5C7DA

Fragment-based drug discovery targeting inhibitor of apoptosis proteins: compound 17
Total Genus 35
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
35
sequence length
106
structure length
106
Chain Sequence
NFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
pubmed doi rcsb
molecule tags Apoptosis
source organism Homo sapiens
molecule keywords E3 ubiquitin-protein ligase XIAP
total genus 35
structure length 106
sequence length 106
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2015-06-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00653 BIR Inhibitor of Apoptosis domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1170.10 Mainly Alpha Orthogonal Bundle Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A 5c7dA00
2RAWA 4WVTA 5C83A 4KMNA 5C0KA 4EB9A 2RAXA 4J3YA 3UEFA 4HY5A 3T6PA 1C9QA 4J47A 5C7DA 5C84A 2QRAA 1F9XA 3G76A 1TFTA 1SE0A 2I3IA 4J46A 1E31A 3GT9A 4HY4A 3M1DA 4LGUA 3UIIA 3SIPE 4A0NA 3OZ1A 3HL5A 1XB0A 3EYLA 1I3OE 2UVLA 4A0IA 3M0AD 1OY7A 3UEDA 1G73C 2OPZA 4EC4A 3CM7A 4HY0A 4J48A 1JD5A 4MU7A 3D9UA 1TW6A 1OXNA 4KMPA 2VSLA 3F7IA 2QFAA 4KJUA 3UIHA 4WVSA 5C3KA 4J45A 3UEHA 1QBHA 1SDZA 3UIGA 5C7BA 1XB1A 4LGEA 3CLXA 1XOXA 3GTAA 5C7AA 1TFQA 1JD6A 4MTZA 3SIQA 4J44A 3F7GA 3D9TA 1Q4QA 1G3FA 2POIA 3UIKA 3M0DD 3F7HA 4WVUA 3UW5A 5C0LA 3UIJA 2OPYA 3UW4A 4A0JA 2POPB 4OXCA 3CM2A 3UEEA 1F3HA 1JD4A 1OXQA 4MTIA 1NW9A 2I3HA 3UEGA 1M4MA 2VM5A 2JK7A 5C3HA 3MUPA 5C7CA 3UECA 4KJVA 3UEIA
chains in the Genus database with same CATH superfamily
2RAWA 4WVTA 5C83A 4KMNA 5C0KA 4EB9A 2RAXA 4J3YA 3UEFA 4HY5A 3T6PA 1C9QA 4J47A 5C7DA 5C84A 2QRAA 1F9XA 3G76A 1TFTA 1SE0A 2I3IA 4J46A 1E31A 3GT9A 4HY4A 3M1DA 4LGUA 3UIIA 3SIPE 4A0NA 3OZ1A 3HL5A 1XB0A 3EYLA 1I3OE 2UVLA 4A0IA 3M0AD 1OY7A 3UEDA 1G73C 2OPZA 4EC4A 3CM7A 4HY0A 4J48A 1JD5A 4MU7A 3D9UA 1TW6A 1OXNA 4KMPA 2VSLA 3F7IA 2QFAA 4KJUA 3UIHA 4WVSA 5C3KA 4J45A 3UEHA 1QBHA 1SDZA 3UIGA 5C7BA 1XB1A 4LGEA 3CLXA 1XOXA 3GTAA 5C7AA 1TFQA 1JD6A 4MTZA 3SIQA 4J44A 3F7GA 3D9TA 1Q4QA 1G3FA 2POIA 3UIKA 3M0DD 3F7HA 4WVUA 3UW5A 5C0LA 3UIJA 2OPYA 3UW4A 4A0JA 2POPB 4OXCA 3CM2A 3UEEA 1F3HA 1JD4A 1OXQA 4MTIA 1NW9A 2I3HA 3UEGA 1M4MA 2VM5A 2JK7A 5C3HA 3MUPA 5C7CA 3UECA 4KJVA 3UEIA
