2JK7A

Xiap bir3 bound to a smac mimetic
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
96
structure length
96
Chain Sequence
FPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure-Based Design, Synthesis, Evaluation, and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (Xiap).
pubmed doi rcsb
molecule tags Apoptosis
source organism Homo sapiens
molecule keywords BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4
total genus 27
structure length 96
sequence length 96
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2008-08-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00653 BIR Inhibitor of Apoptosis domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1170.10 Mainly Alpha Orthogonal Bundle Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A 2jk7A00
4WVTA 4MU7A 3G76A 4WVUA 3D9UA 1NW9A 1XB1A 3M0AD 1OXNA 4J3YA 3M1DA 2OPYA 1TFQA 5C0KA 1XB0A 1SE0A 5C83A 3UIHA 1Q4QA 3F7IA 3OZ1A 2I3IA 1I3OE 4J45A 2QFAA 3D9TA 4KJVA 1JD5A 3CM7A 4HY5A 4OXCA 3M0DD 4HY4A 2VM5A 3UEDA 3UIKA 3SIQA 2RAXA 3GT9A 3UEFA 5C7AA 3MUPA 4KJUA 4MTIA 4KMNA 4EB9A 5C7CA 2RAWA 5C3KA 4A0JA 3UIIA 1F9XA 1OY7A 4J44A 3UW5A 4WVSA 4EC4A 3CLXA 1F3HA 1G3FA 2QRAA 1E31A 1TW6A 3T6PA 1JD4A 1M4MA 2JK7A 2VSLA 3SIPE 3UIJA 1OXQA 4KMPA 3HL5A 1QBHA 3UEHA 4A0IA 5C3HA 5C7DA 5C84A 4A0NA 3EYLA 1XOXA 3F7HA 2OPZA 1JD6A 1SDZA 1TFTA 4J48A 3UEIA 2POPB 3GTAA 5C7BA 4HY0A 2UVLA 3UEEA 5C0LA 4MTZA 3CM2A 3UW4A 4J47A 4LGUA 2I3HA 3UEGA 2POIA 3UIGA 1C9QA 1G73C 4LGEA 3UECA 4J46A 3F7GA
chains in the Genus database with same CATH superfamily
4WVTA 4MU7A 3G76A 4WVUA 3D9UA 1NW9A 1XB1A 3M0AD 1OXNA 4J3YA 3M1DA 2OPYA 1TFQA 5C0KA 1XB0A 1SE0A 5C83A 3UIHA 1Q4QA 3F7IA 3OZ1A 2I3IA 1I3OE 4J45A 2QFAA 3D9TA 4KJVA 1JD5A 3CM7A 4HY5A 4OXCA 3M0DD 4HY4A 2VM5A 3UEDA 3UIKA 3SIQA 2RAXA 3GT9A 3UEFA 5C7AA 3MUPA 4KJUA 4MTIA 4KMNA 4EB9A 5C7CA 2RAWA 5C3KA 4A0JA 3UIIA 1F9XA 1OY7A 4J44A 3UW5A 4WVSA 4EC4A 3CLXA 1F3HA 1G3FA 2QRAA 1E31A 1TW6A 3T6PA 1JD4A 1M4MA 2JK7A 2VSLA 3SIPE 3UIJA 1OXQA 4KMPA 3HL5A 1QBHA 3UEHA 4A0IA 5C3HA 5C7DA 5C84A 4A0NA 3EYLA 1XOXA 3F7HA 2OPZA 1JD6A 1SDZA 1TFTA 4J48A 3UEIA 2POPB 3GTAA 5C7BA 4HY0A 2UVLA 3UEEA 5C0LA 4MTZA 3CM2A 3UW4A 4J47A 4LGUA 2I3HA 3UEGA 2POIA 3UIGA 1C9QA 1G73C 4LGEA 3UECA 4J46A 3F7GA
