2WFDA

Structure of the human cytosolic leucyl-trna synthetase editing domain
Total Genus 61
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
61
sequence length
252
structure length
252
Chain Sequence
AMGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGDALIYME
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal Structures of the Human and Fungal Cytosolic Leucyl-tRNA Synthetase Editing Domains: A Structural Basis for the Rational Design of Antifungal Benzoxaboroles.
pubmed doi rcsb
molecule tags Ligase
source organism Homo sapiens
molecule keywords LEUCYL-TRNA SYNTHETASE, CYTOPLASMIC
total genus 61
structure length 252
sequence length 252
chains with identical sequence B
ec nomenclature ec 6.1.1.4: Leucine--tRNA ligase.
pdb deposition date 2009-04-03
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.740.10 Alpha Beta Alpha-Beta Complex Isoleucyl-tRNA Synthetase; domain 2 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain 2wfdA00
1WNYA 3O0AA 5AGJA 2WFDA 5AGIA 1ILEA 1WK8A 2V0CA 4K47A 4AS1A 1QU3A 1FFYA 3ZGZA 1WK9A 2BTEA 1WKAA 3PZ5A 3PZ6A 3ZJTA 1OBHA 1WKBA 2V0GA 2AJGA 3PZ0A 4CQNA 1WZ2A 3ZJVA 1GAXA 1JZQA 5AGTA 1H3NA 1OBCA 1JZSA 1WNZA 3ZJUA 5AGSA 2WFGA 1UDZA 4ARCA 2AJIA 2WFEA 1IVSA 4ARIA 5AGRA 2AJHA 2BYTA 4K48A 1QU2A 4AQ7A 5AGHA 1UE0A
chains in the Genus database with same CATH superfamily
1WNYA 3O0AA 5AGJA 2WFDA 5AGIA 1ILEA 1WK8A 2V0CA 4K47A 4AS1A 1QU3A 1FFYA 3ZGZA 1WK9A 2BTEA 1WKAA 3PZ5A 3PZ6A 3ZJTA 1OBHA 1WKBA 2V0GA 2AJGA 3PZ0A 4CQNA 1WZ2A 3ZJVA 1GAXA 1JZQA 5AGTA 1H3NA 1OBCA 1JZSA 1WNZA 3ZJUA 5AGSA 2WFGA 1UDZA 4ARCA 2AJIA 2WFEA 1IVSA 4ARIA 5AGRA 2AJHA 2BYTA 4K48A 1QU2A 4AQ7A 5AGHA 1UE0A
chains in the Genus database with same CATH topology
1WNYA 3O0AA 5AGJA 2WFDA 5AGIA 1ILEA 1WK8A 2V0CA 4K47A 4AS1A 1QU3A 1FFYA 3ZGZA 1WK9A 2BTEA 1WKAA 3PZ5A 3PZ6A 3ZJTA 1OBHA 1WKBA 2V0GA 2AJGA 3PZ0A 4CQNA 1WZ2A 3ZJVA 1GAXA 1JZQA 5AGTA 1H3NA 1OBCA 1JZSA 1WNZA 3ZJUA 5AGSA 2WFGA 1UDZA 4ARCA 2AJIA 2WFEA 1IVSA 4ARIA 5AGRA 2AJHA 2BYTA 4K48A 1QU2A 4AQ7A 5AGHA 1UE0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WNY A;  3O0A A;  5AGJ A;  2WFD A;  5AGI A;  1ILE A;  1WK8 A;  2V0C A;  4K47 A;  4AS1 A;  1QU3 A;  1FFY A;  3ZGZ A;  1WK9 A;  2BTE A;  1WKA A;  3PZ5 A;  3PZ6 A;  3ZJT A;  1OBH A;  1WKB A;  2V0G A;  2AJG A;  3PZ0 A;  4CQN A;  1WZ2 A;  3ZJV A;  1GAX A;  1JZQ A;  5AGT A;  1H3N A;  1OBC A;  1JZS A;  1WNZ A;  3ZJU A;  5AGS A;  2WFG A;  1UDZ A;  4ARC A;  2AJI A;  2WFE A;  1IVS A;  4ARI A;  5AGR A;  2AJH A;  2BYT A;  4K48 A;  1QU2 A;  4AQ7 A;  5AGH A;  1UE0 A; 
#chains in the Genus database with same CATH topology
 1WNY A;  3O0A A;  5AGJ A;  2WFD A;  5AGI A;  1ILE A;  1WK8 A;  2V0C A;  4K47 A;  4AS1 A;  1QU3 A;  1FFY A;  3ZGZ A;  1WK9 A;  2BTE A;  1WKA A;  3PZ5 A;  3PZ6 A;  3ZJT A;  1OBH A;  1WKB A;  2V0G A;  2AJG A;  3PZ0 A;  4CQN A;  1WZ2 A;  3ZJV A;  1GAX A;  1JZQ A;  5AGT A;  1H3N A;  1OBC A;  1JZS A;  1WNZ A;  3ZJU A;  5AGS A;  2WFG A;  1UDZ A;  4ARC A;  2AJI A;  2WFE A;  1IVS A;  4ARI A;  5AGR A;  2AJH A;  2BYT A;  4K48 A;  1QU2 A;  4AQ7 A;  5AGH A;  1UE0 A; 
#chains in the Genus database with same CATH homology
 1WNY A;  3O0A A;  5AGJ A;  2WFD A;  5AGI A;  1ILE A;  1WK8 A;  2V0C A;  4K47 A;  4AS1 A;  1QU3 A;  1FFY A;  3ZGZ A;  1WK9 A;  2BTE A;  1WKA A;  3PZ5 A;  3PZ6 A;  3ZJT A;  1OBH A;  1WKB A;  2V0G A;  2AJG A;  3PZ0 A;  4CQN A;  1WZ2 A;  3ZJV A;  1GAX A;  1JZQ A;  5AGT A;  1H3N A;  1OBC A;  1JZS A;  1WNZ A;  3ZJU A;  5AGS A;  2WFG A;  1UDZ A;  4ARC A;  2AJI A;  2WFE A;  1IVS A;  4ARI A;  5AGR A;  2AJH A;  2BYT A;  4K48 A;  1QU2 A;  4AQ7 A;  5AGH A;  1UE0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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