2YPAA

Structure of the scl:e47:lmo2:ldb1 complex bound to dna
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
67
structure length
67
Chain Sequence
PHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLAKLLNDQEE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for Lmo2-Driven Recruitment of the Scl:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1
total genus 23
structure length 67
sequence length 67
ec nomenclature
pdb deposition date 2012-10-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00010 HLH Helix-loop-helix DNA-binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.280.10 Few Secondary Structures Irregular MYOD Basic-Helix-Loop-Helix Domain, subunit B Helix-loop-helix DNA-binding domain 2ypaA00
4AYAA 2YPAB 2YPBA 1UKLC 3U5VA 1R05A 4F3LB 1MDYA 1HLOA 1NLWA 2YPBB 2QL2A 1A0AA 4H10A 2MH3A 5I4ZA 5I50A 1MDYB 4ATIA 1NKPA 1NLWB 2LFHA 2QL2B 3MUJA 1AN2A 5EYOA 4H10B 2YPAA 4ATKA 1AN4A 1NKPB 1AM9A 4F3LA 4ATHA
chains in the Genus database with same CATH superfamily
4AYAA 2YPAB 2YPBA 1UKLC 1K1FA 3U5VA 1ZZAA 1R05A 4F3LB 1MDYA 1HLOA 1NLWA 2YPBB 2QL2A 1A0AA 4H10A 2MH3A 5I4ZA 5I50A 1MDYB 4ATIA 1NKPA 1NLWB 2LFHA 2QL2B 3MUJA 1AN2A 5EYOA 4H10B 2YPAA 4ATKA 1AN4A 1NKPB 1AM9A 4F3LA 4ATHA
chains in the Genus database with same CATH topology
4AYAA 2YPAB 2YPBA 1UKLC 3U5VA 1R05A 4F3LB 1MDYA 1HLOA 1NLWA 2YPBB 2QL2A 1A0AA 4H10A 2MH3A 5I4ZA 5I50A 1MDYB 4ATIA 1NKPA 1NLWB 2LFHA 2QL2B 3MUJA 1AN2A 5EYOA 4H10B 2YPAA 4ATKA 1AN4A 1NKPB 1AM9A 4F3LA 4ATHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AYA A;  2YPA B;  2YPB A;  1UKL C;  3U5V A;  1R05 A;  4F3L B;  1MDY A;  1HLO A;  1NLW A;  2YPB B;  2QL2 A;  1A0A A;  4H10 A;  2MH3 A;  5I4Z A;  5I50 A;  1MDY B;  4ATI A;  1NKP A;  1NLW B;  2LFH A;  2QL2 B;  3MUJ A;  1AN2 A;  5EYO A;  4H10 B;  2YPA A;  4ATK A;  1AN4 A;  1NKP B;  1AM9 A;  4F3L A;  4ATH A; 
#chains in the Genus database with same CATH topology
 4AYA A;  2YPA B;  2YPB A;  1UKL C;  1K1F A;  3U5V A;  1ZZA A;  1R05 A;  4F3L B;  1MDY A;  1HLO A;  1NLW A;  2YPB B;  2QL2 A;  1A0A A;  4H10 A;  2MH3 A;  5I4Z A;  5I50 A;  1MDY B;  4ATI A;  1NKP A;  1NLW B;  2LFH A;  2QL2 B;  3MUJ A;  1AN2 A;  5EYO A;  4H10 B;  2YPA A;  4ATK A;  1AN4 A;  1NKP B;  1AM9 A;  4F3L A;  4ATH A; 
#chains in the Genus database with same CATH homology
 4AYA A;  2YPA B;  2YPB A;  1UKL C;  3U5V A;  1R05 A;  4F3L B;  1MDY A;  1HLO A;  1NLW A;  2YPB B;  2QL2 A;  1A0A A;  4H10 A;  2MH3 A;  5I4Z A;  5I50 A;  1MDY B;  4ATI A;  1NKP A;  1NLW B;  2LFH A;  2QL2 B;  3MUJ A;  1AN2 A;  5EYO A;  4H10 B;  2YPA A;  4ATK A;  1AN4 A;  1NKP B;  1AM9 A;  4F3L A;  4ATH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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