3F7IA

Structure of an ml-iap/xiap chimera bound to a peptidomimetic
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
90
structure length
90
Chain Sequence
GPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHAKWFPGCQFLLRSKGQEYINNIH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold
pubmed doi rcsb
molecule tags Apoptosis
source organism Homo sapiens
molecule keywords Baculoviral IAP repeat-containing protein 7
total genus 25
structure length 90
sequence length 90
chains with identical sequence B
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2008-11-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00653 BIR Inhibitor of Apoptosis domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1170.10 Mainly Alpha Orthogonal Bundle Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A 3f7iA00
1TFTA 4KJUA 1SE0A 3CLXA 4OXCA 1C9QA 4KMPA 3T6PA 1JD4A 1JD6A 3M0AD 3GTAA 4EB9A 5C0LA 3G76A 3UEIA 1E31A 4J3YA 2VSLA 4A0IA 1TW6A 3UIGA 3F7GA 1I3OE 4A0JA 2QFAA 3UEDA 2I3IA 5C3KA 3UIJA 3UEFA 4EC4A 2VM5A 3EYLA 3M0DD 5C3HA 5C7DA 5C84A 1XB1A 3OZ1A 2JK7A 3UIIA 3GT9A 1OY7A 2QRAA 2RAWA 5C7CA 4A0NA 1TFQA 3UW5A 2RAXA 3M1DA 1XOXA 3CM2A 5C7BA 1XB0A 4MTZA 3F7HA 4J46A 2OPZA 3UEEA 1M4MA 3SIQA 4WVTA 4WVSA 1JD5A 1F9XA 2UVLA 3D9TA 1OXNA 2I3HA 4LGEA 4MTIA 3F7IA 1OXQA 3UIHA 1G3FA 4HY0A 4J44A 5C0KA 1G73C 3UIKA 4WVUA 3SIPE 1NW9A 2POIA 3MUPA 3D9UA 5C7AA 2OPYA 3UECA 1Q4QA 3UW4A 1SDZA 3UEGA 3CM7A 2POPB 4MU7A 3UEHA 1QBHA 1F3HA 4HY4A 4J45A 4J48A 4KMNA 5C83A 4LGUA 3HL5A 4HY5A 4KJVA 4J47A
chains in the Genus database with same CATH superfamily
1TFTA 4KJUA 1SE0A 3CLXA 4OXCA 1C9QA 4KMPA 3T6PA 1JD4A 1JD6A 3M0AD 3GTAA 4EB9A 5C0LA 3G76A 3UEIA 1E31A 4J3YA 2VSLA 4A0IA 1TW6A 3UIGA 3F7GA 1I3OE 4A0JA 2QFAA 3UEDA 2I3IA 5C3KA 3UIJA 3UEFA 4EC4A 2VM5A 3EYLA 3M0DD 5C3HA 5C7DA 5C84A 1XB1A 3OZ1A 2JK7A 3UIIA 3GT9A 1OY7A 2QRAA 2RAWA 5C7CA 4A0NA 1TFQA 3UW5A 2RAXA 3M1DA 1XOXA 3CM2A 5C7BA 1XB0A 4MTZA 3F7HA 4J46A 2OPZA 3UEEA 1M4MA 3SIQA 4WVTA 4WVSA 1JD5A 1F9XA 2UVLA 3D9TA 1OXNA 2I3HA 4LGEA 4MTIA 3F7IA 1OXQA 3UIHA 1G3FA 4HY0A 4J44A 5C0KA 1G73C 3UIKA 4WVUA 3SIPE 1NW9A 2POIA 3MUPA 3D9UA 5C7AA 2OPYA 3UECA 1Q4QA 3UW4A 1SDZA 3UEGA 3CM7A 2POPB 4MU7A 3UEHA 1QBHA 1F3HA 4HY4A 4J45A 4J48A 4KMNA 5C83A 4LGUA 3HL5A 4HY5A 4KJVA 4J47A
