1IDTA

Structural studies on a prodrug-activating system-cb1954 and fmn-dependent nitroreductase
Total Genus 66
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
66
sequence length
217
structure length
217
Chain Sequence
MDIISVALKRHSTKAFDASKKLTPEQAEQIKTLLQYSPSSTNSQPWHFIVASTEEGKARVAKSAAGNYVFNERKMLDASHVVVFCAKTAMDDVWLKLVVDQEDADGRFATPEAKAANDKGRKFFADMHRKDLHDDAEWMAKQVYLNVGNFLLGVAALGLDAVPIEGFDAAILDAEFGLKEKGYTSLVVVPVGHHSVEDFNATLPKSRLPQNITLTEV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords MINOR FMN-DEPENDENT NITROREDUCTASE
total genus 66
structure length 217
sequence length 217
chains with identical sequence B
ec nomenclature ec 1.5.1.34: 6,7-dihydropteridine reductase.
pdb deposition date 2001-04-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00881 Nitroreductase Nitroreductase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.109.10 Alpha Beta 3-Layer(aba) Sandwich NADH Oxidase NADH Oxidase 1idtA00
3HZNA 3E39A 3QDLA 3BM1A 3TO0A 4XOMA 1ICVA 1YWQA 2R01A 3HOIA 3E10A 1ICUA 3GAGA 3M5KA 3H4OA 3EOFA 1ICRA 2WQFA 3KOQA 3GBHA 1F5VA 3GFAA 3BM2A 4QLYA 5KRDA 4XOOA 4BN9A 1YLRA 2ISKA 2WZVA 2ISJA 1V5YA 4QLXA 5KO8A 1KQBA 4BN7A 1V5ZA 2H0UA 4URPA 3GE5A 3X22A 4XOQA 3GB5A 1OONA 2B67A 1OOQA 2IFAA 5J6CA 3BEMA 5HEIA 4TTCA 1KQCA 1DS7A 4BN8A 1VKWA 1KQDA 1ZCHA 3EK3A 3HJ9A 3PXVA 1OO5A 1NECA 1YLUA 2WZWA 2FREA 1NOXA 4BN6A 3EO8A 3N2SA 3X21A 1YKIA 2YMVA 5KO7A 3GH8A 3OF4A 3TNZA 3GFDA 3KWKA 1IDTA 1BKJA 1VFRA 2HAYA 3G14A 3EO7A 3GE6A 4TTBA 2I7HA 3GR3A 4EO3A 3K6HA 4DN2A 2ISLA 4BNBA 2BKJA 5HDJA 4G8SA 1OO6A
chains in the Genus database with same CATH superfamily
3HZNA 3E39A 3QDLA 3BM1A 3TO0A 4XOMA 1ICVA 1YWQA 2R01A 3HOIA 3E10A 1ICUA 3GAGA 3M5KA 3H4OA 3EOFA 1ICRA 2WQFA 3KOQA 3GBHA 1F5VA 3GFAA 3BM2A 4QLYA 5KRDA 4XOOA 4BN9A 1YLRA 2ISKA 2WZVA 2ISJA 1V5YA 4QLXA 5KO8A 1KQBA 4BN7A 1V5ZA 2H0UA 4URPA 3GE5A 3X22A 4XOQA 3GB5A 1OONA 2B67A 1OOQA 2IFAA 5J6CA 3BEMA 5HEIA 4TTCA 1KQCA 1DS7A 4BN8A 1VKWA 1KQDA 1ZCHA 3EK3A 3HJ9A 3PXVA 1OO5A 1NECA 1J6RA 1YLUA 2WZWA 2FREA 1NOXA 4BN6A 3EO8A 3N2SA 3X21A 1YKIA 2YMVA 5KO7A 3GH8A 3OF4A 3TNZA 3GFDA 3KWKA 1IDTA 1BKJA 1VFRA 2HAYA 3G14A 3EO7A 3GE6A 4TTBA 2I7HA 3GR3A 4EO3A 3K6HA 4DN2A 2ISLA 4BNBA 2BKJA 5HDJA 4G8SA 1OO6A
chains in the Genus database with same CATH topology
3HZNA 3E39A 3QDLA 3BM1A 3TO0A 4XOMA 1ICVA 1YWQA 2R01A 3HOIA 3E10A 1ICUA 3GAGA 3M5KA 3H4OA 3EOFA 1ICRA 2WQFA 3KOQA 3GBHA 1F5VA 3GFAA 3BM2A 4QLYA 5KRDA 4XOOA 4BN9A 1YLRA 2ISKA 2WZVA 2ISJA 1V5YA 4QLXA 5KO8A 1KQBA 4BN7A 1V5ZA 2H0UA 4URPA 3GE5A 3X22A 4XOQA 3GB5A 1OONA 2B67A 1OOQA 2IFAA 5J6CA 3BEMA 5HEIA 4TTCA 1KQCA 1DS7A 4BN8A 1VKWA 1KQDA 1ZCHA 3EK3A 3HJ9A 3PXVA 1OO5A 1NECA 1J6RA 1YLUA 2WZWA 2FREA 1NOXA 4BN6A 3EO8A 3N2SA 3X21A 1YKIA 2YMVA 5KO7A 3GH8A 3OF4A 3TNZA 3GFDA 3KWKA 1IDTA 1BKJA 1VFRA 2HAYA 3G14A 3EO7A 3GE6A 4TTBA 2I7HA 3GR3A 4EO3A 3K6HA 4DN2A 2ISLA 4BNBA 2BKJA 5HDJA 4G8SA 1OO6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HZN