3EYLA

Crystal structure of xiap bir3 domain in complex with a smac-mimetic compound
Total Genus 29
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
29
sequence length
101
structure length
101
Chain Sequence
TNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2.
pubmed doi rcsb
molecule tags Ligase
source organism Homo sapiens
molecule keywords Baculoviral IAP repeat-containing protein 4
total genus 29
structure length 101
sequence length 101
chains with identical sequence B
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2008-10-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00653 BIR Inhibitor of Apoptosis domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1170.10 Mainly Alpha Orthogonal Bundle Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A 3eylA00
3M0AD 3EYLA 5C7AA 1G3FA 2OPYA 2RAWA 1QBHA 1C9QA 4KJUA 1XB1A 4J48A 3UEGA 1XB0A 5C7DA 4HY0A 2POPB 1TW6A 3CLXA 1E31A 4J46A 3UEFA 4EC4A 5C7CA 3UIGA 4OXCA 4WVSA 3GTAA 1I3OE 5C84A 1F3HA 3UECA 1TFQA 4A0JA 2POIA 4KMPA 4LGEA 3UW5A 5C0LA 1JD4A 3F7IA 3D9TA 3M1DA 2JK7A 2QFAA 3CM2A 4MU7A 5C7BA 3UEIA 1JD6A 1SE0A 2VM5A 1TFTA 3T6PA 1G73C 5C0KA 3UIKA 3D9UA 5C3HA 3UIJA 4J45A 4A0IA 5C3KA 3OZ1A 3MUPA 3SIQA 4WVUA 2RAXA 1JD5A 4KMNA 4J44A 5C83A 4WVTA 1Q4QA 3HL5A 3M0DD 3UEEA 1XOXA 4HY5A 4J3YA 4LGUA 3G76A 2QRAA 1OXQA 3UIHA 4HY4A 1NW9A 4MTIA 2I3HA 1M4MA 3F7GA 4A0NA 3UEHA 2VSLA 3UEDA 1OXNA 2I3IA 3SIPE 4J47A 3F7HA 4KJVA 4MTZA 3CM7A 1SDZA 4EB9A 2OPZA 1F9XA 1OY7A 3UIIA 2UVLA 3GT9A 3UW4A
chains in the Genus database with same CATH superfamily
3M0AD 3EYLA 5C7AA 1G3FA 2OPYA 2RAWA 1QBHA 1C9QA 4KJUA 1XB1A 4J48A 3UEGA 1XB0A 5C7DA 4HY0A 2POPB 1TW6A 3CLXA 1E31A 4J46A 3UEFA 4EC4A 5C7CA 3UIGA 4OXCA 4WVSA 3GTAA 1I3OE 5C84A 1F3HA 3UECA 1TFQA 4A0JA 2POIA 4KMPA 4LGEA 3UW5A 5C0LA 1JD4A 3F7IA 3D9TA 3M1DA 2JK7A 2QFAA 3CM2A 4MU7A 5C7BA 3UEIA 1JD6A 1SE0A 2VM5A 1TFTA 3T6PA 1G73C 5C0KA 3UIKA 3D9UA 5C3HA 3UIJA 4J45A 4A0IA 5C3KA 3OZ1A 3MUPA 3SIQA 4WVUA 2RAXA 1JD5A 4KMNA 4J44A 5C83A 4WVTA 1Q4QA 3HL5A 3M0DD 3UEEA 1XOXA 4HY5A 4J3YA 4LGUA 3G76A 2QRAA 1OXQA 3UIHA 4HY4A 1NW9A 4MTIA 2I3HA 1M4MA 3F7GA 4A0NA 3UEHA 2VSLA 3UEDA 1OXNA 2I3IA 3SIPE 4J47A 3F7HA 4KJVA 4MTZA 3CM7A 1SDZA 4EB9A 2OPZA 1F9XA 1OY7A 3UIIA 2UVLA 3GT9A 3UW4A
