3F7GA

Structure of the bir domain from ml-iap bound to a peptidomimetic
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
99
structure length
99
Chain Sequence
AGATLSRGPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHAKWFPSCQFLLRSKGRDFVHSVQET
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold
pubmed doi rcsb
molecule tags Apoptosis
source organism Homo sapiens
molecule keywords Baculoviral IAP repeat-containing protein 7
total genus 24
structure length 99
sequence length 99
chains with identical sequence B, C, D, E
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2008-11-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00653 BIR Inhibitor of Apoptosis domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1170.10 Mainly Alpha Orthogonal Bundle Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A 3f7gA00
4WVSA 3GT9A 2QFAA 5C7BA 4J48A 3UEDA 4WVTA 3UW4A 3SIPE 1M4MA 5C0LA 2JK7A 5C7AA 3D9TA 1I3OE 2I3HA 4MTZA 1JD4A 4J46A 4EB9A 4KMNA 3UIIA 5C7CA 2RAWA 1OXNA 3F7HA 3M1DA 4KJVA 2POIA 4LGEA 3MUPA 3CM2A 4OXCA 5C3HA 3EYLA 3D9UA 5C83A 3UEGA 1G73C 4WVUA 3OZ1A 1Q4QA 2OPYA 1G3FA 1F9XA 1OXQA 2QRAA 2OPZA 4MTIA 3UEIA 4J44A 4EC4A 3G76A 1XB0A 3HL5A 4HY0A 4KMPA 3F7IA 4A0IA 5C84A 4HY4A 4LGUA 5C7DA 1TFQA 4J47A 1SE0A 3CLXA 3UIHA 3CM7A 3M0AD 1TFTA 5C3KA 4MU7A 3SIQA 1SDZA 3F7GA 1JD5A 3UW5A 1TW6A 4HY5A 4KJUA 4J45A 2UVLA 1XB1A 2POPB 3UEEA 1QBHA 1XOXA 3UECA 3UIKA 4A0NA 2VSLA 3M0DD 3T6PA 1E31A 1NW9A 5C0KA 2I3IA 1JD6A 2RAXA 2VM5A 3UIJA 4A0JA 4J3YA 3GTAA 1F3HA 3UEHA 1OY7A 3UIGA 3UEFA 1C9QA
chains in the Genus database with same CATH superfamily
4WVSA 3GT9A 2QFAA 5C7BA 4J48A 3UEDA 4WVTA 3UW4A 3SIPE 1M4MA 5C0LA 2JK7A 5C7AA 3D9TA 1I3OE 2I3HA 4MTZA 1JD4A 4J46A 4EB9A 4KMNA 3UIIA 5C7CA 2RAWA 1OXNA 3F7HA 3M1DA 4KJVA 2POIA 4LGEA 3MUPA 3CM2A 4OXCA 5C3HA 3EYLA 3D9UA 5C83A 3UEGA 1G73C 4WVUA 3OZ1A 1Q4QA 2OPYA 1G3FA 1F9XA 1OXQA 2QRAA 2OPZA 4MTIA 3UEIA 4J44A 4EC4A 3G76A 1XB0A 3HL5A 4HY0A 4KMPA 3F7IA 4A0IA 5C84A 4HY4A 4LGUA 5C7DA 1TFQA 4J47A 1SE0A 3CLXA 3UIHA 3CM7A 3M0AD 1TFTA 5C3KA 4MU7A 3SIQA 1SDZA 3F7GA 1JD5A 3UW5A 1TW6A 4HY5A 4KJUA 4J45A 2UVLA 1XB1A 2POPB 3UEEA 1QBHA 1XOXA 3UECA 3UIKA 4A0NA 2VSLA 3M0DD 3T6PA 1E31A 1NW9A 5C0KA 2I3IA 1JD6A 2RAXA 2VM5A 3UIJA 4A0JA 4J3YA 3GTAA 1F3HA 3UEHA 1OY7A 3UIGA 3UEFA 1C9QA
