2M3UA

Solution-state nmr structure of cataract-related human gamma(s)-crystallin point variant g18v
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
178
structure length
178
Chain Sequence
GSKTGTKITFYEDKNFQVRRYDCDCDCADFHTYLSRCNSIKVEGGTWAVYERPNFAGYMYILPQGEYPEYQRWMGLNDRLSSCRAVHLPSGGQYKIQIFEKGDFSGQMYETTEDCPSIMEQFHMREIHSCKVLEGVWIFYELPNYRGRQYLLDKKEYRKPIDWGAASPAVQSFRRIVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Preferential and Specific Binding of Human alpha B-Crystallin to a Cataract-Related Variant of gamma S-Crystallin.
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords Beta-crystallin S
total genus 11
structure length 178
sequence length 178
ec nomenclature
pdb deposition date 2013-01-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00030 Crystall Beta/Gamma crystallin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.20.10 Mainly Beta Sandwich Gamma-B Crystallin; domain 1 Crystallins 2m3uA02
2.60.20.10 Mainly Beta Sandwich Gamma-B Crystallin; domain 1 Crystallins 2m3uA01
3IAJA 1AG4A 1H4AX 1E7NA 3SO0A 4GCRA 1PRRA 1ZIQA 1PRSA 5HT9A 1ZWOA 4IAUA 1ZGTA 2JDFA 1ZIEA 1A5DA 2M3UA 3SNZA 2BB2A 3HZBA 2DADA 4FD9A 4PSPA 1DSLA 1GAMA 4EL6A 1M8UA 1A7HA 1AMMA 1BD7A 2M3CA 2JDGA 3QK3A 4W9BA 2BV2A 2NBRA 3ENTA 2B1OA 1HDFA 2KFBA 1ZWMA 3CW3A 4JGFA 1BLBA 3ENUA 4AKAA 2G98A 2K1XA 3HZ2A 1I5IA 2V2UA 1YTQA 3SNYA 3I9HA 1NPSA 1ZIRA 2K1WA 2KP5A 3LWKA 1GCSA 4PSRA 4W9AA 1ELPA 1A45A 1OKIA 2A5MA 2M3TA 1YHPA 4GR7A 4NI3A 3SO1A 5HT8A 1HA4A 1HK0X
chains in the Genus database with same CATH superfamily
5HT9A 1ZGTA 4FD9A 1DSLA 1A7HA 1BD7A 1HDFA 2KFBA 1BLBA 4AKAA 1WKTA 2V2UA 3I9HA 1A45A 1F53A 4GR7A 3SO1A 1YHPA 1ZWOA 3IAJA 1AG4A 1H4AX 4GCRA 1PRRA 3SNZA 2JDFA 4PSPA 3HZBA 4EL6A 1M8UA 1AMMA 2M3CA 3QK3A 4JGFA 1YTQA 3SNYA 1NPSA 1ZIRA 3LWKA 2KP5A 4PSRA 1GCSA 5HT8A 1OKIA 2M3TA 1E7NA 3SO0A 1PRSA 1A5DA 1GAMA 1C01A 2JDGA 4W9BA 3ENTA 2B1OA 3CW3A 3ENUA 1BHUA 3HZ2A 4W9AA 1G6EA 1ELPA 2A5MA 1HK0X 1ZIQA 4IAUA 2M3UA 1ZIEA 2BB2A 2DADA 2BV2A 2NBRA 3UJZA 1ZWMA 2G98A 2K1XA 1GH5A 1I5IA 2K1WA 4NI3A 1HA4A
chains in the Genus database with same CATH topology
3IAJA 1AG4A 1H4AX 1E7NA 3SO0A 4GCRA 1PRRA 1ZIQA 1PRSA 5HT9A 1ZWOA 4IAUA 1ZGTA 2JDFA 1ZIEA 1A5DA 2M3UA 3SNZA 2BB2A 3HZBA 2DADA 4FD9A 4PSPA 1DSLA 1GAMA 4EL6A 1M8UA 1A7HA 1AMMA 1BD7A 2M3CA 2JDGA 3QK3A 4W9BA 2BV2A 2NBRA 3ENTA 2B1OA 1HDFA 2KFBA 1ZWMA 3CW3A 4JGFA 1BLBA 3ENUA 4AKAA 2G98A 2K1XA 3HZ2A 1I5IA 2V2UA 1YTQA 3SNYA 3I9HA 1NPSA 1ZIRA 2K1WA 2KP5A 3LWKA 1GCSA 4PSRA 4W9AA 1ELPA 1A45A 1OKIA 2A5MA 2M3TA 1YHPA 4GR7A 4NI3A 3SO1A 5HT8A 1HA4A 1HK0X
