3F7HA

Structure of an ml-iap/xiap chimera bound to a peptidomimetic
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
90
structure length
90
Chain Sequence
GPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHAKWFPGCQFLLRSKGQEYINNIH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold
pubmed doi rcsb
molecule tags Apoptosis
source organism Homo sapiens
molecule keywords Baculoviral IAP repeat-containing protein 7
total genus 24
structure length 90
sequence length 90
chains with identical sequence B
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2008-11-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00653 BIR Inhibitor of Apoptosis domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1170.10 Mainly Alpha Orthogonal Bundle Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A 3f7hA00
4OXCA 3SIPE 3UECA 2VM5A 4MU7A 5C0KA 1JD6A 5C3KA 3UIHA 5C83A 3M1DA 3UIGA 3CLXA 4KJUA 4HY4A 4J47A 3M0AD 1G3FA 2UVLA 1XOXA 1TFTA 4J48A 3UEFA 4EC4A 4A0IA 2OPYA 5C7AA 1I3OE 5C7BA 1XB0A 1XB1A 3UEHA 4J46A 4MTIA 3T6PA 2POPB 2JK7A 3HL5A 2QFAA 2I3IA 4KMNA 4EB9A 1F9XA 4A0NA 3MUPA 4HY0A 5C7CA 1TFQA 4J45A 4KMPA 3UEIA 4KJVA 2RAXA 4LGUA 2POIA 4MTZA 4J3YA 3UEDA 1OY7A 4HY5A 3D9UA 3UEEA 1JD4A 1SDZA 5C3HA 1C9QA 1M4MA 1E31A 3UW4A 3D9TA 3GT9A 1F3HA 4WVTA 1QBHA 3OZ1A 2I3HA 3F7HA 4J44A 2QRAA 3GTAA 3CM2A 3F7GA 1OXNA 1OXQA 5C84A 2RAWA 3UIIA 1JD5A 4WVSA 3UEGA 5C0LA 1TW6A 2VSLA 4LGEA 3UW5A 4A0JA 3CM7A 5C7DA 1SE0A 3UIKA 3EYLA 3F7IA 3M0DD 3SIQA 2OPZA 3UIJA 4WVUA 1Q4QA 1NW9A 3G76A 1G73C
chains in the Genus database with same CATH superfamily
4OXCA 3SIPE 3UECA 2VM5A 4MU7A 5C0KA 1JD6A 5C3KA 3UIHA 5C83A 3M1DA 3UIGA 3CLXA 4KJUA 4HY4A 4J47A 3M0AD 1G3FA 2UVLA 1XOXA 1TFTA 4J48A 3UEFA 4EC4A 4A0IA 2OPYA 5C7AA 1I3OE 5C7BA 1XB0A 1XB1A 3UEHA 4J46A 4MTIA 3T6PA 2POPB 2JK7A 3HL5A 2QFAA 2I3IA 4KMNA 4EB9A 1F9XA 4A0NA 3MUPA 4HY0A 5C7CA 1TFQA 4J45A 4KMPA 3UEIA 4KJVA 2RAXA 4LGUA 2POIA 4MTZA 4J3YA 3UEDA 1OY7A 4HY5A 3D9UA 3UEEA 1JD4A 1SDZA 5C3HA 1C9QA 1M4MA 1E31A 3UW4A 3D9TA 3GT9A 1F3HA 4WVTA 1QBHA 3OZ1A 2I3HA 3F7HA 4J44A 2QRAA 3GTAA 3CM2A 3F7GA 1OXNA 1OXQA 5C84A 2RAWA 3UIIA 1JD5A 4WVSA 3UEGA 5C0LA 1TW6A 2VSLA 4LGEA 3UW5A 4A0JA 3CM7A 5C7DA 1SE0A 3UIKA 3EYLA 3F7IA 3M0DD 3SIQA 2OPZA 3UIJA 4WVUA 1Q4QA 1NW9A 3G76A 1G73C
