3AH8G

Structure of heterotrimeric g protein galpha-q beta gamma in complex with an inhibitor ym-254890
Total Genus 10
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
10
sequence length
50
structure length
50
Chain Sequence
QARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule.
pubmed doi rcsb
molecule keywords Guanine nucleotide-binding protein G(i) subunit alpha-1/Guan
molecule tags Signaling protein/inhibitor
source organism Rattus norvegicus
total genus 10
structure length 50
sequence length 50
ec nomenclature
pdb deposition date 2010-04-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
G PF00631 G-gamma GGL domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.260.10 Few Secondary Structures Irregular G Protein Gi Gamma 2 Transducin (heterotrimeric G protein), gamma chain 3ah8G00
1OMWG 3PVWG 5HE0G 5HE3G 1A0RG 1B9XB 3SN6G 5KDOG 1GP2G 3KRWG 1B9YB 2PBIA 5TDHG 4PNKG 4MK0G 1GOTG 2BCJG 3PSCG 3V5WG 3AH8G 4KFMG 5HE2G 3KRXG 5HE1G 1GG2G 1TBGE 3CIKG 2TRCG 3PVUG 1XHMB
chains in the Genus database with same CATH superfamily
1OMWG 3PVWG 5HE0G 5HE3G 1IOJA 1A0RG 1B9XB 3SN6G 5KDOG 1GP2G 3KRWG 1B9YB 2PBIA 5TDHG 4PNKG 4MK0G 1GOTG 2BCJG 3PSCG 3V5WG 3AH8G 4KFMG 5HE2G 3KRXG 5HE1G 1GG2G 1TBGE 3CIKG 1HFES 2TRCG 3PVUG 1XHMB
chains in the Genus database with same CATH topology
1OMWG 3PVWG 5HE0G 5HE3G 1A0RG 1B9XB 3SN6G 5KDOG 1GP2G 3KRWG 1B9YB 2PBIA 5TDHG 4PNKG 4MK0G 1GOTG 2BCJG 3PSCG 3V5WG 3AH8G 4KFMG 5HE2G 3KRXG 5HE1G 1GG2G 1TBGE 3CIKG 2TRCG 3PVUG 1XHMB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1OMW G;  3PVW G;  5HE0 G;  5HE3 G;  1A0R G;  1B9X B;  3SN6 G;  5KDO G;  1GP2 G;  3KRW G;  1B9Y B;  2PBI A;  5TDH G;  4PNK G;  4MK0 G;  1GOT G;  2BCJ G;  3PSC G;  3V5W G;  3AH8 G;  4KFM G;  5HE2 G;  3KRX G;  5HE1 G;  1GG2 G;  1TBG E;  3CIK G;  2TRC G;  3PVU G;  1XHM B; 
#chains in the Genus database with same CATH topology
 1OMW G;  3PVW G;  5HE0 G;  5HE3 G;  1IOJ A;  1A0R G;  1B9X B;  3SN6 G;  5KDO G;  1GP2 G;  3KRW G;  1B9Y B;  2PBI A;  5TDH G;  4PNK G;  4MK0 G;  1GOT G;  2BCJ G;  3PSC G;  3V5W G;  3AH8 G;  4KFM G;  5HE2 G;  3KRX G;  5HE1 G;  1GG2 G;  1TBG E;  3CIK G;  1HFE S;  2TRC G;  3PVU G;  1XHM B; 
#chains in the Genus database with same CATH homology
 1OMW G;  3PVW G;  5HE0 G;  5HE3 G;  1A0R G;  1B9X B;  3SN6 G;  5KDO G;  1GP2 G;  3KRW G;  1B9Y B;  2PBI A;  5TDH G;  4PNK G;  4MK0 G;  1GOT G;  2BCJ G;  3PSC G;  3V5W G;  3AH8 G;  4KFM G;  5HE2 G;  3KRX G;  5HE1 G;  1GG2 G;  1TBG E;  3CIK G;  2TRC G;  3PVU G;  1XHM B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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