3N7SA

Crystal structure of the ectodomain complex of the cgrp receptor, a class-b gpcr, reveals the site of drug antagonism
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
97
structure length
94
Chain Sequence
IQLGVTRNKIMTAQYECYQKIMQDPIEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism.
pubmed doi rcsb
molecule tags Membrane protein
source organism Homo sapiens
molecule keywords Calcitonin gene-related peptide type 1 receptor
total genus 24
structure length 94
sequence length 97
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-05-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02793 HRM Hormone receptor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.1240.10 Few Secondary Structures Irregular Hormone receptor fold GPCR, family 2, extracellular hormone receptor domain 3n7sA00
3EHSA 2JNDA 4HJ0A 3H3GA 2JNCA 5II0A 2XDGA 3C4MA 4LF3C 3N7PA 3C5TA 1U34A 2QKHA 3N7RA 2L27A 3EHUA 3L2JA 4DLQA 4ERSA 3C59A 3AQFB 4DLOA 3EHTA 4ZGMA 2JODA 3IOLA 3N7SA
chains in the Genus database with same CATH superfamily
3EHSA 2JNDA 4HJ0A 3H3GA 2JNCA 5II0A 2XDGA 3C4MA 4LF3C 3N7PA 3C5TA 1U34A 2QKHA 3N7RA 2L27A 3EHUA 3L2JA 4DLQA 4ERSA 3C59A 3AQFB 4DLOA 3EHTA 4ZGMA 2JODA 3IOLA 3N7SA
chains in the Genus database with same CATH topology
3EHSA 2JNDA 4HJ0A 3H3GA 2JNCA 5II0A 2XDGA 3C4MA 4LF3C 3N7PA 3C5TA 1U34A 2QKHA 3N7RA 2L27A 3EHUA 3L2JA 4DLQA 4ERSA 3C59A 3AQFB 4DLOA 3EHTA 4ZGMA 2JODA 3IOLA 3N7SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3EHS A;  2JND A;  4HJ0 A;  3H3G A;  2JNC A;  5II0 A;  2XDG A;  3C4M A;  4LF3 C;  3N7P A;  3C5T A;  1U34 A;  2QKH A;  3N7R A;  2L27 A;  3EHU A;  3L2J A;  4DLQ A;  4ERS A;  3C59 A;  3AQF B;  4DLO A;  3EHT A;  4ZGM A;  2JOD A;  3IOL A;  3N7S A; 
#chains in the Genus database with same CATH topology
 3EHS A;  2JND A;  4HJ0 A;  3H3G A;  2JNC A;  5II0 A;  2XDG A;  3C4M A;  4LF3 C;  3N7P A;  3C5T A;  1U34 A;  2QKH A;  3N7R A;  2L27 A;  3EHU A;  3L2J A;  4DLQ A;  4ERS A;  3C59 A;  3AQF B;  4DLO A;  3EHT A;  4ZGM A;  2JOD A;  3IOL A;  3N7S A; 
#chains in the Genus database with same CATH homology
 3EHS A;  2JND A;  4HJ0 A;  3H3G A;  2JNC A;  5II0 A;  2XDG A;  3C4M A;  4LF3 C;  3N7P A;  3C5T A;  1U34 A;  2QKH A;  3N7R A;  2L27 A;  3EHU A;  3L2J A;  4DLQ A;  4ERS A;  3C59 A;  3AQF B;  4DLO A;  3EHT A;  4ZGM A;  2JOD A;  3IOL A;  3N7S A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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