1I7OA

Crystal structure of hpce
Total Genus 126
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
126
sequence length
429
structure length
421
Chain Sequence
MKGTIFAVALNHRSQLDAWQEAFQQSPYKAPPKTAVWFIKPRNTVIGCGEPIPFPQGEKVLSGATVALIVGKTATKVREEDAAEYIAGYALANDVSLPEESFYRPAIKAKCRDGFCPIGETVALSNVDNLTIYTEINGRPADHWNTADLQRNAAQLLSALSEFATLNPGDAILLGTPQARVEIQPGDRVRVLAEGFPPLENPVVDEREVTTRKSFPTLPHPHGTLFALGLNYADHPEEPLVFLKAPNTLTGDNQTSVRPNNIEYMHYEAELVVVIGKQARNVSEADAMDYVAGYTVCNDYAIRDYLENYYRPNLRVKSRDGLTPMLSTIVPKEAIPDPHNLTLRTFVNGELRQQGTTADLIFSVPFLIAYLSEFMTLNPGDMIATGTPKGLSDVVPGDEVVVEVEGVGRLVNRIVSEETAK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title The crystal structure of HpcE, a multi-functional enzyme fold
rcsb
molecule tags Isomerase, lyase
source organism Escherichia coli
molecule keywords 4-HYDROXYPHENYLACETATE DEGRADATION BIFUNCTIONAL ISOMERASE/DE
total genus 126
structure length 421
sequence length 429
chains with identical sequence B, C, D
ec nomenclature ec 4.1.1.68: 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase.
pdb deposition date 2001-03-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01557 FAA_hydrolase Fumarylacetoacetate (FAA) hydrolase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.850.10 Alpha Beta Alpha-Beta Complex Fumarylacetoacetate hydrolase; domain 2 Fumarylacetoacetase-like, C-terminal domain 1i7oA01
3.90.850.10 Alpha Beta Alpha-Beta Complex Fumarylacetoacetate hydrolase; domain 2 Fumarylacetoacetase-like, C-terminal domain 1i7oA02
3LZKA 1GTTA 1SAWA 4PFZA 4DBFA 4MAQA 5D2IA 1QQJA 2EB5A 3S52A 3V77A 3QDFA 1NKQA 2HZYA 2WQTA 2Q19X 1NR9A 5D2FA 1QCNA 2EB4A 2Q1DX 3RR6A 5D2KA 2Q1AX 5D2JA 1SV6A 1HYOA 2Q18X 1QCOA 5D2HA 3R6OA 5D2GA 3BQBA 4QKUA 2Q1CX 1I7OA 4DBHA 1WZOA 2EB6A 2DFUA
chains in the Genus database with same CATH superfamily
3LZKA 1GTTA 1SAWA 4PFZA 4DBFA 4MAQA 5D2IA 1QQJA 2EB5A 3S52A 3V77A 3QDFA 1NKQA 2HZYA 2WQTA 2Q19X 1NR9A 5D2FA 1QCNA 2EB4A 2Q1DX 3RR6A 5D2KA 2Q1AX 5D2JA 1SV6A 1HYOA 2Q18X 1QCOA 5D2HA 3R6OA 5D2GA 3BQBA 4QKUA 2Q1CX 1I7OA 4DBHA 1WZOA 2EB6A 2DFUA
chains in the Genus database with same CATH topology
3LZKA 1GTTA 1SAWA 4PFZA 4DBFA 4MAQA 5D2IA 1QQJA 2EB5A 3S52A 3V77A 3QDFA 1NKQA 2HZYA 2WQTA 2Q19X 1NR9A 5D2FA 1QCNA 2EB4A 2Q1DX 3RR6A 5D2KA 2Q1AX 5D2JA 1SV6A 1HYOA 2Q18X 1QCOA 5D2HA 3R6OA 5D2GA 3BQBA 4QKUA 2Q1CX 1I7OA 4DBHA 1WZOA 2EB6A 2DFUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LZK A;  1GTT A;  1SAW A;  4PFZ A;  4DBF A;  4MAQ A;  5D2I A;  1QQJ A;  2EB5 A;  3S52 A;  3V77 A;  3QDF A;  1NKQ A;  2HZY A;  2WQT A;  2Q19 X;  1NR9 A;  5D2F A;  1QCN A;  2EB4 A;  2Q1D X;  3RR6 A;  5D2K A;  2Q1A X;  5D2J A;  1SV6 A;  1HYO A;  2Q18 X;  1QCO A;  5D2H A;  3R6O A;  5D2G A;  3BQB A;  4QKU A;  2Q1C X;  1I7O A;  4DBH A;  1WZO A;  2EB6 A;  2DFU A; 
#chains in the Genus database with same CATH topology
 3LZK A;  1GTT A;  1SAW A;  4PFZ A;  4DBF A;  4MAQ A;  5D2I A;  1QQJ A;  2EB5 A;  3S52 A;  3V77 A;  3QDF A;  1NKQ A;  2HZY A;  2WQT A;  2Q19 X;  1NR9 A;  5D2F A;  1QCN A;  2EB4 A;  2Q1D X;  3RR6 A;  5D2K A;  2Q1A X;  5D2J A;  1SV6 A;  1HYO A;  2Q18 X;  1QCO A;  5D2H A;  3R6O A;  5D2G A;  3BQB A;  4QKU A;  2Q1C X;  1I7O A;  4DBH A;  1WZO A;  2EB6 A;  2DFU A; 
#chains in the Genus database with same CATH homology
 3LZK A;  1GTT A;  1SAW A;  4PFZ A;  4DBF A;  4MAQ A;  5D2I A;  1QQJ A;  2EB5 A;  3S52 A;  3V77 A;  3QDF A;  1NKQ A;  2HZY A;  2WQT A;  2Q19 X;  1NR9 A;  5D2F A;  1QCN A;  2EB4 A;  2Q1D X;  3RR6 A;  5D2K A;  2Q1A X;  5D2J A;  1SV6 A;  1HYO A;  2Q18 X;  1QCO A;  5D2H A;  3R6O A;  5D2G A;  3BQB A;  4QKU A;  2Q1C X;  1I7O A;  4DBH A;  1WZO A;  2EB6 A;  2DFU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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