3V5WG

Human g protein-coupled receptor kinase 2 in complex with soluble gbetagamma subunits and paroxetine
Total Genus 15
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
57
structure length
57
Chain Sequence
SIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Homo sapiens
molecule keywords G-protein coupled receptor kinase 2
total genus 15
structure length 57
sequence length 57
ec nomenclature
pdb deposition date 2011-12-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
G PF00631 G-gamma GGL domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.260.10 Few Secondary Structures Irregular G Protein Gi Gamma 2 Transducin (heterotrimeric G protein), gamma chain 3v5wG00
4PNKG 1GOTG 1B9XB 2BCJG 3AH8G 4KFMG 3V5WG 1OMWG 5HE3G 1GP2G 5HE2G 5HE0G 5TDHG 5HE1G 1B9YB 3PVWG 1GG2G 3KRXG 3PSCG 5KDOG 3KRWG 1TBGE 2PBIA 3SN6G 3CIKG 3PVUG 2TRCG 1A0RG 1XHMB 4MK0G
chains in the Genus database with same CATH superfamily
4PNKG 1GOTG 1B9XB 2BCJG 3AH8G 4KFMG 3V5WG 1OMWG 5HE3G 1GP2G 5HE2G 5HE0G 1IOJA 5TDHG 5HE1G 1B9YB 3PVWG 1GG2G 3KRXG 3PSCG 5KDOG 3KRWG 1TBGE 2PBIA 3SN6G 3CIKG 3PVUG 2TRCG 1A0RG 1XHMB 1HFES 4MK0G
chains in the Genus database with same CATH topology
4PNKG 1GOTG 1B9XB 2BCJG 3AH8G 4KFMG 3V5WG 1OMWG 5HE3G 1GP2G 5HE2G 5HE0G 5TDHG 5HE1G 1B9YB 3PVWG 1GG2G 3KRXG 3PSCG 5KDOG 3KRWG 1TBGE 2PBIA 3SN6G 3CIKG 3PVUG 2TRCG 1A0RG 1XHMB 4MK0G
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4PNK G;  1GOT G;  1B9X B;  2BCJ G;  3AH8 G;  4KFM G;  3V5W G;  1OMW G;  5HE3 G;  1GP2 G;  5HE2 G;  5HE0 G;  5TDH G;  5HE1 G;  1B9Y B;  3PVW G;  1GG2 G;  3KRX G;  3PSC G;  5KDO G;  3KRW G;  1TBG E;  2PBI A;  3SN6 G;  3CIK G;  3PVU G;  2TRC G;  1A0R G;  1XHM B;  4MK0 G; 
#chains in the Genus database with same CATH topology
 4PNK G;  1GOT G;  1B9X B;  2BCJ G;  3AH8 G;  4KFM G;  3V5W G;  1OMW G;  5HE3 G;  1GP2 G;  5HE2 G;  5HE0 G;  1IOJ A;  5TDH G;  5HE1 G;  1B9Y B;  3PVW G;  1GG2 G;  3KRX G;  3PSC G;  5KDO G;  3KRW G;  1TBG E;  2PBI A;  3SN6 G;  3CIK G;  3PVU G;  2TRC G;  1A0R G;  1XHM B;  1HFE S;  4MK0 G; 
#chains in the Genus database with same CATH homology
 4PNK G;  1GOT G;  1B9X B;  2BCJ G;  3AH8 G;  4KFM G;  3V5W G;  1OMW G;  5HE3 G;  1GP2 G;  5HE2 G;  5HE0 G;  5TDH G;  5HE1 G;  1B9Y B;  3PVW G;  1GG2 G;  3KRX G;  3PSC G;  5KDO G;  3KRW G;  1TBG E;  2PBI A;  3SN6 G;  3CIK G;  3PVU G;  2TRC G;  1A0R G;  1XHM B;  4MK0 G; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...