chains in the Genus database with same CATH topology
4WVTA 4MU7A 3G76A 4WVUA 3D9UA 1NW9A 1XB1A 3M0AD 1OXNA 4J3YA 3M1DA 2OPYA 1TFQA 5C0KA 1XB0A 1SE0A 5C83A 3UIHA 1Q4QA 3F7IA 3OZ1A 2I3IA 1I3OE 4J45A 2QFAA 3D9TA 4KJVA 1JD5A 3CM7A 4HY5A 4OXCA 3M0DD 4HY4A 2VM5A 3UEDA 3UIKA 3SIQA 2RAXA 3GT9A 3UEFA 5C7AA 3MUPA 4KJUA 4MTIA 4KMNA 4EB9A 5C7CA 2RAWA 5C3KA 4A0JA 3UIIA 1F9XA 1OY7A 4J44A 3UW5A 4WVSA 4EC4A 3CLXA 1F3HA 1G3FA 2QRAA 1E31A 1TW6A 3T6PA 1JD4A 1M4MA 2JK7A 2VSLA 3SIPE 3UIJA 1OXQA 4KMPA 3HL5A 1QBHA 3UEHA 4A0IA 5C3HA 5C7DA 5C84A 4A0NA 3EYLA 1XOXA 3F7HA 2OPZA 1JD6A 1SDZA 1TFTA 4J48A 3UEIA 2POPB 3GTAA 5C7BA 4HY0A 2UVLA 3UEEA 5C0LA 4MTZA 3CM2A 3UW4A 4J47A 4LGUA 2I3HA 3UEGA 2POIA 3UIGA 1C9QA 1G73C 4LGEA 3UECA 4J46A 3F7GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4WVT A;  4MU7 A;  3G76 A;  4WVU A;  3D9U A;  1NW9 A;  1XB1 A;  3M0A D;  1OXN A;  4J3Y A;  3M1D A;  2OPY A;  1TFQ A;  5C0K A;  1XB0 A;  1SE0 A;  5C83 A;  3UIH A;  1Q4Q A;  3F7I A;  3OZ1 A;  2I3I A;  1I3O E;  4J45 A;  2QFA A;  3D9T A;  4KJV A;  1JD5 A;  3CM7 A;  4HY5 A;  4OXC A;  3M0D D;  4HY4 A;  2VM5 A;  3UED A;  3UIK A;  3SIQ A;  2RAX A;  3GT9 A;  3UEF A;  5C7A A;  3MUP A;  4KJU A;  4MTI A;  4KMN A;  4EB9 A;  5C7C A;  2RAW A;  5C3K A;  4A0J A;  3UII A;  1F9X A;  1OY7 A;  4J44 A;  3UW5 A;  4WVS A;  4EC4 A;  3CLX A;  1F3H A;  1G3F A;  2QRA A;  1E31 A;  1TW6 A;  3T6P A;  1JD4 A;  1M4M A;  2JK7 A;  2VSL A;  3SIP E;  3UIJ A;  1OXQ A;  4KMP A;  3HL5 A;  1QBH A;  3UEH A;  4A0I A;  5C3H A;  5C7D A;  5C84 A;  4A0N A;  3EYL A;  1XOX A;  3F7H A;  2OPZ A;  1JD6 A;  1SDZ A;  1TFT A;  4J48 A;  3UEI A;  2POP B;  3GTA A;  5C7B A;  4HY0 A;  2UVL A;  3UEE A;  5C0L A;  4MTZ A;  3CM2 A;  3UW4 A;  4J47 A;  4LGU A;  2I3H A;  3UEG A;  2POI A;  3UIG A;  1C9Q A;  1G73 C;  4LGE A;  3UEC A;  4J46 A;  3F7G A; 
#chains in the Genus database with same CATH topology
