2M3UA

Solution-state nmr structure of cataract-related human gamma(s)-crystallin point variant g18v
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
178
structure length
178
Chain Sequence
GSKTGTKITFYEDKNFQVRRYDCDCDCADFHTYLSRCNSIKVEGGTWAVYERPNFAGYMYILPQGEYPEYQRWMGLNDRLSSCRAVHLPSGGQYKIQIFEKGDFSGQMYETTEDCPSIMEQFHMREIHSCKVLEGVWIFYELPNYRGRQYLLDKKEYRKPIDWGAASPAVQSFRRIVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Preferential and Specific Binding of Human alpha B-Crystallin to a Cataract-Related Variant of gamma S-Crystallin.
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords Beta-crystallin S
total genus 11
structure length 178
sequence length 178
ec nomenclature
pdb deposition date 2013-01-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00030 Crystall Beta/Gamma crystallin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.20.10 Mainly Beta Sandwich Gamma-B Crystallin; domain 1 Crystallins 2m3uA02
2.60.20.10 Mainly Beta Sandwich Gamma-B Crystallin; domain 1 Crystallins 2m3uA01
1ZIQA 1HDFA 3HZ2A 1DSLA 2K1WA 1PRSA 2K1XA 1AMMA 1ZWOA 2JDFA 1E7NA 4W9AA 2JDGA 1ZWMA 4AKAA 1NPSA 3I9HA 1ZGTA 2A5MA 1HK0X 4PSPA 4EL6A 3QK3A 1GAMA 2KFBA 2NBRA 3LWKA 3SO1A 1YTQA 2BV2A 1ELPA 2G98A 3IAJA 4FD9A 2BB2A 1YHPA 4GR7A 2M3TA 1ZIEA 3CW3A 1A5DA 1OKIA 4GCRA 2V2UA 1AG4A 4NI3A 1A45A 1BD7A 4JGFA 2M3CA 1ZIRA 3SNZA 3SO0A 3ENTA 3HZBA 1HA4A 1BLBA 2DADA 2M3UA 2B1OA 1M8UA 4IAUA 4PSRA 1GCSA 1A7HA 3ENUA 5HT8A 2KP5A 1PRRA 5HT9A 4W9BA 3SNYA 1H4AX 1I5IA
chains in the Genus database with same CATH superfamily
1HDFA 1DSLA 1PRSA 4AKAA 1E7NA 4EL6A 3SO1A 2BV2A 1ELPA 3IAJA 2M3TA 1ZIEA 3UJZA 1A5DA 1AG4A 1A45A 3ENTA 1BLBA 4IAUA 4W9BA 1I5IA 1ZWOA 4W9AA 1ZWMA 1ZGTA 4PSPA 2G98A 2BB2A 1YHPA 1F53A 4GCRA 3SO0A 3HZBA 3SNYA 5HT8A 3ENUA 1C01A 2KP5A 1PRRA 1H4AX 3HZ2A 2K1WA 2K1XA 1NPSA 2NBRA 1YTQA 1OKIA 1BD7A 2M3CA 1G6EA 1HA4A 2M3UA 1GH5A 2B1OA 1M8UA 4PSRA 1GCSA 1A7HA 5HT9A 1ZIQA 1AMMA 2JDFA 2JDGA 3I9HA 2A5MA 1HK0X 3QK3A 1GAMA 1WKTA 2KFBA 1BHUA 3LWKA 4FD9A 4GR7A 3CW3A 4NI3A 2V2UA 3SNZA 4JGFA 1ZIRA 2DADA
chains in the Genus database with same CATH topology