chains in the Genus database with same CATH topology
4OXCA 3SIPE 3UECA 2VM5A 4MU7A 5C0KA 1JD6A 5C3KA 3UIHA 5C83A 3M1DA 3UIGA 3CLXA 4KJUA 4HY4A 4J47A 3M0AD 1G3FA 2UVLA 1XOXA 1TFTA 4J48A 3UEFA 4EC4A 4A0IA 2OPYA 5C7AA 1I3OE 5C7BA 1XB0A 1XB1A 3UEHA 4J46A 4MTIA 3T6PA 2POPB 2JK7A 3HL5A 2QFAA 2I3IA 4KMNA 4EB9A 1F9XA 4A0NA 3MUPA 4HY0A 5C7CA 1TFQA 4J45A 4KMPA 3UEIA 4KJVA 2RAXA 4LGUA 2POIA 4MTZA 4J3YA 3UEDA 1OY7A 4HY5A 3D9UA 3UEEA 1JD4A 1SDZA 5C3HA 1C9QA 1M4MA 1E31A 3UW4A 3D9TA 3GT9A 1F3HA 4WVTA 1QBHA 3OZ1A 2I3HA 3F7HA 4J44A 2QRAA 3GTAA 3CM2A 3F7GA 1OXNA 1OXQA 5C84A 2RAWA 3UIIA 1JD5A 4WVSA 3UEGA 5C0LA 1TW6A 2VSLA 4LGEA 3UW5A 4A0JA 3CM7A 5C7DA 1SE0A 3UIKA 3EYLA 3F7IA 3M0DD 3SIQA 2OPZA 3UIJA 4WVUA 1Q4QA 1NW9A 3G76A 1G73C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OXC A;  3SIP E;  3UEC A;  2VM5 A;  4MU7 A;  5C0K A;  1JD6 A;  5C3K A;  3UIH A;  5C83 A;  3M1D A;  3UIG A;  3CLX A;  4KJU A;  4HY4 A;  4J47 A;  3M0A D;  1G3F A;  2UVL A;  1XOX A;  1TFT A;  4J48 A;  3UEF A;  4EC4 A;  4A0I A;  2OPY A;  5C7A A;  1I3O E;  5C7B A;  1XB0 A;  1XB1 A;  3UEH A;  4J46 A;  4MTI A;  3T6P A;  2POP B;  2JK7 A;  3HL5 A;  2QFA A;  2I3I A;  4KMN A;  4EB9 A;  1F9X A;  4A0N A;  3MUP A;  4HY0 A;  5C7C A;  1TFQ A;  4J45 A;  4KMP A;  3UEI A;  4KJV A;  2RAX A;  4LGU A;  2POI A;  4MTZ A;  4J3Y A;  3UED A;  1OY7 A;  4HY5 A;  3D9U A;  3UEE A;  1JD4 A;  1SDZ A;  5C3H A;  1C9Q A;  1M4M A;  1E31 A;  3UW4 A;  3D9T A;  3GT9 A;  1F3H A;  4WVT A;  1QBH A;  3OZ1 A;  2I3H A;  3F7H A;  4J44 A;  2QRA A;  3GTA A;  3CM2 A;  3F7G A;  1OXN A;  1OXQ A;  5C84 A;  2RAW A;  3UII A;  1JD5 A;  4WVS A;  3UEG A;  5C0L A;  1TW6 A;  2VSL A;  4LGE A;  3UW5 A;  4A0J A;  3CM7 A;  5C7D A;  1SE0 A;  3UIK A;  3EYL A;  3F7I A;  3M0D D;  3SIQ A;  2OPZ A;  3UIJ A;  4WVU A;  1Q4Q A;  1NW9 A;  3G76 A;  1G73 C; 
#chains in the Genus database with same CATH topology
