2YPBB

Structure of the scl:e47 complex bound to dna
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
74
structure length
74
Chain Sequence
SLEEKDLRDRERRMANNARERVRVRDINEAFRELGRMCQMHLKSDKAQTKLLILQQAVQVILGLEQQVRERNLN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for Lmo2-Driven Recruitment of the Scl:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1
total genus 28
structure length 74
sequence length 74
ec nomenclature
pdb deposition date 2012-10-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00010 HLH Helix-loop-helix DNA-binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.280.10 Few Secondary Structures Irregular MYOD Basic-Helix-Loop-Helix Domain, subunit B Helix-loop-helix DNA-binding domain 2ypbB00
1NLWA 3U5VA 2YPAB 1AN2A 2YPAA 4ATHA 4F3LB 4F3LA 4AYAA 2LFHA 1AM9A 5I50A 1UKLC 1MDYB 1MDYA 5EYOA 1R05A 1HLOA 5I4ZA 2MH3A 2YPBB 4ATIA 2YPBA 1A0AA 4ATKA 2QL2B 3MUJA 1AN4A 4H10B 4H10A 2QL2A 1NKPB 1NKPA 1NLWB
chains in the Genus database with same CATH superfamily
1NLWA 3U5VA 1ZZAA 2YPAB 1AN2A 2YPAA 4ATHA 4F3LB 4F3LA 4AYAA 2LFHA 1AM9A 1K1FA 5I50A 1UKLC 1MDYB 1MDYA 5EYOA 1R05A 1HLOA 5I4ZA 2MH3A 2YPBB 4ATIA 2YPBA 1A0AA 4ATKA 2QL2B 3MUJA 1AN4A 4H10B 4H10A 2QL2A 1NKPB 1NKPA 1NLWB
chains in the Genus database with same CATH topology
1NLWA 3U5VA 2YPAB 1AN2A 2YPAA 4ATHA 4F3LB 4F3LA 4AYAA 2LFHA 1AM9A 5I50A 1UKLC 1MDYB 1MDYA 5EYOA 1R05A 1HLOA 5I4ZA 2MH3A 2YPBB 4ATIA 2YPBA 1A0AA 4ATKA 2QL2B 3MUJA 1AN4A 4H10B 4H10A 2QL2A 1NKPB 1NKPA 1NLWB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1NLW A;  3U5V A;  2YPA B;  1AN2 A;  2YPA A;  4ATH A;  4F3L B;  4F3L A;  4AYA A;  2LFH A;  1AM9 A;  5I50 A;  1UKL C;  1MDY B;  1MDY A;  5EYO A;  1R05 A;  1HLO A;  5I4Z A;  2MH3 A;  2YPB B;  4ATI A;  2YPB A;  1A0A A;  4ATK A;  2QL2 B;  3MUJ A;  1AN4 A;  4H10 B;  4H10 A;  2QL2 A;  1NKP B;  1NKP A;  1NLW B; 
#chains in the Genus database with same CATH topology
 1NLW A;  3U5V A;  1ZZA A;  2YPA B;  1AN2 A;  2YPA A;  4ATH A;  4F3L B;  4F3L A;  4AYA A;  2LFH A;  1AM9 A;  1K1F A;  5I50 A;  1UKL C;  1MDY B;  1MDY A;  5EYO A;  1R05 A;  1HLO A;  5I4Z A;  2MH3 A;  2YPB B;  4ATI A;  2YPB A;  1A0A A;  4ATK A;  2QL2 B;  3MUJ A;  1AN4 A;  4H10 B;  4H10 A;  2QL2 A;  1NKP B;  1NKP A;  1NLW B; 
#chains in the Genus database with same CATH homology
 1NLW A;  3U5V A;  2YPA B;  1AN2 A;  2YPA A;  4ATH A;  4F3L B;  4F3L A;  4AYA A;  2LFH A;  1AM9 A;  5I50 A;  1UKL C;  1MDY B;  1MDY A;  5EYO A;  1R05 A;  1HLO A;  5I4Z A;  2MH3 A;  2YPB B;  4ATI A;  2YPB A;  1A0A A;  4ATK A;  2QL2 B;  3MUJ A;  1AN4 A;  4H10 B;  4H10 A;  2QL2 A;  1NKP B;  1NKP A;  1NLW B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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