1HDFA

Evolution of the eye lens beta-gamma-crystallin domain fold
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
100
structure length
100
Chain Sequence
SVCKGVSGNPAKGEVFLYKHVNFQGDSWKVTGNVYDFRSVSGLNDVVSSVKVGPNTKAFIFKDDRFNGNFIRLEESSQVTDLTTRNLNDAISSMIVATFE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of the Calcium-Loaded Spherulin 3A Dimer Sheds Light on the Evolution of the Eye Lens Betagamma-Crystallin Domain Fold
pubmed doi rcsb
molecule tags Structural protein
source organism Physarum polycephalum
molecule keywords SPHERULIN 3A
total genus 26
structure length 100
sequence length 100
chains with identical sequence B
ec nomenclature
pdb deposition date 2000-11-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF08964 Crystall_3 Beta/Gamma crystallin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.20.10 Mainly Beta Sandwich Gamma-B Crystallin; domain 1 Crystallins 1hdfA00
3SNZA 1ZWMA 1GCSA 1I5IA 1OKIA 1ZIEA 3SNYA 4NI3A 1A5DA 2A5MA 2V2UA 1HA4A 1HK0X 3HZBA 2G98A 1AG4A 1PRRA 2BV2A 1NPSA 5HT9A 2BB2A 4GCRA 1BD7A 1ELPA 2NBRA 2DADA 1HDFA 2JDFA 2KP5A 4GR7A 1M8UA 3IAJA 1GAMA 2M3UA 2K1XA 2M3CA 2M3TA 3SO0A 4AKAA 4IAUA 1YHPA 2KFBA 3ENUA 3HZ2A 3LWKA 1ZWOA 4W9BA 1AMMA 1H4AX 1ZGTA 2JDGA 1DSLA 1ZIRA 2K1WA 1BLBA 1PRSA 1A45A 1A7HA 3CW3A 3QK3A 4FD9A 2B1OA 3SO1A 4PSPA 1E7NA 5HT8A 4JGFA 4PSRA 1ZIQA 3I9HA 3ENTA 4EL6A 4W9AA 1YTQA
chains in the Genus database with same CATH superfamily
3SNZA 1GCSA 1I5IA 1OKIA 2A5MA 1HA4A 2BB2A 2NBRA 1HDFA 4GR7A 1M8UA 3IAJA 1GAMA 2M3UA 2M3CA 2M3TA 3SO0A 4IAUA 1ZWOA 1ZGTA 2JDGA 2K1WA 1A45A 1E7NA 4JGFA 4PSRA 4EL6A 1YTQA 2V2UA 1F53A 1HK0X 2BV2A 4GCRA 1ELPA 2DADA 4AKAA 1DSLA 1ZIRA 1BLBA 3CW3A 3SO1A 3I9HA 3ENTA 1ZWMA 4NI3A 1A5DA 3HZBA 1AG4A 1NPSA 5HT9A 2K1XA 2KFBA 1BHUA 3LWKA 1C01A 1AMMA 1H4AX 1G6EA 3QK3A 4FD9A 2B1OA 5HT8A 4W9AA 1ZIEA 2G98A 3SNYA 1PRRA 1BD7A 2JDFA 2KP5A 1YHPA 3ENUA 3HZ2A 1WKTA 4W9BA 1PRSA 3UJZA 1A7HA 4PSPA 1ZIQA 1GH5A
chains in the Genus database with same CATH topology
3SNZA 1ZWMA 1GCSA 1I5IA 1OKIA 1ZIEA 3SNYA 4NI3A 1A5DA 2A5MA 2V2UA 1HA4A 1HK0X 3HZBA 2G98A 1AG4A 1PRRA 2BV2A 1NPSA 5HT9A 2BB2A 4GCRA 1BD7A 1ELPA 2NBRA 2DADA 1HDFA 2JDFA 2KP5A 4GR7A 1M8UA 3IAJA 1GAMA 2M3UA 2K1XA 2M3CA 2M3TA 3SO0A 4AKAA 4IAUA 1YHPA 2KFBA 3ENUA 3HZ2A 3LWKA 1ZWOA 4W9BA 1AMMA 1H4AX 1ZGTA 2JDGA 1DSLA 1ZIRA 2K1WA 1BLBA 1PRSA 1A45A 1A7HA 3CW3A 3QK3A 4FD9A 2B1OA 3SO1A 4PSPA 1E7NA 5HT8A 4JGFA 4PSRA 