1H4AX

Human gammad crystallin r58h mutant structure at 1.15 a resolution
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
173
structure length
173
Chain Sequence
GKITLYEDRGFQGRHYECSSDHPNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLHRGDYADHQQWMGLSDSVRSCRLIPHSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFNEIHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVIDFS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title High-Resolution X-Ray Crystal Structures of Human GammaD Crystallin (1.25A) and the R58H Mutant (1.15A) Associated with Aculeiform Cataract
pubmed doi rcsb
molecule tags Eye lens protein
source organism Homo sapiens
molecule keywords Gamma-crystallin D
total genus 46
structure length 173
sequence length 173
ec nomenclature
pdb deposition date 2003-02-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
X PF00030 Crystall Beta/Gamma crystallin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.20.10 Mainly Beta Sandwich Gamma-B Crystallin; domain 1 Crystallins 1h4aX02
2.60.20.10 Mainly Beta Sandwich Gamma-B Crystallin; domain 1 Crystallins 1h4aX01
1A5DA 2V2UA 3ENUA 2K1XA 1A7HA 2K1WA 4NI3A 2M3TA 3SO1A 2B1OA 1ZGTA 4W9AA 1ZIEA 2JDGA 4PSRA 3SNYA 1ZWMA 2G98A 3LWKA 5HT8A 3HZBA 4W9BA 2A5MA 5HT9A 3QK3A 1E7NA 1YTQA 3ENTA 1OKIA 1NPSA 1ZIRA 2DADA 3SO0A 3CW3A 4IAUA 1HK0X 1ZIQA 3I9HA 4JGFA 1PRRA 1GAMA 1I5IA 1M8UA 2BB2A 1ELPA 2KFBA 3IAJA 1A45A 2JDFA 1PRSA 3HZ2A 4FD9A 2BV2A 1YHPA 2M3CA 4GR7A 1AMMA 1GCSA 4EL6A 1BD7A 1BLBA 2KP5A 4PSPA 4AKAA 4GCRA 3SNZA 1AG4A 1ZWOA 1HA4A 1HDFA 1H4AX 1DSLA 2NBRA 2M3UA
chains in the Genus database with same CATH superfamily
2JDGA 1ZWMA 2G98A 3LWKA 5HT8A 1NPSA 3I9HA 4JGFA 2BV2A 1YHPA 4GR7A 1BLBA 3SNZA 1AG4A 1HA4A 4GCRA 1A5DA 2K1XA 2K1WA 4NI3A 3SO1A 1GH5A 4W9BA 3QK3A 1BHUA 1OKIA 1HK0X 1GAMA 1I5IA 1A45A 2M3CA 1AMMA 4EL6A 2KP5A 1HDFA 1H4AX 1DSLA 3SNYA 2NBRA 2M3UA 3UJZA 2B1OA 4W9AA 1ZIEA 4PSRA 5HT9A 3HZBA 2A5MA 1YTQA 3ENTA 4IAUA 1M8UA 2KFBA 1ELPA 3IAJA 3HZ2A 1PRSA 1G6EA 4PSPA 1ZWOA 3ENUA 1A7HA 2M3TA 1ZGTA 1E7NA 1F53A 1WKTA 1ZIRA 2DADA 3SO0A 3CW3A 1ZIQA 1PRRA 2BB2A 4FD9A 2JDFA 1GCSA 1BD7A 1C01A 4AKAA 2V2UA
chains in the Genus database with same CATH topology
