2QL2A

Crystal structure of the basic-helix-loop-helix domains of the heterodimer e47/neurod1 bound to dna
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
59
structure length
56
Chain Sequence
RRMANNARERVRVRDINEAFRELGRMCQLHLKAQTKLLILQQAVQVILGLEQQVRE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of E47-NeuroD1/beta2 bHLH domain-DNA complex: heterodimer selectivity and DNA recognition.
pubmed doi rcsb
molecule keywords Transcription factor E2-alpha
molecule tags Transcription/dna
source organism Mus musculus
total genus 25
structure length 56
sequence length 59
chains with identical sequence C
ec nomenclature
pdb deposition date 2007-07-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00010 HLH Helix-loop-helix DNA-binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.280.10 Few Secondary Structures Irregular MYOD Basic-Helix-Loop-Helix Domain, subunit B Helix-loop-helix DNA-binding domain 2ql2A00
4F3LB 4ATHA 1A0AA 4H10A 4ATIA 2YPAB 1UKLC 1MDYA 1NKPA 1AN4A 4AYAA 2YPBB 1NLWB 1NLWA 5I4ZA 3MUJA 1HLOA 4H10B 2QL2A 1NKPB 1MDYB 1AM9A 1R05A 4F3LA 3U5VA 5EYOA 2MH3A 2QL2B 1AN2A 2YPAA 5I50A 4ATKA 2YPBA 2LFHA
chains in the Genus database with same CATH superfamily
4F3LB 4ATHA 1A0AA 4H10A 4ATIA 2YPAB 1UKLC 1MDYA 1NKPA 1AN4A 4AYAA 2YPBB 1NLWB 1NLWA 5I4ZA 3MUJA 1HLOA 4H10B 2QL2A 1NKPB 1MDYB 1ZZAA 1AM9A 1R05A 1K1FA 4F3LA 3U5VA 5EYOA 2MH3A 2QL2B 1AN2A 2YPAA 5I50A 4ATKA 2YPBA 2LFHA
chains in the Genus database with same CATH topology
4F3LB 4ATHA 1A0AA 4H10A 4ATIA 2YPAB 1UKLC 1MDYA 1NKPA 1AN4A 4AYAA 2YPBB 1NLWB 1NLWA 5I4ZA 3MUJA 1HLOA 4H10B 2QL2A 1NKPB 1MDYB 1AM9A 1R05A 4F3LA 3U5VA 5EYOA 2MH3A 2QL2B 1AN2A 2YPAA 5I50A 4ATKA 2YPBA 2LFHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4F3L B;  4ATH A;  1A0A A;  4H10 A;  4ATI A;  2YPA B;  1UKL C;  1MDY A;  1NKP A;  1AN4 A;  4AYA A;  2YPB B;  1NLW B;  1NLW A;  5I4Z A;  3MUJ A;  1HLO A;  4H10 B;  2QL2 A;  1NKP B;  1MDY B;  1AM9 A;  1R05 A;  4F3L A;  3U5V A;  5EYO A;  2MH3 A;  2QL2 B;  1AN2 A;  2YPA A;  5I50 A;  4ATK A;  2YPB A;  2LFH A; 
#chains in the Genus database with same CATH topology
 4F3L B;  4ATH A;  1A0A A;  4H10 A;  4ATI A;  2YPA B;  1UKL C;  1MDY A;  1NKP A;  1AN4 A;  4AYA A;  2YPB B;  1NLW B;  1NLW A;  5I4Z A;  3MUJ A;  1HLO A;  4H10 B;  2QL2 A;  1NKP B;  1MDY B;  1ZZA A;  1AM9 A;  1R05 A;  1K1F A;  4F3L A;  3U5V A;  5EYO A;  2MH3 A;  2QL2 B;  1AN2 A;  2YPA A;  5I50 A;  4ATK A;  2YPB A;  2LFH A; 
#chains in the Genus database with same CATH homology
 4F3L B;  4ATH A;  1A0A A;  4H10 A;  4ATI A;  2YPA B;  1UKL C;  1MDY A;  1NKP A;  1AN4 A;  4AYA A;  2YPB B;  1NLW B;  1NLW A;  5I4Z A;  3MUJ A;  1HLO A;  4H10 B;  2QL2 A;  1NKP B;  1MDY B;  1AM9 A;  1R05 A;  4F3L A;  3U5V A;  5EYO A;  2MH3 A;  2QL2 B;  1AN2 A;  2YPA A;  5I50 A;  4ATK A;  2YPB A;  2LFH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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