1ZIQA 1HDFA 3HZ2A 1DSLA 2K1WA 1PRSA 2K1XA 1AMMA 1ZWOA 2JDFA 1E7NA 4W9AA 2JDGA 1ZWMA 4AKAA 1NPSA 3I9HA 1ZGTA 2A5MA 1HK0X 4PSPA 4EL6A 3QK3A 1GAMA 2KFBA 2NBRA 3LWKA 3SO1A 1YTQA 2BV2A 1ELPA 2G98A 3IAJA 4FD9A 2BB2A 1YHPA 4GR7A 2M3TA 1ZIEA 3CW3A 1A5DA 1OKIA 4GCRA 2V2UA 1AG4A 4NI3A 1A45A 1BD7A 4JGFA 2M3CA 1ZIRA 3SNZA 3SO0A 3ENTA 3HZBA 1HA4A 1BLBA 2DADA 2M3UA 2B1OA 1M8UA 4IAUA 4PSRA 1GCSA 1A7HA 3ENUA 5HT8A 2KP5A 1PRRA 5HT9A 4W9BA 3SNYA 1H4AX 1I5IA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZIQ A;  1HDF A;  3HZ2 A;  1DSL A;  2K1W A;  1PRS A;  2K1X A;  1AMM A;  1ZWO A;  2JDF A;  1E7N A;  4W9A A;  2JDG A;  1ZWM A;  4AKA A;  1NPS A;  3I9H A;  1ZGT A;  2A5M A;  1HK0 X;  4PSP A;  4EL6 A;  3QK3 A;  1GAM A;  2KFB A;  2NBR A;  3LWK A;  3SO1 A;  1YTQ A;  2BV2 A;  1ELP A;  2G98 A;  3IAJ A;  4FD9 A;  2BB2 A;  1YHP A;  4GR7 A;  2M3T A;  1ZIE A;  3CW3 A;  1A5D A;  1OKI A;  4GCR A;  2V2U A;  1AG4 A;  4NI3 A;  1A45 A;  1BD7 A;  4JGF A;  2M3C A;  1ZIR A;  3SNZ A;  3SO0 A;  3ENT A;  3HZB A;  1HA4 A;  1BLB A;  2DAD A;  2M3U A;  2B1O A;  1M8U A;  4IAU A;  4PSR A;  1GCS A;  1A7H A;  3ENU A;  5HT8 A;  2KP5 A;  1PRR A;  5HT9 A;  4W9B A;  3SNY A;  1H4A X;  1I5I A; 
#chains in the Genus database with same CATH topology
 1HDF A;  1DSL A;  1PRS A;  4AKA A;  1E7N A;  4EL6 A;  3SO1 A;  2BV2 A;  1ELP A;  3IAJ A;  2M3T A;  1ZIE A;  3UJZ A;  1A5D A;  1AG4 A;  1A45 A;  3ENT A;  1BLB A;  4IAU A;  4W9B A;  1I5I A;  1ZWO A;  4W9A A;  1ZWM A;  1ZGT A;  4PSP A;  2G98 A;  2BB2 A;  1YHP A;  1F53 A;  4GCR A;  3SO0 A;  3HZB A;  3SNY A;  5HT8 A;  3ENU A;  1C01 A;  2KP5 A;  1PRR A;  1H4A X;  3HZ2 A;  2K1W A;  2K1X A;  1NPS A;  2NBR A;  1YTQ A;  1OKI A;  1BD7 A;  2M3C A;  1G6E A;  1HA4 A;  2M3U A;  1GH5 A;  2B1O A;  1M8U A;  4PSR A;  1GCS A;  1A7H A;  5HT9 A;  1ZIQ A;  1AMM A;  2JDF A;  2JDG A;  3I9H A;  2A5M A;  1HK0 X;  3QK3 A;  1GAM A;  1WKT A;  2KFB A;  1BHU A;  3LWK A;  4FD9 A;  4GR7 A;  3CW3 A;  4NI3 A;  2V2U A;  3SNZ A;  4JGF A;  1ZIR A;  2DAD A; 
#chains in the Genus database with same CATH homology
 1ZIQ A;  1HDF A;  3HZ2 A;  1DSL A;  2K1W A;  1PRS A;  2K1X A;  1AMM A;  1ZWO A;  2JDF A;  1E7N A;  4W9A A;  2JDG A;  1ZWM A;  4AKA A;  1NPS A;  3I9H A;  1ZGT A;  2A5M A;  1HK0 X;  4PSP A;  4EL6 A;  3QK3 A;  1GAM A;  2KFB A;  2NBR A;  3LWK A;  3SO1 A;  1YTQ A;  2BV2 A;  1ELP A;  2G98 A;  3IAJ A;  4FD9 A;  2BB2 A;  1YHP A;  4GR7 A;  2M3T A;  1ZIE A;  3CW3 A;  1A5D A;  1OKI A;  4GCR A;  2V2U A;  1AG4 A;  4NI3 A;  1A45 A;  1BD7 A;  4JGF A;  2M3C A;  1ZIR A;  3SNZ A;  3SO0 A;  3ENT A;  3HZB A;  1HA4 A;  1BLB A;  2DAD A;  2M3U A;  2B1O A;  1M8U A;  4IAU A;  4PSR A;  1GCS A;  1A7H A;  3ENU A;  5HT8 A;  2KP5 A;  1PRR A;  5HT9 A;  4W9B A;  3SNY A;  1H4A X;  1I5I A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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