chains in the Genus database with same CATH topology
1TFTA 4KJUA 1SE0A 3CLXA 4OXCA 1C9QA 4KMPA 3T6PA 1JD4A 1JD6A 3M0AD 3GTAA 4EB9A 5C0LA 3G76A 3UEIA 1E31A 4J3YA 2VSLA 4A0IA 1TW6A 3UIGA 3F7GA 1I3OE 4A0JA 2QFAA 3UEDA 2I3IA 5C3KA 3UIJA 3UEFA 4EC4A 2VM5A 3EYLA 3M0DD 5C3HA 5C7DA 5C84A 1XB1A 3OZ1A 2JK7A 3UIIA 3GT9A 1OY7A 2QRAA 2RAWA 5C7CA 4A0NA 1TFQA 3UW5A 2RAXA 3M1DA 1XOXA 3CM2A 5C7BA 1XB0A 4MTZA 3F7HA 4J46A 2OPZA 3UEEA 1M4MA 3SIQA 4WVTA 4WVSA 1JD5A 1F9XA 2UVLA 3D9TA 1OXNA 2I3HA 4LGEA 4MTIA 3F7IA 1OXQA 3UIHA 1G3FA 4HY0A 4J44A 5C0KA 1G73C 3UIKA 4WVUA 3SIPE 1NW9A 2POIA 3MUPA 3D9UA 5C7AA 2OPYA 3UECA 1Q4QA 3UW4A 1SDZA 3UEGA 3CM7A 2POPB 4MU7A 3UEHA 1QBHA 1F3HA 4HY4A 4J45A 4J48A 4KMNA 5C83A 4LGUA 3HL5A 4HY5A 4KJVA 4J47A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TFT A;  4KJU A;  1SE0 A;  3CLX A;  4OXC A;  1C9Q A;  4KMP A;  3T6P A;  1JD4 A;  1JD6 A;  3M0A D;  3GTA A;  4EB9 A;  5C0L A;  3G76 A;  3UEI A;  1E31 A;  4J3Y A;  2VSL A;  4A0I A;  1TW6 A;  3UIG A;  3F7G A;  1I3O E;  4A0J A;  2QFA A;  3UED A;  2I3I A;  5C3K A;  3UIJ A;  3UEF A;  4EC4 A;  2VM5 A;  3EYL A;  3M0D D;  5C3H A;  5C7D A;  5C84 A;  1XB1 A;  3OZ1 A;  2JK7 A;  3UII A;  3GT9 A;  1OY7 A;  2QRA A;  2RAW A;  5C7C A;  4A0N A;  1TFQ A;  3UW5 A;  2RAX A;  3M1D A;  1XOX A;  3CM2 A;  5C7B A;  1XB0 A;  4MTZ A;  3F7H A;  4J46 A;  2OPZ A;  3UEE A;  1M4M A;  3SIQ A;  4WVT A;  4WVS A;  1JD5 A;  1F9X A;  2UVL A;  3D9T A;  1OXN A;  2I3H A;  4LGE A;  4MTI A;  3F7I A;  1OXQ A;  3UIH A;  1G3F A;  4HY0 A;  4J44 A;  5C0K A;  1G73 C;  3UIK A;  4WVU A;  3SIP E;  1NW9 A;  2POI A;  3MUP A;  3D9U A;  5C7A A;  2OPY A;  3UEC A;  1Q4Q A;  3UW4 A;  1SDZ A;  3UEG A;  3CM7 A;  2POP B;  4MU7 A;  3UEH A;  1QBH A;  1F3H A;  4HY4 A;  4J45 A;  4J48 A;  4KMN A;  5C83 A;  4LGU A;  3HL5 A;  4HY5 A;  4KJV A;  4J47 A; 
#chains in the Genus database with same CATH topology