chains in the Genus database with same CATH topology
3M0AD 3EYLA 5C7AA 1G3FA 2OPYA 2RAWA 1QBHA 1C9QA 4KJUA 1XB1A 4J48A 3UEGA 1XB0A 5C7DA 4HY0A 2POPB 1TW6A 3CLXA 1E31A 4J46A 3UEFA 4EC4A 5C7CA 3UIGA 4OXCA 4WVSA 3GTAA 1I3OE 5C84A 1F3HA 3UECA 1TFQA 4A0JA 2POIA 4KMPA 4LGEA 3UW5A 5C0LA 1JD4A 3F7IA 3D9TA 3M1DA 2JK7A 2QFAA 3CM2A 4MU7A 5C7BA 3UEIA 1JD6A 1SE0A 2VM5A 1TFTA 3T6PA 1G73C 5C0KA 3UIKA 3D9UA 5C3HA 3UIJA 4J45A 4A0IA 5C3KA 3OZ1A 3MUPA 3SIQA 4WVUA 2RAXA 1JD5A 4KMNA 4J44A 5C83A 4WVTA 1Q4QA 3HL5A 3M0DD 3UEEA 1XOXA 4HY5A 4J3YA 4LGUA 3G76A 2QRAA 1OXQA 3UIHA 4HY4A 1NW9A 4MTIA 2I3HA 1M4MA 3F7GA 4A0NA 3UEHA 2VSLA 3UEDA 1OXNA 2I3IA 3SIPE 4J47A 3F7HA 4KJVA 4MTZA 3CM7A 1SDZA 4EB9A 2OPZA 1F9XA 1OY7A 3UIIA 2UVLA 3GT9A 3UW4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3M0A D;  3EYL A;  5C7A A;  1G3F A;  2OPY A;  2RAW A;  1QBH A;  1C9Q A;  4KJU A;  1XB1 A;  4J48 A;  3UEG A;  1XB0 A;  5C7D A;  4HY0 A;  2POP B;  1TW6 A;  3CLX A;  1E31 A;  4J46 A;  3UEF A;  4EC4 A;  5C7C A;  3UIG A;  4OXC A;  4WVS A;  3GTA A;  1I3O E;  5C84 A;  1F3H A;  3UEC A;  1TFQ A;  4A0J A;  2POI A;  4KMP A;  4LGE A;  3UW5 A;  5C0L A;  1JD4 A;  3F7I A;  3D9T A;  3M1D A;  2JK7 A;  2QFA A;  3CM2 A;  4MU7 A;  5C7B A;  3UEI A;  1JD6 A;  1SE0 A;  2VM5 A;  1TFT A;  3T6P A;  1G73 C;  5C0K A;  3UIK A;  3D9U A;  5C3H A;  3UIJ A;  4J45 A;  4A0I A;  5C3K A;  3OZ1 A;  3MUP A;  3SIQ A;  4WVU A;  2RAX A;  1JD5 A;  4KMN A;  4J44 A;  5C83 A;  4WVT A;  1Q4Q A;  3HL5 A;  3M0D D;  3UEE A;  1XOX A;  4HY5 A;  4J3Y A;  4LGU A;  3G76 A;  2QRA A;  1OXQ A;  3UIH A;  4HY4 A;  1NW9 A;  4MTI A;  2I3H A;  1M4M A;  3F7G A;  4A0N A;  3UEH A;  2VSL A;  3UED A;  1OXN A;  2I3I A;  3SIP E;  4J47 A;  3F7H A;  4KJV A;  4MTZ A;  3CM7 A;  1SDZ A;  4EB9 A;  2OPZ A;  1F9X A;  1OY7 A;  3UII A;  2UVL A;  3GT9 A;  3UW4 A; 
#chains in the Genus database with same CATH topology
