2MH3A

Nmr structure of the basic helix-loop-helix region of the transcriptional repressor hes-1
Total Genus 23
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
70
structure length
70
Chain Sequence
MKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Dna binding protein
source organism Homo sapiens
publication title The basic helix-loop-helix region of the transcriptional repressor hairy and enhancer of split 1 is preorganized to bind DNA.
pubmed doi rcsb
molecule keywords Transcription factor HES-1
total genus 23
structure length 70
sequence length 70
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-11-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00010 HLH Helix-loop-helix DNA-binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.280.10 Few Secondary Structures Irregular MYOD Basic-Helix-Loop-Helix Domain, subunit B Helix-loop-helix DNA-binding domain 2mh3A00
4ATHA 4F3LA 3U5VA 2QL2B 5I50A 2QL2A 4AYAA 1HLOA 4H10B 4ATKA 4H10A 4ATIA 1R05A 1A0AA 1AM9A 2MH3A 2LFHA 5EYOA 2YPBB 1AN2A 2YPBA 1AN4A 1NKPB 1UKLC 1NLWB 1NKPA 1NLWA 1MDYB 1MDYA 2YPAB 3MUJA 2YPAA 5I4ZA 4F3LB
chains in the Genus database with same CATH superfamily
4ATHA 4F3LA 3U5VA 2QL2B 5I50A 2QL2A 4AYAA 1HLOA 4H10B 4ATKA 4H10A 4ATIA 1R05A 1A0AA 1AM9A 2MH3A 1ZZAA 2LFHA 5EYOA 2YPBB 1K1FA 1AN2A 2YPBA 1AN4A 1NKPB 1UKLC 1NLWB 1NKPA 1NLWA 1MDYB 1MDYA 2YPAB 3MUJA 2YPAA 5I4ZA 4F3LB
chains in the Genus database with same CATH topology
4ATHA 4F3LA 3U5VA 2QL2B 5I50A 2QL2A 4AYAA 1HLOA 4H10B 4ATKA 4H10A 4ATIA 1R05A 1A0AA 1AM9A 2MH3A 2LFHA 5EYOA 2YPBB 1AN2A 2YPBA 1AN4A 1NKPB 1UKLC 1NLWB 1NKPA 1NLWA 1MDYB 1MDYA 2YPAB 3MUJA 2YPAA 5I4ZA 4F3LB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ATH A;  4F3L A;  3U5V A;  2QL2 B;  5I50 A;  2QL2 A;  4AYA A;  1HLO A;  4H10 B;  4ATK A;  4H10 A;  4ATI A;  1R05 A;  1A0A A;  1AM9 A;  2MH3 A;  2LFH A;  5EYO A;  2YPB B;  1AN2 A;  2YPB A;  1AN4 A;  1NKP B;  1UKL C;  1NLW B;  1NKP A;  1NLW A;  1MDY B;  1MDY A;  2YPA B;  3MUJ A;  2YPA A;  5I4Z A;  4F3L B; 
#chains in the Genus database with same CATH topology
 4ATH A;  4F3L A;  3U5V A;  2QL2 B;  5I50 A;  2QL2 A;  4AYA A;  1HLO A;  4H10 B;  4ATK A;  4H10 A;  4ATI A;  1R05 A;  1A0A A;  1AM9 A;  2MH3 A;  1ZZA A;  2LFH A;  5EYO A;  2YPB B;  1K1F A;  1AN2 A;  2YPB A;  1AN4 A;  1NKP B;  1UKL C;  1NLW B;  1NKP A;  1NLW A;  1MDY B;  1MDY A;  2YPA B;  3MUJ A;  2YPA A;  5I4Z A;  4F3L B; 
#chains in the Genus database with same CATH homology
 4ATH A;  4F3L A;  3U5V A;  2QL2 B;  5I50 A;  2QL2 A;  4AYA A;  1HLO A;  4H10 B;  4ATK A;  4H10 A;  4ATI A;  1R05 A;  1A0A A;  1AM9 A;  2MH3 A;  2LFH A;  5EYO A;  2YPB B;  1AN2 A;  2YPB A;  1AN4 A;  1NKP B;  1UKL C;  1NLW B;  1NKP A;  1NLW A;  1MDY B;  1MDY A;  2YPA B;  3MUJ A;  2YPA A;  5I4Z A;  4F3L B; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...