 4J48A 5C0LA 4J46A 5C0KA 4A0NA 3D9TA 2POPB 5C7AA 4WVUA 3UIKA 2QRAA 1OXNA 2VSLA 4A0JA 3UEGA 1NW9A 4HY0A 4KJUA 3UIGA 3UIIA 3EYLA 3T6PA 1SE0A 1OY7A 2OPZA 4LGUA 2UVLA 3CM2A 3SIQA 1QBHA 5C83A 3CLXA 4J3YA 3OZ1A 1F3HA 4HY5A 3UW4A 5C3KA 1SDZA 3M0AD 4KMPA 3F7HA 3UIJA 2VM5A 1I3OE 4J47A 3UEIA 3UIHA 3SIPE 3UECA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5C7D A;  5C7C A;  1TFT A;  3MUP A;  3HL5 A;  4LGE A;  2POI A;  1C9Q A;  3GTA A;  4KJV A;  1Q4Q A;  1TW6 A;  3M1D A;  1XOX A;  1JD6 A;  2QFA A;  4WVT A;  1OXQ A;  3UED A;  3F7I A;  4HY4 A;  4OXC A;  1JD5 A;  4EB9 A;  2RAX A;  4A0I A;  1G73 C;  3UEF A;  3G76 A;  3UEH A;  4EC4 A;  3D9U A;  5C7B A;  1E31 A;  2RAW A;  3M0D D;  4WVS A;  2OPY A;  5C84 A;  1G3F A;  2I3H A;  4J45 A;  2I3I A;  4KMN A;  1XB1 A;  4J44 A;  2JK7 A;  1TFQ A;  4MTI A;  3UW5 A;  1M4M A;  4MU7 A;  3F7G A;  5C3H A;  1JD4 A;  3GT9 A;  1XB0 A;  3UEE A;  4MTZ A;  3CM7 A;  1F9X A;  4J48 A;  5C0L A;  4J46 A;  5C0K A;  4A0N A;  3D9T A;  2POP B;  5C7A A;  4WVU A;  3UIK A;  2QRA A;  1OXN A;  2VSL A;  4A0J A;  3UEG A;  1NW9 A;  4HY0 A;  4KJU A;  3UIG A;  3UII A;  3EYL A;  3T6P A;  1SE0 A;  1OY7 A;  2OPZ A;  4LGU A;  2UVL A;  3CM2 A;  3SIQ A;  1QBH A;  5C83 A;  3CLX A;  4J3Y A;  3OZ1 A;  1F3H A;  4HY5 A;  3UW4 A;  5C3K A;  1SDZ A;  3M0A D;  4KMP A;  3F7H A;  3UIJ A;  2VM5 A;  1I3O E;  4J47 A;  3UEI A;  3UIH A;  3SIP E;  3UEC A; 
#chains in the Genus database with same CATH topology
 5C7D A;  5C7C A;  1TFT A;  3MUP A;  3HL5 A;  4LGE A;  2POI A;  1C9Q A;  3GTA A;  4KJV A;  1Q4Q A;  1TW6 A;  3M1D A;  1XOX A;  1JD6 A;  2QFA A;  4WVT A;  1OXQ A;  3UED A;  3F7I A;  4HY4 A;  4OXC A;  1JD5 A;  4EB9 A;  2RAX A;  4A0I A;  1G73 C;  3UEF A;  3G76 A;  3UEH A;  4EC4 A;  3D9U A;  5C7B A;  1E31 A;  2RAW A;  3M0D D;  4WVS A;  2OPY A;  5C84 A;  1G3F A;  2I3H A;  4J45 A;  2I3I A;  4KMN A;  1XB1 A;  4J44 A;  2JK7 A;  1TFQ A;  4MTI A;  3UW5 A;  1M4M A;  4MU7 A;  3F7G A;  5C3H A;  1JD4 A;  3GT9 A;  1XB0 A;  3UEE A;  4MTZ A;  3CM7 A;  1F9X A;  4J48 A;  5C0L A;  4J46 A;  5C0K A;  4A0N A;  3D9T A;  2POP B;  5C7A A;  4WVU A;  3UIK A;  2QRA A;  1OXN A;  2VSL A;  4A0J A;  3UEG A;  1NW9 A;  4HY0 A;  4KJU A;  3UIG A;  3UII A;  3EYL A;  3T6P A;  1SE0 A;  1OY7 A;  2OPZ A;  4LGU A;  2UVL A;  3CM2 A;  3SIQ A;  1QBH A;  5C83 A;  3CLX A;  4J3Y A;  3OZ1 A;  1F3H A;  4HY5 A;  3UW4 A;  5C3K A;  1SDZ A;  3M0A D;  4KMP A;  3F7H A;  3UIJ A;  2VM5 A;  1I3O E;  4J47 A;  3UEI A;  3UIH A;  3SIP E;  3UEC A; 
#chains in the Genus database with same CATH homology
 5C7D A;  5C7C A;  1TFT A;  3MUP A;  3HL5 A;  4LGE A;  2POI A;  1C9Q A;  3GTA A;  4KJV A;  1Q4Q A;  1TW6 A;  3M1D A;  1XOX A;  1JD6 A;  2QFA A;  4WVT A;  1OXQ A;  3UED A;  3F7I A;  4HY4 A;  4OXC A;  1JD5 A;  4EB9 A;  2RAX A;  4A0I A;  1G73 C;  3UEF A;  3G76 A;  3UEH A;  4EC4 A;  3D9U A;  5C7B A;  1E31 A;  2RAW A;  3M0D D;  4WVS A;  2OPY A;  5C84 A;  1G3F A;  2I3H A;  4J45 A;  2I3I A;  4KMN A;  1XB1 A;  4J44 A;  2JK7 A;  1TFQ A;  4MTI A;  3UW5 A;  1M4M A;  4MU7 A;  3F7G A;  5C3H A;  1JD4 A;  3GT9 A;  1XB0 A;  3UEE A;  4MTZ A;  3CM7 A;  1F9X A;  4J48 A;  5C0L A;  4J46 A;  5C0K A;  4A0N A;  3D9T A;  2POP B;  5C7A A;  4WVU A;  3UIK A;  2QRA A;  1OXN A;  2VSL A;  4A0J A;  3UEG A;  1NW9 A;  4HY0 A;  4KJU A;  3UIG A;  3UII A;  3EYL A;  3T6P A;  1SE0 A;  1OY7 A;  2OPZ A;  4LGU A;  2UVL A;  3CM2 A;  3SIQ A;  1QBH A;  5C83 A;  3CLX A;  4J3Y A;  3OZ1 A;  1F3H A;  4HY5 A;  3UW4 A;  5C3K A;  1SDZ A;  3M0A D;  4KMP A;  3F7H A;  3UIJ A;  2VM5 A;  1I3O E;  4J47 A;  3UEI A;  3UIH A;  3SIP E;  3UEC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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