1H4AX

Human gammad crystallin r58h mutant structure at 1.15 a resolution
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
173
structure length
173
Chain Sequence
GKITLYEDRGFQGRHYECSSDHPNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLHRGDYADHQQWMGLSDSVRSCRLIPHSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFNEIHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVIDFS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Eye lens protein
source organism Homo sapiens
publication title High-Resolution X-Ray Crystal Structures of Human GammaD Crystallin (1.25A) and the R58H Mutant (1.15A) Associated with Aculeiform Cataract
pubmed doi rcsb
molecule keywords Gamma-crystallin D
total genus 46
structure length 173
sequence length 173
ec nomenclature
pdb deposition date 2003-02-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
X PF00030 Crystall Beta/Gamma crystallin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.20.10 Mainly Beta Sandwich Gamma-B Crystallin; domain 1 Crystallins 1h4aX02
2.60.20.10 Mainly Beta Sandwich Gamma-B Crystallin; domain 1 Crystallins 1h4aX01
1DSLA 1ZIQA 2V2UA 3HZ2A 1M8UA 4NI3A 1E7NA 2KP5A 1YTQA 2K1XA 3ENTA 1PRRA 1OKIA 2JDFA 3SNYA 3IAJA 2NBRA 3SNZA 1ELPA 3ENUA 3SO0A 2KFBA 1A45A 5HT9A 1ZIEA 1AMMA 2K1WA 1BLBA 3HZBA 1H4AX 1A7HA 4W9BA 1GAMA 3I9HA 1BD7A 3LWKA 4PSPA 2M3TA 4AKAA 2M3UA 1YHPA 4PSRA 3QK3A 2A5MA 4EL6A 4IAUA 1AG4A 1HDFA 4FD9A 4GR7A 3SO1A 5HT8A 1HK0X 2BV2A 1I5IA 1ZWOA 4GCRA 1NPSA 3CW3A 1HA4A 1GCSA 1ZWMA 1PRSA 1ZIRA 2JDGA 4W9AA 4JGFA 1ZGTA 2B1OA 2G98A 2M3CA 2BB2A 1A5DA 2DADA
chains in the Genus database with same CATH superfamily
1DSLA 3IAJA 5HT9A 1BLBA 1GH5A 1A7HA 1WKTA 1YHPA 3QK3A 4EL6A 1AG4A 1HDFA 4FD9A 4GR7A 3SO1A 4GCRA 3CW3A 1HA4A 1GCSA 4W9AA 2G98A 2DADA 1ZIQA 1E7NA 1YTQA 3ENUA 1A45A 3HZBA 1H4AX 3I9HA 1BD7A 3LWKA 2M3UA 1C01A 1HK0X 1I5IA 1ZWMA 4JGFA 1ZGTA 2M3CA 2BB2A 3SNZA 4W9BA 2V2UA 3HZ2A 1M8UA 2KP5A 1OKIA 3SNYA 2NBRA 1ELPA 3SO0A 1AMMA 1GAMA 2M3TA 1BHUA 4PSRA 2A5MA 5HT8A 1ZWOA 1PRSA 2JDGA 1F53A 1A5DA 1G6EA 4NI3A 2K1XA 3ENTA 1PRRA 2JDFA 2KFBA 1ZIEA 2K1WA 4PSPA 4AKAA 3UJZA 2BV2A 1NPSA 1ZIRA 2B1OA 4IAUA
chains in the Genus database with same CATH topology
