2YPBA

Structure of the scl:e47 complex bound to dna
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
67
structure length
67
Chain Sequence
GPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLAKLLNDQE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for Lmo2-Driven Recruitment of the Scl:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1
total genus 25
structure length 67
sequence length 67
ec nomenclature
pdb deposition date 2012-10-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00010 HLH Helix-loop-helix DNA-binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.280.10 Few Secondary Structures Irregular MYOD Basic-Helix-Loop-Helix Domain, subunit B Helix-loop-helix DNA-binding domain 2ypbA00
1MDYB 1UKLC 2QL2B 1NKPA 1R05A 4H10B 4F3LB 2YPAB 2YPBB 1NLWA 5EYOA 4ATHA 1AM9A 1NKPB 1NLWB 1A0AA 1AN4A 2LFHA 2MH3A 4ATKA 4ATIA 5I4ZA 2QL2A 1MDYA 3MUJA 1HLOA 3U5VA 4F3LA 2YPBA 5I50A 4H10A 2YPAA 4AYAA 1AN2A
chains in the Genus database with same CATH superfamily
1MDYB 1UKLC 2QL2B 1NKPA 1R05A 1ZZAA 4H10B 4F3LB 2YPAB 2YPBB 1NLWA 5EYOA 4ATHA 1AM9A 1NKPB 1NLWB 1A0AA 1AN4A 2LFHA 2MH3A 4ATKA 4ATIA 5I4ZA 2QL2A 1MDYA 3MUJA 1HLOA 3U5VA 1K1FA 4F3LA 2YPBA 5I50A 4H10A 2YPAA 4AYAA 1AN2A
chains in the Genus database with same CATH topology
1MDYB 1UKLC 2QL2B 1NKPA 1R05A 4H10B 4F3LB 2YPAB 2YPBB 1NLWA 5EYOA 4ATHA 1AM9A 1NKPB 1NLWB 1A0AA 1AN4A 2LFHA 2MH3A 4ATKA 4ATIA 5I4ZA 2QL2A 1MDYA 3MUJA 1HLOA 3U5VA 4F3LA 2YPBA 5I50A 4H10A 2YPAA 4AYAA 1AN2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MDY B;  1UKL C;  2QL2 B;  1NKP A;  1R05 A;  4H10 B;  4F3L B;  2YPA B;  2YPB B;  1NLW A;  5EYO A;  4ATH A;  1AM9 A;  1NKP B;  1NLW B;  1A0A A;  1AN4 A;  2LFH A;  2MH3 A;  4ATK A;  4ATI A;  5I4Z A;  2QL2 A;  1MDY A;  3MUJ A;  1HLO A;  3U5V A;  4F3L A;  2YPB A;  5I50 A;  4H10 A;  2YPA A;  4AYA A;  1AN2 A; 
#chains in the Genus database with same CATH topology
 1MDY B;  1UKL C;  2QL2 B;  1NKP A;  1R05 A;  1ZZA A;  4H10 B;  4F3L B;  2YPA B;  2YPB B;  1NLW A;  5EYO A;  4ATH A;  1AM9 A;  1NKP B;  1NLW B;  1A0A A;  1AN4 A;  2LFH A;  2MH3 A;  4ATK A;  4ATI A;  5I4Z A;  2QL2 A;  1MDY A;  3MUJ A;  1HLO A;  3U5V A;  1K1F A;  4F3L A;  2YPB A;  5I50 A;  4H10 A;  2YPA A;  4AYA A;  1AN2 A; 
#chains in the Genus database with same CATH homology
 1MDY B;  1UKL C;  2QL2 B;  1NKP A;  1R05 A;  4H10 B;  4F3L B;  2YPA B;  2YPB B;  1NLW A;  5EYO A;  4ATH A;  1AM9 A;  1NKP B;  1NLW B;  1A0A A;  1AN4 A;  2LFH A;  2MH3 A;  4ATK A;  4ATI A;  5I4Z A;  2QL2 A;  1MDY A;  3MUJ A;  1HLO A;  3U5V A;  4F3L A;  2YPB A;  5I50 A;  4H10 A;  2YPA A;  4AYA A;  1AN2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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