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3IAJ A;  1AG4 A;  1H4A X;  1E7N A;  3SO0 A;  4GCR A;  1PRR A;  1ZIQ A;  1PRS A;  5HT9 A;  1ZWO A;  4IAU A;  1ZGT A;  2JDF A;  1ZIE A;  1A5D A;  2M3U A;  3SNZ A;  2BB2 A;  3HZB A;  2DAD A;  4FD9 A;  4PSP A;  1DSL A;  1GAM A;  4EL6 A;  1M8U A;  1A7H A;  1AMM A;  1BD7 A;  2M3C A;  2JDG A;  3QK3 A;  4W9B A;  2BV2 A;  2NBR A;  3ENT A;  2B1O A;  1HDF A;  2KFB A;  1ZWM A;  3CW3 A;  4JGF A;  1BLB A;  3ENU A;  4AKA A;  2G98 A;  2K1X A;  3HZ2 A;  1I5I A;  2V2U A;  1YTQ A;  3SNY A;  3I9H A;  1NPS A;  1ZIR A;  2K1W A;  2KP5 A;  3LWK A;  1GCS A;  4PSR A;  4W9A A;  1ELP A;  1A45 A;  1OKI A;  2A5M A;  2M3T A;  1YHP A;  4GR7 A;  4NI3 A;  3SO1 A;  5HT8 A;  1HA4 A;  1HK0 X; 
#chains in the Genus database with same CATH topology
 5HT9 A;  1ZGT A;  4FD9 A;  1DSL A;  1A7H A;  1BD7 A;  1HDF A;  2KFB A;  1BLB A;  4AKA A;  1WKT A;  2V2U A;  3I9H A;  1A45 A;  1F53 A;  4GR7 A;  3SO1 A;  1YHP A;  1ZWO A;  3IAJ A;  1AG4 A;  1H4A X;  4GCR A;  1PRR A;  3SNZ A;  2JDF A;  4PSP A;  3HZB A;  4EL6 A;  1M8U A;  1AMM A;  2M3C A;  3QK3 A;  4JGF A;  1YTQ A;  3SNY A;  1NPS A;  1ZIR A;  3LWK A;  2KP5 A;  4PSR A;  1GCS A;  5HT8 A;  1OKI A;  2M3T A;  1E7N A;  3SO0 A;  1PRS A;  1A5D A;  1GAM A;  1C01 A;  2JDG A;  4W9B A;  3ENT A;  2B1O A;  3CW3 A;  3ENU A;  1BHU A;  3HZ2 A;  4W9A A;  1G6E A;  1ELP A;  2A5M A;  1HK0 X;  1ZIQ A;  4IAU A;  2M3U A;  1ZIE A;  2BB2 A;  2DAD A;  2BV2 A;  2NBR A;  3UJZ A;  1ZWM A;  2G98 A;  2K1X A;  1GH5 A;  1I5I A;  2K1W A;  4NI3 A;  1HA4 A; 
#chains in the Genus database with same CATH homology
 3IAJ A;  1AG4 A;  1H4A X;  1E7N A;  3SO0 A;  4GCR A;  1PRR A;  1ZIQ A;  1PRS A;  5HT9 A;  1ZWO A;  4IAU A;  1ZGT A;  2JDF A;  1ZIE A;  1A5D A;  2M3U A;  3SNZ A;  2BB2 A;  3HZB A;  2DAD A;  4FD9 A;  4PSP A;  1DSL A;  1GAM A;  4EL6 A;  1M8U A;  1A7H A;  1AMM A;  1BD7 A;  2M3C A;  2JDG A;  3QK3 A;  4W9B A;  2BV2 A;  2NBR A;  3ENT A;  2B1O A;  1HDF A;  2KFB A;  1ZWM A;  3CW3 A;  4JGF A;  1BLB A;  3ENU A;  4AKA A;  2G98 A;  2K1X A;  3HZ2 A;  1I5I A;  2V2U A;  1YTQ A;  3SNY A;  3I9H A;  1NPS A;  1ZIR A;  2K1W A;  2KP5 A;  3LWK A;  1GCS A;  4PSR A;  4W9A A;  1ELP A;  1A45 A;  1OKI A;  2A5M A;  2M3T A;  1YHP A;  4GR7 A;  4NI3 A;  3SO1 A;  5HT8 A;  1HA4 A;  1HK0 X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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