1ZIQA 3I9HA 3ENTA 4EL6A 4W9AA 1YTQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3SNZ A;  1ZWM A;  1GCS A;  1I5I A;  1OKI A;  1ZIE A;  3SNY A;  4NI3 A;  1A5D A;  2A5M A;  2V2U A;  1HA4 A;  1HK0 X;  3HZB A;  2G98 A;  1AG4 A;  1PRR A;  2BV2 A;  1NPS A;  5HT9 A;  2BB2 A;  4GCR A;  1BD7 A;  1ELP A;  2NBR A;  2DAD A;  1HDF A;  2JDF A;  2KP5 A;  4GR7 A;  1M8U A;  3IAJ A;  1GAM A;  2M3U A;  2K1X A;  2M3C A;  2M3T A;  3SO0 A;  4AKA A;  4IAU A;  1YHP A;  2KFB A;  3ENU A;  3HZ2 A;  3LWK A;  1ZWO A;  4W9B A;  1AMM A;  1H4A X;  1ZGT A;  2JDG A;  1DSL A;  1ZIR A;  2K1W A;  1BLB A;  1PRS A;  1A45 A;  1A7H A;  3CW3 A;  3QK3 A;  4FD9 A;  2B1O A;  3SO1 A;  4PSP A;  1E7N A;  5HT8 A;  4JGF A;  4PSR A;  1ZIQ A;  3I9H A;  3ENT A;  4EL6 A;  4W9A A;  1YTQ A; 
#chains in the Genus database with same CATH topology
 3SNZ A;  1GCS A;  1I5I A;  1OKI A;  2A5M A;  1HA4 A;  2BB2 A;  2NBR A;  1HDF A;  4GR7 A;  1M8U A;  3IAJ A;  1GAM A;  2M3U A;  2M3C A;  2M3T A;  3SO0 A;  4IAU A;  1ZWO A;  1ZGT A;  2JDG A;  2K1W A;  1A45 A;  1E7N A;  4JGF A;  4PSR A;  4EL6 A;  1YTQ A;  2V2U A;  1F53 A;  1HK0 X;  2BV2 A;  4GCR A;  1ELP A;  2DAD A;  4AKA A;  1DSL A;  1ZIR A;  1BLB A;  3CW3 A;  3SO1 A;  3I9H A;  3ENT A;  1ZWM A;  4NI3 A;  1A5D A;  3HZB A;  1AG4 A;  1NPS A;  5HT9 A;  2K1X A;  2KFB A;  1BHU A;  3LWK A;  1C01 A;  1AMM A;  1H4A X;  1G6E A;  3QK3 A;  4FD9 A;  2B1O A;  5HT8 A;  4W9A A;  1ZIE A;  2G98 A;  3SNY A;  1PRR A;  1BD7 A;  2JDF A;  2KP5 A;  1YHP A;  3ENU A;  3HZ2 A;  1WKT A;  4W9B A;  1PRS A;  3UJZ A;  1A7H A;  4PSP A;  1ZIQ A;  1GH5 A; 
#chains in the Genus database with same CATH homology
 3SNZ A;  1ZWM A;  1GCS A;  1I5I A;  1OKI A;  1ZIE A;  3SNY A;  4NI3 A;  1A5D A;  2A5M A;  2V2U A;  1HA4 A;  1HK0 X;  3HZB A;  2G98 A;  1AG4 A;  1PRR A;  2BV2 A;  1NPS A;  5HT9 A;  2BB2 A;  4GCR A;  1BD7 A;  1ELP A;  2NBR A;  2DAD A;  1HDF A;  2JDF A;  2KP5 A;  4GR7 A;  1M8U A;  3IAJ A;  1GAM A;  2M3U A;  2K1X A;  2M3C A;  2M3T A;  3SO0 A;  4AKA A;  4IAU A;  1YHP A;  2KFB A;  3ENU A;  3HZ2 A;  3LWK A;  1ZWO A;  4W9B A;  1AMM A;  1H4A X;  1ZGT A;  2JDG A;  1DSL A;  1ZIR A;  2K1W A;  1BLB A;  1PRS A;  1A45 A;  1A7H A;  3CW3 A;  3QK3 A;  4FD9 A;  2B1O A;  3SO1 A;  4PSP A;  1E7N A;  5HT8 A;  4JGF A;  4PSR A;  1ZIQ A;  3I9H A;  3ENT A;  4EL6 A;  4W9A A;  1YTQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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