2KFBA

The structure of the cataract causing p23t mutant of human gamma-d crystallin
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
174
structure length
174
Chain Sequence
QGKITLYEDRGFQGRHYECSSDHTNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLRRGDYADHQQWMGLSDSVRSCRLIPHSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFNEIHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVIDFS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Structural protein
source organism Homo sapiens
publication title The structure of the cataract-causing P23T mutant of human gammaD-crystallin exhibits distinctive local conformational and dynamic changes.
pubmed doi rcsb
molecule keywords Gamma-crystallin D
total genus 24
structure length 174
sequence length 174
ec nomenclature
pdb deposition date 2009-02-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00030 Crystall Beta/Gamma crystallin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.20.10 Mainly Beta Sandwich Gamma-B Crystallin; domain 1 Crystallins 2kfbA02
2.60.20.10 Mainly Beta Sandwich Gamma-B Crystallin; domain 1 Crystallins 2kfbA01
3LWKA 4PSRA 1A7HA 2M3CA 3HZ2A 4W9BA 1DSLA 1GAMA 1ZIRA 2A5MA 2BB2A 1PRSA 4NI3A 4EL6A 5HT8A 1ZGTA 1ZIQA 2JDFA 3SNYA 4AKAA 1ZWOA 3QK3A 1AG4A 2JDGA 3IAJA 1HK0X 1HA4A 1H4AX 4GR7A 2BV2A 1OKIA 2DADA 1HDFA 3SO0A 3SNZA 2M3UA 3HZBA 1BLBA 1AMMA 4FD9A 1NPSA 2G98A 2M3TA 1YHPA 2V2UA 3I9HA 1A5DA 2K1XA 1I5IA 2K1WA 4GCRA 4IAUA 4W9AA 3SO1A 3CW3A 1GCSA 2NBRA 3ENTA 1ZIEA 2KP5A 1M8UA 1ZWMA 1BD7A 2B1OA 1PRRA 3ENUA 5HT9A 4PSPA 1A45A 2KFBA 1ELPA 4JGFA 1E7NA 1YTQA
chains in the Genus database with same CATH superfamily
1A7HA 2BB2A 4EL6A 4AKAA 3QK3A 1WKTA 1OKIA 4FD9A 1NPSA 2M3TA 3I9HA 2K1WA 4W9AA 3ENTA 3UJZA 1A45A 2KFBA 2JDGA 4PSRA 1GAMA 1ZIRA 2A5MA 4NI3A 1PRSA 5HT8A 1ZIQA 3SNYA 3IAJA 1HK0X 4GR7A 2BV2A 2DADA 1HDFA 3SNZA 2M3UA 1BLBA 1AMMA 1A5DA 2K1XA 1I5IA 3SO1A 3CW3A 1GCSA 2KP5A 1ZWMA 1BD7A 5HT9A 1PRRA 3ENUA 1DSLA 1ZGTA 1ZWOA 1AG4A 1HA4A 2G98A 2V2UA 4GCRA 4IAUA 1BHUA 2NBRA 1M8UA 1GH5A 1ELPA 1G6EA 4JGFA 1E7NA 3LWKA 2M3CA 3HZ2A 4W9BA 2JDFA 1H4AX 3SO0A 3HZBA 1C01A 1ZIEA 2B1OA 4PSPA 1F53A 1YHPA 1YTQA
chains in the Genus database with same CATH topology
