1OOQA

Nitroreductase from e-coli in complex with the inhibitor dicoumarol
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
217
structure length
217
Chain Sequence
MDIISVALKRHSTKAFDASKKLTPEQAEQIKTLLQYSPSSTNSQPWHFIVASTEEGKARVAKSAAGNYVFNERKMLDASHVVVFCAKTAMDDVWLKLVVDQEDADGRFATPEAKAANDKGRKFFADMHRKDLHDDAEWMAKQVYLNVGNFLLGVAALGLDAVPIEGFDAAILDAEFGLKEKGYTSLVVVPVGHHSVEDFNATLPKSRLPQNITLTEV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords Oxygen-insensitive NAD(P)H nitroreductase
total genus 59
structure length 217
sequence length 217
chains with identical sequence B
ec nomenclature ec 1.5.1.34: 6,7-dihydropteridine reductase.
pdb deposition date 2003-03-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00881 Nitroreductase Nitroreductase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.109.10 Alpha Beta 3-Layer(aba) Sandwich NADH Oxidase NADH Oxidase 1ooqA00
4TTCA 4BNBA 2HAYA 1OOQA 2I7HA 2WZWA 5KRDA 3GE5A 3X22A 2WZVA 4URPA 1OO6A 4G8SA 3HZNA 3K6HA 1VKWA 4XOQA 1VFRA 2B67A 3M5KA 3N2SA 4DN2A 2FREA 3TO0A 3EK3A 2YMVA 2ISJA 3GBHA 1YLUA 3PXVA 1ZCHA 3BM1A 4QLYA 4XOOA 3GR3A 4QLXA 3GE6A 3EO7A 5KO8A 3E10A 2R01A 1NECA 4BN6A 3GFAA 5HDJA 1YWQA 1YKIA 3GFDA 3G14A 1F5VA 2WQFA 1KQCA 4TTBA 1IDTA 3X21A 1BKJA 1YLRA 3OF4A 4BN7A 1OONA 2H0UA 1NOXA 1DS7A 3GB5A 1V5YA 3GAGA 3BM2A 3GH8A 1ICVA 3H4OA 5J6CA 4XOMA 3KWKA 3E39A 1KQDA 5KO7A 2ISLA 3EOFA 3QDLA 1OO5A 3EO8A 4EO3A 4BN9A 1ICRA 1V5ZA 3HJ9A 2BKJA 1ICUA 2ISKA 3KOQA 1KQBA 2IFAA 5HEIA 3HOIA 4BN8A 3TNZA 3BEMA
chains in the Genus database with same CATH superfamily
4TTCA 4BNBA 2HAYA 1OOQA 2I7HA 2WZWA 5KRDA 3GE5A 3X22A 2WZVA 4URPA 1OO6A 4G8SA 3HZNA 3K6HA 1VKWA 4XOQA 1VFRA 2B67A 3M5KA 3N2SA 4DN2A 2FREA 3TO0A 3EK3A 2YMVA 2ISJA 3GBHA 1YLUA 3PXVA 1ZCHA 3BM1A 4QLYA 4XOOA 3GR3A 4QLXA 3GE6A 3EO7A 5KO8A 3E10A 2R01A 1NECA 4BN6A 3GFAA 5HDJA 1YWQA 1YKIA 3GFDA 3G14A 1F5VA 2WQFA 1KQCA 4TTBA 1IDTA 3X21A 1BKJA 1YLRA 3OF4A 4BN7A 1OONA 2H0UA 1NOXA 1DS7A 3GB5A 1V5YA 3GAGA 3BM2A 3GH8A 1ICVA 3H4OA 5J6CA 4XOMA 3KWKA 3E39A 1KQDA 5KO7A 2ISLA 3EOFA 3QDLA 1OO5A 3EO8A 4EO3A 4BN9A 1ICRA 1J6RA 1V5ZA 3HJ9A 2BKJA 1ICUA 2ISKA 3KOQA 1KQBA 2IFAA 5HEIA 3HOIA 4BN8A 3TNZA 3BEMA
chains in the Genus database with same CATH topology
4TTCA 4BNBA 2HAYA 1OOQA 2I7HA 2WZWA 5KRDA 3GE5A 3X22A 2WZVA 4URPA 1OO6A 4G8SA 3HZNA 3K6HA 1VKWA 4XOQA 1VFRA 2B67A 3M5KA 3N2SA 4DN2A 2FREA 3TO0A 3EK3A 2YMVA 2ISJA 3GBHA 1YLUA 3PXVA 1ZCHA 3BM1A 4QLYA 4XOOA 3GR3A 4QLXA 3GE6A 3EO7A 5KO8A 3E10A 2R01A 1NECA 4BN6A 3GFAA 5HDJA 1YWQA 1YKIA 3GFDA 3G14A 1F5VA 2WQFA 1KQCA 4TTBA 1IDTA 3X21A 1BKJA 1YLRA 3OF4A 4BN7A 1OONA 2H0UA 1NOXA 1DS7A 3GB5A 1V5YA 3GAGA 3BM2A 3GH8A 1ICVA 3H4OA 5J6CA 4XOMA 3KWKA 3E39A 1KQDA 5KO7A 2ISLA 3EOFA 3QDLA 1OO5A 3EO8A 4EO3A 4BN9A 1ICRA 1J6RA 1V5ZA 3HJ9A 2BKJA 1ICUA 2ISKA 3KOQA 1KQBA 2IFAA 5HEIA 3HOIA 4BN8A 3TNZA 3BEMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4TTC A;  4BNB A;  2HAY