 4WVT A;  4MU7 A;  3G76 A;  4WVU A;  3D9U A;  1NW9 A;  1XB1 A;  3M0A D;  1OXN A;  4J3Y A;  3M1D A;  2OPY A;  1TFQ A;  5C0K A;  1XB0 A;  1SE0 A;  5C83 A;  3UIH A;  1Q4Q A;  3F7I A;  3OZ1 A;  2I3I A;  1I3O E;  4J45 A;  2QFA A;  3D9T A;  4KJV A;  1JD5 A;  3CM7 A;  4HY5 A;  4OXC A;  3M0D D;  4HY4 A;  2VM5 A;  3UED A;  3UIK A;  3SIQ A;  2RAX A;  3GT9 A;  3UEF A;  5C7A A;  3MUP A;  4KJU A;  4MTI A;  4KMN A;  4EB9 A;  5C7C A;  2RAW A;  5C3K A;  4A0J A;  3UII A;  1F9X A;  1OY7 A;  4J44 A;  3UW5 A;  4WVS A;  4EC4 A;  3CLX A;  1F3H A;  1G3F A;  2QRA A;  1E31 A;  1TW6 A;  3T6P A;  1JD4 A;  1M4M A;  2JK7 A;  2VSL A;  3SIP E;  3UIJ A;  1OXQ A;  4KMP A;  3HL5 A;  1QBH A;  3UEH A;  4A0I A;  5C3H A;  5C7D A;  5C84 A;  4A0N A;  3EYL A;  1XOX A;  3F7H A;  2OPZ A;  1JD6 A;  1SDZ A;  1TFT A;  4J48 A;  3UEI A;  2POP B;  3GTA A;  5C7B A;  4HY0 A;  2UVL A;  3UEE A;  5C0L A;  4MTZ A;  3CM2 A;  3UW4 A;  4J47 A;  4LGU A;  2I3H A;  3UEG A;  2POI A;  3UIG A;  1C9Q A;  1G73 C;  4LGE A;  3UEC A;  4J46 A;  3F7G A; 
#chains in the Genus database with same CATH homology
 4WVT A;  4MU7 A;  3G76 A;  4WVU A;  3D9U A;  1NW9 A;  1XB1 A;  3M0A D;  1OXN A;  4J3Y A;  3M1D A;  2OPY A;  1TFQ A;  5C0K A;  1XB0 A;  1SE0 A;  5C83 A;  3UIH A;  1Q4Q A;  3F7I A;  3OZ1 A;  2I3I A;  1I3O E;  4J45 A;  2QFA A;  3D9T A;  4KJV A;  1JD5 A;  3CM7 A;  4HY5 A;  4OXC A;  3M0D D;  4HY4 A;  2VM5 A;  3UED A;  3UIK A;  3SIQ A;  2RAX A;  3GT9 A;  3UEF A;  5C7A A;  3MUP A;  4KJU A;  4MTI A;  4KMN A;  4EB9 A;  5C7C A;  2RAW A;  5C3K A;  4A0J A;  3UII A;  1F9X A;  1OY7 A;  4J44 A;  3UW5 A;  4WVS A;  4EC4 A;  3CLX A;  1F3H A;  1G3F A;  2QRA A;  1E31 A;  1TW6 A;  3T6P A;  1JD4 A;  1M4M A;  2JK7 A;  2VSL A;  3SIP E;  3UIJ A;  1OXQ A;  4KMP A;  3HL5 A;  1QBH A;  3UEH A;  4A0I A;  5C3H A;  5C7D A;  5C84 A;  4A0N A;  3EYL A;  1XOX A;  3F7H A;  2OPZ A;  1JD6 A;  1SDZ A;  1TFT A;  4J48 A;  3UEI A;  2POP B;  3GTA A;  5C7B A;  4HY0 A;  2UVL A;  3UEE A;  5C0L A;  4MTZ A;  3CM2 A;  3UW4 A;  4J47 A;  4LGU A;  2I3H A;  3UEG A;  2POI A;  3UIG A;  1C9Q A;  1G73 C;  4LGE A;  3UEC A;  4J46 A;  3F7G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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