1IDTA

Structural studies on a prodrug-activating system-cb1954 and fmn-dependent nitroreductase
Total Genus 66
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
66
sequence length
217
structure length
217
Chain Sequence
MDIISVALKRHSTKAFDASKKLTPEQAEQIKTLLQYSPSSTNSQPWHFIVASTEEGKARVAKSAAGNYVFNERKMLDASHVVVFCAKTAMDDVWLKLVVDQEDADGRFATPEAKAANDKGRKFFADMHRKDLHDDAEWMAKQVYLNVGNFLLGVAALGLDAVPIEGFDAAILDAEFGLKEKGYTSLVVVPVGHHSVEDFNATLPKSRLPQNITLTEV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords MINOR FMN-DEPENDENT NITROREDUCTASE
total genus 66
structure length 217
sequence length 217
chains with identical sequence B
ec nomenclature ec 1.5.1.34: 6,7-dihydropteridine reductase.
pdb deposition date 2001-04-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00881 Nitroreductase Nitroreductase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.109.10 Alpha Beta 3-Layer(aba) Sandwich NADH Oxidase NADH Oxidase 1idtA00
4QLXA 3EOFA 3HZNA 4QLYA 3GFDA 1ICVA 1KQDA 3EO8A 1OOQA 2ISKA 5J6CA 3GR3A 1OO5A 4TTCA 1DS7A 3GB5A 4BN6A 1NOXA 1OONA 3GAGA 1V5ZA 3TNZA 2I7HA 1VFRA 1YWQA 4BN9A 3M5KA 3QDLA 1IDTA 4XOMA 4BN8A 2R01A 2WQFA 3BM2A 3HJ9A 1ICRA 3GE6A 1YLRA 3GBHA 3KWKA 2ISLA 4DN2A 1BKJA 2B67A 2HAYA 2BKJA 3PXVA 4TTBA 3K6HA 5HEIA 2FREA 1VKWA 4BN7A 2IFAA 3EK3A 1V5YA 4EO3A 1KQBA 3E10A 1ZCHA 4URPA 4G8SA 5KO8A 3GFAA 1ICUA 3HOIA 4XOOA 2ISJA 3G14A 1NECA 5KRDA 1OO6A 3GH8A 3BEMA 3E39A 3GE5A 4XOQA 1F5VA 3N2SA 3BM1A 3EO7A 5KO7A 4BNBA 3H4OA 3X22A 2WZVA 3KOQA 2YMVA 2WZWA 1YLUA 1YKIA 1KQCA 3OF4A 5HDJA 2H0UA 3X21A 3TO0A
chains in the Genus database with same CATH superfamily
4QLXA 3EOFA 3HZNA 4QLYA 3GFDA 1ICVA 1KQDA 3EO8A 1OOQA 2ISKA 5J6CA 3GR3A 1OO5A 4TTCA 1DS7A 3GB5A 4BN6A 1NOXA 1OONA 3GAGA 1V5ZA 3TNZA 2I7HA 1VFRA 1YWQA 4BN9A 3M5KA 3QDLA 1IDTA 4XOMA 4BN8A 2R01A 2WQFA 3BM2A 3HJ9A 1ICRA 3GE6A 1YLRA 3GBHA 3KWKA 2ISLA 1J6RA 4DN2A 1BKJA 2B67A 2HAYA 2BKJA 3PXVA 4TTBA 3K6HA 5HEIA 2FREA 1VKWA 4BN7A 2IFAA 3EK3A 1V5YA 4EO3A 1KQBA 3E10A 1ZCHA 4URPA 4G8SA 5KO8A 3GFAA 1ICUA 3HOIA 4XOOA 2ISJA 3G14A 1NECA 5KRDA 1OO6A 3GH8A 3BEMA 3E39A 3GE5A 4XOQA 1F5VA 3N2SA 3BM1A 3EO7A 5KO7A 4BNBA 3H4OA 3X22A 2WZVA 3KOQA 2YMVA 2WZWA 1YLUA 1YKIA 1KQCA 3OF4A 5HDJA 2H0UA 3X21A 3TO0A
chains in the Genus database with same CATH topology
4QLXA 3EOFA 3HZNA 4QLYA 3GFDA 1ICVA 1KQDA 3EO8A 1OOQA 2ISKA 5J6CA 3GR3A 1OO5A 4TTCA 1DS7A 3GB5A 4BN6A 1NOXA 1OONA 3GAGA 1V5ZA 3TNZA 2I7HA 1VFRA 1YWQA 4BN9A 3M5KA 3QDLA 1IDTA 4XOMA 4BN8A 2R01A 2WQFA 3BM2A 3HJ9A 1ICRA 3GE6A 1YLRA 3GBHA 3KWKA 2ISLA 1J6RA 4DN2A 1BKJA 2B67A 2HAYA 2BKJA 3PXVA 4TTBA 3K6HA 5HEIA 2FREA 1VKWA 4BN7A 2IFAA 3EK3A 1V5YA 4EO3A 1KQBA 3E10A 1ZCHA 4URPA 4G8SA 5KO8A 3GFAA 1ICUA 3HOIA 4XOOA 2ISJA 3G14A 1NECA 5KRDA 1OO6A 3GH8A 3BEMA 3E39A 3GE5A 4XOQA 1F5VA 3N2SA 3BM1A 3EO7A 5KO7A 4BNBA 3H4OA 3X22A 2WZVA 3KOQA 2YMVA 2WZWA 1YLUA 1YKIA 1KQCA 3OF4A 5HDJA 2H0UA 3X21A 3TO0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4QLX