A;  1OOQ A;  2I7H A;  2WZW A;  5KRD A;  3GE5 A;  3X22 A;  2WZV A;  4URP A;  1OO6 A;  4G8S A;  3HZN A;  3K6H A;  1VKW A;  4XOQ A;  1VFR A;  2B67 A;  3M5K A;  3N2S A;  4DN2 A;  2FRE A;  3TO0 A;  3EK3 A;  2YMV A;  2ISJ A;  3GBH A;  1YLU A;  3PXV A;  1ZCH A;  3BM1 A;  4QLY A;  4XOO A;  3GR3 A;  4QLX A;  3GE6 A;  3EO7 A;  5KO8 A;  3E10 A;  2R01 A;  1NEC A;  4BN6 A;  3GFA A;  5HDJ A;  1YWQ A;  1YKI A;  3GFD A;  3G14 A;  1F5V A;  2WQF A;  1KQC A;  4TTB A;  1IDT A;  3X21 A;  1BKJ A;  1YLR A;  3OF4 A;  4BN7 A;  1OON A;  2H0U A;  1NOX A;  1DS7 A;  3GB5 A;  1V5Y A;  3GAG A;  3BM2 A;  3GH8 A;  1ICV A;  3H4O A;  5J6C A;  4XOM A;  3KWK A;  3E39 A;  1KQD A;  5KO7 A;  2ISL A;  3EOF A;  3QDL A;  1OO5 A;  3EO8 A;  4EO3 A;  4BN9 A;  1ICR A;  1V5Z A;  3HJ9 A;  2BKJ A;  1ICU A;  2ISK A;  3KOQ A;  1KQB A;  2IFA A;  5HEI A;  3HOI A;  4BN8 A;  3TNZ A;  3BEM A; 
#chains in the Genus database with same CATH topology
 4TTC A;  4BNB A;  2HAY A;  1OOQ A;  2I7H A;  2WZW A;  5KRD A;  3GE5 A;  3X22 A;  2WZV A;  4URP A;  1OO6 A;  4G8S A;  3HZN A;  3K6H A;  1VKW A;  4XOQ A;  1VFR A;  2B67 A;  3M5K A;  3N2S A;  4DN2 A;  2FRE A;  3TO0 A;  3EK3 A;  2YMV A;  2ISJ A;  3GBH A;  1YLU A;  3PXV A;  1ZCH A;  3BM1 A;  4QLY A;  4XOO A;  3GR3 A;  4QLX A;  3GE6 A;  3EO7 A;  5KO8 A;  3E10 A;  2R01 A;  1NEC A;  4BN6 A;  3GFA A;  5HDJ A;  1YWQ A;  1YKI A;  3GFD A;  3G14 A;  1F5V A;  2WQF A;  1KQC A;  4TTB A;  1IDT A;  3X21 A;  1BKJ A;  1YLR A;  3OF4 A;  4BN7 A;  1OON A;  2H0U A;  1NOX A;  1DS7 A;  3GB5 A;  1V5Y A;  3GAG A;  3BM2 A;  3GH8 A;  1ICV A;  3H4O A;  5J6C A;  4XOM A;  3KWK A;  3E39 A;  1KQD A;  5KO7 A;  2ISL A;  3EOF A;  3QDL A;  1OO5 A;  3EO8 A;  4EO3 A;  4BN9 A;  1ICR A;  1J6R A;  1V5Z A;  3HJ9 A;  2BKJ A;  1ICU A;  2ISK A;  3KOQ A;  1KQB A;  2IFA A;  5HEI A;  3HOI A;  4BN8 A;  3TNZ A;  3BEM A; 
#chains in the Genus database with same CATH homology
 4TTC A;  4BNB A;  2HAY A;  1OOQ A;  2I7H A;  2WZW A;  5KRD A;  3GE5 A;  3X22 A;  2WZV A;  4URP A;  1OO6 A;  4G8S A;  3HZN A;  3K6H A;  1VKW A;  4XOQ A;  1VFR A;  2B67 A;  3M5K A;  3N2S A;  4DN2 A;  2FRE A;  3TO0 A;  3EK3 A;  2YMV A;  2ISJ A;  3GBH A;  1YLU A;  3PXV A;  1ZCH A;  3BM1 A;  4QLY A;  4XOO A;  3GR3 A;  4QLX A;  3GE6 A;  3EO7 A;  5KO8 A;  3E10 A;  2R01 A;  1NEC A;  4BN6 A;  3GFA A;  5HDJ A;  1YWQ A;  1YKI A;  3GFD A;  3G14 A;  1F5V A;  2WQF A;  1KQC A;  4TTB A;  1IDT A;  3X21 A;  1BKJ A;  1YLR A;  3OF4 A;  4BN7 A;  1OON A;  2H0U A;  1NOX A;  1DS7 A;  3GB5 A;  1V5Y A;  3GAG A;  3BM2 A;  3GH8 A;  1ICV A;  3H4O A;  5J6C A;  4XOM A;  3KWK A;  3E39 A;  1KQD A;  5KO7 A;  2ISL A;  3EOF A;  3QDL A;  1OO5 A;  3EO8 A;  4EO3 A;  4BN9 A;  1ICR A;  1J6R A;  1V5Z A;  3HJ9 A;  2BKJ A;  1ICU A;  2ISK A;  3KOQ A;  1KQB A;  2IFA A;  5HEI A;  3HOI A;  4BN8 A;  3TNZ A;  3BEM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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