The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
19
|
sequence length |
79
|
structure length |
79
|
Chain Sequence |
GHMRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVL
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
The Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity.
pubmed doi rcsb |
| molecule tags |
Apoptosis
|
| source organism |
Homo sapiens
|
| molecule keywords |
E3 ubiquitin-protein ligase XIAP
|
| total genus |
19
|
| structure length |
79
|
| sequence length |
79
|
| chains with identical sequence |
B
|
| ec nomenclature |
ec
2.3.2.27: RING-type E3 ubiquitin transferase. |
| pdb deposition date | 2014-11-07 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00653 | BIR | Inhibitor of Apoptosis domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Orthogonal Bundle | Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A | Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A |
#chains in the Genus database with same CATH superfamily 1E31 A; 4KJU A; 5C3H A; 4J45 A; 4J44 A; 1SDZ A; 3UED A; 3D9T A; 3UEC A; 3GT9 A; 4LGU A; 1XB1 A; 3EYL A; 5C83 A; 1OXN A; 4MTI A; 3UW4 A; 3CM7 A; 4MTZ A; 1TW6 A; 5C7B A; 5C7D A; 3CLX A; 3SIQ A; 4A0J A; 3UIG A; 4KMP A; 5C0K A; 4HY0 A; 1TFT A; 4A0N A; 1JD5 A; 4EB9 A; 2QRA A; 5C7A A; 1OXQ A; 4WVU A; 1F3H A; 2OPY A; 4J46 A; 3UIH A; 4WVS A; 4KMN A; 1Q4Q A; 4HY4 A; 4J3Y A; 3T6P A; 3UEI A; 1G3F A; 4WVT A; 1I3O E; 2POI A; 3UII A; 2VM5 A; 1JD6 A; 3F7G A; 4J47 A; 3GTA A; 4LGE A; 4KJV A; 1JD4 A; 3UIK A; 4MU7 A; 2JK7 A; 1M4M A; 2I3H A; 4J48 A; 3UEG A; 3M0A D; 5C7C A; 3SIP E; 1SE0 A; 2UVL A; 3M1D A; 5C3K A; 3UEF A; 3UW5 A; 3HL5 A; 1XOX A; 3G76 A; 2RAW A; 3F7H A; 1OY7 A; 5C0L A; 4A0I A; 4EC4 A; 3CM2 A; 3MUP A; 1TFQ A; 2POP B; 4HY5 A; 2OPZ A; 3F7I A; 5C84 A; 1QBH A; 2VSL A; 1G73 C; 1C9Q A; 2RAX A; 3UIJ A; 1NW9 A; 4OXC A; 3D9U A; 1F9X A; 3UEE A; 3UEH A; 2I3I A; 1XB0 A; 2QFA A; 3OZ1 A; 3M0D D; #chains in the Genus database with same CATH topology 1E31 A; 4KJU A; 5C3H A; 4J45 A; 4J44 A; 1SDZ A; 3UED A; 3D9T A; 3UEC A; 3GT9 A; 4LGU A; 1XB1 A; 3EYL A; 5C83 A; 1OXN A; 4MTI A; 3UW4 A; 3CM7 A; 4MTZ A; 1TW6 A; 5C7B A; 5C7D A; 3CLX A; 3SIQ A; 4A0J A; 3UIG A; 4KMP A; 5C0K A; 4HY0 A; 1TFT A; 4A0N A; 1JD5 A; 4EB9 A; 2QRA A; 5C7A A; 1OXQ A; 4WVU A; 1F3H A; 2OPY A; 4J46 A; 3UIH A; 4WVS A; 4KMN A; 1Q4Q A; 4HY4 A; 4J3Y A; 3T6P A; 3UEI A; 1G3F A; 4WVT A; 1I3O E; 2POI A; 3UII A; 2VM5 A; 1JD6 A; 3F7G A; 4J47 A; 3GTA A; 4LGE A; 4KJV A; 1JD4 A; 3UIK A; 4MU7 A; 2JK7 A; 1M4M A; 2I3H A; 4J48 A; 3UEG A; 3M0A D; 5C7C A; 3SIP E; 1SE0 A; 2UVL A; 3M1D A; 5C3K A; 3UEF A; 3UW5 A; 3HL5 A; 1XOX A; 3G76 A; 2RAW A; 3F7H A; 1OY7 A; 5C0L A; 4A0I A; 4EC4 A; 3CM2 A; 3MUP A; 1TFQ A; 2POP B; 4HY5 A; 2OPZ A; 3F7I A; 5C84 A; 1QBH A; 2VSL A; 1G73 C; 1C9Q A; 2RAX A; 3UIJ A; 1NW9 A; 4OXC A; 3D9U A; 1F9X A; 3UEE A; 3UEH A; 2I3I A; 1XB0 A; 2QFA A; 3OZ1 A; 3M0D D; #chains in the Genus database with same CATH homology 1E31 A; 4KJU A; 5C3H A; 4J45 A; 4J44 A; 1SDZ A; 3UED A; 3D9T A; 3UEC A; 3GT9 A; 4LGU A; 1XB1 A; 3EYL A; 5C83 A; 1OXN A; 4MTI A; 3UW4 A; 3CM7 A; 4MTZ A; 1TW6 A; 5C7B A; 5C7D A; 3CLX A; 3SIQ A; 4A0J A; 3UIG A; 4KMP A; 5C0K A; 4HY0 A; 1TFT A; 4A0N A; 1JD5 A; 4EB9 A; 2QRA A; 5C7A A; 1OXQ A; 4WVU A; 1F3H A; 2OPY A; 4J46 A; 3UIH A; 4WVS A; 4KMN A; 1Q4Q A; 4HY4 A; 4J3Y A; 3T6P A; 3UEI A; 1G3F A; 4WVT A; 1I3O E; 2POI A; 3UII A; 2VM5 A; 1JD6 A; 3F7G A; 4J47 A; 3GTA A; 4LGE A; 4KJV A; 1JD4 A; 3UIK A; 4MU7 A; 2JK7 A; 1M4M A; 2I3H A; 4J48 A; 3UEG A; 3M0A D; 5C7C A; 3SIP E; 1SE0 A; 2UVL A; 3M1D A; 5C3K A; 3UEF A; 3UW5 A; 3HL5 A; 1XOX A; 3G76 A; 2RAW A; 3F7H A; 1OY7 A; 5C0L A; 4A0I A; 4EC4 A; 3CM2 A; 3MUP A; 1TFQ A; 2POP B; 4HY5 A; 2OPZ A; 3F7I A; 5C84 A; 1QBH A; 2VSL A; 1G73 C; 1C9Q A; 2RAX A; 3UIJ A; 1NW9 A; 4OXC A; 3D9U A; 1F9X A; 3UEE A; 3UEH A; 2I3I A; 1XB0 A; 2QFA A; 3OZ1 A; 3M0D D;
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