chains in the Genus database with same CATH topology
2RAWA 4WVTA 5C83A 4KMNA 5C0KA 4EB9A 2RAXA 4J3YA 3UEFA 4HY5A 3T6PA 1C9QA 4J47A 5C7DA 5C84A 2QRAA 1F9XA 3G76A 1TFTA 1SE0A 2I3IA 4J46A 1E31A 3GT9A 4HY4A 3M1DA 4LGUA 3UIIA 3SIPE 4A0NA 3OZ1A 3HL5A 1XB0A 3EYLA 1I3OE 2UVLA 4A0IA 3M0AD 1OY7A 3UEDA 1G73C 2OPZA 4EC4A 3CM7A 4HY0A 4J48A 1JD5A 4MU7A 3D9UA 1TW6A 1OXNA 4KMPA 2VSLA 3F7IA 2QFAA 4KJUA 3UIHA 4WVSA 5C3KA 4J45A 3UEHA 1QBHA 1SDZA 3UIGA 5C7BA 1XB1A 4LGEA 3CLXA 1XOXA 3GTAA 5C7AA 1TFQA 1JD6A 4MTZA 3SIQA 4J44A 3F7GA 3D9TA 1Q4QA 1G3FA 2POIA 3UIKA 3M0DD 3F7HA 4WVUA 3UW5A 5C0LA 3UIJA 2OPYA 3UW4A 4A0JA 2POPB 4OXCA 3CM2A 3UEEA 1F3HA 1JD4A 1OXQA 4MTIA 1NW9A 2I3HA 3UEGA 1M4MA 2VM5A 2JK7A 5C3HA 3MUPA 5C7CA 3UECA 4KJVA 3UEIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2RAW A;  4WVT A;  5C83 A;  4KMN A;  5C0K A;  4EB9 A;  2RAX A;  4J3Y A;  3UEF A;  4HY5 A;  3T6P A;  1C9Q A;  4J47 A;  5C7D A;  5C84 A;  2QRA A;  1F9X A;  3G76 A;  1TFT A;  1SE0 A;  2I3I A;  4J46 A;  1E31 A;  3GT9 A;  4HY4 A;  3M1D A;  4LGU A;  3UII A;  3SIP E;  4A0N A;  3OZ1 A;  3HL5 A;  1XB0 A;  3EYL A;  1I3O E;  2UVL A;  4A0I A;  3M0A D;  1OY7 A;  3UED A;  1G73 C;  2OPZ A;  4EC4 A;  3CM7 A;  4HY0 A;  4J48 A;  1JD5 A;  4MU7 A;  3D9U A;  1TW6 A;  1OXN A;  4KMP A;  2VSL A;  3F7I A;  2QFA A;  4KJU A;  3UIH A;  4WVS A;  5C3K A;  4J45 A;  3UEH A;  1QBH A;  1SDZ A;  3UIG A;  5C7B A;  1XB1 A;  4LGE A;  3CLX A;  1XOX A;  3GTA A;  5C7A A;  1TFQ A;  1JD6 A;  4MTZ A;  3SIQ A;  4J44 A;  3F7G A;  3D9T A;  1Q4Q A;  1G3F A;  2POI A;  3UIK A;  3M0D D;  3F7H A;  4WVU A;  3UW5 A;  5C0L A;  3UIJ A;  2OPY A;  3UW4 A;  4A0J A;  2POP B;  4OXC A;  3CM2 A;  3UEE A;  1F3H A;  1JD4 A;  1OXQ A;  4MTI A;  1NW9 A;  2I3H A;  3UEG A;  1M4M A;  2VM5 A;  2JK7 A;  5C3H A;  3MUP A;  5C7C A;  3UEC A;  4KJV A;  3UEI A; 
#chains in the Genus database with same CATH topology