3LWKA 4PSRA 1A7HA 2M3CA 3HZ2A 4W9BA 1DSLA 1GAMA 1ZIRA 2A5MA 2BB2A 1PRSA 4NI3A 4EL6A 5HT8A 1ZGTA 1ZIQA 2JDFA 3SNYA 4AKAA 1ZWOA 3QK3A 1AG4A 2JDGA 3IAJA 1HK0X 1HA4A 1H4AX 4GR7A 2BV2A 1OKIA 2DADA 1HDFA 3SO0A 3SNZA 2M3UA 3HZBA 1BLBA 1AMMA 4FD9A 1NPSA 2G98A 2M3TA 1YHPA 2V2UA 3I9HA 1A5DA 2K1XA 1I5IA 2K1WA 4GCRA 4IAUA 4W9AA 3SO1A 3CW3A 1GCSA 2NBRA 3ENTA 1ZIEA 2KP5A 1M8UA 1ZWMA 1BD7A 2B1OA 1PRRA 3ENUA 5HT9A 4PSPA 1A45A 2KFBA 1ELPA 4JGFA 1E7NA 1YTQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LWK A;  4PSR A;  1A7H A;  2M3C A;  3HZ2 A;  4W9B A;  1DSL A;  1GAM A;  1ZIR A;  2A5M A;  2BB2 A;  1PRS A;  4NI3 A;  4EL6 A;  5HT8 A;  1ZGT A;  1ZIQ A;  2JDF A;  3SNY A;  4AKA A;  1ZWO A;  3QK3 A;  1AG4 A;  2JDG A;  3IAJ A;  1HK0 X;  1HA4 A;  1H4A X;  4GR7 A;  2BV2 A;  1OKI A;  2DAD A;  1HDF A;  3SO0 A;  3SNZ A;  2M3U A;  3HZB A;  1BLB A;  1AMM A;  4FD9 A;  1NPS A;  2G98 A;  2M3T A;  1YHP A;  2V2U A;  3I9H A;  1A5D A;  2K1X A;  1I5I A;  2K1W A;  4GCR A;  4IAU A;  4W9A A;  3SO1 A;  3CW3 A;  1GCS A;  2NBR A;  3ENT A;  1ZIE A;  2KP5 A;  1M8U A;  1ZWM A;  1BD7 A;  2B1O A;  1PRR A;  3ENU A;  5HT9 A;  4PSP A;  1A45 A;  2KFB A;  1ELP A;  4JGF A;  1E7N A;  1YTQ A; 
#chains in the Genus database with same CATH topology
 1A7H A;  2BB2 A;  4EL6 A;  4AKA A;  3QK3 A;  1WKT A;  1OKI A;  4FD9 A;  1NPS A;  2M3T A;  3I9H A;  2K1W A;  4W9A A;  3ENT A;  3UJZ A;  1A45 A;  2KFB A;  2JDG A;  4PSR A;  1GAM A;  1ZIR A;  2A5M A;  4NI3 A;  1PRS A;  5HT8 A;  1ZIQ A;  3SNY A;  3IAJ A;  1HK0 X;  4GR7 A;  2BV2 A;  2DAD A;  1HDF A;  3SNZ A;  2M3U A;  1BLB A;  1AMM A;  1A5D A;  2K1X A;  1I5I A;  3SO1 A;  3CW3 A;  1GCS A;  2KP5 A;  1ZWM A;  1BD7 A;  5HT9 A;  1PRR A;  3ENU A;  1DSL A;  1ZGT A;  1ZWO A;  1AG4 A;  1HA4 A;  2G98 A;  2V2U A;  4GCR A;  4IAU A;  1BHU A;  2NBR A;  1M8U A;  1GH5 A;  1ELP A;  1G6E A;  4JGF A;  1E7N A;  3LWK A;  2M3C A;  3HZ2 A;  4W9B A;  2JDF A;  1H4A X;  3SO0 A;  3HZB A;  1C01 A;  1ZIE A;  2B1O A;  4PSP A;  1F53 A;  1YHP A;  1YTQ A; 
#chains in the Genus database with same CATH homology
 3LWK A;  4PSR A;  1A7H A;  2M3C A;  3HZ2 A;  4W9B A;  1DSL A;  1GAM A;  1ZIR A;  2A5M A;  2BB2 A;  1PRS A;  4NI3 A;  4EL6 A;  5HT8 A;  1ZGT A;  1ZIQ A;  2JDF A;  3SNY A;  4AKA A;  1ZWO A;  3QK3 A;  1AG4 A;  2JDG A;  3IAJ A;  1HK0 X;  1HA4 A;  1H4A X;  4GR7 A;  2BV2 A;  1OKI A;  2DAD A;  1HDF A;  3SO0 A;  3SNZ A;  2M3U A;  3HZB A;  1BLB A;  1AMM A;  4FD9 A;  1NPS A;  2G98 A;  2M3T A;  1YHP A;  2V2U A;  3I9H A;  1A5D A;  2K1X A;  1I5I A;  2K1W A;  4GCR A;  4IAU A;  4W9A A;  3SO1 A;  3CW3 A;  1GCS A;  2NBR A;  3ENT A;  1ZIE A;  2KP5 A;  1M8U A;  1ZWM A;  1BD7 A;  2B1O A;  1PRR A;  3ENU A;  5HT9 A;  4PSP A;  1A45 A;  2KFB A;  1ELP A;  4JGF A;  1E7N A;  1YTQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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