A;  3EOF A;  3HZN A;  4QLY A;  3GFD A;  1ICV A;  1KQD A;  3EO8 A;  1OOQ A;  2ISK A;  5J6C A;  3GR3 A;  1OO5 A;  4TTC A;  1DS7 A;  3GB5 A;  4BN6 A;  1NOX A;  1OON A;  3GAG A;  1V5Z A;  3TNZ A;  2I7H A;  1VFR A;  1YWQ A;  4BN9 A;  3M5K A;  3QDL A;  1IDT A;  4XOM A;  4BN8 A;  2R01 A;  2WQF A;  3BM2 A;  3HJ9 A;  1ICR A;  3GE6 A;  1YLR A;  3GBH A;  3KWK A;  2ISL A;  4DN2 A;  1BKJ A;  2B67 A;  2HAY A;  2BKJ A;  3PXV A;  4TTB A;  3K6H A;  5HEI A;  2FRE A;  1VKW A;  4BN7 A;  2IFA A;  3EK3 A;  1V5Y A;  4EO3 A;  1KQB A;  3E10 A;  1ZCH A;  4URP A;  4G8S A;  5KO8 A;  3GFA A;  1ICU A;  3HOI A;  4XOO A;  2ISJ A;  3G14 A;  1NEC A;  5KRD A;  1OO6 A;  3GH8 A;  3BEM A;  3E39 A;  3GE5 A;  4XOQ A;  1F5V A;  3N2S A;  3BM1 A;  3EO7 A;  5KO7 A;  4BNB A;  3H4O A;  3X22 A;  2WZV A;  3KOQ A;  2YMV A;  2WZW A;  1YLU A;  1YKI A;  1KQC A;  3OF4 A;  5HDJ A;  2H0U A;  3X21 A;  3TO0 A; 
#chains in the Genus database with same CATH topology
 4QLX A;  3EOF A;  3HZN A;  4QLY A;  3GFD A;  1ICV A;  1KQD A;  3EO8 A;  1OOQ A;  2ISK A;  5J6C A;  3GR3 A;  1OO5 A;  4TTC A;  1DS7 A;  3GB5 A;  4BN6 A;  1NOX A;  1OON A;  3GAG A;  1V5Z A;  3TNZ A;  2I7H A;  1VFR A;  1YWQ A;  4BN9 A;  3M5K A;  3QDL A;  1IDT A;  4XOM A;  4BN8 A;  2R01 A;  2WQF A;  3BM2 A;  3HJ9 A;  1ICR A;  3GE6 A;  1YLR A;  3GBH A;  3KWK A;  2ISL A;  1J6R A;  4DN2 A;  1BKJ A;  2B67 A;  2HAY A;  2BKJ A;  3PXV A;  4TTB A;  3K6H A;  5HEI A;  2FRE A;  1VKW A;  4BN7 A;  2IFA A;  3EK3 A;  1V5Y A;  4EO3 A;  1KQB A;  3E10 A;  1ZCH A;  4URP A;  4G8S A;  5KO8 A;  3GFA A;  1ICU A;  3HOI A;  4XOO A;  2ISJ A;  3G14 A;  1NEC A;  5KRD A;  1OO6 A;  3GH8 A;  3BEM A;  3E39 A;  3GE5 A;  4XOQ A;  1F5V A;  3N2S A;  3BM1 A;  3EO7 A;  5KO7 A;  4BNB A;  3H4O A;  3X22 A;  2WZV A;  3KOQ A;  2YMV A;  2WZW A;  1YLU A;  1YKI A;  1KQC A;  3OF4 A;  5HDJ A;  2H0U A;  3X21 A;  3TO0 A; 
#chains in the Genus database with same CATH homology
 4QLX A;  3EOF A;  3HZN A;  4QLY A;  3GFD A;  1ICV A;  1KQD A;  3EO8 A;  1OOQ A;  2ISK A;  5J6C A;  3GR3 A;  1OO5 A;  4TTC A;  1DS7 A;  3GB5 A;  4BN6 A;  1NOX A;  1OON A;  3GAG A;  1V5Z A;  3TNZ A;  2I7H A;  1VFR A;  1YWQ A;  4BN9 A;  3M5K A;  3QDL A;  1IDT A;  4XOM A;  4BN8 A;  2R01 A;  2WQF A;  3BM2 A;  3HJ9 A;  1ICR A;  3GE6 A;  1YLR A;  3GBH A;  3KWK A;  2ISL A;  1J6R A;  4DN2 A;  1BKJ A;  2B67 A;  2HAY A;  2BKJ A;  3PXV A;  4TTB A;  3K6H A;  5HEI A;  2FRE A;  1VKW A;  4BN7 A;  2IFA A;  3EK3 A;  1V5Y A;  4EO3 A;  1KQB A;  3E10 A;  1ZCH A;  4URP A;  4G8S A;  5KO8 A;  3GFA A;  1ICU A;  3HOI A;  4XOO A;  2ISJ A;  3G14 A;  1NEC A;  5KRD A;  1OO6 A;  3GH8 A;  3BEM A;  3E39 A;  3GE5 A;  4XOQ A;  1F5V A;  3N2S A;  3BM1 A;  3EO7 A;  5KO7 A;  4BNB A;  3H4O A;  3X22 A;  2WZV A;  3KOQ A;  2YMV A;  2WZW A;  1YLU A;  1YKI A;  1KQC A;  3OF4 A;  5HDJ A;  2H0U A;  3X21 A;  3TO0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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