3N7SA

Crystal structure of the ectodomain complex of the cgrp receptor, a class-b gpcr, reveals the site of drug antagonism
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
97
structure length
94
Chain Sequence
IQLGVTRNKIMTAQYECYQKIMQDPIEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism.
pubmed doi rcsb
molecule tags Membrane protein
source organism Homo sapiens
molecule keywords Calcitonin gene-related peptide type 1 receptor
total genus 24
structure length 94
sequence length 97
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-05-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02793 HRM Hormone receptor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.1240.10 Few Secondary Structures Irregular Hormone receptor fold GPCR, family 2, extracellular hormone receptor domain 3n7sA00
2L27A 3AQFB 4HJ0A 3C4MA 4ERSA 5II0A 3EHSA 3L2JA 3N7PA 3C5TA 2JODA 3EHUA 3H3GA 3EHTA 2XDGA 4LF3C 1U34A 3N7SA 4DLQA 2QKHA 3C59A 3N7RA 4ZGMA 3IOLA 2JNDA 2JNCA 4DLOA
chains in the Genus database with same CATH superfamily
2L27A 3AQFB 4HJ0A 3C4MA 4ERSA 5II0A 3EHSA 3L2JA 3N7PA 3C5TA 2JODA 3EHUA 3H3GA 3EHTA 2XDGA 4LF3C 1U34A 3N7SA 4DLQA 2QKHA 3C59A 3N7RA 4ZGMA 3IOLA 2JNDA 2JNCA 4DLOA
chains in the Genus database with same CATH topology
2L27A 3AQFB 4HJ0A 3C4MA 4ERSA 5II0A 3EHSA 3L2JA 3N7PA 3C5TA 2JODA 3EHUA 3H3GA 3EHTA 2XDGA 4LF3C 1U34A 3N7SA 4DLQA 2QKHA 3C59A 3N7RA 4ZGMA 3IOLA 2JNDA 2JNCA 4DLOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2L27 A;  3AQF B;  4HJ0 A;  3C4M A;  4ERS A;  5II0 A;  3EHS A;  3L2J A;  3N7P A;  3C5T A;  2JOD A;  3EHU A;  3H3G A;  3EHT A;  2XDG A;  4LF3 C;  1U34 A;  3N7S A;  4DLQ A;  2QKH A;  3C59 A;  3N7R A;  4ZGM A;  3IOL A;  2JND A;  2JNC A;  4DLO A; 
#chains in the Genus database with same CATH topology
 2L27 A;  3AQF B;  4HJ0 A;  3C4M A;  4ERS A;  5II0 A;  3EHS A;  3L2J A;  3N7P A;  3C5T A;  2JOD A;  3EHU A;  3H3G A;  3EHT A;  2XDG A;  4LF3 C;  1U34 A;  3N7S A;  4DLQ A;  2QKH A;  3C59 A;  3N7R A;  4ZGM A;  3IOL A;  2JND A;  2JNC A;  4DLO A; 
#chains in the Genus database with same CATH homology
 2L27 A;  3AQF B;  4HJ0 A;  3C4M A;  4ERS A;  5II0 A;  3EHS A;  3L2J A;  3N7P A;  3C5T A;  2JOD A;  3EHU A;  3H3G A;  3EHT A;  2XDG A;  4LF3 C;  1U34 A;  3N7S A;  4DLQ A;  2QKH A;  3C59 A;  3N7R A;  4ZGM A;  3IOL A;  2JND A;  2JNC A;  4DLO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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