 1TFT A;  4KJU A;  1SE0 A;  3CLX A;  4OXC A;  1C9Q A;  4KMP A;  3T6P A;  1JD4 A;  1JD6 A;  3M0A D;  3GTA A;  4EB9 A;  5C0L A;  3G76 A;  3UEI A;  1E31 A;  4J3Y A;  2VSL A;  4A0I A;  1TW6 A;  3UIG A;  3F7G A;  1I3O E;  4A0J A;  2QFA A;  3UED A;  2I3I A;  5C3K A;  3UIJ A;  3UEF A;  4EC4 A;  2VM5 A;  3EYL A;  3M0D D;  5C3H A;  5C7D A;  5C84 A;  1XB1 A;  3OZ1 A;  2JK7 A;  3UII A;  3GT9 A;  1OY7 A;  2QRA A;  2RAW A;  5C7C A;  4A0N A;  1TFQ A;  3UW5 A;  2RAX A;  3M1D A;  1XOX A;  3CM2 A;  5C7B A;  1XB0 A;  4MTZ A;  3F7H A;  4J46 A;  2OPZ A;  3UEE A;  1M4M A;  3SIQ A;  4WVT A;  4WVS A;  1JD5 A;  1F9X A;  2UVL A;  3D9T A;  1OXN A;  2I3H A;  4LGE A;  4MTI A;  3F7I A;  1OXQ A;  3UIH A;  1G3F A;  4HY0 A;  4J44 A;  5C0K A;  1G73 C;  3UIK A;  4WVU A;  3SIP E;  1NW9 A;  2POI A;  3MUP A;  3D9U A;  5C7A A;  2OPY A;  3UEC A;  1Q4Q A;  3UW4 A;  1SDZ A;  3UEG A;  3CM7 A;  2POP B;  4MU7 A;  3UEH A;  1QBH A;  1F3H A;  4HY4 A;  4J45 A;  4J48 A;  4KMN A;  5C83 A;  4LGU A;  3HL5 A;  4HY5 A;  4KJV A;  4J47 A; 
#chains in the Genus database with same CATH homology
 1TFT A;  4KJU A;  1SE0 A;  3CLX A;  4OXC A;  1C9Q A;  4KMP A;  3T6P A;  1JD4 A;  1JD6 A;  3M0A D;  3GTA A;  4EB9 A;  5C0L A;  3G76 A;  3UEI A;  1E31 A;  4J3Y A;  2VSL A;  4A0I A;  1TW6 A;  3UIG A;  3F7G A;  1I3O E;  4A0J A;  2QFA A;  3UED A;  2I3I A;  5C3K A;  3UIJ A;  3UEF A;  4EC4 A;  2VM5 A;  3EYL A;  3M0D D;  5C3H A;  5C7D A;  5C84 A;  1XB1 A;  3OZ1 A;  2JK7 A;  3UII A;  3GT9 A;  1OY7 A;  2QRA A;  2RAW A;  5C7C A;  4A0N A;  1TFQ A;  3UW5 A;  2RAX A;  3M1D A;  1XOX A;  3CM2 A;  5C7B A;  1XB0 A;  4MTZ A;  3F7H A;  4J46 A;  2OPZ A;  3UEE A;  1M4M A;  3SIQ A;  4WVT A;  4WVS A;  1JD5 A;  1F9X A;  2UVL A;  3D9T A;  1OXN A;  2I3H A;  4LGE A;  4MTI A;  3F7I A;  1OXQ A;  3UIH A;  1G3F A;  4HY0 A;  4J44 A;  5C0K A;  1G73 C;  3UIK A;  4WVU A;  3SIP E;  1NW9 A;  2POI A;  3MUP A;  3D9U A;  5C7A A;  2OPY A;  3UEC A;  1Q4Q A;  3UW4 A;  1SDZ A;  3UEG A;  3CM7 A;  2POP B;  4MU7 A;  3UEH A;  1QBH A;  1F3H A;  4HY4 A;  4J45 A;  4J48 A;  4KMN A;  5C83 A;  4LGU A;  3HL5 A;  4HY5 A;  4KJV A;  4J47 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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