2YPBA

Structure of the scl:e47 complex bound to dna
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
67
structure length
67
Chain Sequence
GPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLAKLLNDQE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for Lmo2-Driven Recruitment of the Scl:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1
total genus 25
structure length 67
sequence length 67
ec nomenclature
pdb deposition date 2012-10-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00010 HLH Helix-loop-helix DNA-binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.280.10 Few Secondary Structures Irregular MYOD Basic-Helix-Loop-Helix Domain, subunit B Helix-loop-helix DNA-binding domain 2ypbA00
2YPAA 2YPBB 1AM9A 1MDYB 4F3LA 4ATHA 1AN4A 4H10B 1UKLC 1AN2A 1NLWA 5I4ZA 2QL2B 4ATIA 2YPAB 5EYOA 3U5VA 2MH3A 1NKPA 4F3LB 1A0AA 1MDYA 2YPBA 3MUJA 4H10A 2LFHA 1NLWB 1R05A 2QL2A 5I50A 4AYAA 1NKPB 4ATKA 1HLOA
chains in the Genus database with same CATH superfamily
2YPAA 2YPBB 1AM9A 1MDYB 4F3LA 4ATHA 1AN4A 4H10B 1UKLC 1AN2A 1NLWA 5I4ZA 2QL2B 4ATIA 2YPAB 5EYOA 3U5VA 2MH3A 1NKPA 4F3LB 1A0AA 1MDYA 2YPBA 3MUJA 4H10A 2LFHA 1NLWB 1R05A 2QL2A 5I50A 4AYAA 1K1FA 1ZZAA 1NKPB 4ATKA 1HLOA
chains in the Genus database with same CATH topology
2YPAA 2YPBB 1AM9A 1MDYB 4F3LA 4ATHA 1AN4A 4H10B 1UKLC 1AN2A 1NLWA 5I4ZA 2QL2B 4ATIA 2YPAB 5EYOA 3U5VA 2MH3A 1NKPA 4F3LB 1A0AA 1MDYA 2YPBA 3MUJA 4H10A 2LFHA 1NLWB 1R05A 2QL2A 5I50A 4AYAA 1NKPB 4ATKA 1HLOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2YPA A;  2YPB B;  1AM9 A;  1MDY B;  4F3L A;  4ATH A;  1AN4 A;  4H10 B;  1UKL C;  1AN2 A;  1NLW A;  5I4Z A;  2QL2 B;  4ATI A;  2YPA B;  5EYO A;  3U5V A;  2MH3 A;  1NKP A;  4F3L B;  1A0A A;  1MDY A;  2YPB A;  3MUJ A;  4H10 A;  2LFH A;  1NLW B;  1R05 A;  2QL2 A;  5I50 A;  4AYA A;  1NKP B;  4ATK A;  1HLO A; 
#chains in the Genus database with same CATH topology
 2YPA A;  2YPB B;  1AM9 A;  1MDY B;  4F3L A;  4ATH A;  1AN4 A;  4H10 B;  1UKL C;  1AN2 A;  1NLW A;  5I4Z A;  2QL2 B;  4ATI A;  2YPA B;  5EYO A;  3U5V A;  2MH3 A;  1NKP A;  4F3L B;  1A0A A;  1MDY A;  2YPB A;  3MUJ A;  4H10 A;  2LFH A;  1NLW B;  1R05 A;  2QL2 A;  5I50 A;  4AYA A;  1K1F A;  1ZZA A;  1NKP B;  4ATK A;  1HLO A; 
#chains in the Genus database with same CATH homology
 2YPA A;  2YPB B;  1AM9 A;  1MDY B;  4F3L A;  4ATH A;  1AN4 A;  4H10 B;  1UKL C;  1AN2 A;  1NLW A;  5I4Z A;  2QL2 B;  4ATI A;  2YPA B;  5EYO A;  3U5V A;  2MH3 A;  1NKP A;  4F3L B;  1A0A A;  1MDY A;  2YPB A;  3MUJ A;  4H10 A;  2LFH A;  1NLW B;  1R05 A;  2QL2 A;  5I50 A;  4AYA A;  1NKP B;  4ATK A;  1HLO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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