1I7O | Genus

Total Genus 126

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	126
sequence length	429
structure length	421
Chain Sequence	MKGTIFAVALNHRSQLDAWQEAFQQSPYKAPPKTAVWFIKPRNTVIGCGEPIPFPQGEKVLSGATVALIVGKTATKVREEDAAEYIAGYALANDVSLPEESFYRPAIKAKCRDGFCPIGETVALSNVDNLTIYTEINGRPADHWNTADLQRNAAQLLSALSEFATLNPGDAILLGTPQARVEIQPGDRVRVLAEGFPPLENPVVDEREVTTRKSFPTLPHPHGTLFALGLNYADHPEEPLVFLKAPNTLTGDNQTSVRPNNIEYMHYEAELVVVIGKQARNVSEADAMDYVAGYTVCNDYAIRDYLENYYRPNLRVKSRDGLTPMLSTIVPKEAIPDPHNLTLRTFVNGELRQQGTTADLIFSVPFLIAYLSEFMTLNPGDMIATGTPKGLSDVVPGDEVVVEVEGVGRLVNRIVSEETAK

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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reading 421 atoms

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Isomerase, lyase
source organism	Escherichia coli
publication title	The crystal structure of HpcE, a multi-functional enzyme fold rcsb
molecule keywords	4-HYDROXYPHENYLACETATE DEGRADATION BIFUNCTIONAL ISOMERASE/DE
total genus	126
structure length	421
sequence length	429
chains with identical sequence	B, C, D
ec nomenclature	ec 4.1.1.68: 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase.
pdb deposition date	2001-03-10

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01557	FAA_hydrolase	Fumarylacetoacetate (FAA) hydrolase family

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.90.850.10	Alpha Beta	Alpha-Beta Complex	Fumarylacetoacetate hydrolase; domain 2	Fumarylacetoacetase-like, C-terminal domain	1i7oA01
3.90.850.10	Alpha Beta	Alpha-Beta Complex	Fumarylacetoacetate hydrolase; domain 2	Fumarylacetoacetase-like, C-terminal domain	1i7oA02

1NKQA 3V77A 3BQBA 1SV6A 1QCNA 2Q18X 2EB6A 1HYOA 4DBFA 3R6OA 1QCOA 2Q1CX 2EB4A 1NR9A 2DFUA 2EB5A 5D2IA 5D2JA 1QQJA 4MAQA 3LZKA 3S52A 5D2FA 2Q19X 2HZYA 5D2HA 2WQTA 2Q1DX 5D2KA 3QDFA 2Q1AX 1SAWA 4QKUA 1I7OA 5D2GA 4DBHA 3RR6A 1GTTA 1WZOA 4PFZA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 1NKQ A;  3V77 A;  3BQB A;  1SV6 A;  1QCN A;  2Q18 X;  2EB6 A;  1HYO A;  4DBF A;  3R6O A;  1QCO A;  2Q1C X;  2EB4 A;  1NR9 A;  2DFU A;  2EB5 A;  5D2I A;  5D2J A;  1QQJ A;  4MAQ A;  3LZK A;  3S52 A;  5D2F A;  2Q19 X;  2HZY A;  5D2H A;  2WQT A;  2Q1D X;  5D2K A;  3QDF A;  2Q1A X;  1SAW A;  4QKU A;  1I7O A;  5D2G A;  4DBH A;  3RR6 A;  1GTT A;  1WZO A;  4PFZ A; 
#chains in the Genus database with same CATH topology
 1NKQ A;  3V77 A;  3BQB A;  1SV6 A;  1QCN A;  2Q18 X;  2EB6 A;  1HYO A;  4DBF A;  3R6O A;  1QCO A;  2Q1C X;  2EB4 A;  1NR9 A;  2DFU A;  2EB5 A;  5D2I A;  5D2J A;  1QQJ A;  4MAQ A;  3LZK A;  3S52 A;  5D2F A;  2Q19 X;  2HZY A;  5D2H A;  2WQT A;  2Q1D X;  5D2K A;  3QDF A;  2Q1A X;  1SAW A;  4QKU A;  1I7O A;  5D2G A;  4DBH A;  3RR6 A;  1GTT A;  1WZO A;  4PFZ A; 
#chains in the Genus database with same CATH homology
 1NKQ A;  3V77 A;  3BQB A;  1SV6 A;  1QCN A;  2Q18 X;  2EB6 A;  1HYO A;  4DBF A;  3R6O A;  1QCO A;  2Q1C X;  2EB4 A;  1NR9 A;  2DFU A;  2EB5 A;  5D2I A;  5D2J A;  1QQJ A;  4MAQ A;  3LZK A;  3S52 A;  5D2F A;  2Q19 X;  2HZY A;  5D2H A;  2WQT A;  2Q1D X;  5D2K A;  3QDF A;  2Q1A X;  1SAW A;  4QKU A;  1I7O A;  5D2G A;  4DBH A;  3RR6 A;  1GTT A;  1WZO A;  4PFZ A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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1I7OA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations