1OO5A

Studies on the nitroreductase prodrug-activating system. crystal structures of the enzyme active form and complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs
Total Genus 66
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
66
sequence length
217
structure length
217
Chain Sequence
MDIISVALKRHSTKAFDASKKLTPEQAEQIKTLLQYSPSSTNSQPWHFIVASTEEGKARVAKSAAGNYVFNERKMLDASHVVVFCAKTAMDDVWLKLVVDQEDADGRFATPEAKAANDKGRKFFADMHRKDLHDDAEWMAKQVYLNVGNFLLGVAALGLDAVPIEGFDAAILDAEFGLKEKGYTSLVVVPVGHHSVEDFNATLPKSRLPQNITLTEV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords Oxygen-insensitive NAD(P)H nitroreductase
total genus 66
structure length 217
sequence length 217
chains with identical sequence B
ec nomenclature ec 1.5.1.34: 6,7-dihydropteridine reductase.
pdb deposition date 2003-03-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00881 Nitroreductase Nitroreductase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.109.10 Alpha Beta 3-Layer(aba) Sandwich NADH Oxidase NADH Oxidase 1oo5A00
2FREA 2WZWA 3KOQA 5HDJA 3GH8A 3K6HA 1YKIA 2B67A 3EOFA 3TO0A 3KWKA 2ISKA 3BM1A 1ZCHA 1YWQA 1V5YA 1F5VA 1KQDA 1ICUA 2HAYA 3X22A 5KO8A 3M5KA 4BN6A 4BN9A 3QDLA 3TNZA 3OF4A 3GFAA 1BKJA 3BEMA 1V5ZA 4BN8A 1YLRA 4URPA 2WZVA 2YMVA 3G14A 3GR3A 4QLYA 4TTCA 5J6CA 3BM2A 2IFAA 1OOQA 3E39A 1KQBA 1VFRA 3GBHA 3GB5A 1OO6A 1DS7A 2I7HA 3HOIA 3EO7A 3EK3A 3PXVA 4DN2A 1NECA 1KQCA 3GFDA 4EO3A 4TTBA 5HEIA 4XOQA 1IDTA 4BN7A 3GAGA 3H4OA 1ICVA 3EO8A 2WQFA 2BKJA 4XOOA 5KRDA 1OO5A 2ISLA 1ICRA 4QLXA 5KO7A 3GE6A 3HJ9A 1YLUA 3N2SA 4G8SA 2ISJA 3X21A 2R01A 3HZNA 3GE5A 2H0UA 1NOXA 1VKWA 1OONA 4BNBA 3E10A 4XOMA
chains in the Genus database with same CATH superfamily
2FREA 2WZWA 3KOQA 5HDJA 3GH8A 3K6HA 1YKIA 2B67A 3EOFA 3TO0A 3KWKA 2ISKA 3BM1A 1ZCHA 1YWQA 1V5YA 1F5VA 1KQDA 1ICUA 2HAYA 3X22A 5KO8A 3M5KA 4BN6A 4BN9A 3QDLA 3TNZA 3OF4A 3GFAA 1BKJA 3BEMA 1V5ZA 4BN8A 1YLRA 4URPA 2WZVA 2YMVA 1J6RA 3G14A 3GR3A 4QLYA 4TTCA 5J6CA 3BM2A 2IFAA 1OOQA 3E39A 1KQBA 1VFRA 3GBHA 3GB5A 1OO6A 1DS7A 2I7HA 3HOIA 3EO7A 3EK3A 3PXVA 4DN2A 1NECA 1KQCA 3GFDA 4EO3A 4TTBA 5HEIA 4XOQA 1IDTA 4BN7A 3GAGA 3H4OA 1ICVA 3EO8A 2WQFA 2BKJA 4XOOA 5KRDA 1OO5A 2ISLA 1ICRA 4QLXA 5KO7A 3GE6A 3HJ9A 1YLUA 3N2SA 4G8SA 2ISJA 3X21A 2R01A 3HZNA 3GE5A 2H0UA 1NOXA 1VKWA 1OONA 4BNBA 3E10A 4XOMA
chains in the Genus database with same CATH topology
2FREA 2WZWA 3KOQA 5HDJA 3GH8A 3K6HA 1YKIA 2B67A 3EOFA 3TO0A 3KWKA 2ISKA 3BM1A 1ZCHA 1YWQA 1V5YA 1F5VA 1KQDA 1ICUA 2HAYA 3X22A 5KO8A 3M5KA 4BN6A 4BN9A 3QDLA 3TNZA 3OF4A 3GFAA 1BKJA 3BEMA 1V5ZA 4BN8A 1YLRA 4URPA 2WZVA 2YMVA 1J6RA 3G14A 3GR3A 4QLYA 4TTCA 5J6CA 3BM2A 2IFAA 1OOQA 3E39A 1KQBA 1VFRA 3GBHA 3GB5A 1OO6A 1DS7A 2I7HA 3HOIA 3EO7A 3EK3A 3PXVA 4DN2A 1NECA 1KQCA 3GFDA 4EO3A 4TTBA 5HEIA 4XOQA 1IDTA 4BN7A 3GAGA 3H4OA 1ICVA 3EO8A 2WQFA 2BKJA 4XOOA 5KRDA 1OO5A 2ISLA 1ICRA 4QLXA 5KO7A 3GE6A 3HJ9A 1YLUA 3N2SA 4G8SA 2ISJA 3X21A 2R01A 3HZNA 3GE5A 2H0UA 1NOXA 1VKWA 1OONA 4BNBA 3E10A 4XOMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FRE A;  2WZW A;  3KOQ A;  5HDJ A;  3GH8 A;  3K6H A;  1YKI A;  2B67 A;  3EOF A;  3TO0 A;  3KWK A;  2ISK A;  3BM1 A;  1ZCH A;  1YWQ A;  1V5Y A;  1F5V A;  1KQD A;  1ICU A;  2HAY A;  3X22 A;  5KO8 A;  3M5K A;  4BN6 A;  4BN9 A;  3QDL A;  3TNZ A;  3OF4 A;  3GFA A;  1BKJ A;  3BEM A;  1V5Z A;  4BN8 A;  1YLR A;  4URP A;  2WZV A;  2YMV A;  3G14 A;  3GR3 A;  4QLY A;  4TTC A;  5J6C A;  3BM2 A;  2IFA A;  1OOQ A;  3E39 A;  1KQB A;  1VFR A;  3GBH A;  3GB5 A;  1OO6 A;  1DS7 A;  2I7H A;  3HOI A;  3EO7 A;  3EK3 A;  3PXV A;  4DN2 A;  1NEC A;  1KQC A;  3GFD A;  4EO3 A;  4TTB A;  5HEI A;  4XOQ A;  1IDT A;  4BN7 A;  3GAG A;  3H4O A;  1ICV A;  3EO8 A;  2WQF A;  2BKJ A;  4XOO A;  5KRD A;  1OO5 A;  2ISL A;  1ICR A;  4QLX A;  5KO7 A;  3GE6 A;  3HJ9 A;  1YLU A;  3N2S A;  4G8S A;  2ISJ A;  3X21 A;  2R01 A;  3HZN A;  3GE5 A;  2H0U A;  1NOX A;  1VKW A;  1OON A;  4BNB A;  3E10 A;  4XOM A; 
#chains in the Genus database with same CATH topology
 2FRE A;  2WZW A;  3KOQ A;  5HDJ A;  3GH8 A;  3K6H A;  1YKI A;  2B67 A;  3EOF A;  3TO0 A;  3KWK A;  2ISK A;  3BM1 A;  1ZCH A;  1YWQ A;  1V5Y A;  1F5V A;  1KQD A;  1ICU A;  2HAY A;  3X22 A;  5KO8 A;  3M5K A;  4BN6 A;  4BN9 A;  3QDL A;  3TNZ A;  3OF4 A;  3GFA A;  1BKJ A;  3BEM A;  1V5Z A;  4BN8 A;  1YLR A;  4URP A;  2WZV A;  2YMV A;  1J6R A;  3G14 A;  3GR3 A;  4QLY A;  4TTC A;  5J6C A;  3BM2 A;  2IFA A;  1OOQ A;  3E39 A;  1KQB A;  1VFR A;  3GBH A;  3GB5 A;  1OO6 A;  1DS7 A;  2I7H A;  3HOI A;  3EO7 A;  3EK3 A;  3PXV A;  4DN2 A;  1NEC A;  1KQC A;  3GFD A;  4EO3 A;  4TTB A;  5HEI A;  4XOQ A;  1IDT A;  4BN7 A;  3GAG A;  3H4O A;  1ICV A;  3EO8 A;  2WQF A;  2BKJ A;  4XOO A;  5KRD A;  1OO5 A;  2ISL A;  1ICR A;  4QLX A;  5KO7 A;  3GE6 A;  3HJ9 A;  1YLU A;  3N2S A;  4G8S A;  2ISJ A;  3X21 A;  2R01 A;  3HZN A;  3GE5 A;  2H0U A;  1NOX A;  1VKW A;  1OON A;  4BNB A;  3E10 A;  4XOM A; 
#chains in the Genus database with same CATH homology
 2FRE A;  2WZW A;  3KOQ A;  5HDJ A;  3GH8 A;  3K6H A;  1YKI A;  2B67 A;  3EOF A;  3TO0 A;  3KWK A;  2ISK A;  3BM1 A;  1ZCH A;  1YWQ A;  1V5Y A;  1F5V A;  1KQD A;  1ICU A;  2HAY A;  3X22 A;  5KO8 A;  3M5K A;  4BN6 A;  4BN9 A;  3QDL A;  3TNZ A;  3OF4 A;  3GFA A;  1BKJ A;  3BEM A;  1V5Z A;  4BN8 A;  1YLR A;  4URP A;  2WZV A;  2YMV A;  1J6R A;  3G14 A;  3GR3 A;  4QLY A;  4TTC A;  5J6C A;  3BM2 A;  2IFA A;  1OOQ A;  3E39 A;  1KQB A;  1VFR A;  3GBH A;  3GB5 A;  1OO6 A;  1DS7 A;  2I7H A;  3HOI A;  3EO7 A;  3EK3 A;  3PXV A;  4DN2 A;  1NEC A;  1KQC A;  3GFD A;  4EO3 A;  4TTB A;  5HEI A;  4XOQ A;  1IDT A;  4BN7 A;  3GAG A;  3H4O A;  1ICV A;  3EO8 A;  2WQF A;  2BKJ A;  4XOO A;  5KRD A;  1OO5 A;  2ISL A;  1ICR A;  4QLX A;  5KO7 A;  3GE6 A;  3HJ9 A;  1YLU A;  3N2S A;  4G8S A;  2ISJ A;  3X21 A;  2R01 A;  3HZN A;  3GE5 A;  2H0U A;  1NOX A;  1VKW A;  1OON A;  4BNB A;  3E10 A;  4XOM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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