1DSLA 1ZIQA 2V2UA 3HZ2A 1M8UA 4NI3A 1E7NA 2KP5A 1YTQA 2K1XA 3ENTA 1PRRA 1OKIA 2JDFA 3SNYA 3IAJA 2NBRA 3SNZA 1ELPA 3ENUA 3SO0A 2KFBA 1A45A 5HT9A 1ZIEA 1AMMA 2K1WA 1BLBA 3HZBA 1H4AX 1A7HA 4W9BA 1GAMA 3I9HA 1BD7A 3LWKA 4PSPA 2M3TA 4AKAA 2M3UA 1YHPA 4PSRA 3QK3A 2A5MA 4EL6A 4IAUA 1AG4A 1HDFA 4FD9A 4GR7A 3SO1A 5HT8A 1HK0X 2BV2A 1I5IA 1ZWOA 4GCRA 1NPSA 3CW3A 1HA4A 1GCSA 1ZWMA 1PRSA 1ZIRA 2JDGA 4W9AA 4JGFA 1ZGTA 2B1OA 2G98A 2M3CA 2BB2A 1A5DA 2DADA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DSL A;  1ZIQ A;  2V2U A;  3HZ2 A;  1M8U A;  4NI3 A;  1E7N A;  2KP5 A;  1YTQ A;  2K1X A;  3ENT A;  1PRR A;  1OKI A;  2JDF A;  3SNY A;  3IAJ A;  2NBR A;  3SNZ A;  1ELP A;  3ENU A;  3SO0 A;  2KFB A;  1A45 A;  5HT9 A;  1ZIE A;  1AMM A;  2K1W A;  1BLB A;  3HZB A;  1H4A X;  1A7H A;  4W9B A;  1GAM A;  3I9H A;  1BD7 A;  3LWK A;  4PSP A;  2M3T A;  4AKA A;  2M3U A;  1YHP A;  4PSR A;  3QK3 A;  2A5M A;  4EL6 A;  4IAU A;  1AG4 A;  1HDF A;  4FD9 A;  4GR7 A;  3SO1 A;  5HT8 A;  1HK0 X;  2BV2 A;  1I5I A;  1ZWO A;  4GCR A;  1NPS A;  3CW3 A;  1HA4 A;  1GCS A;  1ZWM A;  1PRS A;  1ZIR A;  2JDG A;  4W9A A;  4JGF A;  1ZGT A;  2B1O A;  2G98 A;  2M3C A;  2BB2 A;  1A5D A;  2DAD A; 
#chains in the Genus database with same CATH topology
 1DSL A;  3IAJ A;  5HT9 A;  1BLB A;  1GH5 A;  1A7H A;  1WKT A;  1YHP A;  3QK3 A;  4EL6 A;  1AG4 A;  1HDF A;  4FD9 A;  4GR7 A;  3SO1 A;  4GCR A;  3CW3 A;  1HA4 A;  1GCS A;  4W9A A;  2G98 A;  2DAD A;  1ZIQ A;  1E7N A;  1YTQ A;  3ENU A;  1A45 A;  3HZB A;  1H4A X;  3I9H A;  1BD7 A;  3LWK A;  2M3U A;  1C01 A;  1HK0 X;  1I5I A;  1ZWM A;  4JGF A;  1ZGT A;  2M3C A;  2BB2 A;  3SNZ A;  4W9B A;  2V2U A;  3HZ2 A;  1M8U A;  2KP5 A;  1OKI A;  3SNY A;  2NBR A;  1ELP A;  3SO0 A;  1AMM A;  1GAM A;  2M3T A;  1BHU A;  4PSR A;  2A5M A;  5HT8 A;  1ZWO A;  1PRS A;  2JDG A;  1F53 A;  1A5D A;  1G6E A;  4NI3 A;  2K1X A;  3ENT A;  1PRR A;  2JDF A;  2KFB A;  1ZIE A;  2K1W A;  4PSP A;  4AKA A;  3UJZ A;  2BV2 A;  1NPS A;  1ZIR A;  2B1O A;  4IAU A; 
#chains in the Genus database with same CATH homology
 1DSL A;  1ZIQ A;  2V2U A;  3HZ2 A;  1M8U A;  4NI3 A;  1E7N A;  2KP5 A;  1YTQ A;  2K1X A;  3ENT A;  1PRR A;  1OKI A;  2JDF A;  3SNY A;  3IAJ A;  2NBR A;  3SNZ A;  1ELP A;  3ENU A;  3SO0 A;  2KFB A;  1A45 A;  5HT9 A;  1ZIE A;  1AMM A;  2K1W A;  1BLB A;  3HZB A;  1H4A X;  1A7H A;  4W9B A;  1GAM A;  3I9H A;  1BD7 A;  3LWK A;  4PSP A;  2M3T A;  4AKA A;  2M3U A;  1YHP A;  4PSR A;  3QK3 A;  2A5M A;  4EL6 A;  4IAU A;  1AG4 A;  1HDF A;  4FD9 A;  4GR7 A;  3SO1 A;  5HT8 A;  1HK0 X;  2BV2 A;  1I5I A;  1ZWO A;  4GCR A;  1NPS A;  3CW3 A;  1HA4 A;  1GCS A;  1ZWM A;  1PRS A;  1ZIR A;  2JDG A;  4W9A A;  4JGF A;  1ZGT A;  2B1O A;  2G98 A;  2M3C A;  2BB2 A;  1A5D A;  2DAD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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