chains in the Genus database with same CATH topology
4WVSA 3GT9A 2QFAA 5C7BA 4J48A 3UEDA 4WVTA 3UW4A 3SIPE 1M4MA 5C0LA 2JK7A 5C7AA 3D9TA 1I3OE 2I3HA 4MTZA 1JD4A 4J46A 4EB9A 4KMNA 3UIIA 5C7CA 2RAWA 1OXNA 3F7HA 3M1DA 4KJVA 2POIA 4LGEA 3MUPA 3CM2A 4OXCA 5C3HA 3EYLA 3D9UA 5C83A 3UEGA 1G73C 4WVUA 3OZ1A 1Q4QA 2OPYA 1G3FA 1F9XA 1OXQA 2QRAA 2OPZA 4MTIA 3UEIA 4J44A 4EC4A 3G76A 1XB0A 3HL5A 4HY0A 4KMPA 3F7IA 4A0IA 5C84A 4HY4A 4LGUA 5C7DA 1TFQA 4J47A 1SE0A 3CLXA 3UIHA 3CM7A 3M0AD 1TFTA 5C3KA 4MU7A 3SIQA 1SDZA 3F7GA 1JD5A 3UW5A 1TW6A 4HY5A 4KJUA 4J45A 2UVLA 1XB1A 2POPB 3UEEA 1QBHA 1XOXA 3UECA 3UIKA 4A0NA 2VSLA 3M0DD 3T6PA 1E31A 1NW9A 5C0KA 2I3IA 1JD6A 2RAXA 2VM5A 3UIJA 4A0JA 4J3YA 3GTAA 1F3HA 3UEHA 1OY7A 3UIGA 3UEFA 1C9QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4WVS A;  3GT9 A;  2QFA A;  5C7B A;  4J48 A;  3UED A;  4WVT A;  3UW4 A;  3SIP E;  1M4M A;  5C0L A;  2JK7 A;  5C7A A;  3D9T A;  1I3O E;  2I3H A;  4MTZ A;  1JD4 A;  4J46 A;  4EB9 A;  4KMN A;  3UII A;  5C7C A;  2RAW A;  1OXN A;  3F7H A;  3M1D A;  4KJV A;  2POI A;  4LGE A;  3MUP A;  3CM2 A;  4OXC A;  5C3H A;  3EYL A;  3D9U A;  5C83 A;  3UEG A;  1G73 C;  4WVU A;  3OZ1 A;  1Q4Q A;  2OPY A;  1G3F A;  1F9X A;  1OXQ A;  2QRA A;  2OPZ A;  4MTI A;  3UEI A;  4J44 A;  4EC4 A;  3G76 A;  1XB0 A;  3HL5 A;  4HY0 A;  4KMP A;  3F7I A;  4A0I A;  5C84 A;  4HY4 A;  4LGU A;  5C7D A;  1TFQ A;  4J47 A;  1SE0 A;  3CLX A;  3UIH A;  3CM7 A;  3M0A D;  1TFT A;  5C3K A;  4MU7 A;  3SIQ A;  1SDZ A;  3F7G A;  1JD5 A;  3UW5 A;  1TW6 A;  4HY5 A;  4KJU A;  4J45 A;  2UVL A;  1XB1 A;  2POP B;  3UEE A;  1QBH A;  1XOX A;  3UEC A;  3UIK A;  4A0N A;  2VSL A;  3M0D D;  3T6P A;  1E31 A;  1NW9 A;  5C0K A;  2I3I A;  1JD6 A;  2RAX A;  2VM5 A;  3UIJ A;  4A0J A;  4J3Y A;  3GTA A;  1F3H A;  3UEH A;  1OY7 A;  3UIG A;  3UEF A;  1C9Q A; 
#chains in the Genus database with same CATH topology
