3AH8G

Structure of heterotrimeric g protein galpha-q beta gamma in complex with an inhibitor ym-254890
Total Genus 10
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
10
sequence length
50
structure length
50
Chain Sequence
QARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule.
pubmed doi rcsb
molecule keywords Guanine nucleotide-binding protein G(i) subunit alpha-1/Guan
molecule tags Signaling protein/inhibitor
source organism Rattus norvegicus
total genus 10
structure length 50
sequence length 50
ec nomenclature
pdb deposition date 2010-04-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
G PF00631 G-gamma GGL domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.260.10 Few Secondary Structures Irregular G Protein Gi Gamma 2 Transducin (heterotrimeric G protein), gamma chain 3ah8G00
3V5WG 5HE2G 4PNKG 1TBGE 1GOTG 3SN6G 1A0RG 1GG2G 3PVUG 3AH8G 1OMWG 3PSCG 1XHMB 1B9XB 5HE1G 5TDHG 4MK0G 5HE3G 2PBIA 5HE0G 3KRXG 2BCJG 1GP2G 3KRWG 4KFMG 2TRCG 3PVWG 5KDOG 3CIKG 1B9YB
chains in the Genus database with same CATH superfamily
3V5WG 5HE2G 4PNKG 1TBGE 1GOTG 3SN6G 1A0RG 1GG2G 3AH8G 3PVUG 1IOJA 1OMWG 3PSCG 1HFES 1XHMB 1B9XB 5HE1G 5TDHG 4MK0G 5HE3G 2PBIA 5HE0G 3KRXG 2BCJG 1GP2G 3KRWG 4KFMG 2TRCG 3PVWG 5KDOG 3CIKG 1B9YB
chains in the Genus database with same CATH topology
3V5WG 5HE2G 4PNKG 1TBGE 1GOTG 3SN6G 1A0RG 1GG2G 3PVUG 3AH8G 1OMWG 3PSCG 1XHMB 1B9XB 5HE1G 5TDHG 4MK0G 5HE3G 2PBIA 5HE0G 3KRXG 2BCJG 1GP2G 3KRWG 4KFMG 2TRCG 3PVWG 5KDOG 3CIKG 1B9YB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3V5W G;  5HE2 G;  4PNK G;  1TBG E;  1GOT G;  3SN6 G;  1A0R G;  1GG2 G;  3PVU G;  3AH8 G;  1OMW G;  3PSC G;  1XHM B;  1B9X B;  5HE1 G;  5TDH G;  4MK0 G;  5HE3 G;  2PBI A;  5HE0 G;  3KRX G;  2BCJ G;  1GP2 G;  3KRW G;  4KFM G;  2TRC G;  3PVW G;  5KDO G;  3CIK G;  1B9Y B; 
#chains in the Genus database with same CATH topology
 3V5W G;  5HE2 G;  4PNK G;  1TBG E;  1GOT G;  3SN6 G;  1A0R G;  1GG2 G;  3AH8 G;  3PVU G;  1IOJ A;  1OMW G;  3PSC G;  1HFE S;  1XHM B;  1B9X B;  5HE1 G;  5TDH G;  4MK0 G;  5HE3 G;  2PBI A;  5HE0 G;  3KRX G;  2BCJ G;  1GP2 G;  3KRW G;  4KFM G;  2TRC G;  3PVW G;  5KDO G;  3CIK G;  1B9Y B; 
#chains in the Genus database with same CATH homology
 3V5W G;  5HE2 G;  4PNK G;  1TBG E;  1GOT G;  3SN6 G;  1A0R G;  1GG2 G;  3PVU G;  3AH8 G;  1OMW G;  3PSC G;  1XHM B;  1B9X B;  5HE1 G;  5TDH G;  4MK0 G;  5HE3 G;  2PBI A;  5HE0 G;  3KRX G;  2BCJ G;  1GP2 G;  3KRW G;  4KFM G;  2TRC G;  3PVW G;  5KDO G;  3CIK G;  1B9Y B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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