 4OXC A;  3SIP E;  3UEC A;  2VM5 A;  4MU7 A;  5C0K A;  1JD6 A;  5C3K A;  3UIH A;  5C83 A;  3M1D A;  3UIG A;  3CLX A;  4KJU A;  4HY4 A;  4J47 A;  3M0A D;  1G3F A;  2UVL A;  1XOX A;  1TFT A;  4J48 A;  3UEF A;  4EC4 A;  4A0I A;  2OPY A;  5C7A A;  1I3O E;  5C7B A;  1XB0 A;  1XB1 A;  3UEH A;  4J46 A;  4MTI A;  3T6P A;  2POP B;  2JK7 A;  3HL5 A;  2QFA A;  2I3I A;  4KMN A;  4EB9 A;  1F9X A;  4A0N A;  3MUP A;  4HY0 A;  5C7C A;  1TFQ A;  4J45 A;  4KMP A;  3UEI A;  4KJV A;  2RAX A;  4LGU A;  2POI A;  4MTZ A;  4J3Y A;  3UED A;  1OY7 A;  4HY5 A;  3D9U A;  3UEE A;  1JD4 A;  1SDZ A;  5C3H A;  1C9Q A;  1M4M A;  1E31 A;  3UW4 A;  3D9T A;  3GT9 A;  1F3H A;  4WVT A;  1QBH A;  3OZ1 A;  2I3H A;  3F7H A;  4J44 A;  2QRA A;  3GTA A;  3CM2 A;  3F7G A;  1OXN A;  1OXQ A;  5C84 A;  2RAW A;  3UII A;  1JD5 A;  4WVS A;  3UEG A;  5C0L A;  1TW6 A;  2VSL A;  4LGE A;  3UW5 A;  4A0J A;  3CM7 A;  5C7D A;  1SE0 A;  3UIK A;  3EYL A;  3F7I A;  3M0D D;  3SIQ A;  2OPZ A;  3UIJ A;  4WVU A;  1Q4Q A;  1NW9 A;  3G76 A;  1G73 C; 
#chains in the Genus database with same CATH homology
 4OXC A;  3SIP E;  3UEC A;  2VM5 A;  4MU7 A;  5C0K A;  1JD6 A;  5C3K A;  3UIH A;  5C83 A;  3M1D A;  3UIG A;  3CLX A;  4KJU A;  4HY4 A;  4J47 A;  3M0A D;  1G3F A;  2UVL A;  1XOX A;  1TFT A;  4J48 A;  3UEF A;  4EC4 A;  4A0I A;  2OPY A;  5C7A A;  1I3O E;  5C7B A;  1XB0 A;  1XB1 A;  3UEH A;  4J46 A;  4MTI A;  3T6P A;  2POP B;  2JK7 A;  3HL5 A;  2QFA A;  2I3I A;  4KMN A;  4EB9 A;  1F9X A;  4A0N A;  3MUP A;  4HY0 A;  5C7C A;  1TFQ A;  4J45 A;  4KMP A;  3UEI A;  4KJV A;  2RAX A;  4LGU A;  2POI A;  4MTZ A;  4J3Y A;  3UED A;  1OY7 A;  4HY5 A;  3D9U A;  3UEE A;  1JD4 A;  1SDZ A;  5C3H A;  1C9Q A;  1M4M A;  1E31 A;  3UW4 A;  3D9T A;  3GT9 A;  1F3H A;  4WVT A;  1QBH A;  3OZ1 A;  2I3H A;  3F7H A;  4J44 A;  2QRA A;  3GTA A;  3CM2 A;  3F7G A;  1OXN A;  1OXQ A;  5C84 A;  2RAW A;  3UII A;  1JD5 A;  4WVS A;  3UEG A;  5C0L A;  1TW6 A;  2VSL A;  4LGE A;  3UW5 A;  4A0J A;  3CM7 A;  5C7D A;  1SE0 A;  3UIK A;  3EYL A;  3F7I A;  3M0D D;  3SIQ A;  2OPZ A;  3UIJ A;  4WVU A;  1Q4Q A;  1NW9 A;  3G76 A;  1G73 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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