2QL2A

Crystal structure of the basic-helix-loop-helix domains of the heterodimer e47/neurod1 bound to dna
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
59
structure length
56
Chain Sequence
RRMANNARERVRVRDINEAFRELGRMCQLHLKAQTKLLILQQAVQVILGLEQQVRE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of E47-NeuroD1/beta2 bHLH domain-DNA complex: heterodimer selectivity and DNA recognition.
pubmed doi rcsb
molecule tags Transcription/dna
source organism Mus musculus
molecule keywords Transcription factor E2-alpha
total genus 25
structure length 56
sequence length 59
chains with identical sequence C
ec nomenclature
pdb deposition date 2007-07-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00010 HLH Helix-loop-helix DNA-binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.280.10 Few Secondary Structures Irregular MYOD Basic-Helix-Loop-Helix Domain, subunit B Helix-loop-helix DNA-binding domain 2ql2A00
4F3LB 4H10B 1MDYA 2YPAA 1NLWA 1MDYB 1AN4A 1AN2A 2YPAB 4ATKA 1R05A 1NLWB 2YPBA 1HLOA 5EYOA 2QL2A 2LFHA 4ATHA 1A0AA 1NKPA 1AM9A 3MUJA 5I4ZA 2YPBB 5I50A 2MH3A 4ATIA 2QL2B 3U5VA 1NKPB 1UKLC 4F3LA 4AYAA 4H10A
chains in the Genus database with same CATH superfamily
4F3LB 4H10B 1MDYA 2YPAA 1NLWA 1MDYB 1AN4A 1AN2A 2YPAB 4ATKA 1R05A 1NLWB 2YPBA 1HLOA 5EYOA 2QL2A 2LFHA 4ATHA 1A0AA 1NKPA 1AM9A 3MUJA 5I4ZA 2YPBB 5I50A 2MH3A 4ATIA 2QL2B 3U5VA 1NKPB 1UKLC 4F3LA 1ZZAA 1K1FA 4AYAA 4H10A
chains in the Genus database with same CATH topology
4F3LB 4H10B 1MDYA 2YPAA 1NLWA 1MDYB 1AN4A 1AN2A 2YPAB 4ATKA 1R05A 1NLWB 2YPBA 1HLOA 5EYOA 2QL2A 2LFHA 4ATHA 1A0AA 1NKPA 1AM9A 3MUJA 5I4ZA 2YPBB 5I50A 2MH3A 4ATIA 2QL2B 3U5VA 1NKPB 1UKLC 4F3LA 4AYAA 4H10A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4F3L B;  4H10 B;  1MDY A;  2YPA A;  1NLW A;  1MDY B;  1AN4 A;  1AN2 A;  2YPA B;  4ATK A;  1R05 A;  1NLW B;  2YPB A;  1HLO A;  5EYO A;  2QL2 A;  2LFH A;  4ATH A;  1A0A A;  1NKP A;  1AM9 A;  3MUJ A;  5I4Z A;  2YPB B;  5I50 A;  2MH3 A;  4ATI A;  2QL2 B;  3U5V A;  1NKP B;  1UKL C;  4F3L A;  4AYA A;  4H10 A; 
#chains in the Genus database with same CATH topology
 4F3L B;  4H10 B;  1MDY A;  2YPA A;  1NLW A;  1MDY B;  1AN4 A;  1AN2 A;  2YPA B;  4ATK A;  1R05 A;  1NLW B;  2YPB A;  1HLO A;  5EYO A;  2QL2 A;  2LFH A;  4ATH A;  1A0A A;  1NKP A;  1AM9 A;  3MUJ A;  5I4Z A;  2YPB B;  5I50 A;  2MH3 A;  4ATI A;  2QL2 B;  3U5V A;  1NKP B;  1UKL C;  4F3L A;  1ZZA A;  1K1F A;  4AYA A;  4H10 A; 
#chains in the Genus database with same CATH homology
 4F3L B;  4H10 B;  1MDY A;  2YPA A;  1NLW A;  1MDY B;  1AN4 A;  1AN2 A;  2YPA B;  4ATK A;  1R05 A;  1NLW B;  2YPB A;  1HLO A;  5EYO A;  2QL2 A;  2LFH A;  4ATH A;  1A0A A;  1NKP A;  1AM9 A;  3MUJ A;  5I4Z A;  2YPB B;  5I50 A;  2MH3 A;  4ATI A;  2QL2 B;  3U5V A;  1NKP B;  1UKL C;  4F3L A;  4AYA A;  4H10 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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