A;  3E39 A;  3QDL A;  3BM1 A;  3TO0 A;  4XOM A;  1ICV A;  1YWQ A;  2R01 A;  3HOI A;  3E10 A;  1ICU A;  3GAG A;  3M5K A;  3H4O A;  3EOF A;  1ICR A;  2WQF A;  3KOQ A;  3GBH A;  1F5V A;  3GFA A;  3BM2 A;  4QLY A;  5KRD A;  4XOO A;  4BN9 A;  1YLR A;  2ISK A;  2WZV A;  2ISJ A;  1V5Y A;  4QLX A;  5KO8 A;  1KQB A;  4BN7 A;  1V5Z A;  2H0U A;  4URP A;  3GE5 A;  3X22 A;  4XOQ A;  3GB5 A;  1OON A;  2B67 A;  1OOQ A;  2IFA A;  5J6C A;  3BEM A;  5HEI A;  4TTC A;  1KQC A;  1DS7 A;  4BN8 A;  1VKW A;  1KQD A;  1ZCH A;  3EK3 A;  3HJ9 A;  3PXV A;  1OO5 A;  1NEC A;  1YLU A;  2WZW A;  2FRE A;  1NOX A;  4BN6 A;  3EO8 A;  3N2S A;  3X21 A;  1YKI A;  2YMV A;  5KO7 A;  3GH8 A;  3OF4 A;  3TNZ A;  3GFD A;  3KWK A;  1IDT A;  1BKJ A;  1VFR A;  2HAY A;  3G14 A;  3EO7 A;  3GE6 A;  4TTB A;  2I7H A;  3GR3 A;  4EO3 A;  3K6H A;  4DN2 A;  2ISL A;  4BNB A;  2BKJ A;  5HDJ A;  4G8S A;  1OO6 A; 
#chains in the Genus database with same CATH topology
 3HZN A;  3E39 A;  3QDL A;  3BM1 A;  3TO0 A;  4XOM A;  1ICV A;  1YWQ A;  2R01 A;  3HOI A;  3E10 A;  1ICU A;  3GAG A;  3M5K A;  3H4O A;  3EOF A;  1ICR A;  2WQF A;  3KOQ A;  3GBH A;  1F5V A;  3GFA A;  3BM2 A;  4QLY A;  5KRD A;  4XOO A;  4BN9 A;  1YLR A;  2ISK A;  2WZV A;  2ISJ A;  1V5Y A;  4QLX A;  5KO8 A;  1KQB A;  4BN7 A;  1V5Z A;  2H0U A;  4URP A;  3GE5 A;  3X22 A;  4XOQ A;  3GB5 A;  1OON A;  2B67 A;  1OOQ A;  2IFA A;  5J6C A;  3BEM A;  5HEI A;  4TTC A;  1KQC A;  1DS7 A;  4BN8 A;  1VKW A;  1KQD A;  1ZCH A;  3EK3 A;  3HJ9 A;  3PXV A;  1OO5 A;  1NEC A;  1J6R A;  1YLU A;  2WZW A;  2FRE A;  1NOX A;  4BN6 A;  3EO8 A;  3N2S A;  3X21 A;  1YKI A;  2YMV A;  5KO7 A;  3GH8 A;  3OF4 A;  3TNZ A;  3GFD A;  3KWK A;  1IDT A;  1BKJ A;  1VFR A;  2HAY A;  3G14 A;  3EO7 A;  3GE6 A;  4TTB A;  2I7H A;  3GR3 A;  4EO3 A;  3K6H A;  4DN2 A;  2ISL A;  4BNB A;  2BKJ A;  5HDJ A;  4G8S A;  1OO6 A; 
#chains in the Genus database with same CATH homology
 3HZN A;  3E39 A;  3QDL A;  3BM1 A;  3TO0 A;  4XOM A;  1ICV A;  1YWQ A;  2R01 A;  3HOI A;  3E10 A;  1ICU A;  3GAG A;  3M5K A;  3H4O A;  3EOF A;  1ICR A;  2WQF A;  3KOQ A;  3GBH A;  1F5V A;  3GFA A;  3BM2 A;  4QLY A;  5KRD A;  4XOO A;  4BN9 A;  1YLR A;  2ISK A;  2WZV A;  2ISJ A;  1V5Y A;  4QLX A;  5KO8 A;  1KQB A;  4BN7 A;  1V5Z A;  2H0U A;  4URP A;  3GE5 A;  3X22 A;  4XOQ A;  3GB5 A;  1OON A;  2B67 A;  1OOQ A;  2IFA A;  5J6C A;  3BEM A;  5HEI A;  4TTC A;  1KQC A;  1DS7 A;  4BN8 A;  1VKW A;  1KQD A;  1ZCH A;  3EK3 A;  3HJ9 A;  3PXV A;  1OO5 A;  1NEC A;  1J6R A;  1YLU A;  2WZW A;  2FRE A;  1NOX A;  4BN6 A;  3EO8 A;  3N2S A;  3X21 A;  1YKI A;  2YMV A;  5KO7 A;  3GH8 A;  3OF4 A;  3TNZ A;  3GFD A;  3KWK A;  1IDT A;  1BKJ A;  1VFR A;  2HAY A;  3G14 A;  3EO7 A;  3GE6 A;  4TTB A;  2I7H A;  3GR3 A;  4EO3 A;  3K6H A;  4DN2 A;  2ISL A;  4BNB A;  2BKJ A;  5HDJ A;  4G8S A;  1OO6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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