1A5DA 2V2UA 3ENUA 2K1XA 1A7HA 2K1WA 4NI3A 2M3TA 3SO1A 2B1OA 1ZGTA 4W9AA 1ZIEA 2JDGA 4PSRA 3SNYA 1ZWMA 2G98A 3LWKA 5HT8A 3HZBA 4W9BA 2A5MA 5HT9A 3QK3A 1E7NA 1YTQA 3ENTA 1OKIA 1NPSA 1ZIRA 2DADA 3SO0A 3CW3A 4IAUA 1HK0X 1ZIQA 3I9HA 4JGFA 1PRRA 1GAMA 1I5IA 1M8UA 2BB2A 1ELPA 2KFBA 3IAJA 1A45A 2JDFA 1PRSA 3HZ2A 4FD9A 2BV2A 1YHPA 2M3CA 4GR7A 1AMMA 1GCSA 4EL6A 1BD7A 1BLBA 2KP5A 4PSPA 4AKAA 4GCRA 3SNZA 1AG4A 1ZWOA 1HA4A 1HDFA 1H4AX 1DSLA 2NBRA 2M3UA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1A5D A;  2V2U A;  3ENU A;  2K1X A;  1A7H A;  2K1W A;  4NI3 A;  2M3T A;  3SO1 A;  2B1O A;  1ZGT A;  4W9A A;  1ZIE A;  2JDG A;  4PSR A;  3SNY A;  1ZWM A;  2G98 A;  3LWK A;  5HT8 A;  3HZB A;  4W9B A;  2A5M A;  5HT9 A;  3QK3 A;  1E7N A;  1YTQ A;  3ENT A;  1OKI A;  1NPS A;  1ZIR A;  2DAD A;  3SO0 A;  3CW3 A;  4IAU A;  1HK0 X;  1ZIQ A;  3I9H A;  4JGF A;  1PRR A;  1GAM A;  1I5I A;  1M8U A;  2BB2 A;  1ELP A;  2KFB A;  3IAJ A;  1A45 A;  2JDF A;  1PRS A;  3HZ2 A;  4FD9 A;  2BV2 A;  1YHP A;  2M3C A;  4GR7 A;  1AMM A;  1GCS A;  4EL6 A;  1BD7 A;  1BLB A;  2KP5 A;  4PSP A;  4AKA A;  4GCR A;  3SNZ A;  1AG4 A;  1ZWO A;  1HA4 A;  1HDF A;  1H4A X;  1DSL A;  2NBR A;  2M3U A; 
#chains in the Genus database with same CATH topology
 2JDG A;  1ZWM A;  2G98 A;  3LWK A;  5HT8 A;  1NPS A;  3I9H A;  4JGF A;  2BV2 A;  1YHP A;  4GR7 A;  1BLB A;  3SNZ A;  1AG4 A;  1HA4 A;  4GCR A;  1A5D A;  2K1X A;  2K1W A;  4NI3 A;  3SO1 A;  1GH5 A;  4W9B A;  3QK3 A;  1BHU A;  1OKI A;  1HK0 X;  1GAM A;  1I5I A;  1A45 A;  2M3C A;  1AMM A;  4EL6 A;  2KP5 A;  1HDF A;  1H4A X;  1DSL A;  3SNY A;  2NBR A;  2M3U A;  3UJZ A;  2B1O A;  4W9A A;  1ZIE A;  4PSR A;  5HT9 A;  3HZB A;  2A5M A;  1YTQ A;  3ENT A;  4IAU A;  1M8U A;  2KFB A;  1ELP A;  3IAJ A;  3HZ2 A;  1PRS A;  1G6E A;  4PSP A;  1ZWO A;  3ENU A;  1A7H A;  2M3T A;  1ZGT A;  1E7N A;  1F53 A;  1WKT A;  1ZIR A;  2DAD A;  3SO0 A;  3CW3 A;  1ZIQ A;  1PRR A;  2BB2 A;  4FD9 A;  2JDF A;  1GCS A;  1BD7 A;  1C01 A;  4AKA A;  2V2U A; 
#chains in the Genus database with same CATH homology
 1A5D A;  2V2U A;  3ENU A;  2K1X A;  1A7H A;  2K1W A;  4NI3 A;  2M3T A;  3SO1 A;  2B1O A;  1ZGT A;  4W9A A;  1ZIE A;  2JDG A;  4PSR A;  3SNY A;  1ZWM A;  2G98 A;  3LWK A;  5HT8 A;  3HZB A;  4W9B A;  2A5M A;  5HT9 A;  3QK3 A;  1E7N A;  1YTQ A;  3ENT A;  1OKI A;  1NPS A;  1ZIR A;  2DAD A;  3SO0 A;  3CW3 A;  4IAU A;  1HK0 X;  1ZIQ A;  3I9H A;  4JGF A;  1PRR A;  1GAM A;  1I5I A;  1M8U A;  2BB2 A;  1ELP A;  2KFB A;  3IAJ A;  1A45 A;  2JDF A;  1PRS A;  3HZ2 A;  4FD9 A;  2BV2 A;  1YHP A;  2M3C A;  4GR7 A;  1AMM A;  1GCS A;  4EL6 A;  1BD7 A;  1BLB A;  2KP5 A;  4PSP A;  4AKA A;  4GCR A;  3SNZ A;  1AG4 A;  1ZWO A;  1HA4 A;  1HDF A;  1H4A X;  1DSL A;  2NBR A;  2M3U A; 
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similar chains in the Genus database (?% sequence similarity)
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