 3M0A D;  3EYL A;  5C7A A;  1G3F A;  2OPY A;  2RAW A;  1QBH A;  1C9Q A;  4KJU A;  1XB1 A;  4J48 A;  3UEG A;  1XB0 A;  5C7D A;  4HY0 A;  2POP B;  1TW6 A;  3CLX A;  1E31 A;  4J46 A;  3UEF A;  4EC4 A;  5C7C A;  3UIG A;  4OXC A;  4WVS A;  3GTA A;  1I3O E;  5C84 A;  1F3H A;  3UEC A;  1TFQ A;  4A0J A;  2POI A;  4KMP A;  4LGE A;  3UW5 A;  5C0L A;  1JD4 A;  3F7I A;  3D9T A;  3M1D A;  2JK7 A;  2QFA A;  3CM2 A;  4MU7 A;  5C7B A;  3UEI A;  1JD6 A;  1SE0 A;  2VM5 A;  1TFT A;  3T6P A;  1G73 C;  5C0K A;  3UIK A;  3D9U A;  5C3H A;  3UIJ A;  4J45 A;  4A0I A;  5C3K A;  3OZ1 A;  3MUP A;  3SIQ A;  4WVU A;  2RAX A;  1JD5 A;  4KMN A;  4J44 A;  5C83 A;  4WVT A;  1Q4Q A;  3HL5 A;  3M0D D;  3UEE A;  1XOX A;  4HY5 A;  4J3Y A;  4LGU A;  3G76 A;  2QRA A;  1OXQ A;  3UIH A;  4HY4 A;  1NW9 A;  4MTI A;  2I3H A;  1M4M A;  3F7G A;  4A0N A;  3UEH A;  2VSL A;  3UED A;  1OXN A;  2I3I A;  3SIP E;  4J47 A;  3F7H A;  4KJV A;  4MTZ A;  3CM7 A;  1SDZ A;  4EB9 A;  2OPZ A;  1F9X A;  1OY7 A;  3UII A;  2UVL A;  3GT9 A;  3UW4 A; 
#chains in the Genus database with same CATH homology
 3M0A D;  3EYL A;  5C7A A;  1G3F A;  2OPY A;  2RAW A;  1QBH A;  1C9Q A;  4KJU A;  1XB1 A;  4J48 A;  3UEG A;  1XB0 A;  5C7D A;  4HY0 A;  2POP B;  1TW6 A;  3CLX A;  1E31 A;  4J46 A;  3UEF A;  4EC4 A;  5C7C A;  3UIG A;  4OXC A;  4WVS A;  3GTA A;  1I3O E;  5C84 A;  1F3H A;  3UEC A;  1TFQ A;  4A0J A;  2POI A;  4KMP A;  4LGE A;  3UW5 A;  5C0L A;  1JD4 A;  3F7I A;  3D9T A;  3M1D A;  2JK7 A;  2QFA A;  3CM2 A;  4MU7 A;  5C7B A;  3UEI A;  1JD6 A;  1SE0 A;  2VM5 A;  1TFT A;  3T6P A;  1G73 C;  5C0K A;  3UIK A;  3D9U A;  5C3H A;  3UIJ A;  4J45 A;  4A0I A;  5C3K A;  3OZ1 A;  3MUP A;  3SIQ A;  4WVU A;  2RAX A;  1JD5 A;  4KMN A;  4J44 A;  5C83 A;  4WVT A;  1Q4Q A;  3HL5 A;  3M0D D;  3UEE A;  1XOX A;  4HY5 A;  4J3Y A;  4LGU A;  3G76 A;  2QRA A;  1OXQ A;  3UIH A;  4HY4 A;  1NW9 A;  4MTI A;  2I3H A;  1M4M A;  3F7G A;  4A0N A;  3UEH A;  2VSL A;  3UED A;  1OXN A;  2I3I A;  3SIP E;  4J47 A;  3F7H A;  4KJV A;  4MTZ A;  3CM7 A;  1SDZ A;  4EB9 A;  2OPZ A;  1F9X A;  1OY7 A;  3UII A;  2UVL A;  3GT9 A;  3UW4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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