 4WVS A;  3GT9 A;  2QFA A;  5C7B A;  4J48 A;  3UED A;  4WVT A;  3UW4 A;  3SIP E;  1M4M A;  5C0L A;  2JK7 A;  5C7A A;  3D9T A;  1I3O E;  2I3H A;  4MTZ A;  1JD4 A;  4J46 A;  4EB9 A;  4KMN A;  3UII A;  5C7C A;  2RAW A;  1OXN A;  3F7H A;  3M1D A;  4KJV A;  2POI A;  4LGE A;  3MUP A;  3CM2 A;  4OXC A;  5C3H A;  3EYL A;  3D9U A;  5C83 A;  3UEG A;  1G73 C;  4WVU A;  3OZ1 A;  1Q4Q A;  2OPY A;  1G3F A;  1F9X A;  1OXQ A;  2QRA A;  2OPZ A;  4MTI A;  3UEI A;  4J44 A;  4EC4 A;  3G76 A;  1XB0 A;  3HL5 A;  4HY0 A;  4KMP A;  3F7I A;  4A0I A;  5C84 A;  4HY4 A;  4LGU A;  5C7D A;  1TFQ A;  4J47 A;  1SE0 A;  3CLX A;  3UIH A;  3CM7 A;  3M0A D;  1TFT A;  5C3K A;  4MU7 A;  3SIQ A;  1SDZ A;  3F7G A;  1JD5 A;  3UW5 A;  1TW6 A;  4HY5 A;  4KJU A;  4J45 A;  2UVL A;  1XB1 A;  2POP B;  3UEE A;  1QBH A;  1XOX A;  3UEC A;  3UIK A;  4A0N A;  2VSL A;  3M0D D;  3T6P A;  1E31 A;  1NW9 A;  5C0K A;  2I3I A;  1JD6 A;  2RAX A;  2VM5 A;  3UIJ A;  4A0J A;  4J3Y A;  3GTA A;  1F3H A;  3UEH A;  1OY7 A;  3UIG A;  3UEF A;  1C9Q A; 
#chains in the Genus database with same CATH homology
 4WVS A;  3GT9 A;  2QFA A;  5C7B A;  4J48 A;  3UED A;  4WVT A;  3UW4 A;  3SIP E;  1M4M A;  5C0L A;  2JK7 A;  5C7A A;  3D9T A;  1I3O E;  2I3H A;  4MTZ A;  1JD4 A;  4J46 A;  4EB9 A;  4KMN A;  3UII A;  5C7C A;  2RAW A;  1OXN A;  3F7H A;  3M1D A;  4KJV A;  2POI A;  4LGE A;  3MUP A;  3CM2 A;  4OXC A;  5C3H A;  3EYL A;  3D9U A;  5C83 A;  3UEG A;  1G73 C;  4WVU A;  3OZ1 A;  1Q4Q A;  2OPY A;  1G3F A;  1F9X A;  1OXQ A;  2QRA A;  2OPZ A;  4MTI A;  3UEI A;  4J44 A;  4EC4 A;  3G76 A;  1XB0 A;  3HL5 A;  4HY0 A;  4KMP A;  3F7I A;  4A0I A;  5C84 A;  4HY4 A;  4LGU A;  5C7D A;  1TFQ A;  4J47 A;  1SE0 A;  3CLX A;  3UIH A;  3CM7 A;  3M0A D;  1TFT A;  5C3K A;  4MU7 A;  3SIQ A;  1SDZ A;  3F7G A;  1JD5 A;  3UW5 A;  1TW6 A;  4HY5 A;  4KJU A;  4J45 A;  2UVL A;  1XB1 A;  2POP B;  3UEE A;  1QBH A;  1XOX A;  3UEC A;  3UIK A;  4A0N A;  2VSL A;  3M0D D;  3T6P A;  1E31 A;  1NW9 A;  5C0K A;  2I3I A;  1JD6 A;  2RAX A;  2VM5 A;  3UIJ A;  4A0J A;  4J3Y A;  3GTA A;  1F3H A;  3UEH A;  1OY7 A;  3UIG A;  3UEF A;  1C9Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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