 2RAW A;  4WVT A;  5C83 A;  4KMN A;  5C0K A;  4EB9 A;  2RAX A;  4J3Y A;  3UEF A;  4HY5 A;  3T6P A;  1C9Q A;  4J47 A;  5C7D A;  5C84 A;  2QRA A;  1F9X A;  3G76 A;  1TFT A;  1SE0 A;  2I3I A;  4J46 A;  1E31 A;  3GT9 A;  4HY4 A;  3M1D A;  4LGU A;  3UII A;  3SIP E;  4A0N A;  3OZ1 A;  3HL5 A;  1XB0 A;  3EYL A;  1I3O E;  2UVL A;  4A0I A;  3M0A D;  1OY7 A;  3UED A;  1G73 C;  2OPZ A;  4EC4 A;  3CM7 A;  4HY0 A;  4J48 A;  1JD5 A;  4MU7 A;  3D9U A;  1TW6 A;  1OXN A;  4KMP A;  2VSL A;  3F7I A;  2QFA A;  4KJU A;  3UIH A;  4WVS A;  5C3K A;  4J45 A;  3UEH A;  1QBH A;  1SDZ A;  3UIG A;  5C7B A;  1XB1 A;  4LGE A;  3CLX A;  1XOX A;  3GTA A;  5C7A A;  1TFQ A;  1JD6 A;  4MTZ A;  3SIQ A;  4J44 A;  3F7G A;  3D9T A;  1Q4Q A;  1G3F A;  2POI A;  3UIK A;  3M0D D;  3F7H A;  4WVU A;  3UW5 A;  5C0L A;  3UIJ A;  2OPY A;  3UW4 A;  4A0J A;  2POP B;  4OXC A;  3CM2 A;  3UEE A;  1F3H A;  1JD4 A;  1OXQ A;  4MTI A;  1NW9 A;  2I3H A;  3UEG A;  1M4M A;  2VM5 A;  2JK7 A;  5C3H A;  3MUP A;  5C7C A;  3UEC A;  4KJV A;  3UEI A; 
#chains in the Genus database with same CATH homology
 2RAW A;  4WVT A;  5C83 A;  4KMN A;  5C0K A;  4EB9 A;  2RAX A;  4J3Y A;  3UEF A;  4HY5 A;  3T6P A;  1C9Q A;  4J47 A;  5C7D A;  5C84 A;  2QRA A;  1F9X A;  3G76 A;  1TFT A;  1SE0 A;  2I3I A;  4J46 A;  1E31 A;  3GT9 A;  4HY4 A;  3M1D A;  4LGU A;  3UII A;  3SIP E;  4A0N A;  3OZ1 A;  3HL5 A;  1XB0 A;  3EYL A;  1I3O E;  2UVL A;  4A0I A;  3M0A D;  1OY7 A;  3UED A;  1G73 C;  2OPZ A;  4EC4 A;  3CM7 A;  4HY0 A;  4J48 A;  1JD5 A;  4MU7 A;  3D9U A;  1TW6 A;  1OXN A;  4KMP A;  2VSL A;  3F7I A;  2QFA A;  4KJU A;  3UIH A;  4WVS A;  5C3K A;  4J45 A;  3UEH A;  1QBH A;  1SDZ A;  3UIG A;  5C7B A;  1XB1 A;  4LGE A;  3CLX A;  1XOX A;  3GTA A;  5C7A A;  1TFQ A;  1JD6 A;  4MTZ A;  3SIQ A;  4J44 A;  3F7G A;  3D9T A;  1Q4Q A;  1G3F A;  2POI A;  3UIK A;  3M0D D;  3F7H A;  4WVU A;  3UW5 A;  5C0L A;  3UIJ A;  2OPY A;  3UW4 A;  4A0J A;  2POP B;  4OXC A;  3CM2 A;  3UEE A;  1F3H A;  1JD4 A;  1OXQ A;  4MTI A;  1NW9 A;  2I3H A;  3UEG A;  1M4M A;  2VM5 A;  2JK7 A;  5C3H A;  3MUP A;  5C7C A;  3UEC A;  4KJV A;  3UEI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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