The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
33
|
sequence length |
106
|
structure length |
106
|
Chain Sequence |
NFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVR
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
pubmed doi rcsb |
| molecule tags |
Apoptosis
|
| source organism |
Homo sapiens
|
| molecule keywords |
E3 ubiquitin-protein ligase XIAP
|
| total genus |
33
|
| structure length |
106
|
| sequence length |
106
|
| ec nomenclature |
ec
2.3.2.27: RING-type E3 ubiquitin transferase. |
| pdb deposition date | 2015-06-17 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00653 | BIR | Inhibitor of Apoptosis domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Orthogonal Bundle | Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A | Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A |
#chains in the Genus database with same CATH superfamily 3F7H A; 4WVT A; 3G76 A; 3UIG A; 1SE0 A; 3UIH A; 3UEH A; 1OXN A; 3GT9 A; 4EB9 A; 4KJV A; 3SIP E; 3UIJ A; 3EYL A; 3UW5 A; 1I3O E; 4MU7 A; 1C9Q A; 1JD5 A; 5C84 A; 2I3I A; 1TW6 A; 1JD6 A; 1XOX A; 1TFT A; 1XB1 A; 3OZ1 A; 2I3H A; 4J44 A; 3MUP A; 2VSL A; 3CLX A; 4HY5 A; 3UEE A; 3M0D D; 4MTI A; 2RAW A; 3CM2 A; 3GTA A; 4J47 A; 2VM5 A; 3CM7 A; 3UEC A; 3UII A; 3UED A; 3M1D A; 3M0A D; 2QFA A; 2OPY A; 3D9T A; 1OXQ A; 5C0L A; 4KMP A; 5C3K A; 3F7I A; 1G73 C; 2OPZ A; 3UEG A; 5C7C A; 1SDZ A; 4KJU A; 1TFQ A; 2POP B; 4J45 A; 2UVL A; 1XB0 A; 3UW4 A; 3D9U A; 4LGE A; 3UIK A; 1G3F A; 3UEI A; 5C0K A; 4LGU A; 5C83 A; 3UEF A; 4J48 A; 5C7A A; 1M4M A; 4WVS A; 4KMN A; 1JD4 A; 4OXC A; 2POI A; 3F7G A; 4EC4 A; 4HY0 A; 3SIQ A; 4HY4 A; 4J3Y A; 1F3H A; 1QBH A; 4A0I A; 4A0J A; 5C3H A; 3HL5 A; 5C7D A; 2RAX A; 1Q4Q A; 1F9X A; 3T6P A; 1OY7 A; 5C7B A; 4A0N A; 4WVU A; 2QRA A; 4MTZ A; 2JK7 A; 4J46 A; 1E31 A; 1NW9 A; #chains in the Genus database with same CATH topology 3F7H A; 4WVT A; 3G76 A; 3UIG A; 1SE0 A; 3UIH A; 3UEH A; 1OXN A; 3GT9 A; 4EB9 A; 4KJV A; 3SIP E; 3UIJ A; 3EYL A; 3UW5 A; 1I3O E; 4MU7 A; 1C9Q A; 1JD5 A; 5C84 A; 2I3I A; 1TW6 A; 1JD6 A; 1XOX A; 1TFT A; 1XB1 A; 3OZ1 A; 2I3H A; 4J44 A; 3MUP A; 2VSL A; 3CLX A; 4HY5 A; 3UEE A; 3M0D D; 4MTI A; 2RAW A; 3CM2 A; 3GTA A; 4J47 A; 2VM5 A; 3CM7 A; 3UEC A; 3UII A; 3UED A; 3M1D A; 3M0A D; 2QFA A; 2OPY A; 3D9T A; 1OXQ A; 5C0L A; 4KMP A; 5C3K A; 3F7I A; 1G73 C; 2OPZ A; 3UEG A; 5C7C A; 1SDZ A; 4KJU A; 1TFQ A; 2POP B; 4J45 A; 2UVL A; 1XB0 A; 3UW4 A; 3D9U A; 4LGE A; 3UIK A; 1G3F A; 3UEI A; 5C0K A; 4LGU A; 5C83 A; 3UEF A; 4J48 A; 5C7A A; 1M4M A; 4WVS A; 4KMN A; 1JD4 A; 4OXC A; 2POI A; 3F7G A; 4EC4 A; 4HY0 A; 3SIQ A; 4HY4 A; 4J3Y A; 1F3H A; 1QBH A; 4A0I A; 4A0J A; 5C3H A; 3HL5 A; 5C7D A; 2RAX A; 1Q4Q A; 1F9X A; 3T6P A; 1OY7 A; 5C7B A; 4A0N A; 4WVU A; 2QRA A; 4MTZ A; 2JK7 A; 4J46 A; 1E31 A; 1NW9 A; #chains in the Genus database with same CATH homology 3F7H A; 4WVT A; 3G76 A; 3UIG A; 1SE0 A; 3UIH A; 3UEH A; 1OXN A; 3GT9 A; 4EB9 A; 4KJV A; 3SIP E; 3UIJ A; 3EYL A; 3UW5 A; 1I3O E; 4MU7 A; 1C9Q A; 1JD5 A; 5C84 A; 2I3I A; 1TW6 A; 1JD6 A; 1XOX A; 1TFT A; 1XB1 A; 3OZ1 A; 2I3H A; 4J44 A; 3MUP A; 2VSL A; 3CLX A; 4HY5 A; 3UEE A; 3M0D D; 4MTI A; 2RAW A; 3CM2 A; 3GTA A; 4J47 A; 2VM5 A; 3CM7 A; 3UEC A; 3UII A; 3UED A; 3M1D A; 3M0A D; 2QFA A; 2OPY A; 3D9T A; 1OXQ A; 5C0L A; 4KMP A; 5C3K A; 3F7I A; 1G73 C; 2OPZ A; 3UEG A; 5C7C A; 1SDZ A; 4KJU A; 1TFQ A; 2POP B; 4J45 A; 2UVL A; 1XB0 A; 3UW4 A; 3D9U A; 4LGE A; 3UIK A; 1G3F A; 3UEI A; 5C0K A; 4LGU A; 5C83 A; 3UEF A; 4J48 A; 5C7A A; 1M4M A; 4WVS A; 4KMN A; 1JD4 A; 4OXC A; 2POI A; 3F7G A; 4EC4 A; 4HY0 A; 3SIQ A; 4HY4 A; 4J3Y A; 1F3H A; 1QBH A; 4A0I A; 4A0J A; 5C3H A; 3HL5 A; 5C7D A; 2RAX A; 1Q4Q A; 1F9X A; 3T6P A; 1OY7 A; 5C7B A; 4A0N A; 4WVU A; 2QRA A; 4MTZ A; 2JK7 A; 4J46 A; 1E31 A; 1NW9 A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
