2YPAB

Structure of the scl:e47:lmo2:ldb1 complex bound to dna
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
73
structure length
73
Chain Sequence
EKDLRDRERRMANNARERVRVRDINEAFRELGRMCQMHLKSDKAQTKLLILQQAVQVILGLEQQVRERNLNPK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for Lmo2-Driven Recruitment of the Scl:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1
total genus 28
structure length 73
sequence length 73
ec nomenclature
pdb deposition date 2012-10-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00010 HLH Helix-loop-helix DNA-binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.280.10 Few Secondary Structures Irregular MYOD Basic-Helix-Loop-Helix Domain, subunit B Helix-loop-helix DNA-binding domain 2ypaB00
4H10A 1NLWA 4ATIA 4ATKA 2YPBB 4F3LB 2YPAB 1AN2A 1MDYB 1A0AA 1NKPA 2QL2B 5I4ZA 1R05A 4H10B 2MH3A 4ATHA 5I50A 3U5VA 1NLWB 1AM9A 4F3LA 2YPBA 1MDYA 2YPAA 3MUJA 4AYAA 1UKLC 5EYOA 1AN4A 1HLOA 2LFHA 2QL2A 1NKPB
chains in the Genus database with same CATH superfamily
4H10A 1NLWA 4ATIA 4ATKA 2YPBB 1K1FA 4F3LB 2YPAB 1AN2A 1MDYB 1A0AA 1NKPA 2QL2B 5I4ZA 1R05A 4H10B 2MH3A 4ATHA 5I50A 3U5VA 1NLWB 1AM9A 4F3LA 2YPBA 1MDYA 2YPAA 3MUJA 4AYAA 1UKLC 1ZZAA 5EYOA 1AN4A 1HLOA 2LFHA 2QL2A 1NKPB
chains in the Genus database with same CATH topology
4H10A 1NLWA 4ATIA 4ATKA 2YPBB 4F3LB 2YPAB 1AN2A 1MDYB 1A0AA 1NKPA 2QL2B 5I4ZA 1R05A 4H10B 2MH3A 4ATHA 5I50A 3U5VA 1NLWB 1AM9A 4F3LA 2YPBA 1MDYA 2YPAA 3MUJA 4AYAA 1UKLC 5EYOA 1AN4A 1HLOA 2LFHA 2QL2A 1NKPB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4H10 A;  1NLW A;  4ATI A;  4ATK A;  2YPB B;  4F3L B;  2YPA B;  1AN2 A;  1MDY B;  1A0A A;  1NKP A;  2QL2 B;  5I4Z A;  1R05 A;  4H10 B;  2MH3 A;  4ATH A;  5I50 A;  3U5V A;  1NLW B;  1AM9 A;  4F3L A;  2YPB A;  1MDY A;  2YPA A;  3MUJ A;  4AYA A;  1UKL C;  5EYO A;  1AN4 A;  1HLO A;  2LFH A;  2QL2 A;  1NKP B; 
#chains in the Genus database with same CATH topology
 4H10 A;  1NLW A;  4ATI A;  4ATK A;  2YPB B;  1K1F A;  4F3L B;  2YPA B;  1AN2 A;  1MDY B;  1A0A A;  1NKP A;  2QL2 B;  5I4Z A;  1R05 A;  4H10 B;  2MH3 A;  4ATH A;  5I50 A;  3U5V A;  1NLW B;  1AM9 A;  4F3L A;  2YPB A;  1MDY A;  2YPA A;  3MUJ A;  4AYA A;  1UKL C;  1ZZA A;  5EYO A;  1AN4 A;  1HLO A;  2LFH A;  2QL2 A;  1NKP B; 
#chains in the Genus database with same CATH homology
 4H10 A;  1NLW A;  4ATI A;  4ATK A;  2YPB B;  4F3L B;  2YPA B;  1AN2 A;  1MDY B;  1A0A A;  1NKP A;  2QL2 B;  5I4Z A;  1R05 A;  4H10 B;  2MH3 A;  4ATH A;  5I50 A;  3U5V A;  1NLW B;  1AM9 A;  4F3L A;  2YPB A;  1MDY A;  2YPA A;  3MUJ A;  4AYA A;  1UKL C;  5EYO A;  1AN4 A;  1HLO A;  2LFH A;  2QL2 A;  1NKP B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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