3V5WG

Human g protein-coupled receptor kinase 2 in complex with soluble gbetagamma subunits and paroxetine
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
57
structure length
57
Chain Sequence
SIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase/transferase inhibitor
molecule keywords G-protein coupled receptor kinase 2
publication title Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.
pubmed doi rcsb
source organism Homo sapiens
total genus 15
structure length 57
sequence length 57
ec nomenclature
pdb deposition date 2011-12-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
G PF00631 G-gamma GGL domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.260.10 Few Secondary Structures Irregular G Protein Gi Gamma 2 Transducin (heterotrimeric G protein), gamma chain 3v5wG00
3SN6G 3KRXG 1GP2G 2BCJG 3KRWG 1B9YB 4KFMG 3PVWG 3V5WG 5HE3G 1XHMB 3PVUG 1GG2G 1OMWG 2TRCG 5TDHG 5KDOG 2PBIA 3PSCG 1TBGE 4MK0G 4PNKG 3CIKG 5HE1G 1A0RG 1B9XB 5HE0G 5HE2G 3AH8G 1GOTG
chains in the Genus database with same CATH superfamily
1HFES 3SN6G 3KRXG 1GP2G 2BCJG 3KRWG 1B9YB 4KFMG 3PVWG 3V5WG 5HE3G 1XHMB 3PVUG 1GG2G 1OMWG 2TRCG 5TDHG 5KDOG 2PBIA 3PSCG 1TBGE 4MK0G 4PNKG 3CIKG 5HE1G 1A0RG 1B9XB 5HE0G 5HE2G 3AH8G 1IOJA 1GOTG
chains in the Genus database with same CATH topology
3SN6G 3KRXG 1GP2G 2BCJG 3KRWG 1B9YB 4KFMG 3PVWG 3V5WG 5HE3G 1XHMB 3PVUG 1GG2G 1OMWG 2TRCG 5TDHG 5KDOG 2PBIA 3PSCG 1TBGE 4MK0G 4PNKG 3CIKG 5HE1G 1A0RG 1B9XB 5HE0G 5HE2G 3AH8G 1GOTG
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3SN6 G;  3KRX G;  1GP2 G;  2BCJ G;  3KRW G;  1B9Y B;  4KFM G;  3PVW G;  3V5W G;  5HE3 G;  1XHM B;  3PVU G;  1GG2 G;  1OMW G;  2TRC G;  5TDH G;  5KDO G;  2PBI A;  3PSC G;  1TBG E;  4MK0 G;  4PNK G;  3CIK G;  5HE1 G;  1A0R G;  1B9X B;  5HE0 G;  5HE2 G;  3AH8 G;  1GOT G; 
#chains in the Genus database with same CATH topology
 1HFE S;  3SN6 G;  3KRX G;  1GP2 G;  2BCJ G;  3KRW G;  1B9Y B;  4KFM G;  3PVW G;  3V5W G;  5HE3 G;  1XHM B;  3PVU G;  1GG2 G;  1OMW G;  2TRC G;  5TDH G;  5KDO G;  2PBI A;  3PSC G;  1TBG E;  4MK0 G;  4PNK G;  3CIK G;  5HE1 G;  1A0R G;  1B9X B;  5HE0 G;  5HE2 G;  3AH8 G;  1IOJ A;  1GOT G; 
#chains in the Genus database with same CATH homology
 3SN6 G;  3KRX G;  1GP2 G;  2BCJ G;  3KRW G;  1B9Y B;  4KFM G;  3PVW G;  3V5W G;  5HE3 G;  1XHM B;  3PVU G;  1GG2 G;  1OMW G;  2TRC G;  5TDH G;  5KDO G;  2PBI A;  3PSC G;  1TBG E;  4MK0 G;  4PNK G;  3CIK G;  5HE1 G;  1A0R G;  1B9X B;  5HE0 G;  5HE2 G;  3AH8 G;  1GOT G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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