The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
20
|
sequence length |
87
|
structure length |
87
|
Chain Sequence |
MQTHAARMRTFMYWPSSVPVQPEQLAAAGFYYVGRNDDVKCFSCDGGLRCWESGDDPWVEHAKWFPGCEFLIRMKGQEYINNIHLTH
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152).
pubmed doi rcsb |
| molecule tags |
Apoptosis inhibitor
|
| source organism |
Homo sapiens
|
| molecule keywords |
Baculoviral IAP repeat-containing protein 2, Baculoviral IAP
|
| total genus |
20
|
| structure length |
87
|
| sequence length |
87
|
| ec nomenclature |
ec
2.3.2.27: RING-type E3 ubiquitin transferase. |
| pdb deposition date | 2011-11-30 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00653 | BIR | Inhibitor of Apoptosis domain |
| A | PF00653 | BIR | Inhibitor of Apoptosis domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Orthogonal Bundle | Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A | Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A |
#chains in the Genus database with same CATH superfamily 3CM7 A; 1OXQ A; 1TFT A; 1E31 A; 3UIG A; 1M4M A; 3F7H A; 3UEF A; 4A0I A; 3UIH A; 3OZ1 A; 3UEH A; 4LGE A; 3D9T A; 1G3F A; 4J45 A; 4J48 A; 3UEC A; 4A0J A; 4OXC A; 3UED A; 4MTI A; 5C7B A; 4KMN A; 2QRA A; 5C0L A; 5C7C A; 1QBH A; 1XB0 A; 4WVS A; 5C0K A; 3M0D D; 1C9Q A; 5C83 A; 4WVU A; 4A0N A; 4EB9 A; 2I3H A; 3MUP A; 4MTZ A; 4MU7 A; 2UVL A; 2OPZ A; 3SIP E; 1JD5 A; 2QFA A; 3CLX A; 3UIJ A; 1JD6 A; 4J46 A; 3M1D A; 5C3H A; 4KJV A; 1JD4 A; 3EYL A; 2JK7 A; 4KMP A; 3UEI A; 4LGU A; 4KJU A; 3UEG A; 1NW9 A; 3M0A D; 4HY4 A; 3UEE A; 3F7G A; 4EC4 A; 4J44 A; 4WVT A; 1G73 C; 2POI A; 3HL5 A; 3UIK A; 5C7A A; 3UII A; 1OXN A; 3SIQ A; 1SE0 A; 3CM2 A; 3G76 A; 2RAW A; 1XB1 A; 2VM5 A; 4J3Y A; 2I3I A; 3T6P A; 4J47 A; 5C3K A; 5C7D A; 1TW6 A; 1TFQ A; 2RAX A; 3D9U A; 2POP B; 1F3H A; 3GTA A; 3GT9 A; 1F9X A; 3UW5 A; 2OPY A; 3UW4 A; 1OY7 A; 4HY0 A; 5C84 A; 4HY5 A; 1SDZ A; 1I3O E; 1XOX A; 1Q4Q A; 2VSL A; 3F7I A; #chains in the Genus database with same CATH topology 3CM7 A; 1OXQ A; 1TFT A; 1E31 A; 3UIG A; 1M4M A; 3F7H A; 3UEF A; 4A0I A; 3UIH A; 3OZ1 A; 3UEH A; 4LGE A; 3D9T A; 1G3F A; 4J45 A; 4J48 A; 3UEC A; 4A0J A; 4OXC A; 3UED A; 4MTI A; 5C7B A; 4KMN A; 2QRA A; 5C0L A; 5C7C A; 1QBH A; 1XB0 A; 4WVS A; 5C0K A; 3M0D D; 1C9Q A; 5C83 A; 4WVU A; 4A0N A; 4EB9 A; 2I3H A; 3MUP A; 4MTZ A; 4MU7 A; 2UVL A; 2OPZ A; 3SIP E; 1JD5 A; 2QFA A; 3CLX A; 3UIJ A; 1JD6 A; 4J46 A; 3M1D A; 5C3H A; 4KJV A; 1JD4 A; 3EYL A; 2JK7 A; 4KMP A; 3UEI A; 4LGU A; 4KJU A; 3UEG A; 1NW9 A; 3M0A D; 4HY4 A; 3UEE A; 3F7G A; 4EC4 A; 4J44 A; 4WVT A; 1G73 C; 2POI A; 3HL5 A; 3UIK A; 5C7A A; 3UII A; 1OXN A; 3SIQ A; 1SE0 A; 3CM2 A; 3G76 A; 2RAW A; 1XB1 A; 2VM5 A; 4J3Y A; 2I3I A; 3T6P A; 4J47 A; 5C3K A; 5C7D A; 1TW6 A; 1TFQ A; 2RAX A; 3D9U A; 2POP B; 1F3H A; 3GTA A; 3GT9 A; 1F9X A; 3UW5 A; 2OPY A; 3UW4 A; 1OY7 A; 4HY0 A; 5C84 A; 4HY5 A; 1SDZ A; 1I3O E; 1XOX A; 1Q4Q A; 2VSL A; 3F7I A; #chains in the Genus database with same CATH homology 3CM7 A; 1OXQ A; 1TFT A; 1E31 A; 3UIG A; 1M4M A; 3F7H A; 3UEF A; 4A0I A; 3UIH A; 3OZ1 A; 3UEH A; 4LGE A; 3D9T A; 1G3F A; 4J45 A; 4J48 A; 3UEC A; 4A0J A; 4OXC A; 3UED A; 4MTI A; 5C7B A; 4KMN A; 2QRA A; 5C0L A; 5C7C A; 1QBH A; 1XB0 A; 4WVS A; 5C0K A; 3M0D D; 1C9Q A; 5C83 A; 4WVU A; 4A0N A; 4EB9 A; 2I3H A; 3MUP A; 4MTZ A; 4MU7 A; 2UVL A; 2OPZ A; 3SIP E; 1JD5 A; 2QFA A; 3CLX A; 3UIJ A; 1JD6 A; 4J46 A; 3M1D A; 5C3H A; 4KJV A; 1JD4 A; 3EYL A; 2JK7 A; 4KMP A; 3UEI A; 4LGU A; 4KJU A; 3UEG A; 1NW9 A; 3M0A D; 4HY4 A; 3UEE A; 3F7G A; 4EC4 A; 4J44 A; 4WVT A; 1G73 C; 2POI A; 3HL5 A; 3UIK A; 5C7A A; 3UII A; 1OXN A; 3SIQ A; 1SE0 A; 3CM2 A; 3G76 A; 2RAW A; 1XB1 A; 2VM5 A; 4J3Y A; 2I3I A; 3T6P A; 4J47 A; 5C3K A; 5C7D A; 1TW6 A; 1TFQ A; 2RAX A; 3D9U A; 2POP B; 1F3H A; 3GTA A; 3GT9 A; 1F9X A; 3UW5 A; 2OPY A; 3UW4 A; 1OY7 A; 4HY0 A; 5C84 A; 4HY5 A; 1SDZ A; 1I3O E; 1XOX A; 1Q4Q A; 2VSL A; 3F7I A;
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